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Occupational Stress and its Relation to Grave’s Disease Ade Mutiara; Dewi S Soemarko; Indah S Widyahening
The Indonesian Journal of Community and Occupational Medicine Vol. 1 No. 2 (2021): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.386 KB) | DOI: 10.53773/ijcom.v1i2.14.72-7

Abstract

Background: Graves’ disease is an autoimmune thyroid gland disease that causes increased activity of the thyroid hormones. But, the mechanism by which the autoantibodies are generated is still unclear. Some theory suggests that daily life stress may be a risk factor that triggers Graves’ disease. The aim of this report is to enrol a systematically searching in order to get an answer about the risk factor of the Grave’s disease and the prevention measure.Methods: In this case report, a 47-year-old career woman with prominent occupational stress was diagnosed with Graves’ disease. Literature searching was done on database such as Pubmed, Cochrane Library, and Science Direct with occupational stress, stressful life event, and Graves’ disease as the keywords. One article was selected and critically appraised. Results: One case-control study showed that patients with Graves’ disease had odds ratio (OR) of having stressful life events as big as 8.59; 95%CI = 2.35-20.80, and the number needed to harm (NNH) is 2.35.Conclusion: Occupational stress is a prominent risk factor for developing Graves’ disease. However, this is based on one article
Chronic Lower Back Pain and Its Relationship with Vibration Exposure and Sitting Duration; A Cross-Sectional Study Among Commercial Motorcycle Driver Bernath Siagian; Ambar W Roestam; Dewi S Soemarko; Sudadi Hirawan; Indah S Widyahening; Suryo Wibowo
The Indonesian Journal of Community and Occupational Medicine Vol. 1 No. 3 (2022): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v1i3.30.154-61

Abstract

Background: Lower back pain (LBP) complaints are a health issue that may lead to restrictions on work activities. Motorcycles vibrations and long sitting duration on the motorcycles can cause chronic lower back pain complaints. Base motorcycles drivers receive motorcycles vibration exposure while riding a motorcycle. With the large number of base motorcycles drivers in Indonesia, the specific health problems (LBP complaints) in this group need to be examined.Methods: This research method uses a cross sectional study design to examine the relationship of motor vibration exposure and length of sitting to chronic low back pain with sampling technique used is Consecutive sampling. Consecutive sampling is a way of taking samples by selecting samples that meet the inclusion criteria until a certain time period so that the number of samples is met. The sampling period in this study is 2 days. The variables that measured were chronic lower back pain complaints, vibration, long sitting time, age, IMT, smoking, and working time. Data analysis using SPSS Statistics version 25.0. Results: A total of 95 subjects were included in this study. Based on Fisher’s test, the result of the correlation of chronic lower back pain complaints with motor vibrations > 0.5 m/s2 was obtained p = 0.102; OR = N / A). While for long sitting time of >4 hours result in p = 0.717; OR 0.85; CI 95% = 0.34-2.09. There is no difference in age-related chronic lower back pain complaints. At age> 35 years of age p = 0.722; OR 1.57; CI 95% = 0.31-7,9. No significant association between IMT and chronic lower back pain was found. In the IMT group> 25, p = 0.103 was obtained; OR 2.14; 95% CI = 0.85-5.36. There was no significant difference in chronic lower back pain complaints based on smoking status, where smoking group had p = 0.451; OR 1,45; CI 95% = 0.55-3.78. According to the Fisher test, there was no difference in chronic lower back pain complaints based on working age, where groups with> 4 years of work had a p = 0.908 value; OR 1.07; CI 95% = 0.31-3.91. Conclusion: In this study the hypothesis was rejected. There is no association between motorcycles vibration exposure and the occurrence of chronic lower back pain complaints in the base motorcycles driver in Bekasi city. There is no association long sitting time with the occurrence of chronic lower back pain complaints in the base motorcycles driver in Bekasi city.
Knowledge, Attitude, and Practice of Mothers on the First 1000 Days of Life Indah Suci Widyahening; Muhammad A Aufa; Muhammad F Alhas; Aji B Widodo; Dewi Friska
eJournal Kedokteran Indonesia Vol 9, No. 2 - Agustus 2021
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.545 KB) | DOI: 10.23886/ejki.9.65.129

