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All Journal Jurnal Pembangunan Pendidikan: Fondasi dan Aplikasi Jurnal Penelitian dan Evaluasi Pendidikan Dinamika Pendidikan International Journal on Emerging Mathematics Education Jurnal Ilmiah Mandala Education (JIME) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) JURNAL INOVASI DAN MANAJEMEN PENDIDIKAN The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Manajemen Pendidikan
Suyata Suyata
dinamikapendidikan
Arts Humanities Decision Sciences, Operations Research & Management Dentistry Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Correlation of Neutrophil-Lymphocyte Ratio, Alpha-Fetoprotein, and PIVKA-II with Staging of HCC Related HBV at Dr. Mohammad Hoesin Hospital, Palembang Rahmayani, Febry; Suyata, Suyata; ., Legiran
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025219-227

Abstract

Background: The staging of Hepatocellular carcinoma (HCC) requires evaluating the tumor size and number, liver function, physical performance, tumor invasion, extrahepatic metastasis, and clinical symptoms. Biomarkers such as neutrophil-lymphocyte ratio (NLR), alpha-fetoprotein (AFP), and protein induced by the absence of vitamin K or antagonist-II (PIVKA-II) have been identified as valuable diagnostic and prognostic tools for HCC. This study aims to investigate the correlation between NLR, AFP, and PIVKA-II and HCC stages.Methods: This observational study was conducted at the Department of Internal Medicine, Dr. Mohammad Hoesin Hospital, Palembang, from April to July 2024. HCC stages were classified using the Barcelona Clinic Liver Cancer (BCLC) system. NLR, AFP, and PIVKA-II levels were measured using  ELISA method. Data were analyzed susing one-way ANOVA or the Kruskal-Wallis test.Results: A total of 38 patients with HCC who met the inclusion criteria were included in the study. There was a weak positive correlation between NLR and HCC stage (r = 0.334; p = 0.040), a moderate positive correlation between AFP and HCC stage (r = 0.499; p = 0.001), and a strong positive correlation between PIVKA-II and HCC stage (r = 0.797; p = 0.000). PIVKA-II and AFP were found to have a significant sequential effect on the BCLC stage.Conclusion: PIVKA-II and AFP are significant indicators for assessing BCLC stages, offering valuable support for the diagnosis and management of HCC.
Co-Authors ., Legiran Eny Winaryati Erita Bustami Fauzia Fauzia Fuad Bakry Ghazi, M Ikhsan Al Hasanah, Enung Heri Retnawati Herly Janet Lesilolo Hidayati, Dian Imam Supriyanto Primardiana Hermilia Wijayati Rahmayani, Febry Sahrul Akbar Sumarno . Suripah Suripah Syadra Bardiman Syadra Bardiman Rasyad Widihastuti Wiyana, Adi Zamroni Zamroni