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All Journal Indonesian Journal of Cancer Chemoprevention Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences HERBAPHARMA : Journal of Herb Farmacological Jurnal Kesehatan Tambusai Journal of Fundamental and Applied Pharmaceutical Science Medimuh : Jurnal Kesehatan Muhammadiyah Indonesian Community Journal Jurnal Ilmiah Bakti Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Borobudur Pharmacy Review Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Sinteza CERATA Journal Of Medicine And Health Sciences (Medisci) Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Baktimu : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmacology and Therapy Baktimu : Jurnal Pengabdian Kepada Masyarakat Medimuh : Jurnal Kesehatan Muhammadiyah
Hadi, Ismanurrahman
Universitas Muhammadiyah Ahmad Dahlan, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Alpha Glucosidase Inhibitory Activity of Tiger Milk Mushroom (Lignosus rhinocerus) Ethanolic Extract Ulfah, Mariam; Efirani, Like; Hadi, Ismanurrahman
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.20299

Abstract

Tiger's milk mushroom (TMM) is a plant that can only grow in certain regions in Asia. Indonesia is the country that has the most TMM plants in the world. This plant grows wild in the forests of Kalimantan and Papua. This plant is widely used by people to treat fever, breast cancer and asthma. TMM is known to have various pharmacological activities such as anticancer. The research about TMM originate from Indonesia is still rarely carried out. So, the aim of this research is to carry out an alpha glucosidase inhibition activity test of TMM ethananolic extract. The method used for extraction the TMM is maceration method using ethanol solvent. To identify the secondary metabolite compounds from TMM, phytochemical tests and thin layer chromatography (TLC) tests were carried out.  Inhibition test of alpha glucosidase enzyme activity of TMM ethanolic extract was carried using p-nitrophenyl-alpha-D-glucopyranoside reagent. The results of this phytochemical test are the ethanol extract of TMM contains flavonoid, alkaloid, terpenoid and phenolic compounds. This is confirmed by the TLC test where this test indicates the presence of flavonoid and alkaloid compounds. The results of the alpha glucosidase enzyme inhibition activity test showed that the ethanol extract of tiger milk mushrooms had an IC 50 value of  39.96 ppm which are categorized strong antidiabetic activity. From this research can be concluded that TMM ethanlolic extract very potential as an antidiabetic drug.
Potential of Several Phytochemicals of Mangrove Species (Rhizopora stylosa) as Inhibitor of Both Viral Gene Expression and Bacterial Nucleic Acid Synthesis Hadi, Ismanurrahman; Irawan, Ade; Ulfah, Mariam; Putra, Teguh Adiyas; Efriani, Like; Haq, Mailatul Ilal; Purnama, Muhamad Rifki
Jurnal Ilmu Kesehatan Vol 10 No 1 (2022): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v10i1.3278

Abstract

The mangrove family (Rhizophora stylosa) has been used as traditional medicine. Due to the habitat of mangroves, they develop unique phytochemicals. Thus, they have the potential to become a source of plant-based therapeutic agents. However, many of the them remain uninvestigated. The purpose of this study was to predict the potential of some phytochemicals of the mangrove family as an inhibitor of both viral gene expression and bacterial nucleic acid. Some bioactive compounds of mangrove (taraxerol, pyrethrin, 2-Furancarboxaldehyde, and avicequinone A) were used as subject of this study. The main protease (Mpro) of SARS-Cov-2 virus (PDB ID: 6y2e), the staphylococcus aureus's proteins: topoisomerase II DNA gyrase (PDB id: 2XCT), and tyrosyl-tRNA synthetase (PDB id: 1JIJ) were used as targeted protein. The drug-likeness of compounds were analyzed using Swiss ADME based on the Lipinsky rule of five. Meanwhile, the affinity value between proteins and ligands was predicted using Autodock Vina. The root means square distance (RMSD) value (<2 A) and the binding cavity of drugs (ivermectin and ciprofloxacin) were used as validation parameters. This study resulted that only taraxerol compounds have a violation of Lipinsky's rule. Even so, out of the phytochemical compound of mangrove, the taraxerol has the highest affinity in Mpro and topoisomerase II DNA gyrase protein, although still lesser than ivermectin against Mpro; while avicequinone A has the highest affinity against tyrosyl-tRNA synthetase. This concludes that some phytochemicals of the mangrove family could be developed as an antibacterial and antiviral agents of therapy.
Description of Mother’s Knowledge and Adherence to Use of Helminthic Drugs in Kuwaluhan Village, Magelang Regency, Central Java Amanda, Shalma Risqi; Haresmita, Perdana Priya; Wardani, Arief Kusuma; Hadi, Ismanurrahman
Jurnal Ilmu Kesehatan Vol 11 No 1 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i1.3626

