Nadia Farhanah Syafhan
Division Of Clinical Pharmacy, Faculty Of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia | Universitas Indonesia Hospital, Jl. Prof. DR. Bahder Djohan, Pondok Cina, Beji, Depok, West Java 16424, Indonesia

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 21 Documents
Search

Pemakaian Obat Nefrotoksik Sebagai Determinan Drug-Induced Acute Kidney Injury (D-AKI) Hadiwati, Rangkay; Andrajati, Retnosari; Syafhan, Nadia Farhanah; Wahono, Dwi Edi
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 15, No 1 (2024): Januari-Maret 2024
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf15130

Abstract

Events related to drug reactions are very difficult to recognize, because they often look like other diseases and many symptoms of drug reactions appear, especially for short drug exposures. Acute Kidney Injury is a condition that affects the structure and function of the kidneys, which is characterized by a sudden decrease in kidney function which causes necrosis of the tubules. The aim of this study was to analyze the prevalence of Drug-Induced Acute Kidney Injury and determine the main risk factors as well as drug data that can influence the increase in serum creatinine levels during treatment. This study implemented a cross-sectional design. The sampling location was the Medical Records section of Gatot Soebroto Army Hospital, with a sample size of 56 patients identified using the Kidney Disease Improving Global Outcomes (KDIGO) criteria and using trigger tools. Data were analyzed using the Chi-square test. The results of the analysis showed that the prevalence of Drug-Induced Acute Kidney Injury in the RSPAD Gatot Soebroto inpatient room was 8.975%-18.527%. Factors that influence the occurrence of Drug-Induced Acute Kidney Injury in the inpatient room were comorbidities (PR = 8.975; 95% CI = 1.317-61.159; p-value = 0.025) and drug interactions (PR = 18.527; 95% CI = 1.727 -177.909; p-value = 0.011). In general, the most widely used nephrotoxic drugs were a combination of >3 types of nephrotoxic drugs, diuretics, NSAIDs, cephalosporins, ARBs, ACEi and chemotherapy drugs. Based on the research results, it was concluded that the use of nephrotoxic drugs was a determinant of Drug-Induced Acute Kidney Injury in the Gatot Soebroto Army Hospital inpatient room.Keywords: kidney disease; Drug-Induced Acute Kidney Injury; nephrotoxic drugs; trigger tools; creatinine ABSTRAK Kejadian yang berhubungan dengan reaksi obat sangat sulit dikenali, karena sering tampak seperti penyakit lain dan banyak gejala reaksi obat yang muncul, terutama untuk paparan obat yang singkat. Acute Kidney Injury adalah salah satu dari kondisi yang mempengaruhi struktur dan fungsi ginjal, yang ditandai dengan penurunan fungsi ginjal secara tiba-tiba yang menyebabkan nekrosis pada tubulus. Tujuan penelitian ini adalah menganalisis prevalensi Drug-Induced Acute Kidney Injury dan menentukan faktor risiko utama serta data obat-obatan yang dapat mempengaruhi peningkatan kadar kreatinin serum selama dirawat. Penelitian ini menerapkan desain cross-sectional. Tempat pengambilan sampel adalah bagian Rekam Medis RSPAD Gatot Soebroto, dengan ukuran sampel adalah 56 pasien yang diidentifikasi dengan menggunakan kriteria Kidney Disease Improving Global Outcomes (KDIGO) dan menggunakan trigger tools. Data dianalisis menggunakan uji Chi-square. Hasil analisis menunjukkan bahwa prevalensi Drug-Induced Acute Kidney Injury di ruang rawat inap RSPAD Gatot Soebroto adalah 8,975%-18,527%. Faktor-faktor yang mempengaruhi terjadinya Drug-Induced Acute Kidney Injury di ruang rawat inap adalah komorbid (PR = 8,975; 95% CI = 1,317-61,159; p-value = 0,025) dan interaksi obat (PR = 18,527; 95% CI = 1,727-177,909; p-value = 0,011). Secara umum obat nefrotoksik yang paling banyak digunakan adalah kombinasi obat nefrotoksik >3 macam, obat diuretik, NSAID, sefalosporin, ARB, ACEi dan obat kemoterapi. Berdasarkan hasil penelitian disimpulkan bahwa pemakaian obat nefrotoksik merupakan determinan dari Drug-Induced Acute Kidney Injury di ruang rawat inap RSPAD Gatot Soebroto.Kata kunci: kidney disease;  Drug-Induced Acute Kidney Injury; obat nefrotoksik; trigger tool; kreatinin
Medication Adherence, Glycemic Control and Quality of Life in Patients with Type 2 Diabetes Mellitus: a cross-sectional study Eliza, Delila; Syafhan, Nadia Farhanah; Andrajati, Retnosari; Fitriani, Sri Wulandah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.21-27.2023

