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All Journal Jurnal Jurusan Ilmu Keolahragaan Jurnal Visi Ilmu Pendidikan Journal of Politic and Government Studies Jurnal Keperawatan Bina Sehat Jurnal Aplikasi Bisnis dan Manajemen (JABM) E-Journal Jurnal Teknologi Elektro JURNAL KEPERAWATAN SEHAT Journal of Governance and Public Policy Syntax Literate: Jurnal Ilmiah Indonesia JURNAL PENJAKORA Jurnal Pengabdian Magister Pendidikan IPA Minda Baharu Faletehan Health Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Al-Khwarizmi: Jurnal Pendidikan Matematika dan Ilmu Pengetahuan Alam Community Development Journal: Jurnal Pengabdian Masyarakat jurnal ilmu keolahragaan Sport and Nutrition Journal Heart Science Journal International Journal Of Science, Technology & Management (IJSTM) JPTE: Jurnal Pendidikan Teknik Elektro Indonesian Journal of Applied Environmental Studies Cermin Dunia Kedokteran Assets : Jurnal Ilmiah Ilmu Akuntansi, Keuangan dan Pajak Journal Of World Science Pelita Teknologi : Jurnal Ilmiah Informatika, Arsitektur dan Lingkungan Jurnal Indonesia Sosial Teknologi EDUCATUM: Scientific Journal of Education Mutiara: Multidiciplinary Scientifict Journal Jurnal Penelitian dan Pengabdian Masyarakat Kultura: Jurnal Ilmu Sosial dan Humaniora Tevunah: Jurnal Teologi dan Pendidikan Kristen Jurnal Geografi LIngkungan Tropik (Journal of Geography of Tropical Environments) International Journal of Business and Quality Research International Journal of Economics, Business and Innovation Research Cosmic Jurnal Teknik Khamisyim : Jurnal Teologi dan Pendidikan Kristiani Sports Collaboration Journal
Arif Wicaksono
Mahasiswa Magister Ilmu Pemerintahan Universitas Muhammadiyah Yogyakarta
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Journal : Heart Science Journal

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Management of Pregnant Women with Atrial Septal Defect and Pulmonary Hypertension: A Case Report Wicaksono, Arif; Martini, Heny; Rizal, Ardian; Rahimah, Anna Fuji
Heart Science Journal Vol. 5 No. 2 (2024): Challenges in the Management of Congenital Heart and Structural Heart Diseases
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.02.13

Abstract

Backgrounds:Pulmonary Hypertension (PH) is a condition where there is an increase in Pulmonary Vascular Resistance (PVR) and an increase in the mean Pulmonary Arterial Pressure (mPAP) to more than 20 mmHg. PH can occur in someone with Congenital Heart Disease (CHD). PH conditions can aggravate pregnancy in women with CHD. So that women with PH are recommended not to undergo pregnancy. However, it is possible for women with CHD with PH conditions to undergo pregnancy. In these conditions, optimizing PH therapy is important so that pregnant women with PH do not experience a worsening of the condition and can carry out their pregnancy well until delivery. Case Presentations:A 38-year-old female patient with a history of Atrial Septal Defect-Pulmonary Hypertension came for routine control to the cardiac clinic with the condition of pregnancy of her 4th child who was just discovered when she was 6 months pregnant. Since giving birth to her third child, the patient began to complain of being easily tired when doing activities accompanied by swollen legs that disappeared with rest. At that time, the patient went to a cardiologist for an echocardiography examination and was diagnosed as Atrial Septal Defect (ASD)-Pulmonary Hypertension (PH). Since then, the patient has been routinely treated at a cardiologist with Pulmonary Hypertension drugs, including Phospodiesterase5 (PDE5) inhibitors (Sildenafil) and Prostacyclin Analogue (Dorner). The patient had done Transesophageal Echocardiography (TEE) with the results of ASD secundum suitable for closure by device. Patients with Right Heart Catheterization (RHC) results, ASD secundum with PH High Flow High Resistance reactive to Vasoreactivity Test. Since the patient was found to be pregnant, the patient continued to use Sildenafil and discontinued the use of Dorner. The patient then continued treatment in a multidisciplinary team. Conclusion :Management of pregnant women with CHD and PH is important because the condition of PH itself further aggravates the condition of pregnancy. Medical management for PH in pregnant women follows the guidelines for the safety of drugs in pregnancy. So that the choice of therapy is crucial related to the goal of treatment to control the PH condition in the patient but still pay attention to safety in pregnancy conditions.
Interleukin-6 (IL-6) as a Marker of Endothelial Dysfunction Confirmed Using Flow Mediated Dilatation in Active Smoker Wicaksono, Arif; Kurnianingsih, Novi; Tjahjono, Cholid Tri; Widito, Sasmojo; Swastikaputri, Valerina Yogibuana; Wihastuti, Titin Andri
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.4

