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All Journal Majalah Obat Tradisional PROSIDING SEMINAR KIMIA KOVALEN: Jurnal Riset Kimia Jurnal Kimia Mulawarman Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JFL : Jurnal Farmasi Lampung JI-KES (Jurnal Ilmu Kesehatan) Jurnal Riset Kefarmasian Indonesia Mattawang: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita Sciences of Pharmacy Jurnal Kefarmasian Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JI-KES (Jurnal Ilmu Kesehatan)
Eka Siswanto Syamsul
Sekolah Tinggi Ilmu Kesehatan Samarinda
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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KINERJA DAN MUTU PELAYANAN KEFARMASIAN DI PUSKESMAS BAQA DI KOTA SAMARINDA Husnul Warnida; Sari Putri Pertiwi; Eka Siswanto Syamsul
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.447

Abstract

Community Health Center (puskesmas) is the basic service health facility in Indonesia. Community Health Center organizes individual health efforts and community health efforts that must be supported by a quality pharmaceutical care. Pharmaceutical care at health center must comply with Pharmaceutical Care Standards. This study aims to determine the performance and quality of pharmaceutical care at Baqa Health Center according to Permenkes no 74/2016 and Permenpan 14/2017. This research is a descriptive research. Respondents were 306 patients who received pharmaceutical care at Baqa Health Center. The data collected were patient satisfaction level, measurement of the average time for drug compounding, the average time for drug delivery and drug information administration, and the percentage of compliance with the service standards. The results showed that the quality of pharmaceutical care at Baqa Community Health Center was 93.33% in the good category, and the performance value of pharmaceutical care at the Baqa Community Health Center was 81.09 in the good category.
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN PIDADA MERAH (Sonneratia caseolaris L) PADA MENCIT PUTIH (Mus musculus L) Siti Jubaidah; Eka Siswanto Syamsul; Supomo Supomo
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.513

Abstract

The leaves of the red pidada plant (Sonneratia caseolaris L.) are traditionally used by the people of Kalimantan to mix cold powder, treat wounds and have antioxidant properties. The aim was to determine the symptoms of acute toxicity and lethal dose of 50 ethanol extract of red pidada leaf (Sonneratia caseolaris L.) against white mice. Methods: This study used 20 rats which were divided into four groups and given a graded dose of 0.65 g/kgBW, 1.3 g/kgBW, 2.6 g/kgBW, and 5.2 g/kgBW ethanol extract of red pidada leaf with two oral administrations then observed for symptoms of toxicity and the number of deaths in each test animal after 24 hours, then observations were made. body weight for 14 days without treatment. The results showed that the apparent LD50 was: >5.2g/kgBB. Clinical symptoms observed in mice were decreased motor activity at the highest dose and increased grooming frequency. The LD50 of the ethanol extract of red pidada leaves is in the mild toxic category (5-15 g/kgBW).
Nanoemulsion Optimization of Dayak Onion (Eleutherine bulbosa (Mill) Urb.) Tuber Ethanol Extract Using Varying Concentration of VCO, Tween 80, and PEG 400 Putri, Rizqa Akhriana; Syamsul, Eka Siswanto; Warnida, Husnul
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia hosts various medicinal plants, including Dayak onion (Eleutherine bulbosa (Mill.) Urb), which contains isoliquiritigenin, a flavonoid with potential anticancer activity. However, its low solubility limits bioavailability and therapeutic effectiveness. To improve drug delivery, nanoscale formulations such as nanoemulsions can enhance membrane penetration and target reach. This study aimed to optimize a nanoemulsion formulation of Dayak onion ethanol extract using the Self-Nanoemulsifying Drug Delivery System (SNEDDS) method with variations of VCO, Tween 80, and PEG 400. The nanoemulsion’s characteristics and stability were evaluated experimentally and analyzed statistically using the Independent T-Test, comparing results from Design Expert 12 and laboratory data. The optimized formulation produced a clear pink, stable nanoemulsion for one month, with a pH of 3.94 ± 0.22, transmittance of 58.45 ± 6.01%, particle size of 319.07 ± 1.05 nm, PDI of 0.44 ± 0.06, zeta potential of −31.5 ± 0.26 mV, and a creaming index of 0.
PENETAPAN KADAR RUTIN PADA EKSTRAK ETANOL DAUN PIDADA MERAH (Sonneratia caseolaris) DENGAN KLT DENSITOMETER Lestari, Dwi; Syamsul, Eka Siswanto; Mentari, Ika Ayu
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v613.559

