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All Journal Jurnal Pembangunan Pendidikan: Fondasi dan Aplikasi Jurnal Penelitian dan Evaluasi Pendidikan Dinamika Pendidikan International Journal on Emerging Mathematics Education Jurnal Ilmiah Mandala Education (JIME) J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) JURNAL INOVASI DAN MANAJEMEN PENDIDIKAN The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Manajemen Pendidikan
Suyata Suyata
dinamikapendidikan
Arts Humanities Decision Sciences, Operations Research & Management Dentistry Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Correlation of Neutrophil-Lymphocyte Ratio, Alpha-Fetoprotein, and PIVKA-II with Staging of HCC Related HBV at Dr. Mohammad Hoesin Hospital, Palembang Rahmayani, Febry; Suyata, Suyata; ., Legiran
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025219-227

Abstract

Background: The staging of Hepatocellular carcinoma (HCC) requires evaluating the tumor size and number, liver function, physical performance, tumor invasion, extrahepatic metastasis, and clinical symptoms. Biomarkers such as neutrophil-lymphocyte ratio (NLR), alpha-fetoprotein (AFP), and protein induced by the absence of vitamin K or antagonist-II (PIVKA-II) have been identified as valuable diagnostic and prognostic tools for HCC. This study aims to investigate the correlation between NLR, AFP, and PIVKA-II and HCC stages.Methods: This observational study was conducted at the Department of Internal Medicine, Dr. Mohammad Hoesin Hospital, Palembang, from April to July 2024. HCC stages were classified using the Barcelona Clinic Liver Cancer (BCLC) system. NLR, AFP, and PIVKA-II levels were measured using  ELISA method. Data were analyzed susing one-way ANOVA or the Kruskal-Wallis test.Results: A total of 38 patients with HCC who met the inclusion criteria were included in the study. There was a weak positive correlation between NLR and HCC stage (r = 0.334; p = 0.040), a moderate positive correlation between AFP and HCC stage (r = 0.499; p = 0.001), and a strong positive correlation between PIVKA-II and HCC stage (r = 0.797; p = 0.000). PIVKA-II and AFP were found to have a significant sequential effect on the BCLC stage.Conclusion: PIVKA-II and AFP are significant indicators for assessing BCLC stages, offering valuable support for the diagnosis and management of HCC.
Pemanfaatan Limbah Minyak Jelantah dalam Pembuatan Sabun Padat: Program Pengabdian Masyarakat di Desa Kebanggan Khoeriyyah, Fatimah Zahza; Muslihah, Niken istikhari; Lestari, Puji; Suyata, Suyata; Irmanto, Irmanto
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 11 No 1 (2026): April
Publisher : Politeknik Negeri Jember

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Waste is unused material that comes from various human activities. One type of waste that is widely produced from household activities is used cooking oil. Used cooking oil is cooking oil that has been used repeatedly and has deteriorated, making it hazardous to health and the environmental ecosystem. Processing used cooking oil into solid soap is a simple, economical, and environmentally friendly innovation that can be applied on a household scale based on the principle of zero waste industry. This community service activity was carried out in collaboration with the Aisyiyah Branch in Kebanggan Village, Sumbang District, Banyumas, where most of the members are housewives. The main objective of the program was to raise environmental awareness while empowering partners through training in making solid soap from used cooking oil. The methods used included socialization on the dangers of used cooking oil waste, the practice of making solid soap using the cold process method, and the application of the soap produced for washing kitchen utensils. Evaluation was carried out through pre-tests and post-tests to assess the increase in community knowledge and skills. The results of the activity showed a significant increase in the participants' understanding and skills in processing used cooking oil into useful products with quality that meets the 2021 Indonesian National Standard (SNI).
Correlation Between Serum Soluble PD-1, CD8+ , CD4+ T Lymphocyte Counts and Liver Stiffness in Antiviral-Naïve Chronic Hepatitis B Patients Aliana, Rizki; Yuristo, Eddy; Legiran, Legiran; Suprianto, Imam; Busro, Vidi Orba; Astoni, Muhamad Ayus; Sya'roni, Anjab Akmal; Suyata, Suyata; Zaky, Samy
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202610-18

Abstract

Background: Chronic hepatitis B (CHB) disease is a major global health problem with a high burden in Asia, including Indonesia. Liver stiffness measurement by transient elastography is a non-invasive key tool to assess fibrosis severity. The immune response in CHB involves T cell exhaustion marked by elevated soluble PD-1 (sPD-1) and changes in T lymphocyte subsets, which may influence fibrosis progression. This study aimed to assess the correlation between serum sPD-1, CD4+, and CD8+ T lymphocyte counts and liver stiffness in antiviral-naïve CHB patients.Methods: A cross-sectional study was conducted among 60 untreated CHB patients at Mohammad Hoesin Hospital, Palembang, Indonesia. The sPD-1 was measured by ELISA, while CD4+ and CD8+ T cell counts were determined via flow cytometry. Liver stiffness was assessed by transient elastography. Spearman correlation and multivariate linear regression were used to analyze associations between immune markers and liver stiffness.Results: Serum sPD-1 showed a significant positive correlation with liver stiffness (r = 0.481, p 0.001), while CD8+ T lymphocyte count was negatively correlated (r = –0.553, p 0.001). CD4+ T lymphocyte count showed no significant bivariate correlation (r = –0.189, p = 0.149). In the multivariate analysis, sPD-1 (β = 0.050, p 0.001), CD4+ T cells (β = –0.018, p = 0.001), and AST (β = 0.061, p = 0.005) were independent predictors of liver stiffness.Conclusion: Serum sPD-1 and CD4+ T-lymphocyte count are independently associated with liver stiffness in antiviral-naïve CHB patients. These findings suggested the involvement of immune exhaustion and liver injury in HBV-related fibrosis.
Co-Authors ., Legiran Aliana, Rizki Busro, Vidi Orba Eny Winaryati Erita Bustami Fauzia Fauzia Fuad Bakry Ghazi, M Ikhsan Al Hasanah, Enung Heri Retnawati Herly Janet Lesilolo Hidayati, Dian Imam Supriyanto Irmanto, Irmanto Khoeriyyah, Fatimah Zahza Legiran Legiran Muhamad Ayus Astoni Muslihah, Niken Istikhari Primardiana Hermilia Wijayati PUJI LESTARI Rahmayani, Febry Sahrul Akbar Sumarno . Suprianto, Imam Suripah Suripah Sya'roni, Anjab Akmal Syadra Bardiman Syadra Bardiman Rasyad Widihastuti Wiyana, Adi Yuristo, Eddy Zaky, Samy Zamroni Zamroni