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The Bioactive Constituents of Piper aduncum L. as Estrogen Receptor-α Inhibitors: in silico studies Shafa, Nafis; Lathifah, Salma Sri; Alifa, Zahra; Syahid, Muhammad; Ismail, Dzava Prawinsyah Fairus; Mahardika, Bintang Satrio; Novitasari, Dhania
Indonesian Journal of Biological Pharmacy Vol 5, No 3 (2025): IJBP (Desember)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v5i3.69270

Abstract

Wild betel (Piper aduncum L.) is a traditional medicinal plant with reported anticancer potential, particularly against breast cancer. Breast cancer remains a leading cause of cancer-related mortality worldwide, largely driven by estrogen receptor alpha (ERα)–mediated tumor growth. This study aimed to evaluate the potential of bioactive compounds from P. aduncum as ERα inhibitors using an in silico approach. Twenty compounds identified from P. aduncum were assessed for drug-likeness and ADMETox properties, followed by pharmacophore modeling and molecular docking against ERα. Phlorizin, linalool, and phloretin exhibited the highest pharmacophore fit scores, with the optimal model demonstrating strong predictive performance (AUC = 0.95). Among these compounds, phlorizin showed the strongest binding affinity for ERα (−10.38 kcal/mol), with a predicted inhibition constant of 24.77 µM, forming key interactions with GLU353, ALA350, and LEU525, comparable to those of the reference ligand 4-hydroxytamoxifen. Overall, these findings indicate that P. aduncum–derived compounds, particularly phlorizin, phloretin, and linalool, are promising ERα inhibitor candidates and merit further experimental validation for breast cancer therapy.
The Influence of Working Capital Financing, Micro Financing and Qardhul Hasan Funds on the Performance of Islamic Commercial Banks in Indonesia Syahid, Muhammad; Elzaanin, Amina A.A; Noviarita, Heni; Kartika, Akbar Pratama; Noval, Muhammad
Jurnal Ilmiah Ekonomi Islam Vol. 10 No. 3 (2024): JIEI : Vol.10, No.3, 2024
Publisher : ITB AAS INDONESIA Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29040/jiei.v10i3.15433

Abstract

To maintain existence and competitiveness, various products are needed that can reach all levels of business needs. Working Capital Financing is intended for SME Retail to commercial scale, Micro Financing is intended for medium-sized MSMEs, while Qardhul Hasan financing is intended if lending lacks capital in the current contract. For this reason, this article wants to test how much influence Working Capital Financing and Micro Financing and with Qardhul Hasan Funds as moderating variables have on the Profitability of Islamic Banks in Indonesia. This study involved 14 Islamic Commercial Banks from 2019-2023 registered with the Financial Services Authority. The data was obtained from the OSIRIS website. The data analysis method used was multiple regression analysis. The hypothesis tests carried out were the F test, T test, and Adjusted R 2 determination coefficient. The results of the study simultaneously showed that independent variables had a significant effect on Islamic Bank Performance with a significance of 67%, this was because DQH was allocated to the productive sector and was included in the priority scale of superior customers. While partially PMK has a negative effect because it uses a profit sharing contract that is quite risky, and the PM and DQH variables have a positive effect on the performance of Islamic Banks, this is because PM uses a sale and purchase contract so that the risk is minimal and DQH uses the Qardhul hasan contract which is allocated to the productive sector so that the risk is minimal. The finding of this lending can be evaluated or converted with various products according to customer needs so that the performance of Islamic Banks can continue to increase as long as it does not deviate from Banking Quality Sharia which is its main mission.
Determination Of Commercial Banks’ Profitability In Indonesia Syahid, Muhammad; Elzaanin, Amina A.A; Purnamasari, Sinta Ayu; Sari, Wahyu Nita; Badriah, Siti
Jurnal Ilmiah Ekonomi Islam Vol. 10 No. 3 (2024): JIEI : Vol.10, No.3, 2024
Publisher : ITB AAS INDONESIA Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29040/jiei.v10i3.15485

Abstract

This research explores the relationship between specific characteristics of banks and their profitability. Bank profitability is related to external and internal factors regarding assets, capital, and loans in general. This study is mainly concerned with internal factors that influence the profitability of commercial banks in Indonesia. 55 Banks including 51 National Private Banks, and 4 Public Sector Banks. Data taken in its entirety from the Financial Services Authority website in 2023. Using the Ordinary Least Square (OLS) method with the help of Stata software. The results of the research show that in a simultaneous test, the asset, capital, and loan variables have a positive and significant effect on profitability with the figure obtained being 78% while other variables explain the rest, while in a partial test, the asset and bank loan variables harm bank profitability, and only the capital variable which is positively related to profitability by 86%, and the rest is explained by other variables. This shows that large banks may face similar challenges as marginal profits decrease as targets must be achieved because in fact the bank Asset and Loan variables are also expected to be the main source of income so that they have a positive relationship with bank performance.
Sosialisasi Energi Terbarukan dan Pelatihan Perakitan Listrik Tenaga Surya pada Siswa Sekolah Alam Le Cendekia Gowa Muhammad Syahid; Jalaluddin .; Andi Amijoyo Mochtar; Gerard Antonini Duma; Rudi Amme; Lukman Kasim; Muh. Arjun
JURNAL TEPAT : Teknologi Terapan untuk Pengabdian Masyarakat Vol 7 No 1 (2024): Community Development
Publisher : Faculty of Engineering UNHAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25042/jurnal_tepat.v7i1.455

