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Adrian Umboh
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Medical Scope Journal (MSJ)

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Perbandingan Leukosituria, Nitrit, Leukosit Esterase dengan Kultur Urin dalam Mendiagnosis Infeksi Saluran Kemih pada Anak Sabriani, Jehan; Umboh, Adrian; Manoppo, Jeanette I. Ch.
Medical Scope Journal Vol 2, No 2 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.2.2.2021.32596

Abstract

Abstract: Urinary tract infection (UTI) in children is the most common infection after upper airway infection. The diagnosis of UTI is based on urine culture, however, this examination takes a longer time and is quite expensive. Therefore, the diagnosis of UTI can also be confirmed by using leukocyturia, nitrite, and leukocyte esterase tests although they can not replace urine culture as the gold standard. This study was aimed to determine the accuracy of positive leukocyturia, positive nitrite, positive leukocyte esterase examination, combination of positive leukocyturia and nitrite examinations, positive leukocyturia and leukocyte esterase, and leukocyturia, nitrite, positive leukocyte esterase in diagnosing UTI. This was a literature review study. The results of the literature review showed that the range of accuracy of UTI diagnosis using positive leukocyte esterase examinations was 9-6.8%, positive nitrite was 2.8-100%, leukocyte esterase was 13.7-86%, combination of positive leukocyturia and nitrite had a sensitivity value of 33 %, and specificity of 94%, combination of positive leukocytic and leukocytic esterase had a sensitivity value of 70% and a specificity of 90%, and combination of leukocyturia, nitrite, and leukocyte esterase had an accuracy range of 100%. In conclusion, these examinations coul be used to confirm the diagnosis of UTI in children especially if the urine culture can not be performed on them.Keywords: urinary tract infection (UTI), leukocyturia, nitrite, leukocyte esterase, urine culture, children Abstrak: Infeksi saluran kemih (ISK) merupakan infeksi yang paling sering terjadi pada anak setelah infeksi saluran napas atas. Diagnosis ISK ditegakkan berdasarkan hasil pemeriksaan kultur urin, namun pemeriksaan ini membutuhkan waktu yang lama dan biaya yang cukup mahal. Pemeriksaan leukosituria, nitrit, dan leukosit esterase juga membantu dalam mendiagnosis ISK, namun ketiga pemeriksaan ini belum dapat menggantikan kultur urin sebagai baku emas untuk mendiagnosis ISK. Penelitian ini bertujuan untuk mengetahui seberapa besar ketepatan pemeriksaan leukosituria positif, nitrit positif, leukosit esterase positif, gabungan pemeriksaan leukosituria dan nitrit positif, leukosituria dan leukosit esterase positif, dan gabungan leukosituria, nitrit, leukosit esterase positif dalam mendiagnosis ISK. Jenis penelitian ialah literature review. Hasil penelitian menunjukkan kisaran ketepatan diagnosis ISK menggunakan pemeriksaan leukosituria positif yaitu 9-6,8%, nitrit positif sebesar 2,8-100%, leukosit esterase sebesar 13,7-86%, gabungan leukosituria dan nitrit positif memiliki nilai sensitivitas 33%, dan spesifisitas sebesar 94%, gabungan leukosituria dan leukosit esterase positif memiliki nilai sensitivitas 70% dan spesifisitas sebesar 90%, serta gabungan pemeriksaan leukosituria, nitrit, dan leukosit esterase memiliki kisaran ketepatan sebesar 100%. Simpulan penelitian ini ialah pemeriksan-pemeriksaan tersebut dapat membantu menegakkan diagnosis ISK pada anak terutama bila kultur urin tidak memungkinkan dilakukan.Kata kunci: infeksi saluran kemih (ISK), leukosituria, nitrit, leukosit esterase, kultur urin, anak
Profil Acute Kidney Injury pada Anak yang Dirawat di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado Ango, Putri C.; Umboh, Adrian; Salendu, Praevilia M.
Medical Scope Journal Vol. 7 No. 1 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i1.53862