Abstract

The first 1000 days of life is the window period which critically determines the children’s growth and development and individual’s health afterwards. The knowledge, attitude, and practice (KAP) of pregnant mothers and mothers with children under two years old greatly influence the optimum upbringing of the fetus and children during the period. This study was aimed to evaluate the KAP of mothers about the first 1000 days of life and its associated factors. A cross-sectional study was conducted at a district in Depok city in August 2017. Subjects were purposively recruited to fill the validated KAP questionnaire on the first 1000 days. A total of 110 subjects were recruited, the higher proportion of them have adequate knowledge (42.7%), good attitude ((62.7%), and good practice (61.8%). The mothers’ knowledge was associated with attitude and practice (p<0.001) but the attitude and practice were not associated (p=0.175). Maternal education was the only factor that associated with knowledge (p=0.018) and attitude (p=0.013) while family income was associated with practice (p=0.018). This finding strengthened the importance of the existing community empowerment program such as posyandu in improving the KAP of mothers to achieve better results in the first 1000 days period of their children. Keywords: the first 1000 days of life, knowledge, attitude, practice, nutrition.   Pengetahuan, Sikap dan Perilaku Ibu mengenai 1000 Hari Pertama Abstrak Seribu hari pertama kehidupan (1000 HPK) adalah periode emas yang sangat menentukan tumbuh kembang anak hingga kesehatan individu pada masa selanjutnya. Pengetahuan, sikap dan perilaku (PSP) ibu hamil dan ibu yang mengasuh anak berusia dua tahun ke bawah sangat menentukan asuhan 1000 HPK yang optimal. Penelitian ini bertujuan untuk mengetahui PSP ibu hamil dan ibu dengan anak berusia di bawah 2 tahun mengenai konsep 1000 HPK serta faktor – faktor yang berhubungan dengan ketiga aspek tersebut. Studi potong lintang dilakukan di Kampung Lio, Depok pada Agustus 2017. Ibu hamil dan ibu dengan anak berusia kurang dari 2 tahun direkrut secara purposif untuk mengisi kuesioner PSP tentang 1000 HPK. Sebanyak 110 subjek direkrut, proporsi terbesar subject memiliki tingkat pengetahuan cukup (42,7%), sikap sebagian besar baik (62,7%) dan perilaku sebagian besar juga baik (61,8%). Pengetahuan berhubungan dengan sikap dan perilaku (p<0.001) tetapi sikap dan perilaku tidak berhubungan (p=0,175). Tingkat pendidikan ibu adalah faktor yang berhubungan dengan pengetahuan (p=0,019) dan sikap (p=0,013). Tingkat penghasilan keluarga adalah faktor yang berhubungan dengan perilaku (p=0,018) mengenai 1000 HPK. Hasil ini menguatkan pentingnya posyandu sebagai upaya partisipasi masyarakat dalam meningkatkan PSP ibu untuk mencapai perkembangan anak yang optimal pada periode 1000 HPK. Kata kunci: seribu hari pertama kehidupan, pengetahuan, sikap, perilaku, nutrisi.
Association between Helicobacter pylori Infection and Graves’ Disease: A Meta-Analysis Guntur Darmawan; Marcellus Simadibrata; Indah Suci Widyahening
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 2 (2017): VOLUME 18, NUMBER 2, AUGUST 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.463 KB) | DOI: 10.24871/182201767-72

Abstract

Background: Helicobacter pylori (H. pylori) infection is proposed to be related with autoimmune diseases, such as Graves’ disease. This study aimed to assess the association between H. pylori infection and Graves’ disease.Method: A systematic literature review was conducted using Pubmed and Cochrane library. The quality of enrolled studies was assessed by the Critical Appraisal Skills Program Oxford. A fixed-effect model approach was used if there was no heterogeneity; otherwise, a random-effect model was used. Heterogeneity was assessed using I2. Publication bias was assessed by funnel plot. All data were analyzed using REVIEW MANAGER 5.3.Results: Six studies from Europe and Asia involving 983 patients were included. Overall H. pylori infection was significantly associated with Graves’ disease (OR = 2.7; 95% CI: 1.47-4.99; p 0.001). In subgroup analysis of 3 studies using non-serological diagnostic method, the prevalence rate of H. pylori infection was higher in Graves’ disease group (78.26% vs. 42.42%) with significant relationship (OR = 4.93; 95% CI: 3.16-7.69; p 0.00001; I2 = 0%). The Cytotoxin associated gene A (CagA) antibody prevalence was significantly higher in Graves’ disease group (46.57% vs. 20.29%; OR = 4.41; 95% CI: 2.65-7.33; p 0.00001; I2 = 56%). No publication bias was observed.Conclusion: Our study showed association between H. pylori infection and Graves’ disease. It might suggest the need of H. pylori examination in Graves’ disease patients and the impact of H. pylori eradication in the treatment of Graves’ disease.
The Risk of Absenteeism among Workers with Psoriasis Rakhmi Savitri Hoesein; Indah S. Widyahening; Dewi S. Soemarko
The Indonesian Journal of Community and Occupational Medicine Vol. 2 No. 1 (2022): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v2i1.42.32-9

