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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) Agromet BALI MEDICAL JOURNAL (BMJ) Jurnal Kimia (Journal of Chemistry) INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Jurnal Keteknikan Pertanian Jurnal Ilmu Komputer dan Agri-Informatika Jurnal Teknologi Informasi dan Ilmu Komputer Scientific Journal of Informatics JOIN (Jurnal Online Informatika) JOIV : International Journal on Informatics Visualization Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) Journal Of Vocational Health Studies Syntax Literate: Jurnal Ilmiah Indonesia Gema Wiralodra Journal of Robotics and Control (JRC) Jurnal Sewaka Bhakti Jurnal Ilmu dan Teknologi Peternakan Terpadu (JITPU) Dharma Jnana Journal of Global Pharma Technology Eduvest - Journal of Universal Studies Jurnal Sistem Informasi
Sri Wahjuni
Chemistry Department, Faculty Of Math And Science, Udayana University, Bali-Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Social Sciences Other

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Journal : Journal of Global Pharma Technology

 1 
Effects of Binahong (Anredera Cordifolia) Leaf Ethanol Extracts on Blood Glucose Levels and Pancreas Histopathology in Hyperglycemic Rats Sri Wahjuni
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Background: The use of binahong leaf has been carried out for medical purposes for centuries. Severalstudies have shown that binahong contain alkaloids, saponins, tannins, glycosides, and terpenes,which can be known to have effects to reduce blood sugar levels. Objective: This study to determinethe effect of binahong leaf ethanol extract in reducing blood glucose and histopathological change inhyperglycemic rats. Method: This study was an experimental study using Wistar rats that weredivided into five groups. The normal group was given with distilled water (P0), the positive controlgroup received glibenclamide (P1), and intervention group was given orally binahong leaf extract ofethanol with a dose of 10mg/kg (P2), 15 mg/kg (P3) and 20 mg/kg (P4). Blood sugar level wasevaluated from the initial day of measurement to two weeks. Pancreas tissue was obtained toevaluate the histopathological change. Results: Mean blood sugar level in each group respectively94.28±6.19 mg/dL, 133.61±47.05 mg/dL, 117.56±26.73 mg/dL, 124.77±37.05 mg/dL, and 136.57±47.55mg/dL. The result of Kruskal-Wallis test was p=0.011. Multiple comparison test showed significantresult between P4 with P0 (p=0.011). Conclusion: Binahong leaf ethanol extract with a dose of 20mg/kg significantly reduce blood glucose level in the hyperglycemic rat.Keywords: Binahong, Anredera cordifolia, Blood glucose, Hyperglycemic rat.
Red Piper Crocatum Leaves Extract Ethanol Lowering Malondialdehyde (MDA) and Blood Glucose Level In Hyperglycemic Wistar Rat Sri Wahjuni; I Made Sukadana; dan Luh Putu Arisanti
Journal of Global Pharma Technology Volume 09 Issue 05
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Changes in fast-food behavior became one cause of diabetes. Potential of the red betel leaf (Piper crocatum) can lower blood sugar levels allegedly because it contains antioxidant-potent compounds inductively induce certain organs to produce insulin hormones that play a role in lowering glucose levels in the blood.The aim of the study is to determine the effectiveness of Piper crocatum leaf ethanol extract in fixing the pancreas β-cell damage rate in alloxan induced hyperglycemic Wistar Rat. Methods: This study used randomized pre-and posttest control group design. Twenty-four (24) male Wistar rats divided into 6 groups namely P0 positive control (P0), P1 as a negative control (allowance 125 mg Kg -1BW), P2 (alloxan and extract dose 50 mgKg-1 BW), P3 (alloxan and extract dose 100 mg Kg -1 BW), P4 (alloxan and extract dose 150 mg Kg - 1 BW), P5 (alloxan and glibenclamide 0.18 mg/day 200g -1BW). Blood glucose measurement was taken through a vein tail performed by the glucose test method. Measurement of MDA levels, blood was taken from the jugular vein and analyzed by the TBARS method. The yield of Piper crocatum extraction with ethanol solvent was 13,1%.  The most significant results were shown by dosing of 150 mg Kg -1BW and extract of 50 mg Kg -1 BW gave a comparable effect to glibenclamide as a blood sugar-lowering drug. The results of phytochemical tests showed that Piper crocatum contains phenolic, alkaloid, and steroid. The results of GC-MS analysis of extracts active Piper crocatum were suspected to contain 29 compounds of 13 compounds known as phytol, neophytadiene, β-bisabolene, germacrene-D, α-humulene, sulfamethoxazole, caryophyllene, nandrolone phenylpropionate, thiamin, linalool, β-ocimene, Anthocyanin, and β-myrcene.Keyword: Red Piper crocatum leaf, Blood glucose, MDA (Malondialdehyde).
