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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Medic Nutricia : Jurnal Ilmu Kesehatan Seroja Husada: Jurnal Kesehatan Masyarakat Jurnal Sains, Teknologi dan Kesehatan
Rudy Afriant
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil, Padang 25163, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Role of Corticosteroids in the Management of Drug Allergy: A Narrative Literature Review Rivani Sintia Suratman; Rudy Afriant; Roza Mulyana; Saptino Miro; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.773

Abstract

Drug allergy is an adverse drug reaction that occurs through an immune reaction that occurs through IgE or a rapid hypersensitivity reaction with various mechanisms and clinical presentations. One of the therapeutic modalities for drug allergies is corticosteroids. In allergic processes, corticosteroids can suppress the production and effects of humoral factors involved in the inflammatory response, inhibit the migration of leukocytes to sites of inflammation, and interfere with the function of endothelial cells, granulocytes, mast cells, and fibroblasts. This literature review aimed to describe the role of corticosteroids in the management of drug allergies. Corticosteroids are used very widely in the treatment of various allergic diseases because of their strong anti-inflammatory properties. Corticosteroids inhibit the synthesis of a number of cytokines, such as the interleukins IL-1 to IL-6, tumor necrosis factor-α (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF). In conclusion, corticosteroids are one of the therapeutic modalities in various manifestations of drug allergies. Every drug allergy gets the anti-inflammatory effects of corticosteroids with different choices, routes, and doses for each manifestation.
The Role of Corticosteroids in the Management of Drug Allergy: A Narrative Literature Review Rivani Sintia Suratman; Rudy Afriant; Roza Mulyana; Saptino Miro; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.773

Abstract

Drug allergy is an adverse drug reaction that occurs through an immune reaction that occurs through IgE or a rapid hypersensitivity reaction with various mechanisms and clinical presentations. One of the therapeutic modalities for drug allergies is corticosteroids. In allergic processes, corticosteroids can suppress the production and effects of humoral factors involved in the inflammatory response, inhibit the migration of leukocytes to sites of inflammation, and interfere with the function of endothelial cells, granulocytes, mast cells, and fibroblasts. This literature review aimed to describe the role of corticosteroids in the management of drug allergies. Corticosteroids are used very widely in the treatment of various allergic diseases because of their strong anti-inflammatory properties. Corticosteroids inhibit the synthesis of a number of cytokines, such as the interleukins IL-1 to IL-6, tumor necrosis factor-α (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF). In conclusion, corticosteroids are one of the therapeutic modalities in various manifestations of drug allergies. Every drug allergy gets the anti-inflammatory effects of corticosteroids with different choices, routes, and doses for each manifestation.
Evans Syndrome in a Forty-Four Years Old Male Patient: A Case Report Rudy Afriant; Avino Mulana Fikri; Alexander Kam
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 4 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i4.805

Abstract

Background: Evans syndrome (ES) is an autoimmune disease characterized by the presence of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP), together with unknown causes. ES disease is the least common, diagnosed in only 0.8% - 3.7% of all patients with AIHA or ITP. This study aimed to describe Evans syndrome in a 44-year-old male patient. Case presentation: A 44-year-old male patient was reported with complaints of weakness and fatigue, red spots, a history of bleeding gums, a history of bleeding from the nose, and a history of red urination. A routine blood examination revealed mild anemia, reticulocytosis, and thrombocytopenia, and the peripheral blood showed polychromatic erythrocytes. Other laboratory examinations revealed an increase in LDH. The results of a positive Comb’s test and antibody screening examination showed the impression of warm-type AIHA. The diagnosis of Evans syndrome in this patient was confirmed by the presence of AIHA and ITP, which co-occur and are primarily due to unknown causes. Conclusion: ES is a rare disorder and a diagnosis of exclusion. The diagnosis of ES was established by the presence of signs and symptoms of AIHA and ITP accompanied by a positive direct antiglobulin test with no other etiology found.
Evans Syndrome in a Forty-Four Years Old Male Patient: A Case Report Rudy Afriant; Avino Mulana Fikri; Alexander Kam
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 4 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i4.805