Abstract

Red pidada leaves (Sonneratia caseolaris L) which is a species of mangrove plant that can grow in rivers and has been widely used as a natural medicine. Red Pidada leaves are often used by the people of East Kalimantan as a cold powder and wound remover. This study aims to determine the routine content of red pidada leaf extract. The research included extraction by maceration, routine assay using a TLC densitometer, phytochemical screening and validation of methods determined by parameters including: linearity and precision. A mixture of butanol-ethyl acetate-formic acid-asor (5:5:2:1) was chosen as the mobile phase. The results of this research for the maximum routine wavelength are 265 nm. The linearity test obtained from the regression function is y = 151.6 + 80.88x with a correlation coefficient (r) and Vxo of 0.97566 and 0.842% respectively. The concentration of routine in the extract was 1.9215±0.028%
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL UMBI BAWANG DAYAK (Eleutherine palmifolia) TERHADAP MENCIT YANG DIINDUKSI KARAGENIN Milasari, Novi; Adhila, Ghina; Syamsul, Eka Siswanto
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.679

Abstract

            Inflammation is a normal response to protect tissue injury from toxic chemicals, physical trauma, or microbial agents. Treatment of inflammation generally uses synthetic drugs, but the use of these drugs in addition to eliminating inflammation also has many side effects and is relatively expensive. Therefore, anti-inflammatory drugs derived from plants are used. One of the natural medicines used is Dayak onion (Eleutherine palmifolia) because empirically it is widely used by the Dayak and Kutai communities, which has the potential as a medicinal plant with various enormous properties. This study aimed to determine the anti-inflammatory activity of an ethanol extract of Dayak onion bulbs (Eleutherine palmifolia) in carrageenin-induced mice. The test of anti-inflammatory activity was carried out by forming artificial inflammation on the soles of the feet of white mice. The study was conducted on 15 mice, which were divided into 5 groups. The first group as a negative control was given a 0.5% CMC solution. The second group as a positive control was given diclofenac sodium at a dose of 27 mg/ 20 g BW. The third, fourth, and fifth groups were given a dayak onion bulb extract dose of 100 mg /kgBB, 200 mg /kgBB, and 400 mg /kgBB. Based on the measurement of the percent inhibition of inflammation from the 30th minute to the 300th minute, it was found that the average dose of Dayak onion extract 1 (100 mg/KgBB) had the lowest percent inhibition of inflammation, which was 23.064±1.286%, dose 2 was 37.701±2.354%, and dose 3 was 52.324±4.751% and positive control of 76.348±8.702% which has the highest percent of inflammation inhibition. Based on the study, it can be concluded that the ethanol extract of dayak onion bulbs has the best anti-inflammatory activity at dose 3 of 52.324±4.751% in mice induced by carrageenin.
PENETAPAN KADAR FLAVONOID EKSTRAK DAUN KELAKAI (Stenochlaena palustris (Burm. F.) Bedd.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Syamsul, Eka Siswanto; Hakim, Yana Yunita; Nurhasnawati, Henny
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.46

Abstract

Kelakai (Stenochlaena palustris (Burm F.) Bedd.) is a medicinal plant of Borneo. The purpose of this research is to determine the level of flavonoid in crude extract of kelakai leaf by UV-Vis Spectrophotometer. The research was conducted by collection of the kelakai leaves and plant determination. The ethanolic extract of kelakai leaves was collected using macceration methode. The determination of flavonoid level was conducted by UV-Vis Spectrophotometer using quersetin as standard compound. The study showed that the rendemen of crude extract of kelakai leaf was (22,92%). The moisture content in viscous extract was (19,71%). The level of Flavonoids in extract was (2,2159±0,083%).
PERBANDINGAN EKSTRAK LAMUR Aquilaria malaccensis DENGAN METODE MASERASI DAN REFLUKS Syamsul, Eka Siswanto; Amanda, Nadhila Ajrina; Lestari, Dwi
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 2 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i2.85

Abstract

Gaharu (Aquilaria malaccensis Lamk) is a plant of the thymelaeaceae family that is widely used by the people of West Kutai Regency as a medicinal plant for skin wounds, diabetes, asthma, stomach pain and sleep disorders, aromatherapy and used as ingredients for perfume because it has a distinctive aroma. The extraction process will determine how much yield is produced. This study aims to determine the percent (%) yield of agarwood leaf ethanol extract using maceration and reflux methods. The research stage includes plant determination, sample processing, extraction using maceration and reflux methods with 70% ethanol solvent, determination of the yield and phytochemical screening. Data analysis in the form of descriptive data analysis and presented in tabular form. The results showed that the reflux method produced a higher average yield of 30.70% and maceration method of 29.97%. Statistical test results using the Independent Sample T-Test method showed that there was no significant difference in the yield produced from the maceration and reflux method because (p> 0.05). Phytochemical screening test results showed that agarwood leaf extract contains flavonoids, tannins, saponins and steroids
PENETAPAN RENDEMEN EKSTRAK DAUN JAMBU MAWAR (Syzygium jambos L. Alston) BERDASARKAN VARIASI KONSENTRASI ETANOL DENGAN METODE MASERASI Syamsul, Eka Siswanto; Anugerah, Olanda; Supriningrum, Risa
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 3 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i3.98

