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Nafiatul Umami
Fakultas Peternakan Universitas Gadjah Mada, Yogyakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Veterinary Other

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Journal : Communications in Science and Technology

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Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats Agussalim; Umami, Nafiatul; Nurliyani; Wan Ismail, Wan Iryani; Masyithoh, Dewi; Ustadi; Agus, Ali
Communications in Science and Technology Vol 9 No 2 (2024)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.9.2.2024.1503

Abstract

This study aims to assess the daily ingestion of Klanceng Honey (KH) on fasting blood glucose (FBG), high-density lipoprotein (HDL), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and pancreatic histopathology. Thirty rats were involved and divided into six groups: G1 = untreated normal rats, G2 = untreated diabetic rats (DR), G3 = DR treated with 0.9 mg/kg BW glibenclamide, G4, G5, and G6 = DR treated with 1, 2, and 3 g/kg BW KH, respectively for 28 days. The FBG level of G1 was found lower than that of diabetic rat groups (G2–G6) (p<0.01). The TC level of G1 group on 14th and 28th days was lower than that of G2–G6 groups (p<0.01). The TG levels in all rat groups showed no significant difference at 0–28 days. On 14th day, the LDL level of diabetic groups were higher than the one in G1 group (p<0.01). Meanwhile, on 14th and 28th, the HDL levels of G3–G6 groups, were higher than the one in G1 group (p<0.01). The pancreatic histopathology of all rat groups showed no abnormalities of the Langerhans islets. The daily ingestion of KH prevented FBG, TC, TG, and LDL levels from rising, increased the HDL levels, and protected the pancreatic glands against damage. T. laeviceps honey can potentially be used as a functional food for therapy of DM patients.
Co-Authors Agussalim Agussalim Ahmad, SN Ali Agus Ali Agus Ali Agus Ali Agus Ali Agus Aloysia Tenny Damayanti Ananto Triyogo Andriyani Astuti Andru Andru Apriyani Nur Sariffudin Asih Kurniawati Asrie Hardianing Indra Kusuma Bambang Suhartanto Bambang Suhartanto Bambang Suwignyo Bambang Suwignyo Bekti Larasati Budi Guntoro Budi Prasetyo Widyobroto Cahyo Wulandari Chusnul Hanim Cuk Tri Noviandi David Cook Dian Astuti Dian Astuti Diana Sri Susanti Dwiko Budi Permadi Dyah Afryana Miftah Nurdani E.D. Sulistijo Galih Pawening Genki Ishigaki, Genki Gusri, Rahmat Hari Hartadi Heny Marlina Wijayanti Hermanto Hermanto Hidenori Tanaka, Hidenori I Gede Suparta Budisatria I Gede Suparta Budisatria I Kadek Yoga Kertiyasa Indratiningsih Indratiningsih Irine Ike Praptiwi, Irine Ike Isnaini, Nofi Kustantinah Kustantinah Leisa Armstrong Lies Mira Yusiati Masyithoh, Dewi Maudi Nayanda Delastra Meita Puspa Dewi Miftahush Shirothul Haq Miftahush Shirotul Haq Muhammad Humaidi Haris Muhammad Zayyan Muafi Muhlisin Muhlisin Nanung Agus Fitriyanto Nilo Suseno Nilo Suseno Nilo Suseno, Nilo Nofi Isnaini Nur Zaini Nurliyani Putra, Bela R. Djoko Soetrisno R. Sapto Hendri Boedi Soesatyo Rahayu Rahayu Rahmi Tri Sayekti Ratih Madya Septiana Rezki Amalyadi Rini Pujiarti Rini Widiati Ristianto Utomo Ristianto Utomo Ristianto Utomo Rochijan Rochijan Ruslina Fajarwati, Ruslina Ryo Akashi, Ryo Sarah Adrian Fenila, Sarah Adrian Sariffudin, Apriyani Nur Sudi Nurtini Sumani Sumani Supriyadi Supriyadi Takahiro Gondo, Takahiro Taryono Taryono Totok Gunawan Ustadi Wan Ismail, Wan Iryani Widayati, Okti Widiyatno Widiyatno Yogi Sidik Prasojo Yogi Sidik Prasojo Yosefina Mangera Zaenal Bachruddin