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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Medic Nutricia : Jurnal Ilmu Kesehatan Seroja Husada: Jurnal Kesehatan Masyarakat Jurnal Sains, Teknologi dan Kesehatan
Rudy Afriant
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil, Padang 25163, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Karakteristik Pasien Leukemia Granulositik Kronik Berdasarkan Hasil Direct Coomb’s Test di RSUP Dr. M. Djamil Zahira, Aisyah Dhia; Rofinda, Zelly Dia; Izzah, Amirah Zatil; Efrida, Efrida; Afriant, Rudy; Rahmatini, Rahmatini
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 3 (2024): September 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i3.1314

Abstract

Abstrak Latar Belakang: Leukemia Granulositik Kronik (LGK) merupakan penyakit mieloproliferatif yang ditandai dengan adanya proliferasi seri granulosit tanpa ada gangguan diferensiasi. Direct Coomb’s Test (DCT) digunakan untuk mendekteksi adanya antibodi imun, baik IgG maupun komponen komplemen (umumnya C3d) yang menutupi atau mensensitisasi sel eritrosit. Pemeriksaan coomb’s test pada pasien LGK dilakukan apabila adanya kecurigaan anemia dan terjadinya retikulositosis tanpa ditemukan adanya sumber perdarahan yang jelas. Objektif: Tujuan penelitian ini untuk mengetahui karakteristik pasien LGK berdasarkan hasil direct coomb’s test di RSUP Dr. M.Djamil Padang. Metode: Penelitian deskriptif dilakukan terhadap semua pasien yang didiagnosis LGK yang memiliki hasil direct coomb’s test. Pengambilan sampel dilakukan secara consecutive sampling dengan 30 sampel yang memiliki data berupa usia, jenis kelamin, hasil direct coomb’s test, derajat anemia, hitung retikulosit, dan jenis terapi. Hasil: Penelitian berdasarkan jenis kelamin pada pasien leukemia granulositik kronik didapatkan lebih banyak perempuan yaitu 18 pasien (60%) dan laki-laki 12 pasien (40%) dengan rerata usia 44 tahun. Direct coomb’s test menunjukkan hasil positif pada 21 pasien (70%) dan negatif pada 9 pasien (30%). Anemia berat paling banyak ditemukan pada direct coomb’s test negatif dengan 55,6%. Retikulositosis lebih banyak ditemukan pada hasil direct coomb’s test positif. Kesimpulan: Pasien LGK dengan hasil direct coomb’s test positif lebih banyak ditemukan anemia berat, anemia sedang, dan retikulositosis. Kata kunci: direct coomb’s test, leukemia granulositik kronik, luka sedang
Unfractionated Heparin versus Low Molecular Weight Heparin for Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients: A Meta-analysis Rendi Dwi Prasetyo; Rudy Afriant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1287

Abstract

Background: Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in acutely ill medical patients. Both unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are effective for VTE prophylaxis, but their relative efficacy and safety remain unclear. Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing UFH and LMWH for VTE prophylaxis in acutely ill medical patients. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from 2013 to 2024. The primary outcome was the incidence of VTE. Secondary outcomes included major bleeding and mortality. Results: Seven RCTs with a total of 5,412 patients were included. LMWH was associated with a significantly lower risk of VTE compared to UFH (relative risk [RR] 0.68; 95% confidence interval [CI] 0.52-0.88; p = 0.004). There was no significant difference in major bleeding (RR 0.91; 95% CI 0.65-1.27; p = 0.58) or mortality (RR 0.93; 95% CI 0.78-1.11; p = 0.43) between the two groups. Conclusion: LMWH is more effective than UFH for VTE prophylaxis in acutely ill medical patients without increasing the risk of major bleeding or mortality. LMWH should be considered the preferred agent for VTE prophylaxis in this population.
Trombosis Vena Dalam pada Sindrom Nefrotik Afriant, Rudy; Fikri, Avino Mulana; Kam, Alexander
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p764-771.2023

