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All Journal Indonesian Journal of Cancer Chemoprevention Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences HERBAPHARMA : Journal of Herb Farmacological Jurnal Kesehatan Tambusai Journal of Fundamental and Applied Pharmaceutical Science Medimuh : Jurnal Kesehatan Muhammadiyah Indonesian Community Journal Jurnal Ilmiah Bakti Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Borobudur Pharmacy Review Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Sinteza CERATA Journal Of Medicine And Health Sciences (Medisci) Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Baktimu : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmacology and Therapy Baktimu : Jurnal Pengabdian Kepada Masyarakat Medimuh : Jurnal Kesehatan Muhammadiyah SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Hadi, Ismanurrahman
Universitas Muhammadiyah Ahmad Dahlan, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Hubungan Tingkat Pengetahuan Terhadap Kepatuhan Penggunaan Antibiotik di Puskesmas X Kabupaten Cirebon Ayu Zakkiyah; Like Efriani; Ismanurrahman Hadi
CERATA Jurnal Ilmu Farmasi Vol 14 No 2 (2023): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v14i2.827

Abstract

Antibiotik merupakan senyawa antimikroba yang dapat menghambat dan membunuh bakteri. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara pengetahuan terhadap kepatuhan pasien di Puskesmas X Kabupaten Cirebon tentang penggunaan antibiotik. Metode penelitian yang digunakan adalah cross sectional dan pengambilan data menggunakan kuesioner tingkat pengetahuan dan kuesioner kepatuhan. Hasil dari kuesioner tingkat pengetahuan yang didapatkan adalah responden dengan kategori kurang tahu 56 responden (70%), responden dengan kategori tahu 18 responden (22%) dan kategori sangat tahu 6 responden (8%) sedangkan hasil dari kuesioner kepatuhan didapatkan responden dengan kategori rendah 67 responden (84%), kategori sedang 10 responden (12%) dan kategori tinggi 3 responden (4%). Hasil analisis hubungan antara variabel tingkat pengetahuan terhadap kepatuhan penggunaan antibiotik didapatkan sebesar 0,233 dengan nilai p value 0,038 < 0,05 yang menunjukan adanya hubungan antara tingkat pengetahuan terhadap kepatuhan penggunaan antibiotik.
Telaah Potensi Antivirus Mitraginin terhadap Protease 3CLpro SARS-CoV-2 dengan Pendekatan Molecular Docking Arif Setiawansyah; Gita Susanti; Nurul Hidayati; Baiq Maylinda Gemantari; Reza Alrayan; Ismanurrahman Hadi; Dewi Luthfiana; Nurul Hasanah
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.25634

Abstract

SARS-CoV-2 is a novel coronavirus identified as a major caused of COVID-19. COVID-19 can be prevented and managed by preventing the SARS-CoV-2 infection through inhibition of SARS-CoV-2 main protease. Mitragynine is one of the major compounds found in Mitragyna speciosa leaves that has the potential to be developed as an anti-COVID-19 agent. This research was implemented to evaluate that potential by observing the molecular interaction of mitragynine with the essential amino acid residues of SARS-CoV-2 3CLpro. The study was undertaken by in silico method via molecular docking approach using Autodock 4.2. The potential of mitragynine in inhibiting the SARS-CoV-2 main protease was justified based on its free binding energy and Ki. The result revealed that mitragynine exhibited a lower free binding energy and Ki than remdesivir with the free binding energy and Ki value of -7.80 kcal/mol dan 1.92 µM dan -7.41 kcal/mol dan 3.72 µM, respectively. This concluded that mitragynine has the potential as a SARS-CoV-2 main protease inhibitor with the affinity was better than remdesivir. However, further in vitro research must be carried out to prove this potential. 
Formulation and Evaluation of Body Scrub Using Flour-Based from Fruits of Indramayu Variety of Cengkir Mango (Mangifera indica L) Hadi, Ismanurrahman; Hidayattullah, Dadan; Irawan, Ade
Journal of Fundamental and Applied Pharmaceutical Science Vol. 3 No. 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15569

