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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Medicine Proceedings of the International Conference on Applied Science and Health Global Health Management Journal Tunas Medika Jurnal Kedokteran & Kesehatan InaBHS (Indonesian Journal of Biomedicine and Health Science)
Donny Nauphar
Fakultas Kedokteran Unswagati
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Global Health Management Journal

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The International Conferences on Applied Science and Health (ICASH): Efforts and Commitments in Translating Research Results into Policy and Practices, for a Better Society Widyastari, Dyah Anantalia; Sinaga, Doni Marisi; Wibowo, Canggih Puspo; Rahman, Pamuko Aditya; Noor, Hafizh Muhammad; Irawan, Dimas Sondang; Fatmarizka, Tiara; Diary, Dwina Gustia; Putra, I Gusti Ngurah Edi; Maretalinia, Maretalinia; Viniriani, Marina Ayu; Destiwi, Monita; Shidiq, Galih Albarra; Pratiwi, Ivana Aprilia; Kusuma, Made Dian Shanti; Dharmapatni, Ni Wayan Kesari; Pratama, Mahendrawan Nugraha Aji; Norsaputra, Ary; Pancanugraha, Andi; Kurniawan, Febrian Hendra; Putra, Wahyu Manggala; Fattah, Rifqi Abdul; Moehas, Puput Kusumawardani; Samosir, Ricky Alexander; Hananto, Andang Adi Fitria; Agastya, I Gusti Ngurah; Susilo, Taufik Eko; Vejvisithsakul, Pichpisith Pierre; Nauphar, Donny; Sari, Ariestya Indah Permata; Macnab, Andrew John
GHMJ (Global Health Management Journal) Vol 3, No 3 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (787.653 KB) | DOI: 10.35898/ghmj-33451

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The International Conferences on Applied Science and Health (ICASH): Efforts and Commitments in Translating Research Results into Policy and Practices, for a Better Society Dyah Anantalia Widyastari; Doni Marisi Sinaga; Canggih Puspo Wibowo; Pamuko Aditya Rahman; Hafizh Muhammad Noor; Dimas Sondang Irawan; Tiara Fatmarizka; Dwina Gustia Diary; I Gusti Ngurah Edi Putra; Maretalinia Maretalinia; Marina Ayu Viniriani; Monita Destiwi; Galih Albarra Shidiq; Ivana Aprilia Pratiwi; Made Dian Shanti Kusuma; Ni Wayan Kesari Dharmapatni; Mahendrawan Nugraha Aji Pratama; Ary Norsaputra; Andi Pancanugraha; Febrian Hendra Kurniawan; Wahyu Manggala Putra; Rifqi Abdul Fattah; Puput Kusumawardani Moehas; Ricky Alexander Samosir; Andang Adi Fitria Hananto; I Gusti Ngurah Agastya; Taufik Eko Susilo; Pichpisith Pierre Vejvisithsakul; Donny Nauphar; Ariestya Indah Permata Sari; Andrew John Macnab
GHMJ (Global Health Management Journal) Vol. 3 No. 3 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-33451

Abstract

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The International Conferences on Applied Science and Health (ICASH): Efforts and Commitments in Translating Research Results into Policy and Practices, for a Better Society Dyah Anantalia Widyastari; Doni Marisi Sinaga; Canggih Puspo Wibowo; Pamuko Aditya Rahman; Hafizh Muhammad Noor; Dimas Sondang; Tiara Fatmarizka; Dwina Gustia Diary; I Gusti Ngurah Edi Putra; Maretalinia; Marina Ayu Viniriani; Monita Destiwi; Galih Albarra Shidiq; Ivana Aprilia Pratiwi; Made Dian Shanti Kusuma; Ni Wayan Kesari Dharmapatni; Mahendrawan Nugraha Aji Pratama; Ary Norsaputra; Andi Pancanugraha; Febrian Hendra Kurniawan; Wahyu Manggala Putra; Rifqi Abdul Fattah; Puput Kusumawardani Moehas; Ricky Alexander Samosir; Andang Adi Fitria Hananto; I Gusti Ngurah Agastya; Taufik Eko Susilo; Pichpisith Pierre Vejvisithsakul; Donny Nauphar; Ariestya Indah Permata Sari; Andrew John Macnab
GHMJ (Global Health Management Journal) Vol. 3 No. 3 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-33580