Abstract

Background: Evans syndrome (ES) is an autoimmune disease characterized by the presence of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP), together with unknown causes. ES disease is the least common, diagnosed in only 0.8% - 3.7% of all patients with AIHA or ITP. This study aimed to describe Evans syndrome in a 44-year-old male patient. Case presentation: A 44-year-old male patient was reported with complaints of weakness and fatigue, red spots, a history of bleeding gums, a history of bleeding from the nose, and a history of red urination. A routine blood examination revealed mild anemia, reticulocytosis, and thrombocytopenia, and the peripheral blood showed polychromatic erythrocytes. Other laboratory examinations revealed an increase in LDH. The results of a positive Comb’s test and antibody screening examination showed the impression of warm-type AIHA. The diagnosis of Evans syndrome in this patient was confirmed by the presence of AIHA and ITP, which co-occur and are primarily due to unknown causes. Conclusion: ES is a rare disorder and a diagnosis of exclusion. The diagnosis of ES was established by the presence of signs and symptoms of AIHA and ITP accompanied by a positive direct antiglobulin test with no other etiology found.
Trombosis Vena Dalam pada Sindrom Nefrotik Rudy Afriant; Avino Mulana Fikri; Alexander Kam
Majalah Kedokteran Andalas Vol 46, No 4 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p764-771.2023

Abstract

Seorang pasien laki-laki usia 34 tahun yang dirawat dengan dengan diagnosis deep vein thrombosis tungkai kanan dan sindrom nefrotik primer relaps. Trombosis pada sindrom nefrotik dapat timbul dari kebocoran protein dengan berat molekul yang tinggi sehingga menyebabkan hiperkoagulabilitas, peningkatan sintesis faktor yang mendorong trombosis, aktivasi dan agregasi trombosit, aktivasi sistem koagulasi, atau penurunan antikoagulan endogen. Pasien sudah diterapi dengan heparin dan terapi untuk sindrom nefrotik. Pasien dipulangkan dengan perbaikan klinis dan kontrol rutin ke poliklinik.
Gambaran Fungsional Sendi Bahu Pasien Pasca Mastektomi Radikal Berdasarkan Skor QuickDASH Khalisha Azzahra Pramesti Abdillah; Rizki Rahmadian; Rudy Afriant
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 3 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i3.1152

Abstract

Latar belakang: Gangguan pada fungsi sendi bahu sering ditemukan pada pasien setelah menjalani prosedur mastektomi radikal. Gejala yang sering ditemukan pasca pembedahan adalah keterbatasan fungsi bahu, kelemahan ekstremitas atas, limfedema, dan nyeri dengan tingkat keparahan yang bervariasi. Objektif: Penelitian ini bertujuan untuk mengetahui gambaran fungsional sendi bahu pasien pasca mastektomi radikal berdasarkan skor QuickDASH di RSUP Dr. M Djamil Padang. Metode: Penelitian ini merupakan penelitian deskriptif retrospektif. Data dikumpulkan menggunakan teknik consecutive sampling. Sampel penelitian ini menggunakan data primer berupa wawancara pasien pasca mastektomi radikal di RSUP Dr. M Djamil Padang periode 2020 – 2021 menggunakan kuesioner QuickDASH. Jumlah sampel yang memenuhi kriteria didapatkan sebanyak 35 sampel. Hasil analisis data disajikan dalam bentuk tabel distribusi frekuensi. Hasil: Hasil penelitian menunjukkan kelompok usia terbanyak pada rentang ≥ 45 tahun (77,1%), tingkat pendidikan SMA/Sederajat (51,4%), tidak bekerja (74,3%), dan tingkat pendapatan Rp1.000.000,- s.d. Rp5.000.000,- (68,6%). Sisi pengangkatan terbanyak pada sisi unilateral kiri (54,3%), dengan riwayat terapi radiasi (51,4%), dan dengan kategori stadium lanjut (54,3%). Pasien paling sering berada pada kategori disabilitas minimum (60%). Kesimpulan: Kesimpulan penelitian ini adalah pasien pasca mastektomi radikal paling sering memiliki gangguan fungsional sendi bahu pada kategori disabilitas minimum. Gangguan tersebut ditemukan meningkat seiring meningkatnya stadium dan pada pasien yang mendapatkan radioterapi. Fungsi sendi bahu dipengaruhi oleh sisi pengangkatan, stadium, dan riwayat terapi radiasi. Sedangkan pendidikan, pendapatan, dan lama waktu sejak operasi tidak memengaruhi fungsi sendi bahu.
HUBUNGAN KADAR HBA1C TERHADAP DERAJAT RETINOPATI DIABETIK DI RSUP DR. M. DJAMIL Alifia Damanil Putri; Hendriati, Hendriati; Rudy Afriant
Medic Nutricia : Jurnal Ilmu Kesehatan Vol. 8 No. 5 (2024): Medic Nutricia : Jurnal Ilmu Kesehatan
Publisher : Cahaya Ilmu Bangsa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5455/nutricia.v8i5.6349

