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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Infinity Jurnal Riset Pendidikan Matematika Kontinu: Jurnal Penelitian Didaktik Matematika AKSIOMA: Jurnal Program Studi Pendidikan Matematika Jurnal Varidika Jurnal Terapan Abdimas HISTOGRAM: Jurnal Pendidikan Matematika AL ISHLAH Jurnal Pendidikan Jurnal Pendidikan Matematika (JUDIKA EDUCATION) Teorema: Teori dan Riset Matematika Jurnal Cendekia : Jurnal Pendidikan Matematika Jurnal Basicedu Prima: Jurnal Pendidikan Matematika Indonesian Journal on Learning and Advanced Education (IJOLAE) Symmetry: Pasundan Journal of Research in Mathematics Learning and Education M A T H L I N E : Jurnal Matematika dan Pendidikan Matematika Vygotsky: Jurnal Pendidikan Matematika dan Matematika Jurnal Absis : Jurnal Pendidikan Matematika dan Matematika JP2M (Jurnal Pendidikan dan Pembelajaran Matematika) Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Basicedu Jurnal Keilmuan dan Keislaman Prosiding Konferensi Nasional Penelitian Matematika dan Pembelajarannya Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Pelita: Jurnal Pengabdian kepada Masyarakat Academic Hospital Journal Sanus Medical Journal Jurnal Infinity Proceeding International Conference on Mathematics and Learning Research
Sri Sutarni
Universitas Muhammadiyah Surakarta
Religion Humanities Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections Hayati, Hanifah Fajarisna; Satiti, Sekar; Paryono, Paryono; Intansari, Umi; Sutarni, Sri; Subagya, Subagya; Indarwati, Indarwati; Setyopranoto, Ismail
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202306

Abstract

Central nervous system (CNS) infections such as encephalitis, meningitis, or myelitis have high morbidity and mortality in Indonesia. High sensitivity C-reactive protein (hs-CRP) is a sensitive marker of acute inflammation, while albumin is the most abundant protein component in plasma and cerebrospinal fluid (CSS). Infection triggers an inflammatory response so that an increase in the hs-CRP/albumin ratio (CAR) can be a predictor of worsening clinical outcome in patients with CNS infections. However, studies examining the predictor value of serum and CSF CAR on worsening clinical outcomes of patients are limited, particularly in CNS infections. The purpose of this study was to prove the CAR as a predictor of worsening clinical outcome in patients with CNS infections.  It was an observational study using a prospective cohort design. Fifty subjects recruited until October 2021 at Dr. Sardjito General Hospital were involved.  The multivariate regression analysis showed that serum CAR (OR=3.604; 95%CI=1.487-8.736; p =0.005) could be a single predictor. However, by combining three variables, namely serum CAR, CSF CAR, and decreased consciousness at admission, could be a stronger predictor of worsening clinical outcome in patients with CNS infection (AUC = 97.1%; 95%CI = 0.929-1.00; p <0.001). The optimal cut-off value for serum CAR was 1.35 (Youden index = 0.88, sensitivity = 96%, specificity = 92%) while for CSF CAR was 0.14 (Youden index = 0.60, sensitivity = 76%, specificity = 84%). In conclusion, a combination predictive model of three variables, namely serum CAR, CSF CAR, and awareness at admission can be a stronger predictor of clinical outcome in patients with CNS infection than serum CAR alone.
Co-Authors Abdul Gofir Abidah Rohmatillah Ahmad Syafi'i Ma'arif Amelia Nur Vidyanti Anam Sutopo Anis Mahmudah Anis Mahmudah, Anis Antok Aryuana Aprilianto, Muhamad Farhan Ardelia, Berliani Aulia, Syafira Nur Azmi Cahyaningtyas, Putri Charomah Sri Setianing Rahayu Damastuti, Ayun Siwi Dina Maulita Efi Maysaroh Emese Kovácsné Nagy Erlina, Diah Ayu Fafria Fari Hastuti Gatiniggsih, Rustiwi Harun Joko Prayitno Hasan, Titis Rohmat Hasnawati, Zakiyah Hastuti , Windi Hayati, Hanifah Fajarisna Hermawati Hermawati, Hermawati Hidayati, Miftachul Indarwati Indarwati Irmanopaliza, Ade Ismail Setyopranoto Khairunnisaa', Danik Martha Kurniawan Budi Santoso, Kurniawan Budi Laksmiwati, Pasttita Ayu Lestari, Enur Rara Lina Listiana Lina Listiana Mahmudah, Mutiara Hisda Mairina, Upik Masduki Masduki Masduki Maulida, Dini Wardani Muhamad Arief Rahman Muhamad Farhan Aprilianto Muhamad Toyib Muhammad Kholid Muhammad Noor Kholid Muhammad Toyib, Muhammad Nagy, Emese Kovácsné Nathania, Caroline Evanthe Nida Sri Utami Nining Setyaningsih Nuqthy Faiziyah Nur Rohman Nur Rohman Pamungkas, Haris Wahyu Pandhita S, Gea Paryono Pasttita Ayu Laksmiwati Peni Suharti Prabandari, Radha Sita Pratama, Muhammad Alif Prodjohardjono, Astuti Puteri, Mei Yunika Putri, Reni Widya Qhadhavy Putri, Iqlima Khartini Radha Sita Prabandari Rania, Nadhifa Riayuliatun, Evi Rita P Khotimah, Rita P Rita Pramujiyanti Khotimah Rita Rahmaniati Rusdijanto, Titania Alya Ruspeni Daesusi Ruspeni Daesusi Salsabila Nur Faizzah Satiti, Sekar Setyaningrum, Cempaka Thursina Srie Setyaningsih, Indarwati Silalahi, Lothar Matheus Manson Vanende Sri Rejeki Subagya Subagya, Subagya Subagya, Nanang Legawa Suharti, Peni Susianti, Noor Alia Sutama Toyib, Muhamad Trihapsari, Nadia Trisni, Rizka Umi S. Intansari Ida Savitri Laksanawati Wibowo, Eko Ari Yolanda Ika Damayati Yusuf Zakaria Zakaria, Yusuf