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All Journal MEDIA MEDIKA INDONESIANA Jurnal Kesehatan Masyarakat Majalah Obat Tradisional Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Biopendix: Jurnal Biologi, Pendidikan dan Terapan Science Map Journal JSMARTech : Journal of Smart Bioprospecting and Technology Bioscientist : Jurnal Ilmiah Biologi Rumphius Pattimura Biological Journal Kalwedo Sains (KASA) KAMBOTI Journal of Education Research and Development
Theopilus W Watuguly
Program Pendidikan Biologi, Jurusan PMIPA FKIP Dan Program Pendidikan Dokter Universitas Pattimura Ambon, Jl. Dr. Tamaela, Kampus Universitas Pattimura Ambon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Rumphius Pattimura Biological Journal

 1 
ANALYSIS OF POTASSIUM (K) AND IRON (Fe) ON ORIGINAL HONEY OF WETAR ISLAND ILPUTI VILLAGE, SOUTHWEST MALUKU Lestari, Hana Ayu; Watuguly, Theopilus Wilhelmus
RUMPHIUS Vol 3 No 2 (2021): RUMPHIUS Pattimura Biological Journal
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/rumphiusv3i2p051-055

Abstract

Evaluation of Analgesic Activity Corypalmine and Panasenoside Compounds on Cox-2 Receptors In-Silico Lesbatta, Kezia Josawel; Watuguly, Theopilus Wilhelmus; Kakisina, Alter Glen; Anggraeni, Andi Sri Dewi
RUMPHIUS Vol 7 No 1 (2025): RUMPHIUS Pattimura Biological Journal
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/rumphiusv7i1p031-037

Abstract

Pain is a mechanism that occurs due to stimulation of nociceptors as pain receptors that cause ongoing or future tissue damage. Analgesic drugs that are usually used are COX-2 inhibitor drugs that can inhibit the activity of the COX-2 enzyme in synthesizing Prostaglandins (PG) which respond to pain and inflammation. Specific research on active compounds such as corypalmine and panasenoside related to their effects as analgesics has not been widely carried out, so it is necessary to predict the effects of both compounds by analyzing their activity on the COX-2 protein through in silico docking studies. This study aims to see the analgesic activity between the two compounds as COX-2 inhibitors. Testing was carried out through the stages of protein and ligand preparation, method validation, molecular docking of corypalmine and panasenoside compounds with COX-2 and visualization of bonds using Ligplot+. The results showed that the corypalmine docking score was more negative than panasenoside on COX-2, respectively -60.33 and -42.02. It can be concluded that the corypalmine compound is able to bind more strongly to COOX-2 and predicted to have a strong and more stable analgesic effect than panacea.
Co-Authors Adrien Jems Akiles Unitly Aknes Tahya Alfia Sabban Amos Killay Anggraeni, Andi Sri Dewi Anik Uniarti ARINI, INE Bare, Yohanes Baszary, Chomsa Dintasari Umi Beatrixs Rupilu Didik Wahyudi Dominggus Rumahlatu Edi Dharmana Eldo Dandirwalu F Leiwakabessy Fredy Leiwakabessy H Sinay Hanna Kalorbobir Harfalien Tehubijuluw Haslina Kole Icak Darling Rahakbauw Indahsari, Lilin Ika Nur Indranila KS Jecklyn A Lekal Johanis Fritzgal Rehena Kakisina, Alter Glen La Eddy La Sitiman, Hediaty Lesbatta, Kezia Josawel Lesiela, Laidonirka O. S. Lesirolo, Medlin Lestari, Hana Ayu Liline, Sintje Lopulalan, Silvia E M Kaihena Maria Nindatu Martha Kaihena Moniharapon, Debby D. Moniharapon, Mechiavel Mose, Windi Nindatu, Maria Nindatu, Maria Nurmila Nurmila Nusaly, Windy Natalia Pamella Mercy Papilaya Pattiasina, Eifan Boyke Patty, Rezza Julian Pay, Chrismenda Prelly M.J Tuapattinaya Prelly Tuapattinaya R Malawat Rumangun, Febi Stevano Sari, Dewi Ratih Tirto Sikafir, Beatrix Belina Silahooy, Veince Benjamin Sillehu, Eka Safitri Sopacua, Gracia N. Sriyanti Imelda Aksamina Salmanu Syahran Wael Syahran Wael Syahran Wael Titdoy, Nia Rusfita Tjahjono Tjahjono Tuapattinaya, Prelly M Tuapattinaya, Prelly M.J Uniarti, Anik Viesta Sampe Yosep Matruty Yulviany Latuihamallo