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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung Language Circle : Journal of Language and Literature Public Health of Indonesia Universa Medicina Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Asian Journal of Health and Applied Sciences JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Jurnal Ilmiah Sultan Agung Gema Lingkungan Kesehatan Narra X Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Setyo Trisnadi
Bagian Forensik dan Unit Bioetik Fakultas Kedokteran Universitas Islam Sultan Agung Semarang
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Strengthening emotional intelligence intervention on behavior changes of mothers in stunting prevention Sari, Rita Kartika; Mayangsari, Citra Primavita; Mashoedi, Imam Djamaluddin; Intan, Yulice Soraya Nur; Trisnadi, Setyo; Aprilyanti, Dwi Fikha
International Journal of Public Health Science (IJPHS) Vol 13, No 2: June 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i2.23652

Abstract

This study aimed to determine the effect of applying Emotional intelligence reinforcement to changes in stunting prevention behavior at the Kedung 2 Health Center, Jepara. This study employed a cross-sectional approach and data from participants at the Kedung 2 Public Health Center in Jepara. Public Health Center, Jepara. Participants were taken by purposive sampling according to predetermined maternal criteria, and 82 participants were obtained. Quasi-experimental research methods with two groups of emotional intelligence strengthening design, pre-intervention and post-intervention. Data collection used a questionnaire to measure the emotional intelligence of respondents and stunting prevention behavior. The data were then analyzed using the SPSS program. The correlation value shows that there is a strong relationship between the strengthening of emotional intelligence interventions and changes in maternal stunting prevention behavior, with a correlation value of 0.905 and a significance value of less than 0.001. The results of the T-test also showed significant behavioral changes in stunting prevention behavior before and after the application of strengthening emotional intelligence, with a significance value of 0.008. Strengthening emotional intelligence has a strong positive correlation with stunting prevention behavior, and the results of the T-test show that there is a significant effect on the results of stunting prevention behavior between before and after strengthening emotional intelligence. As a result, strengthening maternal emotional intelligence should be a priority to prevent stunting.
The Effect Honey Has on SOD and Caspase9 Levels with Exposure to Cigarette Smoke in Wistar Rats Fentri, Ela; Isradji, Israhnanto; Trisnadi, Setyo
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 2 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i2.9102

Abstract

Cigarettes are a source of exogenous free radicals which disrupt the balance between free radicals and antioxidants in the body, causing oxidative stress. The aim of this study was to determine the effect of giving honey (Mel depuratum) on SOD and caspase-9 levels in Wistar rats exposed to cigarette smoke. This research used a laboratory experimental approach with a post-test only control group design. 24 Wistar rats were divided randomly into 4 groups then analysis tests were carried out using the One-Way ANOVA test and followed by the Post-Hoc LSD test. The results showed that the mean SOD levels in groups K1, K2, K3, K4 were 73.51 ± 1.68, 21.72 ± 2.23, 52.08 ± 2.03, and 73.51 ± 1.68. The results of the One Way Anova test showed a significant difference in SOD levels with a value of p = 0.000. The results of the LSD Post-Hoc Test showed that SOD levels between groups had significant differences in all groups (p=0.000). The IHK staining results showed that samples K1 and K4 were negative, while K2 showed strong positive and K3 was moderately positive.
Hypoxic mesenchymal stem cell secretome upregulates IL-10 and STAT3 gene expressions in mice model with polycystic ovary syndrome Lusiana, Lusiana; Darlan, Dewi M.; Trisnadi, Setyo; Putra, Agung; Amalina, Nur D.; Husain, Sofian A.
Narra X Vol. 2 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i3.176