Abstract

Latar Belakang: Retinopati diabetik merupakan salah satu komplikasi mikrovaskuler yang sering terjadi pada pasien diabetes melitus. Hal ini disebabkan oleh hiperglikemia kronis. Pemeriksaan HbA1c akan memberikan gambaran terhadap kadar glukosa darah selama 2-3 bulan terakhir. Objektif: Penelitian ini dilakukan untuk mengetahui hubungan kadar HbA1c terhadap derajat retinopati diabetik di RSUP Dr. M. Djamil Padang. Metode: Jenis penelitian ini ialah analitik dengan pendekatan cross sectional. Penelitian ini Berlangsung selama bulan November 2021-Januari 2022 di Instalasi Rekam Medik dan Poliklinik Mata RSUP Dr. M. Djamil dengan menggunakan teknik pengambilan total sampling. Hasil: Sampel yang ditemukan pada penelitian ini ialah 20 sampel. Ditemukan bahwa NPDR sedang merupakan derajat retinopati diabetik yang paling banyak ditemui (70%) pada pasien yang melakukan pemeriksaan HbA1c. Berdasarkan kadar HbA1cnya, didapati sebesar 60% pasien memiliki kadar HbA1c tidak terkontrol. Uji statistik dilakukan untuk mengetahui hubungan antara kadar HbA1c terhadap derajat retinopati diabetik, hasil yang didapatkan ialah nilai p=1,000. Kesimpulan: Tidak ditemukannya hubungan antara kadar HbA1c terhadap derajat retinopati diabetik di RSUP Dr. M. Djamil Padang
PERBEDAAN RERATA KADAR D-DIMER DENGAN USIA DAN JENIS KELAMIN PADA PASIEN COVID- 19 YANG DIRAWAT DI RSUP DR. M. DJAMIL PADANG Ghany, Firhan Fadlillah; Yulia, Dwi; Afriant, Rudy
Seroja Husada: Jurnal Kesehatan Masyarakat Vol. 1 No. 6 (2024): Seroja Husada: Jurnal Kesehatan Masyarakat
Publisher : Seroja Husada: Jurnal Kesehatan Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.572349/serojahusada.v1i6.3914

Abstract

Coronavirus disease 2019 (COVID-19) adalah penyakit virus yang sangat menular yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pasien lanjut usia dengan infeksi COVID-19, terutama pada kasus yang lebih parah, memiliki risiko dalam keadaan hiperkoagulasi serta meningkatkan kejadian trombosis. Mekanisme genetik dan mekanisme endokrin, memengaruhi mekanisme koagulopati dan trombosis pada COVID-19. D-dimer yang tinggi pada pasien COVID-19 disebabkan oleh hiperinflamasi yang kemudian menyebabkan koagulopati. Penelitian ini bertujuan untuk mengetahui perbedaan rerata kadar D-dimer dengan usia dan jenis kelamin pada pasien COVID-19 yang dirawat di RSUP. Dr. M. Djamil Padang. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross- sectional menggunakan data rekam medis 107 pasien COVID- 19 yang dirawat di RSUP. Dr. M. Djamil Padang tahun 2021. Teknik pengambilan sampel adalah consecutive sampling. Analisis yang digunakan adalah analisis univariat dan bivariat. Kelompok usia terbanyak pada pasien COVID-19 yang dirawat adalah kelompok usia 46-65 tahun, jenis kelamin terbanyak adalah perempuan dan rerata kadar D-dimer adalah 2632,6 ng/ml. Hasil penelitian ini menunjukkan terdapat perbedaan yang bermakna antara rerata kadar D-dimer pada kelompok usia yang berbeda pada pasien COVID-19 (p=0,02). Tidak ada perbedaan yang bermakna rerata kadar D-dimer antara laki-laki dan perempuan pada pasien COVID-19 (p=0,413). Kesimpulan dari penelitian ini adalah terdapat perbedaan yang bermakna antara rerata kadar D-dimer pada kelompok usia yang berbeda pada pasien COVID- 19 dan tidak ada perbedaan yang bermakna rerata kadar D-dimer antara laki-laki dan perempuan pada pasien COVID-19.
PROFIL PASIEN COVID-19 DI RUMAH SAKIT UNIVERSITAS ANDALAS Putri, Azhara Dhiya Yosse; Lestari, Yuniar; Susanti, Restu; Afriant, Rudy; Putra, Syandrea Prima; Yusri, Elfira
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.986