Abstract

Worm infection has become public health issue with the highest prevalence in children under the age of five and elementary school-aged children. The children have difficulty maintaining the hygienist, especially when they are playing. This study aims to describe the level of knowledge and mothers’ adherence to the use of helminthic drugs in Kuwaluhan Village, Magelang Regency. This research used a descriptive study with both a survey method and a cross-sectional approach. The purposive sampling technique was used, while the questionnaire was distributed to mothers with children under the age of five and elementary school-age children in Kuwaluhan Village RW 2, Magelang Regency, in December 2022. The results showed that the level of knowledge of mothers in Kuwaluhan Village RW 2, Magelang Regency, regarding the use of helminthic drugs out of a total of 74 mothers indicated that 33 respondents (44.59%) had good knowledge, 29 respondents (39.19%) had sufficient knowledge, and as many as 12 respondents (16.22%) had less knowledge. Meanwhile, at the adherence level, respondents were categorized as having high adherence by 1 respondent (1.35%), medium adherence by 73 respondents (98.65%), and low adherence by 0 respondents (0%). Based on these results, most of the mothers in Kuwaluhan RW 2, Magelang Regency have good knowledge and have a medium level of adherence to using helminthic drugs for children.
PERBANDINGAN KANDUNGAN FITOKIMIA FRAKSI ETIL ASETAT DAUN KEMANGI (Ocimum basilicum Folium) DENGAN PERBEDAAN KETINGGIAN GEOGRAFIS TUMBUH Hadi, Ismanurrahman; Nurfazera, Asya; Rohmatika, Nirma
Jurnal Ilmiah Bakti Farmasi Vol 7 No 1 (2022): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v7i1.85

Abstract

Daun kemangi (Ocimum basilicum folium) merupakan salah satu tumbuhan yang biasa digunakan sebagai obat tradisional adalah daun kemangi. Kemangi dapat tumbuh liar ataupun dibudidayakan. Perbedaan letak geografis tumbuh memberikan pengaruh pada senyawa fitokimia yang dihasilkan tumbuhan. Penelitian ini bertujuan untuk membandingkan senyawa fitokimia daun kemangi yang tumbuh pada perbedaan letak geografis. Daun kemangi didapatkan dari dataran rendah Cirebon dan dataran tinggi kabupaten Kuningan. Sampel yang digunakan yaitu fraksi etil asetat daun kemangi.Identifikasi senyawa fitokimia dilakukan untuk mengidentifikasi senyawa flavonoid, saponin dan terpenoid. Hasil uji menunjukkan fraksi daun kemangi dari datarn rendah dan dataran tinggi mengandung ketiga senyawa tersebut. Menariknya, pada identifikasi flavonoid dan terpenoid, dataran rendah memiliki flavonoid lebih banyak serta terpenoid yang lebih sedikit dari sampel dari dataran tinggi. Berdasarkan hal tersebut, dapat disimpulkan bahwa perbedaan geografis tumbuh menyebabkan adanya perbedaan kandungan senyawa fitokimia pada fraksi etil asetat daun kemangi
PENENTUAN KADAR PROTEIN DAN CEMARAN MIKROORGANISME TAHU PUTIH DARI PASAR TRADISIONAL X KOTA CIREBON Hadi, Ismanurrahman; Azhari, Samsudin; Nurlutfiana, Deby
Jurnal Ilmiah Bakti Farmasi Vol 7 No 2 (2022): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v7i2.94

Abstract

Kacang Kedelai merupakan komoditi pangan populer yang ada di masyarakat. Tahu memiliki kandunagn protein dan air yang tinggi. Kandungan air yang tinggi menyebab mudahnya pertumbuhan mikroba pada tahu putih. Penelitian ini bertujuan untuk menganalisis kadar protein serta cemaran mikroba pada tahu putih pada pasar tradisional X kota cirebon. Pengujian cemaran mikroba dilakukan menggunakan metode Methylen Blue Reduction Test (MBRT). Adapun metode uji penentuan kadar protein dilakukan dengan biuret test. Hasil yang didapatkan menunjukkan bahwa sampel tahu putih memiliki kandungan protein rata – rata yang tinggi (20%). Meskipun begitu, hasil uji cemaran mikroba memberikan gambaran tingginya nilai cemaran mikroba pada tahu putih tersebut. Berdasarkan hal tersebut, dapat disimpulkan bahwa tahu putih dari pasar tradisional X kota cirebon mengandung protein yang tinggi, namun dengan kualitas cemaran yang buruk
FORMULASI DAN EVALUASI SEDIAAN GEL HANDSANITIZER KOMBINASI EKTRAK ETANOL MERANG PADI (Oryza sativa) DENGAN MINYAK ATSIRI KULIT JERUK BALI (Citrus maxima) Hadi, Ismanurrahman; tuzzahra, fatimah; Irawan, Ade
Jurnal Ilmiah Bakti Farmasi Vol 9 No 1 (2024): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v9i1.117