Abstract

Medication adherence is important in controlling blood sugar levels (HbA1c) in patients with Diabetes Mellitus (DM). Studies on the relationship between medication adherence and blood sugar control on the quality of life (QoL) in Type 2 DM patients are limited in Indonesia. This study aims to assess the relation between medication adherence with blood sugar control and the quality of life of Type 2 DM patients. This study used a cross-sectional design conducted at Universitas Indonesia Hospital. It used Medication Adherence questionnaires and EuroQoL 5D-5L questionnaires to assess patients’ medication adherence and quality of life. This study involved a total of 74 Type 2 DM patients with an average age of 57 ± 10.74 years. Medication adherence with good blood sugar control (HbA1c <7%) showed a significant relationship (p-value <0.05) with COR values of 3.74 (1.21 - 11.6) compared to non-adherent patients. But not on the QoL Index and VAS (Visual Analog Scale) values, where the value is lower in patients with high adherence and good blood sugar control. Factor asscociated with blood sugar controlled were comorbidites and medication adhrence while factor that associated with quality of life were comorbidities, ages, education and employment status
Assessment of medication-related liver and kidney impairment in admitted patients in Depok, Indonesia: an observational study employing the Naranjo algorithm Syafhan, Nadia Farhanah; Aldora, Ghea Shafa; Kamila, Shinta
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29012

Abstract

Liver and kidney impairment caused by medications represents serious side effects that may extend hospital stays and increase the risk of patient death. Implementing strategies to recognize, document, and analyze cases of patient harm related to drug use is crucial for medicines optimization. This study aimed to evaluate the prevalence of medication-related liver and kidney impairment among hospitalized patients, while also identifying the specific medication categories implicated. A retrospective review of patient records was conducted at Universitas Indonesia Hospital (Depok, Indonesia), focusing on adult patients diagnosed with liver or kidney impairment during their 2021 hospital admission. The Naranjo algorithm was applied to assess the likelihood that these injuries were caused by medications. Among the 4,273 admitted patients, it was found that 1.01% experienced medication-related liver impairment (MRLI), while 0.77% experienced medication-related kidney impairment (MRKI). The most common medications associated with liver impairment were antibiotics (31.58%), cardiovascular medications (24.21%), pain relievers (14.74%), anti-ulcer medications (11.58%), antiviral medications (8.42%), antiemetics (8.42%), and antidiabetic medications (1.05%). In contrast, kidney disease was primarily linked to diuretics (29.76%), antibiotics (21.43%), ACE inhibitors/ARBs (21.43%), antiviral medications (9.52%), and NSAIDs (7.14%). Importantly, there was no statistically significant correlation between the occurrence of MRLI or MRKI and factors such as gender, age, body mass index (BMI), or the presence of other health conditions (p > 0.05). These findings underscore the need for heightened awareness regarding the potential for medication-related impairments in hospitalized patients and suggest that careful monitoring of medication use is essential to mitigate these risks.
Pengaruh Faktor Risiko terhadap Kejadian Peningkatan Kadar Enzim Transaminase pada Pasien Covid-19 dengan Terapi Tocilizumab Nasution, Izza Aulia Rizqika; Andrajati, Retnosari; Syafhan, Nadia Farhanah; Imaniar, Rania
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 15 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (398.476 KB) | DOI: 10.35617/jfionline.v15i1.137

