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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung Language Circle : Journal of Language and Literature Indonesian Journal of Cancer Chemoprevention MEDISAINS Public Health of Indonesia Universa Medicina International Journal of Law Reconstruction Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Cahaya Mandalika Asian Journal of Health and Applied Sciences JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Journal of Health and Nutrition Research Jurnal Ilmiah Sultan Agung Gema Lingkungan Kesehatan Narra X Indonesian Journal of Biomedicine and Clinical Sciences Media Penelitian dan Pengembangan Kesehatan Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Setyo Trisnadi
Bagian Forensik dan Unit Bioetik Fakultas Kedokteran Universitas Islam Sultan Agung Semarang
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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The Responsibility of Social Security Organizing Agency (BPJS) When Participants are Rejected by Hospital in the Perspective of Civil Agreement Law Trisnadi, Setyo
International Journal of Law Reconstruction Vol 7, No 2 (2023): International Journal of Law Reconstruction
Publisher : UNISSULA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/ijlr.v7i2.32488

Abstract

BPJS participants often experience discrimination by hospitals, hospital services for general patients and BPJS participants are very different. The purpose of this research is to analyze Position of Health Insurance Agreement and to analyze Liability of the Social Security Agency in the Case of Rejection of BPJS Participants by Hospitals in the Perspective of Civil Agreement Law. The method used in this study was normative method. Normative legal research in its development is research that uses the study of legal behavior concluded in legislation. BPJS neglect of its participants when there is a rejection by its partner hospitals is an act of default for BPJS participants. So it is clear that the neglect of BPJS towards its participants in the issue of rejection of BPJS participants by BPJS partner hospitals is clearly an action that violates the obligations, duties, and responsibilities of BPJS towards BPJS participants, this is not in accordance with what is promised in the health social security agreement made by BPJS with its participants.
In Vivo Evaluation of Butterfly Pea (Clitoria ternatea) Flower Gel on IL-10 and STAT3 Expression in Thermally Induced Skin Burns Mediana, Mecha Amalia; Hussaana, Atina; Trisnadi, Setyo
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.563

Abstract

Burn injuries caused by thermal exposure trigger oxidative stress and inflammation, largely driven by reactive oxygen species (ROS) and systemic inflammatory response syndrome (SIRS). These mechanisms may disrupt the production of cytokines involved in tissue repair, such as interleukin-10 (IL-10) and signal transducer and activator of transcription 3 (STAT3). Clitoria ternatea L. (butterfly pea) contains potent antioxidant and anti-inflammatory phytochemicals, making it a promising candidate for modulating inflammatory responses and promoting wound healing. This study evaluated the effects of Clitoria ternatea extract gel on IL-10 and STAT3 expression in second-degree burn injuries using a Wistar rat (Rattus norvegicus) model. A post-test only control group design was employed, involving 30 male rats randomly assigned to five groups (G1–G5). Second-degree burns were induced using a 1.8 cm diameter heated metal plate applied to the dorsal skin for 3 seconds after heating for 15 minutes. Treatments with the extract gel were administered topically for seven days. Skin samples were collected 24 hours after the last application and analyzed for IL-10 and STAT3 mRNA expression using qRT-PCR. Data were statistically tested with One-Way ANOVA. The results showed no significant differences in IL-10 expression among all groups. However, STAT3 expression was significantly higher in the groups treated with 5% and 10% Clitoria ternatea extract gel, with the highest observed in the 10% group (6.73 ± 2.94). These findings indicate that while IL-10 remained unaffected, butterfly pea extract gel effectively increased STAT3 expression, suggesting its potential role in modulating regenerative pathways in burn-injured skin
Modulation of inflammatory pathways in ischemic stroke rats by hypoxia-primed umbilical cord mesenchymal stem cells (UC-MSCs): Implications for IFN-γ and IL-10 signaling Fahreza, Rakha; Setiawan, Eko; Trisnadi, Setyo; Putra, Agung; Hidayah, Nurul; Fikriya Novita Sari; Ibrahim, Sugeng
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.24529