Abstract

Polycystic ovary syndrome (PCOS) is a condition characterized by chronic anovulation and hyperandrogenism, which often leads to infertility. It is closely associated with chronic inflammation triggered by glucose and saturated fat, contributing to hyperandrogenism and negatively impacting a patient’s quality of life. Effective therapeutic approaches are essential to address these issues. The secretome of mesenchymal stem cells (MSCs) have demonstrated the ability to suppress pro-inflammatory cytokine secretion and regulate growth factors. The aim of this study was to investigate the effect of hypoxic mesenchymal stem cell secretome (MHSSCs) on the expression of interleukin-10 (IL-10) and signal transducer and activator of transcription 3 (STAT3) genes in a PCOS-induced mouse model. An in vivo experimental study was conducted using a post-test-only control group design. A total of 24 female C57BL/6 mice were divided into four groups: healthy control, negative control (PCOS mice injected with 0.9% NaCl), T1 (PCOS mice administered 200 μL of MHSSCs), and T2 (PCOS mice administered 400 μL of MHSSCs) for 33 days. Gene expression of IL-10 and STAT3 were quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR), normalized to the expression of the housekeeping β-actin gene. Statistical analysis using one-way ANOVA followed by the least significant difference (LSD) post-hoc test was then performed. The results showed a significant increase in IL-10 expression in the T2 group compared to the negative control group (p<0.001). STAT3 expression was also significantly higher in the T2 group compared to the negative control group (p=0.035). A dose-dependent effect was observed, with the T2 group demonstrating the highest upregulation of both IL-10 and STAT3 expression levels. The study highlights that the administration of MHSSCs effectively increased IL-10 and STAT3 gene expression, suggesting their potential as a therapeutic strategy to alleviate inflammation in PCOS.
Effect of Turmeric Ethanol Extract (Curcuma Longa Linn) on IL-6, IL-10 Levels and Skin Moisture Anggraeni, Gilda Putri; Sumarawati, Titiek; Chodidjah; Wibowo, Joko Wahyu; Zulaikah, Siti Thomas; Trisnadi, Setyo
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.330

Abstract

Ultraviolet B (UVB) radiation is known to induce skin damage, including erythema, roughness, sagging, wrinkles, and reduced skin moisture, contributing to premature aging. Turmeric (Curcuma longa Linn.) contains curcumin, an active compound with potent anti-inflammatory properties. This study investigated the effect of turmeric ethanol extract on IL-6 and IL-10 levels, as well as skin moisture, in UVB-exposed rats. A total of 24 Wistar rats were randomly divided into four groups: healthy controls (K1), UVB-exposed without treatment (K2), UVB-exposed treated with turmeric ethanol extract at 100 mg/kg BW (K3), and 200 mg/kg BW (K4). The extract was administered orally for 14 days. IL-6 and IL-10 levels were measured using ELISA, and skin moisture was assessed macroscopically. Statistical analysis was performed using one-way ANOVA. Rats in groups K2, K3, and K4 exhibited very dry skin, redness, visible wrinkles, and peeling following UVB exposure. IL-6 levels were significantly lower in treated groups, with the lowest levels observed in K4 (1.85 ± 0.24 ng/L), compared to K1 (4.36 ± 0.75 ng/L) and K2 (4.46 ± 0.74 ng/L) (p = 0.000). IL-10 levels increased in the treated groups, notably in K3 (376.48 ± 78.24 pg/mL) and K4 (351.06 ± 78.24 pg/mL), compared to K1 (285.34 ± 45.54 pg/mL) and K2 (306.89 ± 45.54 pg/mL) (p = 0.001). These findings suggest that oral administration of turmeric ethanol extract modulates inflammatory responses by reducing IL-6 and enhancing IL-10 in UVB-exposed skin, although significant dryness persists.
Effect of Turmeric Ethanol Extract (Curcuma Longa Linn.) on Tumor Necrosis Factor alpha (TNFα) and the extent of wound lesions (Experimental Study on Wistar Rats Exposed to UVB Rays) Rahim, Denasa Dwi Sopandita; Sumarawati, Titiek; Chodidjah; Zulaikhah, Siti Thomas; Priyantini, Sri; Trisnadi, Setyo
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.331