Abstract

Cengkir Mango (Mangifera indica L) is a variety of mango known in the northern part of West Java and widely used as food, beverage, and natural-based pharmaceutical product. This fruit is potentially used as body scrub ingredients due to its richness in polyphenols contain. This study aims to formulate natural-based body scrub using the Cengkir Mango as an active ingredient. The formulation was divided into 3 groups with different concentrations of mango fruit flour, respectively 35, 46, and 50 grams (F1, F2, and F3). The product evaluation included homogeneity, stability, pH, and hedonic test. The organoleptic of body scrub indicated mango scent and light brownish-darker colors, responding to an increase of concentration for each formulation. The homogeneity test showed that the body scrub had no granulation of mango flour. The evaluation of pH showed the product had pH respectively at 7.5, 7.5, and 7.0 (F1, F2, and F3). These results indicated that the body scrub had good physical properties. Investigation of body scrub stability was used to evaluate the fragrance, color, and consistency of the formulation in storage for 3 weeks at room temperature. The results showed no change in color and consistency but a loss of mango fragrance after 3 weeks. The hedonic test indicated that most participants favored F1 (35 grams of mango flour). Based on these results, the flour of Cengkir mango had good performance as an active ingredient in a natural-based body scrub.
Formulation of Shampoo from Rice Bran Extract (Oryza sativa) and Essential Oil Pomelo Peel (Citrus maxima) Hadi, Ismanurrahman; Silviyani, Amerta; Ulfah, Mariam
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19328

Abstract

Rice bran (Oryza sativa) is a by-product of rice processing that contains bioactive terpenoid compounds such as oryzanol. This compound has many pharmacological effects such as antioxidant, anti-fungal, anti-bacterial, etc. On the other hand, the essential oil of pomelo peel (Citrus maxima) has a refreshing aroma and also contains a variety of phytochemicals that are efficacious as antioxidants. This study aims to identify optimal formulations of shampoo with a combination of acetone extract from rice bran and essential oil of pomelo peel. Rice bran was extracted using acetone solvent, while essential oil from pomelo peel was obtained by distillation. Phytochemical screening of acetone extract showed the presence of terpenoids, flavonoids, alkaloids, tannins, and saponins. The extracts and essential oil were formulated into shampoo into 4 groups (FI, FII, FIII, FIV), which respectively contained 0%, 10%, 15%, and 20% extract. The results showed the evaluation of the best physical shampoo in Formula III because volunteers preferred Formula III and its better foam stability. Based on these results, it can be concluded that the acetone extract of rice bran and the essential oil of pomelo  peel could be formulated into good shampoo.
Alpha Glucosidase Inhibitory Activity of Tiger Milk Mushroom (Lignosus rhinocerus) Ethanolic Extract Ulfah, Mariam; Efirani, Like; Hadi, Ismanurrahman
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.20299

Abstract

Tiger's milk mushroom (TMM) is a plant that can only grow in certain regions in Asia. Indonesia is the country that has the most TMM plants in the world. This plant grows wild in the forests of Kalimantan and Papua. This plant is widely used by people to treat fever, breast cancer and asthma. TMM is known to have various pharmacological activities such as anticancer. The research about TMM originate from Indonesia is still rarely carried out. So, the aim of this research is to carry out an alpha glucosidase inhibition activity test of TMM ethananolic extract. The method used for extraction the TMM is maceration method using ethanol solvent. To identify the secondary metabolite compounds from TMM, phytochemical tests and thin layer chromatography (TLC) tests were carried out.  Inhibition test of alpha glucosidase enzyme activity of TMM ethanolic extract was carried using p-nitrophenyl-alpha-D-glucopyranoside reagent. The results of this phytochemical test are the ethanol extract of TMM contains flavonoid, alkaloid, terpenoid and phenolic compounds. This is confirmed by the TLC test where this test indicates the presence of flavonoid and alkaloid compounds. The results of the alpha glucosidase enzyme inhibition activity test showed that the ethanol extract of tiger milk mushrooms had an IC 50 value of  39.96 ppm which are categorized strong antidiabetic activity. From this research can be concluded that TMM ethanlolic extract very potential as an antidiabetic drug.
Pengaruh Variasi Minyak Kelapa Terhadap Karakteristik Fisik Sabun Padat Minyak Atsiri Sereh Wangi Oktavia Listiyani; Arief Kusuma Wardani; Fitriana Yuliastuti; Ismanurrahman Hadi
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 5 No. 1 (2026): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v5i1.164