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TNF-α -308 G/A Gene Polymorphism as a Risk Factor for Pulmonary Tuberculosis in Cirebon, Indonesia Oktaviyati, Nurfithria; Pratamawati, Tiar Masykuroh; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1159

Abstract

Background: Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, spreads via droplets. The TNF-α-308 G/A gene polymorphism is one of the host genetic variables that may affect an individual's vulnerability to the disease. However, this polymorphism has not been studied in Cirebon. Aims: To analyze the TNF-α -308 G/A gene polymorphism as a risk factor for the occurrence of pulmonary tuberculosis in Cirebon. Methods: A total of 64 participants joined part in an analytical observational study using a case-control design at the Biomolecular and Genetics Laboratory, Faculty of Medicine, Universitas Swadaya Gunung Jati, Indonesia. DNA extraction from blood samples, ARMS-PCR genotyping, and 1.5% electrophoresis gel visualization were all part of the data gathering process. The chi-square test was used to analyze the data. This study including inclusion criteria, exclusion criteria, and sample control for the research. Results: According to the study, there is no link between Cirebon's risk of pulmonary tuberculosis and the polymorphism in the TNF-α-308 G/A gene (OR = 0.462; P > 0.05). However, the study shown a protective factors which means that individuals with the TNF-α -308 G/A gene polymorphism have a lower risk of developing pulmonary tuberculosis compared to those without the polymorphism. Conclusion: The TNF-α-308 G/A gene variant is not associated with an increased risk of pulmonary tuberculosis in the Cirebon community.
Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) RS5219 Gene Polymorphism as a Risk Factor for Type 2 Diabetes Mellitus in Indonesia: A Case Control Study Putri, Annisa Septiani Putri; Pratamawati, Tiar Masykuroh; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1160

Abstract

Background: Diabetes Mellitus (DM) is a chronic metabolic disease caused by the failure of the pancreas to produce the hormone insulin or ineffective use of the hormone insulin. It is estimated that 537 million adults aged 20-79 years worldwide suffer from DM. Genetics is one of the risk factors involved in the pathophysiology of type 2 DM. The KCNJ11 gene encodes the Kir6.2 protein that is responsible for adenosine triphosphate-sensitive potassium ion channels (kATP) synthesis in pancreatic beta cells plasma membrane. Aims: This study aims to examine the KCNJ11 rs5219 gene polymorphism as a risk factor for type 2 diabetes mellitus in Cirebon population. Methods: This case control study involved 29 cases of type 2 diabetes mellitus and 29 healthy controls with purposive sampling technique. Sample data was obtained through the examination of blood sugar, DNA extraction, PCR-RFLP with Eco24I restriction enzyme, then visualization of the results with Gel Electrophoresis. Results: The frequency of G allele was found more in the case group (70%) while the frequency of A allele was found more in the control group (38%). The frequency of heterozygous GA genotype was found more in the control group (48.3%) and the frequency of homozygous mutant AA genotype was more in the case group (17.2%) compared to the control group (13.8%). Chi-Square Test results obtained p-value 0.115, OR value 2.318. Conclusion: This study showed no significant association between Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) rs5219 gene polymorphism and the incidence of Type 2 Diabetes Mellitus in Cirebon population.
Angiotensin Converting Enzyme 2 (ACE2) G8790A Gene Polymorphism as a Risk Factor for Essential Hypertension Husna, Nazaul; Nauphar, Donny; Pratamawati, Tiar Masykuroh
GHMJ (Global Health Management Journal) Vol. 8 No. 2s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-82s1231