Abstract

Abstract: Tocilizumab is an anti-IL-6 which is recommended as cytokine release syndrome therapy in the treatment of Covid-19. One of the side effects of tocilizumab that can occur is hepatotoxicity, from mild elevated transaminases to severe drug-induced liver injury (DILI). Currently, research related to tocilizumab hepatotoxicity and the risk factors affecting Covid-19 patients is limited and still needs to conduct. This research is an observational study with cross-sectional design. Data collection was carried out retrospectively using secondary data obtained from medical records department, patients with Covid-19 at Universitas Indonesia Hospital in 2020-2021. Patients confirmed with positive Covid-19 receiving Tocilizumab therapy in medical record were included in this study. Patient demographics, clinical diagnoses, laboratory examinations, history of others medication were also reviewed. Patients with less than 18 years old, incomplete medical record data, and referred to other hospitals were excluded. The sampling technique used was total sampling, namely all patients who met the inclusion criteria were taken as subject in this research. Chi-square test was used to analyze the relationship between each risk factors and the incidence of elevated transaminases. The results of Chi-square test showed that several risk factors significantly increased the incidence of elevated transaminases in patients given tocilizumab therapy, including age, obesity, diabetes mellitus, and ceftriaxone as antibiotic therapy.
Evaluation of drug services based on prescription indicators and patient care according to who at the hospital general practitioner (GP) outpatient clinic in Depok, Indonesia Syafhan, Nadia Farhanah; Risni, Hindun Wilda; Salsabila, Azzahra Fahira; Purnama Putri, Raden Jacinda Yasmin; Prasetyaningrum, Marchen
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1609

Abstract

The World Health Organization (WHO) has developed prescription and patient care indicators, accompanied by optimal benchmarks, aimed at promoting the rational and optimal medicine use. This study aims to evaluate drug services utilizing WHO prescription and patient care indicators at the hospital General Practitioner (GP) outpatient clinic. The research was conducted retrospectively for prescription indicators, consisting of 1505 prescriptions totaling 4647 medication items administered for 804 individuals between January and December 2022. Prospective data collection to evaluate patient care was conducted from April to May 2023. Evaluation of WHO prescription indicators yielded the following results: the average number of drugs prescribed per patient was 3.09 ± 2.00; the percentage of drug prescribed by generic drug names was 47.47%; the percentage of antibiotic prescriptions was 5.46%; the percentage of injectable drug prescriptions was 6.80%; and the percentage of prescriptions in accordance with the national formulary was 75.91%. The percentages of antibiotic and injectable drug prescriptions met the optimal WHO prescription values. In terms of patient care, the results showed that the average duration of a medical consultation was 12.44±8.1 minutes, the average duration of a drug dispensing was 45.65±28.8 minutes, 96.25% of the drugs were dispensed appropriately, 100% of the drugs were labeled adequately, and 78.78% of the patients were knowledgeable. Age (p=0.111) and gender (p=0.075) showed no significant correlation with patient knowledge. There was a significant relationship between education level (p=0.014) and patient knowledge. Prescription and patient care indicators are aspects of improvement to meet the optimal benchmarks according to WHO standards.
Efektivitas intervensi apoteker terhadap optimalisasi terapi opioid dan manajemen nyeri pada pasien kanker: A literature review Budiastuti, Rizky Farmasita; Sari, Santi Purna; Andrajati, Retnosari; Syafhan, Nadia Farhanah
Holistik Jurnal Kesehatan Vol. 19 No. 5 (2025): Volume 19 Nomor 5
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i5.872