Abstract

Ischemic stroke is a major global cause of disability and mortality. Inflammation plays a central role in its pathogenesis, characterized by elevated pro-inflammatory cytokines such as IFN-γ and reduced anti-inflammatory cytokines like IL-10. Mesenchymal stem cells (MSCs), especially those derived from the umbilical cord (UC-MSCs), exhibit enhanced immunomodulatory potential when preconditioned under hypoxia. This study aims to evaluate the effect of hypoxic-preconditioned UC-MSCs administration on IFN-γ and IL-10 levels in an ischemic stroke rat model. This in vivo experimental study employed a randomized posttest-only control group design with four groups of male Wistar rats (n=6 each), ranging from healthy controls, untreated group to stroke-induced groups treated with hypoxic UC-MSCs at different doses (1.5x106 and 3x106). IFN-γ and IL-10 levels in brain tissue of each group were measured via ELISA. Significant reduction in IFN-γ and elevation in IL-10 were observed in UC-MSC-treated groups, particularly at the 3×10⁶ cell dose compared to the untreated ischemic group (p<0.05). Hypoxic UC-MSCs reduce post-stroke inflammation by lowering IFN-γ and enhancing IL-10, indicating a promising immunomodulatory potential.
Topical Catharanthus roseus gel modulates TNF-α expression and SOD activity in UVB-induced skin: an in vivo experimental study Noviana Gunawan, Gina; Trisnadi, Setyo; Sarosa , Hadi
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.28817

Abstract

Background: Subchronic UVB exposure induces oxidative stress and skin inflammation, characterized by increased TNF-α expression and decreased antioxidant activity, including superoxide dismutase (SOD). Catharanthus roseus contains bioactive compounds with potential anti-inflammatory and antioxidant properties; however, evidence regarding its topical effects on UVB-induced skin damage remains limited. Objective: To evaluate the effects of Catharanthus roseus extract gel on TNF-α expression and SOD activity in UVB-induced skin and to compare the effectiveness of 15% and 30% concentrations. Methods: A post-test-only controlled experimental study was conducted using 30 mice divided into five groups: normal control, negative control, positive control (vitamin E), 15% extract gel, and 30% extract gel. TNF-α expression and SOD activity were measured using ELISA and analyzed with one-way ANOVA. Results: UVB exposure significantly increased TNF-α expression and decreased SOD activity in the negative control group compared with the normal group. Treatment with Catharanthus roseus extract gel improved both parameters. No significant differences were observed between the 15% and 30% concentrations for TNF-α (p = 0.376) or SOD activity (p = 0.237), indicating comparable effects. Conclusions: Topical Catharanthus roseus extract gel modulates TNF-α expression and SOD activity in UVB-induced skin. Comparable effects between 15% and 30% concentrations suggest that the lower concentration may be sufficient to achieve the desired biological response.
Co-Authors Agung Putra Agus Suprijono Amalina, Nur D. Anggara, Andhika Dwi Anggraeni, Gilda Putri Aprilyanti, Dwi Fikha Ardani, Yanuar Atina Hussaana Atmanegara, Kartika Azizah Retno Kustiyah Cahyono, Erwin Budi Chodidjah Chodidjah Chodidjah Darlan, Dewi M. Dian Novitasari Didik Murwantono Djannah, Durrotul Dwi Lestari, Rinna Effendi, Anita Putri Eko Setiawan Fahreza, Rakha Fikriya Novita Sari Hasanal, Ihdina Hanifa Henri Perwira Negara, Henri Perwira Husain, Sofian A. Hutagalung, Ananta Ibrahim, Sugeng Imam Djamaluddin Mashoedi Intan, Yulice Soraya Nur Israhnanto Isradji Istiqomah istiqomah istiqomah Iwang Yusuf Joko Wahyu Wibowo Lusiana Lusiana Mayangsari, Citra Primavita Mediana, Mecha Amalia Muhar, Adi Muradi Noviana Gunawan, Gina Nur Anna Chalimah Sadyah Nurul Hidayah Rahim, Denasa Dwi Sopandita Rinawati Rinawati Rinawati Rinna Dwi Lestari Rony, Zahara Tussoleha Sarosa , Hadi Siti Thomas Zulaikhah Soffan, Mochammad Soffan, Muhammad Sri Priyantini Sunarto, Hadi Sundari, Sri Titiek Sumarawati Tjipta, Arya Zulaikah, Siti Thomas