Abstract

Handsanitizer merupakan salah satu bahan antiseptik berupa gel yang sering digunakan masyarakat sebagai media pencuci tangan yang praktis. Salah satu tanaman yang dapat digunakan sebagai obat tradisional yaitu merang padi (Oryza sativa). Penelitian ini bertujuan untuk mengetahui adanya aktivitas antiseptik didalam formula hand sanitizer ekstrak etanol merang padi (Oryza sativa). Proses ekstraksi merang padi dilakukan dengan maserasi menggunakan pelarut etanol 70% dan dibuat menjadi gel handsanitizer menggunakan Karbomer, TEA, propilenglikol, methyl paraben, gliserin dan aquades; yang dibuat menjadi IV formula dengan konsentrasi bahan aktif 0%, 2,5%, 5% dan 10%. Ekstrak yang didapat diujikan secara fitokimia menunjukkan hasil positif memliki kandungan flavonoid dan saponin. Ekstrak yang telah diformulasikan menjadi gel Handsanitizer dilakukan uji fisik, uji organoleptik, uji daya sebar, uji daya lekat, uji pH, uji homogen dan uji iritasi. Hasil penelitian ini menunjukkan ekstrak etanol merang padi (Oryza sativa) dapat berfungsi sebagai antiseptik, konsentrasi 10% memiliki konsentrasi yang paling besar dibandingkan dengan ketiga konsentrasi tersebut.
Hubungan Tingkat Pengetahuan Terhadap Kepatuhan Penggunaan Antibiotik di Puskesmas X Kabupaten Cirebon Ayu Zakkiyah; Efriani, Like; Hadi, Ismanurrahman
CERATA Jurnal Ilmu Farmasi Vol 14 No 2 (2023): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v14i2.827

Abstract

Antibiotik merupakan senyawa antimikroba yang dapat menghambat dan membunuh bakteri. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara pengetahuan terhadap kepatuhan pasien di Puskesmas X Kabupaten Cirebon tentang penggunaan antibiotik. Metode penelitian yang digunakan adalah cross sectional dan pengambilan data menggunakan kuesioner tingkat pengetahuan dan kuesioner kepatuhan. Hasil dari kuesioner tingkat pengetahuan yang didapatkan adalah responden dengan kategori kurang tahu 56 responden (70%), responden dengan kategori tahu 18 responden (22%) dan kategori sangat tahu 6 responden (8%) sedangkan hasil dari kuesioner kepatuhan didapatkan responden dengan kategori rendah 67 responden (84%), kategori sedang 10 responden (12%) dan kategori tinggi 3 responden (4%). Hasil analisis hubungan antara variabel tingkat pengetahuan terhadap kepatuhan penggunaan antibiotik didapatkan sebesar 0,233 dengan nilai p value 0,038 < 0,05 yang menunjukan adanya hubungan antara tingkat pengetahuan terhadap kepatuhan penggunaan antibiotik.
Hubungan Tingkat Pengetahuan Terhadap Perilaku Swamedikasi Penyakit Diare di Pondok Pesantren X Kabupaten Cirebon Muhamad Rifki Purnama; Efriani, Like; Hadi, Ismanurrahman
CERATA Jurnal Ilmu Farmasi Vol 15 No 1 (2024): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v15i1.831

Abstract

Pelaksanaan swamedikasi bisa menjadi sumber atas kesalahan pengobatan karena kurangnya pengetahuan dari obat dan cara penggunaannya. Perilaku swamedikasi untuk mengobati penyakit ringan harus dilakukan dengan tepat, yang termasuk salah satunya adalah penyakit diare. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan terhadap perilaku swamedikasi penyakit diare di Pondok Pesantren X Kabupaten Cirebon. Metode penelitian yang digunakan adalah observasional dengan pendekatan metode cross sectional. Sampel berjumlah 74 orang santri SMP dan SMA dipilih dengan simple random sampling dengan melihat pertimbangan kriteria tertentu. Hasil penelitian menunjukkan bahwa responden yang tingkat pengetahuan tinggi dan perilaku baik sejumlah 50 responden (76%).
BERLIAN (Berkah Limbah Durian): Pemanfaatan Limbah Kulit Durian Menjadi Tepung untuk Meningkatkan Produksi Industri Pempek Rumahan di Desa Patalagan, Kecamatan Pancalang, Kabupaten Kuningan Mariam Ulfah; Like Efriani; Wiwin Widayanti; Ismanurrahman Hadi
I-Com: Indonesian Community Journal Vol 4 No 3 (2024): I-Com: Indonesian Community Journal (September 2024)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33379/icom.v4i3.5411