Abstract

Seorang pasien laki-laki usia 34 tahun yang dirawat dengan dengan diagnosis deep vein thrombosis tungkai kanan dan sindrom nefrotik primer relaps. Trombosis pada sindrom nefrotik dapat timbul dari kebocoran protein dengan berat molekul yang tinggi sehingga menyebabkan hiperkoagulabilitas, peningkatan sintesis faktor yang mendorong trombosis, aktivasi dan agregasi trombosit, aktivasi sistem koagulasi, atau penurunan antikoagulan endogen. Pasien sudah diterapi dengan heparin dan terapi untuk sindrom nefrotik. Pasien dipulangkan dengan perbaikan klinis dan kontrol rutin ke poliklinik.
Hubungan Anemia dengan Remisi Komplit Kemoterapi induksi pada Pasien Leukemia Mieloblastik Akut Dewasa di RSUP Dr. M. Djamil Padang Salsabila, Zahra; Afriant, Rudy; Rofinda, Zelly Dia; Elvira, Dwitya; Yaswir, Rismawati; Izzah, Amirah Zatil
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1169

Abstract

Latar Belakang: leukemia mieloblastik akut merupakan salah satu keganasan darah yang terjadi akibat gangguan proses pertumbuhan sel mieloid, yang menyebabkan terjadinya penumpukan sel blast di sumsum tulang, dan menekan pembentukan sel darah lain yang menyebabkan anemia. Pengobatan yang diberikan pada penderita LMA adalah kemoterapi. Kondisi anemia dapat menyebabkan hipoksia di jaringan, yang dapat mengakibatkan berkurang nya efektivitas kemoterapi. Objektif: Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara derajat anemia dengan tercapainya remisi komplit pada pasien LMA yang di kemoterapi induksi. Metode: Penelitian ini dilakukan dengan menggunakan desain cross sectional dengan pendekatan observasional analitik retrospektif. Sampel pada penelitian ini berjumlah 15 sampel yang diambil dari data rekam medik. Analisis univariate dilakukan untuk mendeskripsi frekuensi variable dan analisis bivariate dengan uji statistic fisher exact test. Hasil: Hasil yang didapat dari penelitian ini adalah pasien LMA banyak yang berusia >40 tahun, berjenis kelamin perempuan, dengan klasifikasi LMA M4, keluhan utama lemah letih, derajat anemia ringan dan berhasil remisi komplit yang lebih banyak. Hasil uji statistik memperlihatkan tidak adanya hubungan derajat anemia dengan tercapainya remisi komplit pada pasien. Hasil analisi LMA dengan nilai p=1,000. Kesimpulan: kesimpulan yang didapatkan adalah tidak adanya hubungan antara derajat anemia dengan tercapainya remisi komplit pada pasien leukemia mieloblastik akut dewasa yang menjalani kemoterapi induksi di RSUP Dr. M Djamil Padang.
Correlation Between C-Reactive Protein Level and Outcome In Coronavirus Disease 2019 Patients At COVID Intensive Care Unit RSUP. Dr. M. Djamil Padang Putri Ariani; Dedy Kurnia; Malinda Meinapuri; Rudy Afriant; Rina Gustia; Rikarni; Rinal Effendi
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 11 No. 3 (2023): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan Special Issues: Jambi M
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v11i3.25078

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is a respiratory system disease transmitted to humans and has infected humans in almost every country. Plasma cytokine levels, such as C-reactive protein (CRP), are elevated inflammatory markers in most COVID-19 patients and are routinely examined, especially in the intensive care Unit (ICU). Elevated CRP levels are associated with higher rates of severity and death. Objective: This study aimed to determine the correlation between CRP levels and outcomes in COVID-19 patients at COVID ICU RSUP. Dr. M. Djamil Padang Period July – December 2021. Method: This research was conducted using by analytic observational method with a retrospective cohort design. Secondary data was collected from the medical records of COVID-19 patients treated in the ICU COVID RSUP. Dr. M. Djamil Padang from July – December 2021, using total sampling as a technique, 107 samples met the inclusion criteria. Data analysis was carried out using univariate and bivariate methods. Result: The result shows more male patients (51.4%) than women (48.6%). From the age range, most age was found in the range > 59 years (54.2%). The most common type of comorbid disease was diabetes (32.7%). The highest CRP level at the initial ICU admission was >160 mg/L (70.1%), and the highest ferritin level was >434 ng/mL (86.0%). The most common patient outcome was death (65.4%). There is a relationship between CRP levels (p = 0.029) and the outcome of COVID-19 patients in the COVID ICU. Conclusion: This study concludes that there is a correlation between C-Reactive Protein (CRP) levels and Outcomes in COVID-19 patients at COVID ICU RSUP. Dr. M. Djamil Padang Period July – December 2021. Keywords : COVID-19, CRP, Patient Outcome, ICU
Warm Autoimmune Hemolytic Anemia with Chronic Hepatitis B Wahyudi, Adefri; Fadrian; Afriant, Rudy
Sumatera Medical Journal Vol. 7 No. 1 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i1.11836