Abstract

Syzygium jambos is a medicinal plant. This study aims to determine the effect of variations in ethanol concentration on yield of guava leaf extract by maceration method. The research conducted was experimental research. The research phase includes sample collection, determination, manufacture of simplicia, extraction by maceration with variations in ethanol concentration, determination of yield, phytochemical screening and determination of drying losses. Phytochemical screening results showed that 50% of ethanol extracts of positive rose guava contained flavonoids, tannins, saponins and steroids / terpenoids, 70% ethanol and 90% positives contained flavonoids, tannins and steroids / terpenoids. The yield of rose guava ethanol extract was 50% (23.01% ± 0.372), 70% ethanol (21.96% ± 1.181) and 90% ethanol (16.57% ± 0.384). LSD test results showed a significant difference (p <0.05) between the 90% to 50% and 70% groups.
Physico-Chemical Characterisation and Determination of Luteolin Content of Pidada merah (Sonneratia Caseolaris L) Leaf Extract Syamsul, Eka Siswanto; Lestari, Dwi; Dachriyanus, Dachriyanus; Supomo, Supomo
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501579

Abstract

Red pidada (Sonneratia caseolaris L.) leaves are used traditionally for skin care and other medicinal purposes. This study aimed to characterise the powdered leaf material and determine the luteolin content of the ethanolic leaf extract. Dried leaf powder was macerated with 95% ethanol. The powdered material was characterised by macroscopic and microscopic examination and by determining the water-soluble extractive value, ethanol-soluble extractive value, moisture content, total ash, and acid-insoluble ash. Metabolite profiling of the extract was performed using high-resolution liquid chromatography-mass spectrometry (HR-LCMS). Luteolin content was estimated by TLC-densitometry using silica gel 60 F254 plates and n-hexane: ethyl acetate (2:3) as the mobile phase. Macroscopically, the leaves were oval to elongated with rounded to blunt apices, entire margins, pinnate venation, and a dark-green colour. Microscopic examination showed upper and lower epidermal tissues, stomata, and vascular bundles. The powdered leaves had a bitter taste. The water-soluble and ethanol-soluble extractive values were 11% and 16%, respectively, while the moisture content, total ash, and acid-insoluble ash were 8.8%, 8.12%, and 0.47%. HR-LCMS generated 38 tentative database matches, including luteolin. Under the assay conditions used, TLC-densitometry showed an Rf value of 0.54 for luteolin and a mean measured luteolin amount of 3.849 µg. These findings provide baseline physicochemical and preliminary phytochemical data for the standardisation of Sonneratia caseolaris L leaf extract.
Co-Authors Adhila, Ghina Agung Endro Nugroho Agung Endro Nugroho Amanda, Nadhila Ajrina Ansyori, Achmad Kadri Ansyori, Achmad Kadri Anugerah, Olanda Ariyanti, Lusi Mardika Bramantyo Adi Nugroho Dachriyanus Dwi Lestari Dwi Lestari Dwi Lestari Eka Novitasari Purwanto Eka Novitasari Purwanto, Eka Novitasari Eva Marlina Fahmi, Supomo Fitriya Andani Hakim, Yana Yunita Hardi Astuti Witasari Hayatus Sa`adah Henny Nurhasnawati Heri Wijaya Husnul Warnida Ika Ayu Mentari Kintoko Kintoko Kintoko Kintoko Kintoko, Kintoko Lusi Mardika Ariyanti Marlina, Eva Milasari, Novi Mulyani, Reny Nur Octaviani, Bella Micha Thesya Putri, Rizqa Akhriana Reksi Sundu Reny Nur Mulyani Rio Adi Saputra Risa Supriningrum Rudi Kartika Rudi Kartika, Rudi Sari Putri Pertiwi Siti Heldyana Siti Jubaidah Siti Jubaidah Siti Jubaidah Siti Jubaidah, Siti Supomo Supomo Supomo Supomo - Supomo Supomo Supomo Supomo Supomo Supomo Supomo Supomo Supomo Supomo Suwijiyo Pramono SUWIJIYO PRAMONO Warnida, Husnul Windi Ana Lestiani Yulistia Budianti Soemarie Yullia Sukawati