Abstract

Patalagan Village is one of the largest durian producers in Kuningan City. Many of the bark is thrown into waste. This waste contains compounds that have antibacterial and antioxidant activities. This waste will be useful if developed, including being used as flour for pempel materials. So this activity is called BERLIAN (Berkah Limbah Kulit Durian). The partner in this service is the Bu Odah pempek industry located in Patalagan Village. The purpose of this program is to provide counseling on the health benefits of durian skin, provide training in making durian peel flour and training in making durian peel pempek. The method carried out is socialization, counseling and training in making durian peel pempek. The result of this service is an increase in partners' understanding of the health benefits of durian skin, an increase in partners' ability to make durian peel flour and durian peel pempek. The conclusion of this service activity is that durian peels can be used as a useful product so as to reduce durian peel waste, especially in Patalagan village.
Antibacterial Activity of Acetone Coconut Husk (Cocos Nucifera Linn) Extract Against Staphylococcus Aureus and Escherichia Coli Bacteria Irawan, Ade; Ulfah, Mariam; Efriani, Like; Hadi, Ismanurrahman; Adiyas Putra, Teguh; Puspitasari, Ayu
Jurnal Medisci Vol 1 No 1 (2023): Vol 1 No 1 August 2023
Publisher : Ann Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62885/medisci.v1i1.19

Abstract

Coconut plant (Cocos nucifera Linn) is an annual plant that is most beneficial to the people of Indonesia, because almost all parts of the plant can be utilized and used for medicine and daily needs. Part of the coconut plant, namely coconut fiber which is considered as waste, can be used as an antibacterial agent because it contains tannin compounds or also called tannic acid which is a complex chemical compound consisting of several polyphenolic compounds which act as antibacterial and antiviral. The purpose of this study was to determine the antibacterial activity of coconut coir acetone extract (Cocos nucifera Linn) against the growth of Staphylococcus aureus and Escherichia coli bacteria. The method used is disc diffusion (Kirby and Bauer test). Coconut coir powder (Cocos nucifera Linn) was macerated with acetone for 3 x 24 hours. Furthermore, the antibacterial test of coconut coir extract (Cocos nucifera Linn) was carried out against Staphylococcus aureus and Escherichia coli bacteria. Chloramphenicol as a positive control and dimethyl sulfoxide (DMSO) was used as a negative control. The results of antibacterial activity that have been carried out show that coco coir extract (Cocos nucifera Linn) with a concentration of 60% is the highest concentration of inhibition zone diameter between 20% and 40% with an average inhibition zone diameter of 11.7 mm against Staphylococcus aureus bacteria and Escherichia coli and belongs to the category of strong sensitivity.
Co-Authors Achmad Dinoto Ade Irawan Ade Irawan Alfayyasy, Akhmad Irfan Alrayan, Reza Amanda, Shalma Risqi Amelia Zannah Andi Suhendi Antika Mardhotillah Meilian Arif Setiawansyah Arsul, Muhammad Ikhlas Aulia, Diva Ayu Puspitasari, Ayu Ayu Zakkiyah Azhari, Samsudin Baiq Maylinda Gemantari Dadan Hidayattullah Dewi Luthfiana Didik Setiawan Dwi Lestari Edy Meiyanto Efirani, Like Efriani, Like Ema Damayanti Febriansah , Rifki Flori Sindi Agwiana Gita Susanti, Gita Haq, Mailatul Ilal Heni Lutfiyati, Heni Hidajah Rachmawati Ikhlas Arsul, Muhammad JAKA WIDADA Joko Priyanto Wibowo Khoirun Nisa Like Efriani Like Efriani Luthfiana, Dewi MARIAM ULFAH Mariam Ulfah MARIAM ULFAH ULFAH Muhamad Rifki Purnama Mustofa Mustofa Nur Aprillia Martalina Nurfazera, Asya Nurlutfiana, Deby Nurul Hasanah Nurul Hidayati oliviana, Resya Perdana Priya Haresmita Perdana Priya Haresmita, Perdana Priya Prihatiningsih, Sherly Purnama, Muhamad Rifki Putra, Teguh Adiyas Reza Alrayan Ria Utami, Primanitha Riris Istighfari Jenie Rohmatika, Nirma Shinta, Tiara Aries Silviyani, Amerta Supandi Tuzzahra, Fatimah Ulfah, Mariam Wardani, Arief Kusuma Wismayani, Leni Wiwin Widayanti