Abstract

Background: Warm autoimmune hemolytic anemia (wAIHA) is caused by erithrocytes destruction by IgG or IgG plus C3d-mediated autoantibody. Objective: To present a case of warm autoimmune hemolytic anemia (wAIHA) in a patient with chronic hepatitis B infection. Methods: This is a case report that showed a special case. Results: Man, 64 y.o, hospitalized with diagnosis wAIHA and chronic hepatitis B. Diagnosis of wAIHA is built by: severe normocytic normochromic anemia, reticulocytosis 42.29%, increasing lactate dehydrogenase 397 U/L, direct Coombs test (+4), antibody screening IgG (+4). Anothers laboratorium findings: HbsAg (+), albumin 3.5 g/dL, ALT U/L, rapid HIV (-), anti HCV (-). There is no blast found in peripheral blood and bone marrow smear. Patient also diagnosed chronic hepatitis B inactive phase with negative HbeAg, HBV DNA 547 IU/L, normal liver finding in abdominal USG and moderate fibrosis from fibroscan. Washed red cell transfussion was administered, 2 x 125 mg methilprednisolone iv (3 days) tapering off until to 40 mg/day doses. He did not get antiviral prophylaxis and be planned to reevaluate in next 6 months. Conclusion: Steroid is first line therapy in wAIHA. When wAIHA is diagnosed, determination of chronic hepatitis B status should confirmed.  There is a risk of reactivation of chronic hepatitis B infection so monitoring is needed.
Diabetic Ketoacidosis in Type 1 Diabetes Mellitus Nurhakim, Lukman; Afriant, Rudy; Aprilia, Dinda
Sumatera Medical Journal Vol. 7 No. 1 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i1.11837

Abstract

Background: Diabetic ketoacidosis (DKA) is a state of metabolic decompensation/disorder characterized by the triad of hyperglycemia, acidosis and ketosis, caused by absolute or relative insulin deficiency and increased counter-regulatory hormones. Objective: To report a case of diabetic ketoacidosis (DKA) in a young adult patient with type 1 diabetes mellitus and scalp abscess, emphasizing the importance of early diagnosis and prompt management to achieve clinical improvement. Methods: This case report describes the clinical presentation, diagnostic approach, and therapeutic management of a 19-year-old male with DKA. Results: A 19-year-old male treated in the internal medicine ward of Dr. M djamil Padang with diabetic ketoacidosis, type 1 DM, and Abscess capitis. The patient was treated with rehydration and intravenous insulin infusion can show clinical improvement. Conclusion: The diagnosis in patients is based on anamnesis, physical examination and supporting examinations. Immediate therapy is needed in the management of DKA in patients. After DKA is resolved, look for the causes of the risk of DKA. On the third day of treatment the patient's condition improved clinically and the laboratory.
Co-Authors Aga Pratama Alexander Kam Alifia Damanil Putri Amirah Zatil Izzah Aprilia, Dinda Avino Mulana Fikri Avino Mulana Fikri Dedy Kurnia Deka Viotra Drajad Priyono Dwitya Elvira, Dwitya Efrida Efrida Eifel Faheri Eti Yerizel Fadil Oenzil Fadrian, Fadrian Fauzar Fikri, Avino Mulana Ghany, Firhan Fadlillah Hannie Qalbina Syaiful Hendriati, Hendriati Irza Wahid Kam, Alexander Khalisha Azzahra Pramesti Abdillah Laksono Trisnantoro LUKMAN NURHAKIM, LUKMAN Malinda Meinapuri Muhammad Ridhwan Fatharanifurqan Putra, Syandrea Prima Putri Ariani Putri, Azhara Dhiya Yosse Rahmatini . Raveinal Rendi Dwi Prasetyo Restu Susanti Rido Wandrivel Rikarni Rina Gustia Rinal Effendi Rismawati Yaswir Rivani Sintia Suratman Rizki Rahmadian Rizky Loviana Roza Roza Mulyana Saptino Miro Seilla Dinta Yastina Wahyudi, Adefri Yenita Yenita Yulia, Dwi Yuniar Lestari Yusri, Elfira Zahira, Aisyah Dhia zahra salsabila Zelly Dia Rofinda Zulkarnain Edward