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All Journal Jurnal Keperawatan dan Fisioterapi (JKF) Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Penelitian Farmasi dan Herbal Jurnal Antara Abdimas Keperawatan Jurnal Pengmas Kestra (JPK)
Yanna Rotua Sihombing
Institut Kesehatan Medistra Lubuk Pakam
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Other

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Anti-Aging Activity Test and Physical Stability Evaluation of NanoCream  Containing Ethanolic Extract of Binara Herb (Artemisia vulgaris L.) Romauli Anna Marbun; *, Yanna Rotua Sihombing; Ratih Anggraeni
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/xecp6c81

Abstract

Background: Antioxidants are compounds that neutralize free radicals or prevent their formation by slowing oxidative reactions, thereby helping to inhibit premature skin aging. Binara herb (Artemisia vulgaris L.) is one of the plants with potential antioxidant properties. Previous studies have shown that binara herb contains flavonoids and exhibits moderate to strong antioxidant activity. Objective: This study aimed to formulate a stable and effective nanoCream  preparation containing binara herb extract (Artemisia vulgaris L.) as an anti-aging agent. Methods: This study employed an experimental research design. The pH test results met the acceptable range (4.5–7), and the viscosity test results complied with the required standard (2,000–5,000 cps). Results: The ethanolic extract of binara herb (Artemisia vulgaris L.) demonstrated very strong antioxidant activity with an IC₅₀ value of 40.36 ± 1.21 µg/mL. The nanoCream  formulation showed good physical stability during storage, as indicated by stable organoleptic characteristics, pH values within the skin-compatible range (6.6–6.8), and viscosity increasing with higher extract concentrations. The irritation test revealed that the 10% nanoCream  formulation was safe and did not cause irritation in volunteers. These findings indicate that the nanoCream  containing ethanolic extract of binara herb has potential for development as a herbal-based anti-aging preparation. Conclusion: The ethanol extract of binara herb showed very strong antioxidant activity (IC₅₀ 40.36 ± 1.21 µg/mL). The formulated nanoCream  was physically stable, had a skin-compatible pH (6.6–6.8), showed increased viscosity with higher extract concentrations, and caused no irritation up to a 10% concentration. Therefore, this nanoCream  has potential as a stable, safe, and effective herbal anti-aging formulation.
Socialization and Education on the Utilization of Binara Herb (Artemisia vulgaris L.) as a Herbal Anti-Aging Cosmetic Ingredient Romauli Anna Marbun; Ratih Anggraeni; Yanna Rotua Sihombing; Novidawati Boru Situmorang; Cucu Arum Dwi Cahya
JURNAL PENGMAS KESTRA (JPK) Vol. 6 No. 1 (2026): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/40epy157

Abstract

Background: Premature aging is a common skin health problem caused by exposure to ultraviolet radiation, pollution, and free radicals. Antioxidants play an important role in preventing skin damage by neutralizing free radicals that contribute to premature aging. Binara herb (Artemisia vulgaris  L.) is known to contain flavonoids and other bioactive compounds with strong antioxidant activity. Previous studies have shown that the ethanolic extract of binara herb formulated as a Nanocream exhibits high antioxidant activity, good physical stability, and is safe for topical application. However, information regarding the potential of binara herb as a herbal anti-aging candidate remains limited among the public and students. Objective: his community service activity aimed to provide socialization and education regarding the utilization of Nanocream containing binara herb extract as a safe and innovative natural-based anti-aging product candidate. Methods: The activity was conducted through an online educational program involving students of the Pharmacy Study Program at the Medistra Institute of Health, Lubuk Pakam. Participants’ knowledge was evaluated using pre-test and post-test questionnaires. Results: The educational materials covered the antioxidant benefits of binara herb, the concept of Nanocream, findings from anti-aging activity studies, product safety, and the potential development of herbal cosmetic products based on nanotechnology. The evaluation results showed that more than 90% of participants understood the benefits of binara herb as a natural antioxidant source and recognized the potential of Nanocream as a future anti-aging formulation. The success indicator of the activity was achieved, with more than 80% of participants obtaining post-test scores above 75. Conclusion: The educational and socialization program successfully improved students’ knowledge regarding the utilization of Nanocream containing binara herb extract as a natural-based anti-aging candidate. The students also demonstrated interest in conducting further research related to the development of herbal cosmetics and nanotechnology applications in the pharmaceutical field.
In Vitro Acute Toxicity Evaluation as an Approach to Developing a Safe Feminine Hygiene   Product Containing Citronella Grass (Cymbopogon nardus) Yosi Darmirani; Yanna Rotua Sihombing; Preety Sinthya; Restina Br Samosir; Yohana Friska Ana Liduina Marbun
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.3824

Abstract

Background: Natural-based Feminine Hygiene   products have the potential to serve as an alternative for intimate cleansing preparations. Citronella grass (Cymbopogon nardus L.) is one potential ingredient due to its secondary metabolites and antimicrobial activity. However, its application to sensitive areas requires safety evaluation to ensure that it does not cause toxic effects at the cellular level. Objective: This study aimed to evaluate the acute in vitro toxicity and viability of Human Dermal Fibroblast (HDF) cells exposed to a Feminine Hygiene   preparation containing citronella grass extract. Methods: An experimental in vitro design was employed. The preparation was formulated into four formulas: F1 without extract as the negative control, F2 containing 2% extract, F3 containing 3% extract, and F4 containing 4% extract. Toxicity was evaluated using HDF cells by measuring cell viability using the MTT assay. Each treatment was performed in triplicate, and the results were expressed as cell viability percentages.Results: F1 showed a cell viability of 97.81 ± 0.35%, while F2, F3, and F4 showed viabilities of 94.18 ± 0.45%, 91.34 ± 0.43%, and 87.67 ± 0.54%, respectively. All formulas showed cell viability above 70% and were categorized as non-toxic under the test conditions.Conclusion: The Feminine Hygiene   preparations containing 2–4% citronella grass extract demonstrated high HDF cell viability and no significant acute cytotoxicity. Formulations containing up to 4% extract have potential for further development as natural-based Feminine Hygiene   preparations with good cellular compatibility.
Co-Authors Aminah Syarifudin Asti Pratiwi Cahya, Cucu Arum Dwi Debi Dinha Octora Sitepu Fatima, Nurdilla Fitri Siska Friska Novita Pasaribu Juliana, Iga Karmayanti Klara Jeina Br Tarigan Kristian Cahayani Zebua Lenni Rismayanti Lestari, Dayana Maharani, Anisa Nainggolan, Hotdoriska Nasution, Dina Wahyuni Nasution, Muhammad Hamim Novandi Purba Novidawati Boru Situmorang Novidawati Br Situmorang Nur Ulina M. Br. Turnip Octavian Ashido Nababan Parinduri, Anggi Isnani Pranata, Chandra Preety Sinthya Ratih Anggraeni Ratih Anggraeni Ratih Anggraeni Restina Br Samosir Rinaldo Berutu Romaulianna Theresia Marbun SAADAH SIREGAR Sinaga, Falentina Sinurat, Jhon Patar Siska, Fitri Siti Wahyuni Suci Wulandari Suci Wulandari Syarifuddin, Aminah Nur Yohana Friska Ana Liduina Marbun Yosi Darmirani Zebua, Kristian Cahayani