Abstract

Background: The pro-inflammatory cytokine interleukin-6 (IL-6) is thought to be the catalyst for endothelial dysfunction caused by smoking. Flow-mediated dilatation (FMD) is a non-invasive method to identify the development of blood vessel endothelial dysfunction at an early stage. However, several studies have not sufficiently explained how smoking and IL-6 interact.Objective: This study focuses on the role of Interleukin-6 (IL-6) in the process of endothelial dysfunction confirmed using non-invasive modalities such as Flow Mediated Dilatation (FMD) in smokers related to the risk of cardiovascular disease in the future with the hope of providing insight in education to smokers to quit smoking.Material and Methods: In this study, we gathered 116 male participants, of which 56 were nonsmokers, and 60 were smokers, and we used IL-6 and FMD testing. SPSS for Windows version 23 will be used to analyze the data.Result: According to the analysis of laboratory tests, the average IL-6 level in light smokers was 67.7±3.2 and in moderate smokers it was 95.1±11.0; with a p-value of 0.009, indicating a significant difference among the groups. The average FMD in the smoking group was 5.4±0.4% (p-value 0.000), whereas the average FMD in the non-smoker samples was 10.9±0.9%. We also looked at the average FMD among light and moderate smokers based on Brinkman Index, which was 5.5±0.4% and 5.0±0.4%, with a p-value of 0.780, indicating no significant difference between the groupsConclusion: Compared to non-smokers, this study demonstrates a correlation between IL-6 and smoking activity. However, there was no statistically significant difference between the prevalence of endothelial dysfunction and the degree of smoking dependence in this investigation.
Co-Authors Abyano, Rafi Aqila Adi Wibowo Anggraeni, Prastika Ririt Arief Andriyanto, Arief Arif Fatahillah Arif Imam Suroso Arina Nurfianti Armyanti, Ita Asnifa, Siti Astrid Damayanti Asyhar, Alfan Nur Badri, Lusi N Bernadeta Suhartini Budi Susetyo Chaidar Miftachur Rifqi, Chaidar Cholid Tri Tjahjono dewi, catur prasastia lukita Dewi, Irma Arlini Djakapermana, Ruchyat Deni Duwi Basuki Dwikorawati, Syarifah Sofiah Fadly, Saeful Gusti Noorlitaria Achmad Hadiwibowo, Hadiwibowo Hernina, Revi Hidayat, Janthy Trilusianthy Hidayati, Oni Huda, Muhammad Al Idris Idris Ifa Roifah Indarti Komala Dewi, Indarti Komala Irfan Asyari, Nur Kagiarin, Siti Kurnianingsih, Novi Kusumaningrum, Umi Azizah Lestari M. Mustaqim Martini, Heny Mashudi, Rudy Masyitah Noviyanti Miranda, Rezha Moch. Achwandi, Moch. Muhammad Sajidin Muttaqin, Ridwan Maf'ul Naswan Harsono Nilawati, Ika Nur Amin, Nur NUR HASANAH Pambudi, Dewa Cahya Pamor Gunoto Panggung Sutapa Pardamean, David Pradnyan, I Gusti Made Swastya Dharma Pranowo, Rebecca Glorya Puji Handayati Purtanto, Hari R. P Sitorus, Santun Rahimah, Anna Fuji Rahmani, Shafira Rahmat Sewa Suraya Randi Pratama Murtikusuma Restusari, Isty Riskha, Oktavia Rizal, Ardian Rustiani, Komang Wahyu Saddam Hussen Safitri, Elsa Mayora Safitri, Ratu D Salniwati Salsabila, Raihana Sandiva, Lucky Setiawan, Mahfudz Rizal Setyawan, Candra Dwi Shalehoodin, Shalehoodin Sihombing, Novta Rouli Sofia Sofia, Sofia Sofiah, Syarifah Sudarmiatin Sumarna, Deddy Suranto Suranto Suryo Hartanto Susi Setiawani Swastikaputri, Valerina Yogibuana Syahran, Unggul Aida Titin Andri Wihastuti Widiana, Ilvi Nur Widito, Sasmojo Wijaya, Rivalino Aji Yusi Febriani Zaqi Al Faritsy, Ari