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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Proceeding Of The International Seminar and Conference 2015 Majalah Ilmiah MOMENTUM Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmascience Media Farmasi Journal of Dedicators Community Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Natural Sciences Engineering and Technology Journal Media Farmasi Indonesia Jurnal Ilmiah Sains Proceeding Seminar Nasional IPA
Aqnes Budiarti
Universitas Wahid Hasyim
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Journal : Jurnal Ilmiah Cendekia Eksakta

 1 
PENGARUH VARIASI KONSENTRASI TWEEN 80 dan SPAN 80 TERHADAP KARAKTERISTIK KRIM EKSTRAK ETANOL DAUN NANGKA Susanti, Emy; Budiarti, Aqnes; Musyafaah, Maul
CENDEKIA EKSAKTA Vol 6, No 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i1.3036

Abstract

ABSTRACT Jackfruit leaves (Artocarpus heterophyllus) are known to have antioxidant activity and formulated in cream. Span 80 and tween 80 are emulsifiers that are widely used in cream formulations. This study aims to determine the antioxidant activity in cream preparations and the effect of concentrations span 80 and tween 80 on the physical characteristics of the cream.The ethanol extract of jackfruit leaves was made by maceration using 70% ethanol. Jackfruit ethanol extract cream is made in 4 formulas based on variations in the concentration of emulgator span 80; tween 80 that is F1 (3%; 3%), F2 (4%; 4%) and F3 (5%; 5%). The cream tested the physical characteristics of the cream including organoleptic, homogeneity, pH, adhesion, spreadability and viscosity, while antioxidant activity carried out by DPPH (1,1-Diphenyl-2-picrylhidrazyl) method. Data on the physical characteristics of the cream obtained were analyzed using linear regression, the results of organoleptic test and homogeneity were analyzed descriptively, and data from the activity of antioxidant creams were statistically tested using One Way Anova. The results obtained showed variation in concentrations of span 80 and tween 80 affecting the physical characteristics of the cream. Increasing the concentration of span 80 and tween 80 in cream preparations can increase viscosity and adhesion but reduce the spreadability. Antioxidant activity of jackfruit leaf ethanol extract obtained from F1 was 23.17%, F2 37.89% and F3 29.82%, significantly different with F(-) was 6.65%,. Variation in concentrations of span 80 and tween 80 do not affect their antioxidant activity. Keywords: Antioxidant, Jackfruit leaf, DPPH, Cream
ANALISIS BAHAN KIMIA OBAT DEKSAMETASON DALAM JAMU PEGAL LINU MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI Aqnes Budiarti; Muhamad Barik Ulfa Faza
CENDEKIA EKSAKTA Vol 3, No 1 (2018)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v3i1.2136

Abstract

Deksametason merupakan bahan kimia obat yang seringkali ditambahkan secara ilegal pada obat tradisional pegal linu sehingga dapat membahayakan kesehatan. Dengan demikian perlu dilakukan analisis penetapan kadar bahan kimia obat dalam obat tradisional menggunakan metode yang akurat, tepat dan sensitif untuk memastikan keamanan obat tradisional. Tujuan penelitian ini adalah melakukan validasi metode penetapan kadar deksametason menggunakan kromatografi cair kinerja tinggi (KCKT) dan mengaplikasikannya pada obat tradisional pegal linu  yang ditambahkan deksametason. Penetapan kadar deksametason menggunakan seperangkat alat KCKT (Jazco) yang dilengkapi dengan detektor UV-Vis. Fase diam yang digunakan yaitu C18 serta fase gerak berupa campuran 0,1% asam ortofosfat dan asetonitril dengan laju alir 1 mL/menit. Uji validasi yang dilakukan meliputi uji presisi, akurasi, selektivitas (spesifisitas), linieritas dan sensitivitas (LOD dan LOQ). Hasil penelitian menunjukkan bahwa metode penetapan kadar deksametason dapat divalidasi. Uji presisi menghasilkan ketelitian (%RSD) =0,32%, uji akurasi memberikan nilai perolehan kembali sebesar 100,19%- 100,80%, selektivitas baik, linieritas dengan nilai korelasinya (r)= 0,999. LOD sebesar 0,93μg/mL dan LOQ sebesar 3,09 µg/mL. Kadar rata-rata deksametason dalam obat tradisional pegal linu adalah 100,18%. Kata kunci : deksametason, jamu pegal linu, KCKT
PENGARUH VARIASI KONSENTRASI TWEEN 80 dan SPAN 80 TERHADAP KARAKTERISTIK KRIM EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus) SEBAGAI ANTIOKSIDAN Emy Susanti; Aqnes Budiarti; Maul Musyafaah
CENDEKIA EKSAKTA Vol 4, No 2 (2019)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v4i2.3052

