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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung Language Circle : Journal of Language and Literature Indonesian Journal of Cancer Chemoprevention MEDISAINS Public Health of Indonesia Universa Medicina International Journal of Law Reconstruction Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Cahaya Mandalika Asian Journal of Health and Applied Sciences JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Journal of Health and Nutrition Research Jurnal Ilmiah Sultan Agung Gema Lingkungan Kesehatan Narra X Indonesian Journal of Biomedicine and Clinical Sciences Media Penelitian dan Pengembangan Kesehatan Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Setyo Trisnadi
Bagian Forensik dan Unit Bioetik Fakultas Kedokteran Universitas Islam Sultan Agung Semarang
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Hypoxic mesenchymal stem cell secretome upregulates IL-10 and STAT3 gene expressions in mice model with polycystic ovary syndrome Lusiana, Lusiana; Darlan, Dewi M.; Trisnadi, Setyo; Putra, Agung; Amalina, Nur D.; Husain, Sofian A.
Narra X Vol. 2 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i3.176

Abstract

Polycystic ovary syndrome (PCOS) is a condition characterized by chronic anovulation and hyperandrogenism, which often leads to infertility. It is closely associated with chronic inflammation triggered by glucose and saturated fat, contributing to hyperandrogenism and negatively impacting a patient’s quality of life. Effective therapeutic approaches are essential to address these issues. The secretome of mesenchymal stem cells (MSCs) have demonstrated the ability to suppress pro-inflammatory cytokine secretion and regulate growth factors. The aim of this study was to investigate the effect of hypoxic mesenchymal stem cell secretome (MHSSCs) on the expression of interleukin-10 (IL-10) and signal transducer and activator of transcription 3 (STAT3) genes in a PCOS-induced mouse model. An in vivo experimental study was conducted using a post-test-only control group design. A total of 24 female C57BL/6 mice were divided into four groups: healthy control, negative control (PCOS mice injected with 0.9% NaCl), T1 (PCOS mice administered 200 μL of MHSSCs), and T2 (PCOS mice administered 400 μL of MHSSCs) for 33 days. Gene expression of IL-10 and STAT3 were quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR), normalized to the expression of the housekeeping β-actin gene. Statistical analysis using one-way ANOVA followed by the least significant difference (LSD) post-hoc test was then performed. The results showed a significant increase in IL-10 expression in the T2 group compared to the negative control group (p<0.001). STAT3 expression was also significantly higher in the T2 group compared to the negative control group (p=0.035). A dose-dependent effect was observed, with the T2 group demonstrating the highest upregulation of both IL-10 and STAT3 expression levels. The study highlights that the administration of MHSSCs effectively increased IL-10 and STAT3 gene expression, suggesting their potential as a therapeutic strategy to alleviate inflammation in PCOS.
Effect of Turmeric Ethanol Extract (Curcuma Longa Linn) on IL-6, IL-10 Levels and Skin Moisture Anggraeni, Gilda Putri; Sumarawati, Titiek; Chodidjah; Wibowo, Joko Wahyu; Zulaikah, Siti Thomas; Trisnadi, Setyo
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.330

Abstract

Ultraviolet B (UVB) radiation is known to induce skin damage, including erythema, roughness, sagging, wrinkles, and reduced skin moisture, contributing to premature aging. Turmeric (Curcuma longa Linn.) contains curcumin, an active compound with potent anti-inflammatory properties. This study investigated the effect of turmeric ethanol extract on IL-6 and IL-10 levels, as well as skin moisture, in UVB-exposed rats. A total of 24 Wistar rats were randomly divided into four groups: healthy controls (K1), UVB-exposed without treatment (K2), UVB-exposed treated with turmeric ethanol extract at 100 mg/kg BW (K3), and 200 mg/kg BW (K4). The extract was administered orally for 14 days. IL-6 and IL-10 levels were measured using ELISA, and skin moisture was assessed macroscopically. Statistical analysis was performed using one-way ANOVA. Rats in groups K2, K3, and K4 exhibited very dry skin, redness, visible wrinkles, and peeling following UVB exposure. IL-6 levels were significantly lower in treated groups, with the lowest levels observed in K4 (1.85 ± 0.24 ng/L), compared to K1 (4.36 ± 0.75 ng/L) and K2 (4.46 ± 0.74 ng/L) (p = 0.000). IL-10 levels increased in the treated groups, notably in K3 (376.48 ± 78.24 pg/mL) and K4 (351.06 ± 78.24 pg/mL), compared to K1 (285.34 ± 45.54 pg/mL) and K2 (306.89 ± 45.54 pg/mL) (p = 0.001). These findings suggest that oral administration of turmeric ethanol extract modulates inflammatory responses by reducing IL-6 and enhancing IL-10 in UVB-exposed skin, although significant dryness persists.
Effect of Turmeric Ethanol Extract (Curcuma Longa Linn.) on Tumor Necrosis Factor alpha (TNFα) and the extent of wound lesions (Experimental Study on Wistar Rats Exposed to UVB Rays) Rahim, Denasa Dwi Sopandita; Sumarawati, Titiek; Chodidjah; Zulaikhah, Siti Thomas; Priyantini, Sri; Trisnadi, Setyo
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.331

