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All Journal Majalah Obat Tradisional PROSIDING SEMINAR KIMIA KOVALEN: Jurnal Riset Kimia Jurnal Kimia Mulawarman Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JFL : Jurnal Farmasi Lampung JI-KES (Jurnal Ilmu Kesehatan) Jurnal Riset Kefarmasian Indonesia Mattawang: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JI-KES (Jurnal Ilmu Kesehatan)
Eka Siswanto Syamsul
Sekolah Tinggi Ilmu Kesehatan Samarinda
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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ANALISIS FRAGMENTASI GC-MS SENYAWA AKTIF ANTIKANKER LEUKEMIA FRAKSI KLOROFORM UMBI BAWANG TIWAI (Eleutherine bulbosa (Mill.) Urb) Dwi Lestari; Rudi Kartika; Eva Marlina; Eka Siswanto Syamsul
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.181

Abstract

Tiwai Onion (Eleutherine bulbosa (Mill.) Urb.) is an Iridaceae tribe which is a typical plant of Borneo. Its used by the Dayak community, among others, for colon cancer, breast cancer, diabetes mellitus, hypertension, lowering cholesterol, strokes, boils, anti-bleeding and abdominal pain. The purpose of this study was to determine the components of anticancer compounds of chloroform fraction by GC-MS method. The results of GC-MS spectrum analysis based on the base peak equation of the chloroform fraction contain 9,12-Octadecadienoic Acid, and 1- (2,3,5,6-Tetramethyl phenyl) Ethanone which has the potential as an anticancer.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAN FRAKSI Archidendron clypearia TERHADAP Staphylococcus aureus dan Salmonella typhi : ANTIBACTERIAL ACTIVITY TEST OF ETANOL EXTRACT AND FRACTIONS OF Archidendron clypearia OF Staphylococcus aureus and Salmonella typhi Octaviani, Bella Micha Thesya; Fahmi, Supomo; Syamsul, Eka Siswanto
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2532

Abstract

Infection is one of the most common causes of disease in society. One type of infection caused by Staphylococcus aureus is a bacterium that causes skin infections in humans characterized by purulent abscesses. In addition, Salmonella typhi is also a pathogenic bacterium that can cause typhoid fever. Infections caused by microorganisms can be overcome by administering antimicrobials. One of the natural ingredients that has the potential as an antimicrobial is the petai belalang plant (Archidendron clypearia). This study aims to test the antibacterial activity of ethanol extracts and fractions of petai belalang leaves against Staphylococcus aureus and Salmonella typhi bacteria. This experimental research includes plants determination, sampling, making simplisia, fractionation, phytochemical screening, and antibacterial activity tests. Extracts and fractions were prepared in concentrations of 1%, 5%, 10%, and 15%, with positive control of amoxicillin 0.1% and negative control of DMSO 1%. The antibacterial activity test was performed using disc diffusion and pitting diffusion methods to measure the zone of inhibition. Data were statistically analyzed using the Kruskal-Wallis test. The results showed that in the disc diffusion method, the inhibition zone against Staphylococcus aureus was 7.3-10.8 mm, and against Salmonella typhi was 7.6-10.1 mm. In the well diffusion method, the zone of inhibition against Staphylococcus aureus ranged from 12.1-16.8 mm, and against Salmonella typhi it ranged from 12.5-16.8 mm. The ethyl acetate fraction obtained the largest inhibition zone with a diameter of 16.8 mm in the well diffusion method. Statistical analysis showed a significant difference in antibacterial activity on positive and negative bacteria with a substantial value of 0.005 in the disc method and 0.006 in the well method. Keywords: Antibacterial, petai belalang, Staphylococcus aureus, Salmonella typhi
Uji Aktivitas Antibakteri EkstrakEtanol dan Fraksi Batang Kuning (Fibraurea Tinctoria Lour) terhadap Bakteri Escherichia coli dan Staphylococcus aureus Ariyanti, Lusi Mardika; Supomo, Supomo; Sa’adah, Hayatus; Syamsul, Eka Siswanto; Kintoko, Kintoko; Witasari, Hardi Astuti
JI-KES (Jurnal Ilmu Kesehatan) Vol. 5 No. 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.323