Abstract

ABSTRACT Jackfruit leaves (Artocarpus heterophyllus) are known to have antioxidant activity and formulated in cream. Span 80 and tween 80 are emulsifiers that are widely used in cream formulations. This study aims to determine the antioxidant activity in cream preparations and the effect of concentrations span 80 and tween 80 on the physical characteristics of the cream.The ethanol extract of jackfruit leaves was made by maceration using 70% ethanol. Jackfruit ethanol extract cream is made in 4 formulas based on variations in the concentration of emulgator span 80; tween 80 that is F1 (3%; 3%), F2 (4%; 4%) and F3 (5%; 5%). The cream tested the physical characteristics of the cream including organoleptic, homogeneity, pH, adhesion, spreadability and viscosity, while antioxidant activity carried out by DPPH (1,1-Diphenyl-2-picrylhidrazyl) method. Data on the physical characteristics of the cream obtained were analyzed using linear regression, the results of organoleptic test and homogeneity were analyzed descriptively, and data from the activity of antioxidant creams were statistically tested using One Way Anova. The results obtained showed variation in concentrations of span 80 and tween 80 affecting the physical characteristics of the cream. Increasing the concentration of span 80 and tween 80 in cream preparations can increase viscosity and adhesion but reduce the spreadability. Antioxidant activity of jackfruit leaf ethanol extract obtained from F1 was 23.17%, F2 37.89% and F3 29.82%, significantly different with F(-) was 6.65%,. Variation in concentrations of span 80 and tween 80 do not affect their antioxidant activity. Keywords: Antioxidant, Jackfruit leaf, DPPH, Cream
VALIDASI METODE PENETAPAN KADAR ISONIAZID DAN VITAMIN B6 MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI SERTA APLIKASINYA DALAM SEDIAAN SIRUP OBAT TUBERKULOSIS Aqnes Budiarti; Nimas Yuniarsih Herdiyanti
CENDEKIA EKSAKTA Vol 3, No 2 (2018)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v3i2.2472

Abstract

Isoniazid (INH) dan piridoksin HCl atau vitamin B6 (vit B6) dikenal sebagai obat kombinasi untuk tuberkulosis. Adanya metode penetapan kadar kedua zat ini secara simultan sangat diperlukan dalam uji stabilitas dan studi nasib obat dalam tubuh. Tujuan penelitian ini adalah mengembangkan metode penetapan kadar INH dan vit B6 menggunakan kromatografi cair kinerja tinggi (KCKT)serta aplikasinya dalam sediaan sirup tuberkulosis. Pengembangan metode menggunakan KCKT Jasco dengan detektor UV-Vis. Fase diam adalah C18  dan fase gerak berupa campuran dapar fosfat dan asetonitril (75:25, v/v) dengan waktu alir 1,2 mL/menit pada panjang gelombang 280 nm. Selanjutnya dilakukan uji validasi meliputi akurasi, presisi, selektivitas, linieritas dan sensitivitas. Metode analisis diaplikasikan pada dua sediaan sirup dari pabrik yang berbeda. Hasil penelitian menunjukkan bahwa metode teliti dengan %RSD 0,48 untuk INH dan 0,64% untuk vit B6. Metode akurat dengan % perolehan kembali kedua  zat antara 98-102%, metode linier dengan nilai r = 0,99 untuk kedua zat. Nilai LoD dan LoQ untuk penetapan kadar INH adalah 2,65 dan 8,85 ppm serta vit B6 adalah 0,33 dan 1,11 ppm. Uji selektifitas  menghasilkan nilai resolusi 4,8. Kadar INH  dan vit B6 masing-masing dalam sirup adalah 100,26-100,27% dan 100,00-100,85%. Metode analisis yang divalidasi dapat diaplikasikan pada sediaan sirup obat tuberkulosis. Kata kunci:INH, isoniazid, KCKT, sirup tuberkulosis, vit B6
Co-Authors AA Sudharmawan, AA Adina Fitria K.W. Agung Tri Prasetya Darmanto Darmanto Devi Nisa Hidayati Dewi Andini Kunti Mulangsri, Dewi Andini Kunti dharmika wijaya sakti Diah Fahmisul Istiyaningrum Dyah Ayu Elisa_Kurnianingrum Elya Zulfa Emy Susanti Endah Novia Saputri Faridha Maera Lokana Fitrotun Husnia Husnia Frista Atika Oktania Henna Rya Soenoko Henna Rya Sunoko Heroweti, Junvidya I. Hartati I. Riwayati Ibnu Gholib Gandjar Ibrahim Arifin Iga Dewinta Putri Igustin Azmi Syahida Inayati, Dian Indah Hartati Indah Parameita Ira Afifah KHOIRUL ANWAR Khoirul Anwar Khoirul Anwar Kusreni Kusreni Laeli Kurniasari Laeli Kurniasari Listyowati Listyowati Maria Ulfah Maul Musyafaah Maulita Cut Nuria Muhamad Barik Ulfa Faza Muhammad Ikhsan Mukti Tri Utomo Musyafaah, Maul Nila Vuqohan Nimas Yuniarsih Herdiyanti Novy Inti Fauziah NUR AINI rini yeni susanti Ririn Lispita Wulandari Risna Angella Putri Pamungkas Rosmini Rosmini Rupmini Rupmini Salsabila, Unik Hanifah Siti Musinah Sri Haryani Sri Mulyo Bondan Respati Sri Susilowati Sumantri Sumantri Supriyanti Supriyanti Tri Murti Andayani Woro Sumarni Yessy Dwi Anggraini Yulias Ninik Windriati