Abstract

Continuous exposure to ultraviolet B (UVB) radiation can induce photoaging and accelerate premature skin aging. Turmeric (Curcuma longa) is a medicinal plant that contains curcumin, an active compound known for its anti-inflammatory properties and its role in accelerating wound healing. This study aimed to evaluate the effect of turmeric ethanol extract on TNF-α levels and wound lesion areas in Wistar rats exposed to UVB radiation. A post-test-only control group design was employed, involving 24 Wistar rats divided into four groups: a healthy control group (K1), a negative control group (K2), and two treatment groups receiving oral turmeric ethanol extract at doses of 100 mg/kg BW (K3) and 200 mg/kg BW (K4) for 14 days, with concurrent UVB exposure. TNF-α levels were assessed using one-way ANOVA followed by Tukey's post hoc test, while wound lesion areas were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney U test. The results showed that the highest TNF-α levels were observed in the healthy control group (129.14 ng/L), although no statistically significant differences were found between groups (p = 0.538). In contrast, a significant difference was observed in wound lesion areas (p < 0.001), with the largest lesions occurring in the negative control group. In conclusion, oral administration of turmeric ethanol extract did not significantly affect TNF-α levels but was effective in reducing the area of wound lesions caused by UVB exposure.
Kekerasan Fisik pada Anak, Faktor Risiko, dan Komplikasinya : Sebuah Tinjauan Pustaka Novitasari, Dian; Istiqomah; Trisnadi, Setyo
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 3 No. 2 (2025)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol3.iss2.art12

Abstract

Kekerasan fisik pada anak secara khusus mengacu pada penggunaan kekuatan fisik yang dapat berdampak buruk secara signifikan terhadap kesehatan, keselamatan, perkembangan, dan martabat anak. Pengalaman yang terjadi selama masa kanak-kanak dapat memberikan dampak besar terhadap pertumbuhan dan perkembangan anak di masa depan. Diharapkan, kekerasan pada anak yang terus meningkat setiap tahun dapat dicegah melalui identifikasi faktor risiko dan tanda-tanda kekerasan, guna meningkatkan kualitas hidup anak yang mengalami kekerasan di masa mendatang. Penelitian literatur mengenai kekerasan fisik pada anak, faktor risiko, dan komplikasinya menggunakan basis data Google Scholar. Berbagai literatur dikumpulkan untuk memberikan informasi terkait kekerasan fisik pada anak yang mencakup definisi, epidemiologi, faktor predisposisi, jenis-jenis kekerasan fisik, identifikasi, serta konsekuensi jangka panjang. Jumlah kasus kekerasan terhadap anak meningkat setiap tahun. Kasus kekerasan pada anak diharapkan dapat dicegah dengan mengenali faktor risiko dan tanda-tanda kekerasan, sehingga kualitas hidup anak yang mengalami kekerasan dapat ditingkatkan di masa depan. Kata Kunci: Kekerasan Fisik pada Anak; Epidemiologi; Faktor Risiko; Jenis Identifikasi; Konsekuensi
How Female Adolescents Exposed To Pornography? Sari, Rita Kartika; Anggara, Andhika Dwi; Intan, Yulice Soraya Nur; Mayangsari, Citra Primavita; Yusuf, Iwang; Trisnadi, Setyo; Rinawati
Public Health of Indonesia Vol. 11 No. 3 (2025): July - September
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i3.1008