Abstract

Sabun padat merupakan produk pembersih yang semakin diminati karena efektif dan ekonomis. Salah satu bahan alami potensial dalam pengembangan sabun padat adalah minyak atsiri sereh wangi sebagai antibakteri, serta minyak kelapa yang berperan dalam pembentukan busa sabun. Penelitian ini bertujuan untuk mengevaluasi pengaruh variasi konsentrasi minyak kelapa terhadap karakteristik fisik sabun padat berbahan aktif minyak atsiri sereh wangi. Penelitian dilakukan secara eksperimental dengan tiga formula berbeda (F1: 18%, F2: 16%, F3: 14% minyak kelapa) dan konsentrasi minyak atsiri tetap 2%. Evaluasi dilakukan terhadap parameter organoleptik, pH, tinggi busa, dan stabilitas busa selama penyimpanan empat minggu. Hasil menunjukkan bahwa F1 memiliki kestabilan bentuk dan warna terbaik, sementara F3 menghasilkan tinggi dan stabilitas busa paling konsisten. Seluruh formula berada dalam rentang pH sesuai SNI 3532:2021. Kesimpulannya, variasi konsentrasi minyak kelapa memengaruhi karakteristik fisik sabun, dan formulasi F1 dinilai paling optimal dalam mendukung pembentukan dan kestabilan busa.
Co-Authors Achmad Dinoto Ade Irawan Ade Irawan Alfayyasy, Akhmad Irfan Alrayan, Reza Amanda, Shalma Risqi Amelia Zannah Andi Suhendi Antika Mardhotillah Meilian Arief Kusuma Wardani Arif Setiawansyah Aulia, Diva Ayu Puspitasari, Ayu Ayu Zakkiyah Azhari, Samsudin Baiq Maylinda Gemantari Dadan Hidayattullah Dewi Luthfiana Dewi Luthfiana Didik Setiawan Dwi Lestari Edy Meiyanto Efirani, Like Efriani, Like Ema Damayanti Febriansah , Rifki Fitriana Yuliastuti Flori Sindi Agwiana Gita Susanti Gita Susanti, Gita Haq, Mailatul Ilal Heni Lutfiyati, Heni Hidajah Rachmawati Hidayattullah, Dadan JAKA WIDADA Joko Priyanto Wibowo Khoirun Nisa Like Efriani Like Efriani Listiyani, Oktavia Luthfiana, Dewi MARIAM ULFAH Mariam Ulfah MARIAM ULFAH ULFAH Muh Ikhlas Arsul Muhamad Rifki Purnama Mustofa Mustofa Nur Aprillia Martalina Nurfazera, Asya Nurlutfiana, Deby Nurul Hasanah Nurul Hidayati Nurul Hidayati Oktavia Listiyani oliviana, Resya Perdana Priya Haresmita Perdana Priya Haresmita, Perdana Priya Prihatiningsih, Sherly Purnama, Muhamad Rifki Putra, Teguh Adiyas Reza Alrayan Reza Alrayan Ria Utami, Primanitha Riris Istighfari Jenie Rohmatika, Nirma Shinta, Tiara Aries Silviyani, Amerta Supandi Tuzzahra, Fatimah Ulfah, Mariam Wardani, Arief Kusuma Wismayani, Leni Wiwin Widayanti