Abstract

Renewable energy is energy that comes from renewable energy sources. Renewable energy sources are energy sources that can be used indefinitely and will never run out because they can be recovered in a relatively short time, including geothermal, wind, bioenergy, sunlight, water flows and waterfalls, as well as movements and temperature differences in ocean layers.” Solar panels are the main equipment in a solar power generation system which functions to convert sunlight energy into electrical energy directly. Nowadays, human dependence on energy concerns almost all aspects of life. Energy reserves originating from fossil fuels throughout the world are estimated to only be up to 40 years for petroleum, 60 years for natural gas, and 200 years for coal. The condition of limited energy sources in the midst of increasing world energy needs from year to year (energy consumption growth in 2004 alone was 4.3 percent), as well as to protect the earth from global warming and environmental pollution makes the demand for immediate realization of new technology for renewable energy sources. Therefore, the Community Service Team of the Department of Mechanical Engineering, Faculty of Engineering, Hasanuddin University held community service at the LE CENDEKIA Nature School on December 14 2023. The aim of this service is to increase understanding regarding renewable energy and carry out simple applications of renewable energy for students. The method of implementing the service is by interview on the importance of renewable energy and training in solar power assembly. There were 25 socialization and training participants. Community service results show an increase in understanding of the importance of renewable energy from 20% to 50%, and knowledge about solar power assembly from 5% to 45%.
Design of a Combination of a Chopping Machine and Mobile Fermentation Tank for Cattle Breeders in Bone Regency Fauzan Djamaluddin; Muhammad Syahid; Ilyas Renreng
JURNAL TEPAT : Teknologi Terapan untuk Pengabdian Masyarakat Vol 8 No 2 (2025): Collaboration for Accelerated Community Achievement
Publisher : Faculty of Engineering UNHAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25042/jurnal_tepat.v8i2.620

Abstract

Smallholder cattle farms in Sanrego Village, Kahu District, Bone Regency, face significant challenges related to the availability of green fodder, particularly during the dry season. To overcome this problem, the adoption of appropriate technology is essential to enhance feed processing efficiency and ensure a consistent supply of high-quality silage. This community service initiative was conducted under the Universitas Hasanuddin (UNHAS) Community Service Program in collaboration with partner institution CV. Reza. The program focused on the redesign of a mobile shredding machine integrated with a fermentation tank, developed to be more efficient, user-friendly, and aligned with the practical needs of local livestock farmers. The implementation process involved several stages, including problem identification, machine redesign, prototype development, user training, and mentoring for farmers. The results demonstrated that the redesigned machine effectively accelerated the shredding process, produced uniformly chopped green fodder, and facilitated efficient silage production. This technological innovation is expected to enhance farmer self-sufficiency, reduce feed production costs, and promote the sustainability of cattle farming enterprises in Bone Regency.
Application of Appropriate Technology to Revitalize Palm Sugar and Pepper Businesses in Lombo Village Syahidah Syahidah; Makkarennu .; Muhammad Syahid; Asriana Abdullah; Andi Ahmad Rizaldy; Aulia Fatimah Khairunnisa
JURNAL TEPAT : Teknologi Terapan untuk Pengabdian Masyarakat Vol 9 No 1 (2026): Environmental-based Awareness for Agile Community Strength
Publisher : Faculty of Engineering UNHAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25042/jurnal_tepat.v9i1.657

Abstract

This community service program aims to increase the added value of palm sugar and pepper commodities in Lombo Village, Pitu Riase District, Sidenreng Rappang Regency, through social innovation downstreaming based on a sustainability approach. The activities were designed using the participatory rural appraisal method involving two partner farmer groups, the village government, and students. Interventions were implemented through socialization, hygienic production training, product diversification (palm sugar powder, liquid palm sugar, cube palm sugar, and pepper powder), assistance in adopting appropriate technologies (sap evaporator, dryer machine, grinder, and packaging machine), micro-enterprise management training, and digital marketing. Evaluation was carried out using pre–post tests, field observations, and semi-structured interviews to measure improvements in knowledge, skills, and business behavior. The results indicate increased community enthusiasm and participation, improved adoption of production technologies leading to higher process efficiency and product quality consistency. In addition, the program encouraged the formulation of a sustainability plan for farmer group institutions in managing village businesses based on local commodities.