Abstract

Background: Globally, the number of people with hypertension has doubled, from 650 million to 1.3 billion. The World Health Organization reported that hypertension is responsible for more than 10 million deaths every year. Essential hypertension is a multifactorial condition with genetics as one of the factors. Genome-Wide Association Study has identified several genes associated with hypertension, one of which is the Angiotensin Converting Enzyme 2 (ACE2) gene. Essential hypertension may be predisposed to by the G8790A polymorphism of the ACE2 gene, which is hypothesized to interfere with the normal function of the Renin Angiotensin System (RAS). Aims: The purpose of this study is to determine whether the ACE2 G8790A gene polymorphism in Cirebon, West Java, Indonesia, is associated with an increased risk of essential hypertension. Methods: This is a case-control study conducted at the Talun Health Center, Cirebon Regency, April-August 2024, involving 30 essential hypertensive patients and 30 healthy controls. The study population comprised adults aged 30 to 72 years. Data was obtained through the examination of blood pressure, DNA extraction, PCR-RFLP with ALUI restriction enzyme, and then visualization of the results with Gel Electrophoresis. The Chi-Square Test technique and the Odds Ratio (OR) computation were used to analyze the data. Results: The G allele was higher in the case group 33 (55%), while the A allele was higher in the control group 34 (56.7%). The statistical analysis showed that there was no significant link between the ACE2 G8790A gene variation and essential hypertension, with a p-value of 0.592 (p > 0.05) (OR = 0.750; CI = 0.262–2.151). Conclusion: The ACE2 gene G8790A polymorphism and the rate of hypertension in Cirebon, West Java, were not significantly correlated. Further research is required on a larger scale to investigate the effects of gene combinations or interactions with other locus genes on essential hypertension.
Angiotensin-Converting Enzyme Insertion/Deletion (ACE I/D) Gene Polymorphism as a Risk Factor for Essential Hypertension Kuswara, Hasna Nurazizah; Nauphar, Donny; Sari, Ariestya Indah Permata
GHMJ (Global Health Management Journal) Vol. 7 No. 3s (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-741044

Abstract

Background: Hypertension is the leading cause of death globally due to its complications, including coronary heart disease and stroke. In 2018, hypertension cases in West Java were the second highest among all populations in Indonesia. Genetics is one of the unmodifiable risk factors for hypertension. Angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism could affect ACE production in the renin-angiotensin-aldosterone system (RAAS), which is linked to the regulation of blood pressure. Aims: To analyze ACE I/D gene polymorphism as a risk factor for hypertension in Cirebon. Methods: An observational analysis with a case-control design was used in this study. Blood samples were collected from 30 hypertensive patients and 30 healthy individuals at Talun Health Center. DNA extraction was performed to evaluate polymorphisms using ARMS-PCR. Statistical analyses, including the Chi-square test, Fisher’s exact test, Mann-Whitney, and Kruskal-Wallis test, were conducted to compare the case and control groups. The odds ratio was calculated to see the risk of the assessed variables, including genotype, allele frequency, and the presence of ACE I/D gene polymorphism. Results: In the case group, the frequency of the II genotype was 2 (6.7%), the ID genotype was 25 (83.3%), and the DD genotype was 3 (10.0%). In the control group, the frequency of the II genotype was 2 (6.7%), the ID genotype was 26 (86.7%), and the DD genotype was 2 (6.7%). Statistically, there was no significant association between ACE I/D gene polymorphisms in essential hypertension patients and healthy people (p=0.500; OR=1.556; 95% CI=0.241-10.049). Conclusion: ACE I/D gene polymorphism was not significantly associated with essential hypertension in Cirebon, West Java, Indonesia.    Received: 25 September 2024  |  Reviewed: 21 October 2024  |  Revised: 23 November 2024  |  Accepted: 30 November 2024.
Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults Pratamawati, Tiar Masykuroh; Sadji, Angel Angriani Elma Budai; Brajadenta, Gara Samara; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 7 No. 1 (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-71967