Abstract

Continuous exposure to ultraviolet B (UVB) radiation can induce photoaging and accelerate premature skin aging. Turmeric (Curcuma longa) is a medicinal plant that contains curcumin, an active compound known for its anti-inflammatory properties and its role in accelerating wound healing. This study aimed to evaluate the effect of turmeric ethanol extract on TNF-α levels and wound lesion areas in Wistar rats exposed to UVB radiation. A post-test-only control group design was employed, involving 24 Wistar rats divided into four groups: a healthy control group (K1), a negative control group (K2), and two treatment groups receiving oral turmeric ethanol extract at doses of 100 mg/kg BW (K3) and 200 mg/kg BW (K4) for 14 days, with concurrent UVB exposure. TNF-α levels were assessed using one-way ANOVA followed by Tukey's post hoc test, while wound lesion areas were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney U test. The results showed that the highest TNF-α levels were observed in the healthy control group (129.14 ng/L), although no statistically significant differences were found between groups (p = 0.538). In contrast, a significant difference was observed in wound lesion areas (p < 0.001), with the largest lesions occurring in the negative control group. In conclusion, oral administration of turmeric ethanol extract did not significantly affect TNF-α levels but was effective in reducing the area of wound lesions caused by UVB exposure.
Kekerasan Fisik pada Anak, Faktor Risiko, dan Komplikasinya : Sebuah Tinjauan Pustaka Novitasari, Dian; Istiqomah; Trisnadi, Setyo
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 3 No. 2 (2025)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol3.iss2.art12

Abstract

Kekerasan fisik pada anak secara khusus mengacu pada penggunaan kekuatan fisik yang dapat berdampak buruk secara signifikan terhadap kesehatan, keselamatan, perkembangan, dan martabat anak. Pengalaman yang terjadi selama masa kanak-kanak dapat memberikan dampak besar terhadap pertumbuhan dan perkembangan anak di masa depan. Diharapkan, kekerasan pada anak yang terus meningkat setiap tahun dapat dicegah melalui identifikasi faktor risiko dan tanda-tanda kekerasan, guna meningkatkan kualitas hidup anak yang mengalami kekerasan di masa mendatang. Penelitian literatur mengenai kekerasan fisik pada anak, faktor risiko, dan komplikasinya menggunakan basis data Google Scholar. Berbagai literatur dikumpulkan untuk memberikan informasi terkait kekerasan fisik pada anak yang mencakup definisi, epidemiologi, faktor predisposisi, jenis-jenis kekerasan fisik, identifikasi, serta konsekuensi jangka panjang. Jumlah kasus kekerasan terhadap anak meningkat setiap tahun. Kasus kekerasan pada anak diharapkan dapat dicegah dengan mengenali faktor risiko dan tanda-tanda kekerasan, sehingga kualitas hidup anak yang mengalami kekerasan dapat ditingkatkan di masa depan. Kata Kunci: Kekerasan Fisik pada Anak; Epidemiologi; Faktor Risiko; Jenis Identifikasi; Konsekuensi
How Female Adolescents Exposed To Pornography? Sari, Rita Kartika; Anggara, Andhika Dwi; Intan, Yulice Soraya Nur; Mayangsari, Citra Primavita; Yusuf, Iwang; Trisnadi, Setyo; Rinawati
Public Health of Indonesia Vol. 11 No. 3 (2025): July - September
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i3.1008