Abstract

   Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS- CoV-2 virus. The outcomes of COVID-19 patients were found to be influenced by the presence of comorbidities of the patient. Furthermore, this will affect the healing process in the patient itself. The most common comorbidity in COVID-19 patients is hypertension followed by diabetes mellitus. Hypertension is mentioned as the predominant factor of COVID-19 infection. Objective: This study aims to determine the profile of COVID-19 patients with hypertension. Methods: The type of this research is observational descriptive which was conducted in October 2021 – November 2022 at the Medical Record Installation of Rumah Sakit Universitas Andalas. This study was conducted using a total sampling technique with a total sample of 161 patient. Results: The results showed that the frequency of female was more than male (60.9:39.1). The frequency of >50 years old is almost the same as 50 years old (50.9:49.1). There are more patients without comorbid hypertension than patients with comorbid hypertension (64.6:35.4). Conclusions: There are more COVID-19 patients treated at Andalas University Hospital aged 50 years with female sex and more patients without hypertension comorbid.  
Unfractionated Heparin versus Low Molecular Weight Heparin for Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients: A Meta-analysis Rendi Dwi Prasetyo; Rudy Afriant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1287

Abstract

Background: Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in acutely ill medical patients. Both unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are effective for VTE prophylaxis, but their relative efficacy and safety remain unclear. Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing UFH and LMWH for VTE prophylaxis in acutely ill medical patients. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from 2013 to 2024. The primary outcome was the incidence of VTE. Secondary outcomes included major bleeding and mortality. Results: Seven RCTs with a total of 5,412 patients were included. LMWH was associated with a significantly lower risk of VTE compared to UFH (relative risk [RR] 0.68; 95% confidence interval [CI] 0.52-0.88; p = 0.004). There was no significant difference in major bleeding (RR 0.91; 95% CI 0.65-1.27; p = 0.58) or mortality (RR 0.93; 95% CI 0.78-1.11; p = 0.43) between the two groups. Conclusion: LMWH is more effective than UFH for VTE prophylaxis in acutely ill medical patients without increasing the risk of major bleeding or mortality. LMWH should be considered the preferred agent for VTE prophylaxis in this population.
Co-Authors Aga Pratama Alexander Kam Alifia Damanil Putri Amirah Zatil Izzah Aprilia, Dinda Avino Mulana Fikri Avino Mulana Fikri Dedy Kurnia Deka Viotra Drajad Priyono Dwitya Elvira, Dwitya Efrida Efrida Eifel Faheri Eti Yerizel Fadil Oenzil Fadrian, Fadrian Fauzar Fikri, Avino Mulana Ghany, Firhan Fadlillah Hannie Qalbina Syaiful Hendriati, Hendriati Irza Wahid Kam, Alexander Khalisha Azzahra Pramesti Abdillah Laksono Trisnantoro LUKMAN NURHAKIM, LUKMAN Malinda Meinapuri Muhammad Ridhwan Fatharanifurqan Putra, Syandrea Prima Putri Ariani Putri, Azhara Dhiya Yosse Rahmatini . Raveinal Rendi Dwi Prasetyo Restu Susanti Rido Wandrivel Rikarni Rina Gustia Rinal Effendi Rismawati Yaswir Rivani Sintia Suratman Rizki Rahmadian Rizky Loviana Roza Roza Mulyana Saptino Miro Seilla Dinta Yastina Wahyudi, Adefri Yenita Yenita Yulia, Dwi Yuniar Lestari Yusri, Elfira Zahira, Aisyah Dhia zahra salsabila Zelly Dia Rofinda Zulkarnain Edward