Abstract

Background: The digital era has markedly increased adolescents’ exposure to explicit content, including pornography, raising significant concerns regarding its impact on sexual and reproductive health. This is particularly critical among female adolescents in Indonesia, where access to comprehensive sexual education remains limited. Objective: This study aims to examine the exposure of female adolescents to pornographic content, with a focus on patterns of media consumption and their implications for reproductive health. Methods: A descriptive cross-sectional study was conducted among 58 female adolescents aged 13 to 18 years in Karanganyar, Indonesia. Data were collected using a validated questionnaire and analyzed through descriptive statistical methods to identify patterns of media usage and exposure to pornography. Results: The findings indicated that the internet and handheld devices were the predominant sources of media consumption (96.6%), significantly contributing to exposure to pornographic material (86.2% and 96.6%, respectively). Television and print media also played contributory roles, particularly through soap operas and Western films. Exposure to pornography was associated with limited awareness of reproductive health, especially among younger participants. The exposure was further linked to distorted perceptions of sexual behavior, negative body image, and potential psychological consequences such as anxiety and low self-esteem. Conclusion: This study highlights the urgent need for targeted interventions to enhance critical media literacy and provide comprehensive sexual education for adolescents. Addressing these issues is essential to mitigate the adverse effects of pornography exposure on reproductive health, while taking into account cultural and contextual factors. Future research should investigate the longitudinal effects and gender-specific outcomes to inform the development of tailored preventive strategies. Keywords: adolescents; pornography; media exposure; reproductive health; sexual education
HUBUNGAN ANTARA KERAWANAN WILAYAH DENGAN DENGAN TINDAKAN KRIMINALITAS REMAJA Atmanegara, Kartika; Trisnadi, Setyo
Jurnal Ilmiah Penelitian Mahasiswa Vol 4, No 3 (2025): SEPTEMBER 2025
Publisher : Jurnal Ilmiah Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kerawanan wilayah mempengaruhi tindakan kriminalitas remaja. Penelitian ini bertujuan untuk mengetahui hubungan antara kerawanan wilayah dengan tindakan kriminalitas remaja. Penelitian observasional dengan rancangan cross sectional melalui teknik consecutive sampling dengan jumlah total sampel varibel sebanyak 144 populasi dengan menggunakan data visum et repertum. Data dianalisis dengan chi square. Hasil penelitian ini menunjukan bahwa usia terbanyak pada pelaku tindakan kriminalitas remaja di usia 18 tahun sebanyak 84 pelaku (58,3%) dengan usia korban terbanyak di usia (1 – 20) tahun sebanyak 68 korban (46,5%) dan usia korban di usia (21- 40) tahun sebanyak 68 korban (46,5%). Jenis kelamin pelaku tindakan kriminalitas remaja, banyak dilakukan oleh pelaku yang berjenis kelamin laki – laki sebanyak 76 pelaku (52,8%). Lokasi kejadian yang paling banyak di temukan berada di wilayah Semarang Selatan sebanyak 43 korban (29,9%) dan di Semarang Timur sebanyak 35 korban (24,3%) dengan tempat kejadian terbanyak di lingkungan permukiman sebanyak 51 korban (35,4%) dengan jam kejadian yang sering dilakukan oleh pelaku di antara jam (00.00 – 06.00) sebanyak 43 korban (29,9%). Regio luka yang sering mengenai korban berada di area wajah sebanyak 34 korban (23,6%) dan jumlah regio luka terbanyak berada di 1 regio sebanyak 79 korban (54,9%). Kata kunci: Kerawanan wilayah, tindakan kriminalitas remaja.
Systematic Literature Review on The Use of Electronic Prescribing (E-Prescribing) At Hospital Installation Dwi Lestari, Rinna; Sundari, Sri; Trisnadi, Setyo
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 2 (2024): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i2.2917