Abstract

Background: The digital era has markedly increased adolescents’ exposure to explicit content, including pornography, raising significant concerns regarding its impact on sexual and reproductive health. This is particularly critical among female adolescents in Indonesia, where access to comprehensive sexual education remains limited. Objective: This study aims to examine the exposure of female adolescents to pornographic content, with a focus on patterns of media consumption and their implications for reproductive health. Methods: A descriptive cross-sectional study was conducted among 58 female adolescents aged 13 to 18 years in Karanganyar, Indonesia. Data were collected using a validated questionnaire and analyzed through descriptive statistical methods to identify patterns of media usage and exposure to pornography. Results: The findings indicated that the internet and handheld devices were the predominant sources of media consumption (96.6%), significantly contributing to exposure to pornographic material (86.2% and 96.6%, respectively). Television and print media also played contributory roles, particularly through soap operas and Western films. Exposure to pornography was associated with limited awareness of reproductive health, especially among younger participants. The exposure was further linked to distorted perceptions of sexual behavior, negative body image, and potential psychological consequences such as anxiety and low self-esteem. Conclusion: This study highlights the urgent need for targeted interventions to enhance critical media literacy and provide comprehensive sexual education for adolescents. Addressing these issues is essential to mitigate the adverse effects of pornography exposure on reproductive health, while taking into account cultural and contextual factors. Future research should investigate the longitudinal effects and gender-specific outcomes to inform the development of tailored preventive strategies. Keywords: adolescents; pornography; media exposure; reproductive health; sexual education
HUBUNGAN ANTARA KERAWANAN WILAYAH DENGAN DENGAN TINDAKAN KRIMINALITAS REMAJA Atmanegara, Kartika; Trisnadi, Setyo
Jurnal Ilmiah Penelitian Mahasiswa Vol 4, No 3 (2025): SEPTEMBER 2025
Publisher : Jurnal Ilmiah Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kerawanan wilayah mempengaruhi tindakan kriminalitas remaja. Penelitian ini bertujuan untuk mengetahui hubungan antara kerawanan wilayah dengan tindakan kriminalitas remaja. Penelitian observasional dengan rancangan cross sectional melalui teknik consecutive sampling dengan jumlah total sampel varibel sebanyak 144 populasi dengan menggunakan data visum et repertum. Data dianalisis dengan chi square. Hasil penelitian ini menunjukan bahwa usia terbanyak pada pelaku tindakan kriminalitas remaja di usia 18 tahun sebanyak 84 pelaku (58,3%) dengan usia korban terbanyak di usia (1 – 20) tahun sebanyak 68 korban (46,5%) dan usia korban di usia (21- 40) tahun sebanyak 68 korban (46,5%). Jenis kelamin pelaku tindakan kriminalitas remaja, banyak dilakukan oleh pelaku yang berjenis kelamin laki – laki sebanyak 76 pelaku (52,8%). Lokasi kejadian yang paling banyak di temukan berada di wilayah Semarang Selatan sebanyak 43 korban (29,9%) dan di Semarang Timur sebanyak 35 korban (24,3%) dengan tempat kejadian terbanyak di lingkungan permukiman sebanyak 51 korban (35,4%) dengan jam kejadian yang sering dilakukan oleh pelaku di antara jam (00.00 – 06.00) sebanyak 43 korban (29,9%). Regio luka yang sering mengenai korban berada di area wajah sebanyak 34 korban (23,6%) dan jumlah regio luka terbanyak berada di 1 regio sebanyak 79 korban (54,9%). Kata kunci: Kerawanan wilayah, tindakan kriminalitas remaja.
Co-Authors Agung Putra Agus Suprijono Amalina, Nur D. Anggara, Andhika Dwi Anggraeni, Gilda Putri Aprilyanti, Dwi Fikha Atmanegara, Kartika Azizah Retno Kustiyah Cahyono, Erwin Budi Chodidjah Darlan, Dewi M. Dian Novitasari Didik Murwantono Djannah, Durrotul Effendi, Anita Putri Fentri, Ela Hasanal, Ihdina Hanifa Henri Perwira Negara, Henri Perwira Husain, Sofian A. Hutagalung, Ananta Imam Djamaluddin Mashoedi Intan, Yulice Soraya Nur Israhnanto Isradji Istiqomah istiqomah istiqomah Iwang Yusuf Joko Wahyu Wibowo Lusiana Lusiana Mayangsari, Citra Primavita Muhar, Adi Muradi Rahim, Denasa Dwi Sopandita Rinawati Rinawati Rinawati Rita Kartika Sari Rony, Zahara Tussoleha Shafia, Arina Siti Thomas Zulaikhah Soffan, Mochammad Soffan, Muhammad Sri Priyantini Titiek Sumarawati Zulaikah, Siti Thomas