Abstract

Background: Cancer pain remains a significant clinical challenge, with a high prevalence across various disease stages. Opioids are the mainstay for moderate to severe pain management but carry risks of dependence, tolerance, and serious side effects, necessitating careful supervision. Purpose: To review the effectiveness of pharmacist interventions in managing opioid use among cancer pain patients. Method: A literature search was conducted using two approaches: keyword-based searches through electronic databases (Google Scholar and Scopus) and the snowballing technique. Keywords included "cancer pain," "opioid," "pharmacist intervention," and "breakthrough pain," combined with Boolean operators. After identifying primary articles, backward and forward snowballing was performed to find additional relevant studies. All articles were screened based on predefined inclusion and exclusion criteria. Results: The review demonstrates that pharmacist interventions can improve pain control by up to 40%, reduce opioid-related side effects such as constipation by up to 50%, and enhance patient adherence to therapy. In Indonesia, however, barriers such as limited access to strong opioids, low patient education levels, and minimal pharmacist involvement in multidisciplinary teams remain significant challenges. Conclusion: Pharmacists play a strategic role in cancer pain management, particularly in optimizing pain control, minimizing opioid dependence, and managing adverse effects. Their active involvement in multidisciplinary teams enhances patients' quality of life and reduces inappropriate opioid use. Strengthening policies, providing continuous professional development, and conducting context-specific research are essential to optimize pharmacist contributions in Indonesia.   Keywords: Cancer Pain; Opioids; Pain Management; Pharmacist Intervention.   Pendahuluan: Nyeri kanker merupakan tantangan klinis utama dengan prevalensi tinggi pada berbagai tahap penyakit kanker, dan opioid menjadi terapi lini utama untuk nyeri sedang hingga berat. Namun, penggunaannya memiliki risiko ketergantungan, toleransi, serta efek samping serius, sehingga diperlukan pengawasan ketat. Tujuan: Untuk meninjau literatur terkait efektivitas intervensi apoteker dalam pengelolaan penggunaan opioid pada pasien nyeri kanker. Metode: Pencarian literatur dilakukan dengan dua pendekatan, yaitu pencarian menggunakan kata kunci melalui basis data elektronik (Google scholar dan Scopus) serta teknik snowballing. Kata kunci yang digunakan meliputi: "cancer pain", "opioid", "pharmacist intervention", dan "breakthrough pain", yang dikombinasikan menggunakan operator Boolean. Setelah diperoleh artikel utama, dilakukan teknik snowballing secara backward dan forward untuk menemukan studi relevan. Semua artikel yang diperoleh diseleksi berdasarkan kriteria inklusi dan eksklusi. Hasil: Tinjauan menunjukkan bahwa intervensi apoteker dapat meningkatkan efektivitas terapi nyeri hingga 40%, menurunkan kejadian konstipasi sebagai efek samping hingga 50%, serta meningkatkan kepatuhan pasien terhadap regimen terapi. Namun, di Indonesia, implementasi peran apoteker masih menghadapi hambatan seperti keterbatasan akses opioid kuat, kurangnya edukasi pasien, dan rendahnya keterlibatan apoteker dalam tim multidisiplin. Simpulan: Dari tinjauan ini menunjukan bahwa intervensi apoteker terbukti memiliki kontribusi strategis dalam pengelolaan nyeri kanker, khususnya melalui pengendalian nyeri yang lebih efektif, pencegahan ketergantungan opioid, dan manajemen efek samping yang lebih terstruktur. Keterlibatan apoteker dalam tim multidisiplin dapat meningkatkan kualitas hidup pasien dan menurunkan risiko penggunaan opioid yang tidak tepat. Namun, untuk mengoptimalkan peran ini, diperlukan dukungan kebijakan, pelatihan berkelanjutan, serta riset lebih lanjut dalam konteks lokal untuk menjawab tantangan implementasi di Indonesia.   Kata Kunci: Intervensi Apoteker; Nyeri Kanker; Opioid; Pengelolaan Nyeri.
Cognitive Function in Type 2 Diabetes Mellitus Patients Taking Metformin and Metformin-Sulfonylurea Rachman, Abu; Sauriasari, Rani; Syafhan, Nadia Farhanah; Prawiroharjo, Pukovisa; Risni, Hindun Wilda
Kesmas Vol. 17, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas sulfonylurea has been shown to reduce this impact. This study aimed to compare the impacts of metformin and metformin-sulfonylurea on cognitive function and determine what factors affected it. This cross-sectional study was conducted at Pasar Minggu Primary Health Care involving 142 type 2 diabetes mellitus patients taking metformin or metformin-sulfonylurea for > 6 months and aged > 36 years. Cognitive function was assessed using the validated Montreal Cognitive Assessment Indonesian version. The effects of metformin and metformin-sulfonylurea on cognitive decline showed no significant difference, even after controlling for covariates (aOR = 1.096; 95% CI = 0.523–2.297; p-value = 0.808). Multivariate analysis showed age (OR = 4.131; 95% CI = 1.271–13.428; p-value = 0.018) and education (OR = 2.746; 95% CI = 1.196–6.305; p-value = 0.017) affected cognitive function. Since a lower education and older age are likely to cause cognitive decline, health professionals are encouraged to work with public health experts to address these risk factors for cognitive function.
Pendidikan dan Pelatihan untuk Peningkatan Kompetensi Apoteker terkait Telefarmasi: Scoping Review Permata Sari, Kartika Citra Dewi; Maria, Nisa; Kusumawardani, Larasati Arrum; Risni, Hindun Wilda; Syafhan, Nadia Farhanah; Fauziyyah, Afina Nur
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1487