Abstract

The service quality of hospitals is a benchmark for the success of health sector development. The use of electronic prescribing (E-prescribing) enables a faster, more accurate, and more efficient service process in hospitals. Related to this matter, current research was carried out aim-ing to examine the use of E-prescribing in the medical sector, especial-ly in hospitals. This study encompassed three phases: (1) identification of relevant literature and data collection; (2) analysis and assessment of the identified literature; and (3) additional categorization of the ob-tained literature. The results of this study concluded that the use of e-prescribing can improve the service quality received by patients in hos-pitals. In addition, its use can also reduce the prescribing errors and increase the cost and time efficiency. However, medical errors are still found, in which it is primarily affected human factors (human error). On the other hand, patient information data must be kept protected, yet the use of e-prescribing can cause the prescription data which is part of confidential medical records and should be protected to be easily ac-cessed by irresponsible parties.
ANALISA DAN INVESTIGASI FORENSIK DALAM MENGUNGKAP SEBAB KEMATIAN PADA KASUS TENGGELAM Novitasari, Dian; Istiqomah, Istiqomah; Trisnadi, Setyo
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 4 No. 1 (2023)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v4i1.1220

Abstract

Drowning atau tenggelam merupakan kondisi mati lemas dikarenakan asfiksia akibat masuknya cairan ke dalam saluran pernapasan. Proses kejadian tenggelam diawali dengan gangguan pernapasan baik karena jalan nafas seseorang berada di bawah permukaan cairan (submersi) ataupun air hanya menutupi bagian wajahnya saja (imersi).Jenazah seorang laki-laki ditemukan di bawah jembatan sungai. Dari hasil pemeriksaan olah TKP, ekshumasi dan otopsi didapatkan hasil adanya tanda-tanda tenggelam yang mengakibatkan kematian. Jenazah berusia antara 40 – 50 tahun ini didapatkan luka akibat kekerasan tumpul berupa luka memar pada wajah, bahu kanan, punggung dan anggota gerak bawah. Didapatkan tanda mati lemas, proses pembusukan dan tanda persentuhan lama dengan air. Didapatkan pasir pada saluran nafas dan saluran cerna, serta ganggang pada paru. Sebab kematian adalah tenggelam yang mengakibatkan mati lemas. Kematian pada peristiwa tenggelam dapat disebabkan oleh reflek vagal, spasme laring, dan pengaruh air yang masuk ke dalam paru. Pada korban juga ditemukan kekerasan tumpul berupa luka memar pada wajah, bahu kanan, punggung dan anggota gerak bawah yang tidak berpotensi sebagai sebab kematian.Hasil laporan kasus yang didapatkan cukup menarik. Data yang diketahui terdapat tanda-tanda tenggelam, pembusukan serta kekerasan tumpul yang membutuhkan pemeriksaan secara mendetail untuk menentukan sebab kematian pada jenasah tersebut. Penelitian lebih lanjut mengenai kematian akibat tenggelam masih perlu dilakukan.
The Role of Hypoxic Mesenchymal Stem Cells Conditioned Medium in Increasing Vascular Endothelial Growth Factors (VEGF) Levels and Collagen Synthesis to Accelerate Wound Healing Sunarto, Hadi; Trisnadi, Setyo; Putra, Agung; Sa'dyah, Nur Anna Chalimah; Tjipta, Arya; Chodidjah, Chodidjah
Indonesian Journal of Cancer Chemoprevention Vol 11, No 3 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss3pp134-143

Abstract

Full-thickness wound are areas damage of skin associated with loss of epidermis and dermis. The wound healing mechanism consists proliferation, migration and remodeling. Hypoxic conditional medium of mesenchymal stem cells (HMSCs-CM) contains lots of soluble molecules, such as protein growth factor and cytokine anti-inflammation. The soluble molecule of HMSCs-CM plays a critical role in wound healing by upregulation of VEGF and collagen synthesis. The objective of this study was to evaluate the effect of HMSCs-CM on VEGF and collagen concentrations in rats with incised wounds. The methods of this study were an experimental animal study with post-test only control group design was performed involving 24 Wistar rats. The rats were randomized into four groups consisting of sham, control and two treatment groups (gel of HMSCs-CM at doses of 200 μL and 400 μL). The VEGF levels and collagen density were analyses using ELISA assay and Masson-trichome specific staining, respectively. One-way ANOVA and Post Hoc LSD were used to analyses the data. The results of this study showed that a VEGF levels was significant increased on day 6 with doses-dependent manner. Interestingly, the VEGF levels gradual decrease on day 9. In addition, the decreased of VEGF levels on day 9 in this study in line with our findings in which we found there was a trend in the decreased of collagen density, it indicated the completion of remodeling phase and there has been an acceleration in wound healing. This study demonstrated that HMSCs-CM were able to regulate VEGF levels and collagen synthesis in accelerate wound healing. The role of HMSCs-CM stimulate cutaneous wound healing should be clarified further.Keywords: hypoxic conditional medium of mesenchymal stem cells (HMSCs-CM), vascular endothelial growth factor, collagen synthesis, paracrine factors
ADOPTION OF ELECTRONIC PRESCRIBING ACCEPTANCE FOR USERS: APPLYING AN EXTENDED TAM MODEL Lestari, Rinna Dwi; Sundari, Sri; Trisnadi, Setyo; Ardani, Yanuar
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 4 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i4.2365