Abstract

Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to environmental factors. Numerous researches have suggested a connection between the prevalence of obesity and the FTO rs9939609 gene polymorphism Aims: The purpose of this study is to ascertain how the FTO rs9939609 gene polymorphism relates to the prevalence of adult obesity. Methods: At the Biomolecular and Genetics Laboratory of the UGJ Faculty of Medicine, an analytical observational study using a case-control design was carried out with 84 participants, 42 subjects in case group, and 42 subjects in control groups. Data were collected utilizing DNA from blood collection, PCR-RFLP for genotyping, and 2.5% electrophoretic gel for visualization. Chi-square was used for data analysis. Results: Findings showed that there is no link between the FTO rs9939609 polymorphism and the prevalence of obesity (p>0.05, OR=0.710). Conclusion: In the Indonesian population, the FTO rs9939609 gene polymorphism is not associated with an increased risk of obesity.
Co-Authors A Fariz Malvi Zamzam Zein Agastya, I Gusti Ngurah Akbarahma, Ikrama Akrom, Akrom Amanah Amanah amanah amanah Ameliana, Elinda Anak Agung Istri Sri Wiadnyani Andang Adi Fitria Hananto Andi Pancanugraha Andrew John Macnab Annida Maharani Ariestya Indah Permata Sari Ary Norsaputra Baihaqi, Muhammad Irsyad Brajadenta, Gara Samara Canggih Puspo Wibowo Catur Setiya Sulistiyana Destiwi, Monita Diary, Dwina Gustia Dimas Sondang Dimas Sondang Irawan Doni Marisi Sinaga Doni Marisi Sinaga, Doni Marisi Dwina Gustia Diary Dyah Anantalia Widyastari Dyah Anantalia Widyastari Elinda Ameliana Eni Suhaeni Fattah, Rifqi Abdul Fauzah, Shofa Nur Fauziah, Sri Utami Febrian Hendra Kurniawan Galih Albarra Shidiq Hadyanto Lim Hafizh Muhammad Noor Hammada, Ronaa Hananto, Andang Adi Fitria Harlianti, Lita Hendry Gunawan, Hendry Henny Erina Saurmauli Ompusunggu Husna, Nazaul I Gusti Ngurah Agastya I Gusti Ngurah Edi Putra Ivana Aprilia Pratiwi Jamhari Jamhari Juwita -, Juwita Kurniawan, Febrian Hendra Kuswara, Hasna Nurazizah Lita Harlianti Macnab, Andrew John Made Dian Shanti Kusuma Maharani, Annida Mahendrawan Nugraha Aji Pratama Maretalinia Maretalinia Maretalinia Maretalinia, Maretalinia Marina Ayu Viniriani Maryam, Ruri Eka Moehas, Puput Kusumawardani Monita Destiwi Muhammad Irsyad Baihaqi Ni Wayan Kesari Dharmapatni Noor, Hafizh Muhammad Norsaputra, Ary Oktaviyati, Nurfithria Ompusunggu, Henny E.S. Pamuko Aditya Rahman Pancanugraha, Andi Pardede, Sumondang M. Pichpisith Pierre Vejvisithsakul Pradana, Muhammad Firyal Pratama, Mahendrawan Nugraha Aji Pratamawati, Tiar M Pratamawati, Tiar Masykuroh Pratiwi, Ivana Aprilia Puput Kusumawardani Moehas Putra, I Gusti Ngurah Edi Putra, Wahyu Manggala Putri, Annisa Septiani Putri Rahman, Pamuko Aditya Ricky Alexander Samosir Rifqi Abdul Fattah Risnandya Primanagara Ronaa Hammada Ruri Eka Maryam Sadji, Angel Angriani Elma Budai Samosir, Ricky Alexander Sari, Ariestya Indah Permata Satrianugraha, Muhammad Duddy Sayyidah Vina Syauqia Shidiq, Galih Albarra Shofa Nur Fauzah Sri Utami Fauziah Syauqia, Sayyidah Vina Tiar M Pratamawati Tiara Fatmarizka Vejvisithsakul, Pichpisith Pierre Viniriani, Marina Ayu Wahyu Manggala Putra Wibowo, Canggih Puspo Witri Pratiwi Witri Pratiwi Yahwardiah Siregar Yuny Hafitry Zein, A Fariz Malvi Zamzam Zein, Ahmad Fariz Malvi Zam Zam