Abstract

Abstrak Akar kuning (Fibraurea tinctoria Lour) merupakan tumbuhan khas yang dapat dijumpai di Kalimantan serta biasa dimanfaatkan oleh masyarakat setempat sebagai obat gatal, penyakit kuning dan diare. Salah satu senyawa kimia yang terkandung dalam akar kuning adalah berberin yang berpotensi memiliki khasiat sebagai antidiabetes, antivirus, antibakteri dan antiinflamasi. Penelitian ini bertujuan untuk  mengetahui potensi tumbuhan Akar Kuning (Fibraurea tinctoria Lour.) sebagai antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dengan menggunakan metode disc diffusion. Ekstrak etanol difraksinasi dengan menggunakan pelarut n-heksan dan etilasetat, ekstrak dan fraksi yang telah didapat ditimbang dengan konsentrasi 2,5%, 5% dan 10%. Kontrol positif yang digunakan yaitu amoxicillin dan DMSO sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa ektrak etanol dan fraksi akar kuning (Fibraurea tinctoria Lour.) memiliki potensi untuk menghambat pertumbuhan bakteri. Aktivitas zona hambat terbesar yang terbentuk pada ekstrak etanol yaitu pada konsentrasi 10% dengan diameter zona hambat 9,18 mm terhadap bakteri Escherichia coli dan 12,16 mm terhadap bakteri Staphylococcus aureus sedangkan fraksi batang akar kuning yang memiliki aktivitas antibakteri paling kuat terhadap bakteri Escherichia coli dan Staphylococcus aureus yaitu fraksi sisa. Staphylococcus aureus memiliki sensitifitas lebih tinggi terhadap akar kuning (Fibraurea tinctoria Lour) dari pada bakteri Escherichia coli. Kata kunci  : antibakteri, akar kuning, berberin, Fibraurea tinctoria Lour. Abstract Akar kuning (Fibraurea tinctoria Lour.) is typically plant that can be found in Kalimantan usually used by local people as itch medicine, jaundice and diarrhea. Berberin, one of the chemical compounds contained in the akar kuning, berberin has the potential to act as an anti-diabetic, antiviral, antibacterial, and anti-inflammatory. This study aimed to determine the activity of akar kuning as an antibacterial against Escherichia coli and Staphylococcus aureus using the disc diffusion method. Ethanol extract are fractionated using n-Heksan and Etilasetat solvents, the obtained of extract and fraction are weighed to 2,5%, 5% and 10%. Positive control antibacterial used amoxicillin and DMSO as negative control. The results showed that ethanol extracts and fraction of akar kuning (Fibraurea tinctoria Lour.) are have potential to inhibited bacteria growth. The highest antibacterial activity that showed at 10% concentration of ethanol extract with diameter inhibition is 9,18 mm to Escherichia coli and 12,16 mm to Staphylococcus aureus while the fraction of akar kuning which has the stronger antibacterial activity to Escherichia coli and Staphylococcus aureus is the rest fraction. Staphylococcus aureus were more susceptible to akar kuning (Fibraurea tinctoria Lour.) extract and fraction than Escherichia coli.Keywords:           antibacterial, akar kuning, berberin, Fibraurea tinctoria Lour
KINERJA DAN MUTU PELAYANAN KEFARMASIAN DI PUSKESMAS BAQA DI KOTA SAMARINDA Husnul Warnida; Sari Putri Pertiwi; Eka Siswanto Syamsul
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.447

Abstract

Community Health Center (puskesmas) is the basic service health facility in Indonesia. Community Health Center organizes individual health efforts and community health efforts that must be supported by a quality pharmaceutical care. Pharmaceutical care at health center must comply with Pharmaceutical Care Standards. This study aims to determine the performance and quality of pharmaceutical care at Baqa Health Center according to Permenkes no 74/2016 and Permenpan 14/2017. This research is a descriptive research. Respondents were 306 patients who received pharmaceutical care at Baqa Health Center. The data collected were patient satisfaction level, measurement of the average time for drug compounding, the average time for drug delivery and drug information administration, and the percentage of compliance with the service standards. The results showed that the quality of pharmaceutical care at Baqa Community Health Center was 93.33% in the good category, and the performance value of pharmaceutical care at the Baqa Community Health Center was 81.09 in the good category.
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN PIDADA MERAH (Sonneratia caseolaris L) PADA MENCIT PUTIH (Mus musculus L) Siti Jubaidah; Eka Siswanto Syamsul; Supomo Supomo
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.513

Abstract

The leaves of the red pidada plant (Sonneratia caseolaris L.) are traditionally used by the people of Kalimantan to mix cold powder, treat wounds and have antioxidant properties. The aim was to determine the symptoms of acute toxicity and lethal dose of 50 ethanol extract of red pidada leaf (Sonneratia caseolaris L.) against white mice. Methods: This study used 20 rats which were divided into four groups and given a graded dose of 0.65 g/kgBW, 1.3 g/kgBW, 2.6 g/kgBW, and 5.2 g/kgBW ethanol extract of red pidada leaf with two oral administrations then observed for symptoms of toxicity and the number of deaths in each test animal after 24 hours, then observations were made. body weight for 14 days without treatment. The results showed that the apparent LD50 was: >5.2g/kgBB. Clinical symptoms observed in mice were decreased motor activity at the highest dose and increased grooming frequency. The LD50 of the ethanol extract of red pidada leaves is in the mild toxic category (5-15 g/kgBW).
Co-Authors Agung Endro Nugroho Agung Endro Nugroho Amanda, Nadhila Ajrina Ansyori, Achmad Kadri Ansyori, Achmad Kadri Anugerah, Olanda Ariyanti, Lusi Mardika Bramantyo Adi Nugroho Dwi Lestari Dwi Lestari Dwi Lestari Eka Novitasari Purwanto Eka Novitasari Purwanto, Eka Novitasari Eva Marlina Fahmi, Supomo Fitriya Andani Hakim, Yana Yunita Hardi Astuti Witasari Hayatus Sa`adah Hayatus Sa’adah Henny Nurhasnawati Heri Wijaya Husnul Warnida Kintoko Kintoko Kintoko Kintoko Kintoko, Kintoko Lusi Mardika Ariyanti Marlina, Eva Mulyani, Reny Nur Octaviani, Bella Micha Thesya Reksi Sundu Reny Nur Mulyani Rio Adi Saputra Risa Supriningrum Rudi Kartika Rudi Kartika, Rudi Sa’adah, Hayatus Sari Putri Pertiwi Siti Heldyana Siti Jubaidah Siti Jubaidah Siti Jubaidah Siti Jubaidah, Siti Supomo Supomo Supomo Supomo - Supomo Supomo Supomo Supomo Supomo Supomo Supomo Supomo Supomo Supomo SUWIJIYO PRAMONO Suwijiyo Pramono Windi Ana Lestiani Yulistia Budianti Soemarie Yullia Sukawati