Effect of Ethanol Extracts of Mustard Green (Brassica rapa L.) on Streptozotocin Induced Rats Sri Wahjuni
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Objective: This experimental study was conducted to evaluate the effect of the mustard green extract on blood glucose and the pancreas histopathological feature. Methods: Five groups of rats divided into the control group that received standard food (P0) and streptozotocin-induced group (P1, P2, P4, and P4). P1 (positive control group) was given glibenclamide; P2, P3, and P4 (treatment group) were given mustard green ethanol extract at a dose of 0.5; 2.0; and 5.0 mg/kg body weight/day respectively. The separation of ethanol extract of mustard green was carried out by  LC-MS/MS. One way ANOVA and Post hoc test was conducted to evaluate the mean difference of the blood glucose. Results: Post hoc test showed significant result for P0 vs P3 (p<0.001), P0 vs P4 (p=0.001), P1 vs P2 (p=0.048), P2 vs P3 (p=0.001). Comparison between P1 and treatment group was found a similar effect on blood glucose between P1 vs P3 (p=0.048) and P1 vs P4 (p=0.830). Histological studies showed the administration of ethanol extract of mustard green showed a restorative effect. Conclusion: Administration of ethanol extract of mustard green decrease the level of blood glucose and might be a usable treatment for hyperglycemia.Keywords: Mustard green (Brassica rapa L.), Streptozotocin, Hyperglycemic effects.
Co-Authors A.A.G. Sudewa Agus Buono Alfiansyah Halomoan Siregar Anisa Nur Halimah Ariq Cahya Wardhana Ariyani Tanti Ashri Rizki Hidayati Auriza Rahmad Akbar Barlianto, Agus Betty Kostradiyanti Budi Indra Setiawan dan Luh Putu Arisanti Edi Santosa Eknanda, Rafael Tektano Grandiawan Eliyah Acantha Manapa Sampetoding Elly Rusdiana, Elly Eny Inayati, Eny Faisyah, Shilvy Arofatul Haqqika Pasha Haris, Abdul Haula Robbi, M. Kautsar Hendra Rahmawan Hendra Rahmawan Hermadi , Irman Hidayat Hidayat Hidayat I M, Sukadana I NYOMAN MANTIK ASTAWA I W. Wita, I W. I Wayan Suirta I Wayan Wita I. A Raka Astiti Asih Ida Bagus Putra Manuaba Iman Rahayu Hidayati Soesanto Irman Hermadi Ishak, Sahrial Ihsani Joko Hermanianto Karlisa Priandana Komara N, Fatthurohman Kudang Boro Seminar Kusdarjanti, Endang Lita Rosa, Mia Laksmi Lokaprasidha, Pramesi Lusiana Tabuni Marimin , Maxiwinata, Maxdha Michel Williams, Michel Ni Ketut Puspa Sari Ni Luh Rustini Ni Made Puspawati Ni Made Puspawati Ni Nyoman Astuti Wulandari Ni Putu Rahayu Artini Nirmala Ratna Harda, Sasadhara Noer Muslimah, Meia Nugroho, Margaretta Andini Nur Halimah, Anisa Oka Ratnayani Putu Yuliantari Rahmadani, Annisa Ratwita, Rr. Dwiyanti Feriana Rebecha Prananta, Rebecha Sanjiwo, Suryo Hamukti Sefy Ayu Mandanie, Sefy Ayu Septianto, Yudhi Setyowati, Okti Shelvie Nidya Neyman Sianiwati Goenharto Sri Rahayu Santi Sri Redjeki Sri Redjeki Indiani, Sri Redjeki Sufiatul Maryana Sujati Sujati Sujati, Sujati Toto Haryanto Wafi, Azmi Sabilakisbatul Wahyu Dwijani Sulihingtyas Wasudewa, K. M. Wibisono, Indra Perdana Willy Bayuardi Suwarno Wulandari Wulandari Yan Mitha Djaksana Yani Nurhadryani Yulianti, Nila Susila Zakiah, Rizqi Alifahasni