Abstract

Abstract: Acute kidney injury (AKI) is a clinical condition as evidenced by elevated levels of creatinine and urea, as well as a decrease in glomerular filtration rate (GFR). This study aimed to determine the profile of AKI in children admitted to the Pediatric Department of Prof. Dr. R. D. Kandou General Hospital, Manado, during the period from January 2020 to August 2023. This was a retrospective and descriptive study with an observational approach and a cross-sectional design. Samples included all children who were diagnosed with AKI. The results obtained 121 patients with AKI, aged 1 month to 18 years, comprising 53.7% males, 46.3% females. Pre-renal AKI accounted for 61.1%, while renal AKI was 38.9%. Common clinical features included fever (75.3%), respiratory distress (61.2%), edema (49.7%), oliguria (93.3%), proteinuria (54.5%), azotemia (100.0%), microscopic hematuria (61.2%), leukocyturia (43.8%), hyponatremia (53.0%), hypocalcemia (47.2%), hypochloremia (48.0%), sepsis (42.1%), septic shock (17.3%), and metabolic acidosis (2.4%). In conclusion, AKI was most commonly found in the age group of 11-15 years, with a higher prevalence in males than females. The most common etiology was pre-renal AKI, with oliguria, fever, and respiratory distress being the most common clinical symptoms. Laboratory examinations commonly showed azotemia, hematuria, proteinuria, and leukocyturia. Keywords: acute kidney injury; children; clinical features; complication   Abstrak: Acute Kidney Injury (AKI) adalah sebuah keadaan klinis dimana terjadi peningkatan kreatinin dan urea serta penurunan laju filtrasi glomerulus (LFG). Penelitian ini bertujuan untuk mengetahui profil AKI pada anak yang dirawat di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2020-Agustus 2023. Jenis penelitian ialah deskriptif retrospektif dan observasional dengan desain potong lintang. Sampel penelitian ini ialah semua anak yang dirawat dan didiagnosis AKI. Hasil penelitian mendapatkan 121 pasien dengan diagnosis AKI, usia 1 bulan-18 tahun, laki-laki 53,7%, perempuan 46,3%. AKI pre-renal 61,1%, AKI renal 38,9%. Demam 75,3%, sesak napas 61,2%, edema 49,7%, oliguria 93,3%, proteinuria 54,5%, azotemia 100,0%, hematuria mikroskopis 61,2%, leukosituria 43,8%, hiponatremia 53,0%, hipokalsemia 47,2%, hipokloremia 48,0%, sepsis 42,1%, syok sepsis 17,3%, dan asidosis metabolik 2,4%. Simpulan penelitian ini ialah AKI ditemukan tersering pada rentang usia 11-15 tahun, lebih sering pada laki-laki dibandingkan perempuan, etiologi terbanyak ialah AKI pre-renal, gejala klinis tersering ialah oliguria, demam dan sesak napas. Pemeriksaan laboratorium tersering ditemukan azotemia, hematuria, proteinuria, serta leukosituria. Kata kunci: acute kidney injury; anak; gangguan ginjal akut; komplikasi
Co-Authors Aaltje E. Manampiring Aaltje Ellen Manapiring Aaltje Manampiring Abram Babakal Adi Suryadinata Krisetya Alan J. Jufri Algi Reafanny Batara Amatus Yudi Ismanto Andi Dwi Bahagia Febriani Andrian Aldo Rantung Angelya Lumoindong Angie G. Roring, Angie G. Ango, Putri C. Ari L. Runtunuwu Ari Runtunuwu Astrid A. Malonda Baksh, Aida K. Bernadus, Janno Berty Bradly Chensilya Kusumanarwasti Christien Gloria Tutu Corona, Fidel Damaris, Damaris David E Kaunang David Kaunang Drova Grano Manorek Eka Patandianan Elia A. P. Hutapea Erling D. Kaunang Fatimawali . Frecillia Regina Herwanto Herwanto Hesti Lestari Hesti Lestari Hidayani, Agung R.E Hosang, Kevin H. Irawan Yusuf Iwan P. Wawointana, Iwan P. Jane A. Kalangi Jeanette I. Ch. Manoppo Jeanette I. Ch. Manoppo, Jeanette I.Ch. Manoppo Jenifer Andalangi Johannes Edwin Johnny Rompis Jose M. Mandei Jose M. Mandei Jully Kasie Kartini W. Adam Kristellina Tirtamulia Kromo, Lucky Kurniawan Tan Lasidi, Oktifani Devi Liow, Jackli Eugene Lonto, Jesica S. Lumingkewas, Pitter Handry Lydia Tendean Maki, Frindi Manopo, Berry R. Manoppo, Jeanette Irene Christiene Mantali, Rizqa Mantik, Keren E.K. Maria Fitricilia Marianne C. Jacobus, Marianne C. Matthew, Febriano Max F. J. Mantik Max F.J Mantik, Max F.J Natharina Yolanda, Natharina Nilawati, . Novie H. Rampengan Novie Homenta Rampengan, Novie Homenta Nurhayati Masloman Oktavin Yollah Umboh Paulina N. Gunawan Phan, Sardito Pinaria, Anthoneta S. Polii, Evan G. Praevilia M. Salendu Queen Mandang Reifanli M. Pai, Reifanli M. Robin Samuel Mamesah, Robin Samuel Rocky Wilar Rompies, Ronald Ronald Chandra Sabriani, Jehan Sanusi, Holly Sarah M. Warouw Sarah Warouw smanto, Yudi Stefanus Gunawan Stefanus Gunawan Stevanus Gunawan, Stevanus Surya, Welong S. Suryani As’ad Suwontopo, Marvin Leonardo T. A. Sudjono Taliwongso, Fernando Ch. Tandiawan, Ledy Tatipang, Pirania Ch. Umboh, Indria M. Umboh, Valetine Valentine Umboh Valentine Umboh, Valentine Vicky M. Kalangie, Vicky M. Vini Maleke, Vini Vivekenanda Pateda Vivekenanda Pateda Waworuntu, David S. Yanni, Iloh Devi Yolanda B. Bataha