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The Effect of Ethanol Extract of Jicama (Pachyrhizus erosus) on Apoptosis Index and Endometrial Thickness in White Rats (Rattus norvegicus) Ovariectomy Model Meirna Eka Fitriasnani; Mayasari Putri Ardela; Clara Anabel Galla; Ayu Tiska Arlik Insiati
STRADA : Jurnal Ilmiah Kesehatan Vol. 14 No. 2 (2025): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v14i2.1286

Abstract

Menopause is the permanent cessation of menstruation due to the loss of ovarian follicular activity, which marks the end of a woman's reproductive function. During menopause, estrogen levels decrease, triggering oxidative stress, leading to cell death (apoptosis) and a decrease in endometrial thickness, which can lead to symptoms such as hot flushes, sleep disturbances, decreased sexual desire, and changes in the menstrual cycle. Menopause-related symptoms are considered natural and are often ignored because they are related to a woman's menstrual cycle. Menopause-related problems increase morbidity and mortality due to inadequate treatment, so interventions are needed to reduce morbidity by alleviating symptoms during menopause.