Abstract

Antihypertensive and antidiabetic drugs in chronic kidney disease (CKD) patients undergoing hemodialyThe high demand for telepharmacy services led to the urge for proper training and education to enhance its quality. This review aimed to assess the implementation and outcomes of telepharmacy training and education programmes. This scoping review was conducted on ScienceDirect, Sage Journal, SpringerLink, and Google Scholar databases using keywords “training” OR “education” AND “telepharmacy,” “training” OR “education” AND “digital competency” AND “pharmacy.” Only English-written articles published between 2000 – 2023, original research and brief report were included in this review. Eight of 171 articles met the criteria and the study’s objectives. Those studies discussed telepharmacy learning programmes for pharmacy students in the USA (5 articles), UAE (2 articles), and Malaysia (1 article). The learning methods included didactic learning, case-based study, simulation/roleplay, and clerkship employing technological tools. Rubrics, quizzes, questionnaires, and objective structured clinical examination (OSCE) were used as assessment methods. All studies reported improved students’ knowledge, perceptions, and telepharmacy competencies. In conclusion, the telepharmacy learning programmes have effectively upgraded students’ knowledge and skills by various methods at every level. However, there remains a considerable need for evidence on suitable training for pharmacists to improve their telepharmacy competencies and service quality.
The Implementation of Telepharmacy in Bangka Belitung Islands Province Djuria, Rachmawati Felani; Andrajati, Retnosari; Syafhan, Nadia Farhanah; Wispriyono, Bambang
JURNAL INFO KESEHATAN Vol 21 No 3 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss3.1059

Abstract

Telepharmacy is a telemedicine health service in the pharmaceutical sector that uses telecommunications to assist patients located far away during the Covid-19 pandemic. Furthermore, professional organizations are responsible for continuously providing information to pharmacists, ensuring they stay updated with the latest developments in the field. Mobile applications have emerged as the primary medium through which information can be accessed. Therefore, this research aimed to determine the implementation of telepharmacy in the Bangka Belitung Islands Province using observational research with a qualitative approach. The participants comprised a total of 11 individuals and the technique employed was purposive sampling. Subsequently, the collected data were subjected to analysis using the Miles and Huberman model. The results showed that the utilization of telepharmacy commenced within Bangka Belitung Islands Province and the community pharmacy service implemented the concept in the form of Drug Information Services, drug consultation or patient counseling, and prescription services through e-prescribing. Additionally, field observations highlighted the presence of services such as home delivery of medicines, patient education, and online non-cash payments. The implementation of telepharmacy within hospitals remains absent, despite the widespread adoption of digital services facilitated by the SIMRAS application. Pharmacists also ensured the administrative compliance of their colleagues through the utilization of the SIAP application. The preliminary stages of the implementation commenced in the Bangka Belitung Islands Province.  
Evaluation of drug services based on prescription indicators and patient care according to who at the hospital general practitioner (GP) outpatient clinic in Depok, Indonesia Syafhan, Nadia Farhanah; Risni, Hindun Wilda; Salsabila, Azzahra Fahira; Purnama Putri, Raden Jacinda Yasmin; Prasetyaningrum, Marchen
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1609

Abstract

The World Health Organization (WHO) has developed prescription and patient care indicators, accompanied by optimal benchmarks, aimed at promoting the rational and optimal medicine use. This study aims to evaluate drug services utilizing WHO prescription and patient care indicators at the hospital General Practitioner (GP) outpatient clinic. The research was conducted retrospectively for prescription indicators, consisting of 1505 prescriptions totaling 4647 medication items administered for 804 individuals between January and December 2022. Prospective data collection to evaluate patient care was conducted from April to May 2023. Evaluation of WHO prescription indicators yielded the following results: the average number of drugs prescribed per patient was 3.09 ± 2.00; the percentage of drug prescribed by generic drug names was 47.47%; the percentage of antibiotic prescriptions was 5.46%; the percentage of injectable drug prescriptions was 6.80%; and the percentage of prescriptions in accordance with the national formulary was 75.91%. The percentages of antibiotic and injectable drug prescriptions met the optimal WHO prescription values. In terms of patient care, the results showed that the average duration of a medical consultation was 12.44±8.1 minutes, the average duration of a drug dispensing was 45.65±28.8 minutes, 96.25% of the drugs were dispensed appropriately, 100% of the drugs were labeled adequately, and 78.78% of the patients were knowledgeable. Age (p=0.111) and gender (p=0.075) showed no significant correlation with patient knowledge. There was a significant relationship between education level (p=0.014) and patient knowledge. Prescription and patient care indicators are aspects of improvement to meet the optimal benchmarks according to WHO standards.