Abstract

Penelitian ini bertujuan untuk menganalisis implementasi penerimaan resep elektronik pada pengguna yang menerapkan model extended TAM. Metode yang digunakan dalam penelitian ini adalah penelitian kausal dengan pendekatan kuantitatif. Jumlah sampel yang digunakan sebanyak 74 responden. Penentuan sampel menggunakan teknik simple random sampling yang merupakan teknik yang dapat mengurangi bias dalam penelitian. Variabel yang diteliti adalah Penerimaan Penggunaan, Persepsi Kegunaan, Persepsi Kemudahan Penggunaan dan Sikap Penggunaan. Analisis data menggunakan software Smart PLS untuk mengukur data dengan auto coding. Temuan penelitian ini menunjukkan bahwa seluruh hipotesis yang digunakan dalam penelitian ini diterima dengan hasil uji reliabilitas dengan Cronbach’s Alpha. Penerimaan Penggunaan (0,730), Persepsi Kegunaan (0,877), Persepsi Kemudahan Penggunaan (0,887) dan Sikap Penggunaan (0,894). Persepsi kemudahan penggunaan berpengaruh positif dan signifikan terhadap persepsi kegunaan difusi elektronik. Persepsi kemudahan penggunaan berpengaruh positif dan signifikan terhadap sikap penggunaan infiltrasi elektronik. Persepsi kegunaan berpengaruh positif dan signifikan terhadap sikap penggunaan infiltrasi elektronik. Persepsi kegunaan berpengaruh positif dan signifikan terhadap penerimaan infiltrasi elektronik. Sikap terhadap teknologi ini secara positif dan signifikan memengaruhi penerimaan resep elektronik. Kegunaan yang dirasakan memediasi pengaruh persepsi kemudahan penggunaan terhadap sikap difusi elektronik. Kemudahan penggunaan mempengaruhi kegunaan infiltrasi elektronik. Persepsi kemudahan penggunaan berpengaruh positif dan signifikan terhadap sikap penggunaan infiltrasi elektronik. Implikasi dari penelitian ini hanya menganalisis penerimaan resep elektronik dengan menggunakan model extended TAM. Diharapkan ada penelitian lebih lanjut dengan menggunakan alat dan pendekatan lain.
Co-Authors Agung Putra Agus Suprijono Amalina, Nur D. Anggara, Andhika Dwi Anggraeni, Gilda Putri Aprilyanti, Dwi Fikha Ardani, Yanuar Atina Hussaana Atmanegara, Kartika Azizah Retno Kustiyah Cahyono, Erwin Budi Chodidjah Chodidjah Chodidjah Darlan, Dewi M. Dian Novitasari Didik Murwantono Djannah, Durrotul Dwi Lestari, Rinna Effendi, Anita Putri Eko Setiawan Fahreza, Rakha Fikriya Novita Sari Hasanal, Ihdina Hanifa Henri Perwira Negara, Henri Perwira Husain, Sofian A. Hutagalung, Ananta Ibrahim, Sugeng Imam Djamaluddin Mashoedi Intan, Yulice Soraya Nur Israhnanto Isradji Istiqomah istiqomah istiqomah Iwang Yusuf Joko Wahyu Wibowo Lusiana Lusiana Mayangsari, Citra Primavita Mediana, Mecha Amalia Muhar, Adi Muradi Noviana Gunawan, Gina Nur Anna Chalimah Sadyah Nurul Hidayah Rahim, Denasa Dwi Sopandita Rinawati Rinawati Rinawati Rinna Dwi Lestari Rony, Zahara Tussoleha Sarosa , Hadi Siti Thomas Zulaikhah Soffan, Mochammad Soffan, Muhammad Sri Priyantini Sunarto, Hadi Sundari, Sri Titiek Sumarawati Tjipta, Arya Zulaikah, Siti Thomas