Abstract

Background: Psoriasis is a chronic, painful, destructive, and disabling disease that has no cure, with a large negative impact on a patient’s quality of life. Sick leave is one of common challenges for people with psoriasis.Aim: To know the absenteeism risk of workers with psoriasis.Method: A literature search using search engine PubMed and Google Scholar was conducted. The inclusion criteria are systematic review, cohort, or case control studies; the subjects of studies are workers; the indicator listed in the title is psoriasis that is not differentiated in any form or type of psoriasis; and the outcome is absenteeism and its synonyms. The exclusion criteria are the articles not written in English, full text is not available, the articles have been used in the recent systematic review, the subjects are blue collar worker or non-office worker, and not relevant according to PICO. Critical appraisal was conducted using standard validity criteria for etiologic/harm/risk studies.Result: A retrospective matched case control analysis was selected with the level of evidence 3b –. Psoriasis patients were significantly more likely than controls to skip working hours (OR = 1.37; 95% CI 1.00 - 1.89; p <0.05) and days (OR = 1.21; 95% CI 0.72 - 2.05) at the previous week due to health reasons. Conclusion: Psoriasis increases the risk of sick leave/absenteeism due to illness than those without psoriasis.
The Effect Of Cyclohexanone Exposure On Incidence Of Irritant Contact Dermatitis Denta Aditya Episana; Dewi Sumaryani Soemarko; Indah Suci Widyahening
The Indonesian Journal of Community and Occupational Medicine Vol. 2 No. 1 (2022): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v2i1.47.48-57

Abstract

Background: Skin disorders or abnormalities occur in more than 35% of all occupational disorders. Contact dermatitis is the most recognized occupational disease in many countries (with irritant contact dermatitis accounting for 80% of the cases), yet these cases are often not reported. One of the causes of irritant contact dermatitis is Cyclohexanone, a chemical recognized as an oxidizing agent that can irritate the skin. This evidence-based case report aims to gather evidence about the effect of cyclohexanone exposure on the incidence of irritant contact dermatitis.Method: The case in this study is about a 37-year-old woman who worked as a logo printing operator in a shoe manufacturing company that is exposed to cyclohexanone and was diagnosed with irritant contact dermatitis. A literature search was conducted through PubMed, Scopus, and ProQuest and performed with the hand searching method. The inclusion criteria included systematic review study, cohort study, case-control study, cross-sectional study, irritant contact dermatitis, cyclohexanone, and occupational. Then, critically appraised using relevant criteria by the Oxford Center for Evidence-Based Medicine. Result: Three relevant cross-sectional studies were found through literature searching and are critically appraised. The estimate’s magnitude and precision regarding the association between the exposure and outcome in the first study cannot be assessed; the study only stated no statistically significant p-value in the prevalence of occupational skin dermatitis between departments and the examination between departments. The second study showed that workers with solvent chemical mixture exposure, including cyclohexane, are correlated with skin symptoms, dry or itchy skin on the hands or arms, POR 1.46 (95% CI 1.06-2.01), and redness on hands or arms, POR 1.50 (95% CI 1.09-2.70). In comparison, the third study showed that workers with a high dermal single exposure to cyclohexane have a higher risk for the incidence of hand dermatitis OR 2.15 (95% CI 0.59-7.95) without any statistical significance.Conclusion: The available evidence from cross-sectional studies did not prove an association between cyclohexanone exposure and irritant contact dermatitis in workers; only one study shows a significant association statistically. However, it is recommended to provide tools to prevent direct contact with the chemical; workers should also wear appropriate protective gloves to avoid occupational irritant contact dermatitis. A better study design such as cohort or case-control is needed to provide substantial evidence that cyclohexanone exposure can cause irritant contact dermatitis in workers.
Diagnostic Performance of Urine-based HPV-DNA Test (CerviScan, Bio Farma) as Cervical Cancer Screening Tool in Adult Women: Performa Tes Diagnostik DNA-HPV berbasis Urine (CerviScan, Bio Farma) sebagai Alat Skrining Kanker Serviks pada Perempuan Dewasa Andrijono Andrijono; Dewi Wulandari; Indah Suci Widyahening; Dicky Mahardhika; Neni Nurainy; Rini Mulia Sari; Indriastuti Soetomo; Revata Utama
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1968

Abstract

Objective: Detection of high-risk human papillomavirus (hr-HPV) in urine specimens has been introduced recently and a new local PCR kit has been developed in Indonesia (CerviScan, Bio Farma). The objective of this study was to obtain the accuracy of hr-HPV DNA testing using the new kit (CerviScan, Bio Farma) on urine specimens against the gold standard on cervical swabs.Method: Adult women (aged 20–50 years) underwent routine general check-up or Pap test were enrolled between July and September 2022. Pairs of urine and cervical swab specimens were obtained from all subjects. HPV-DNA tests were performed using the new local PCR kit (CerviScan, Bio Farma) and the standard procedure (COBAS® 6800 HPV, Roche Molecular System). Direct sequencing was added whenever there were dispute results between the two methods. Agreement between both methods was tested using Kappa statistics. Diagnostic performance test was done on CerviScan. Results: A total of 876 women completed the examination. Agreement between CerviScan and COBAS® 6800 was substantial (K=0.662; p<0.001) and was almost perfect against COBAS® 6800 plus sequencing (K=0.828; p<0.001). The accuracy of CerviScan on urine samples was 95.8% against COBAS® 6800 and increased to 97.8% after additional sequencing. The sensitivity and specificity of CerviScan on urine samples compared to cervical swabs are 73.1% and 97.3%, respectively.Conclusion: Urine-based HPV-DNA testing with CerviScan is a reliable tool to detect high-risk HPV subtypes. It could become an alternative method for HPV-DNA testing to improve the coverage of cervical cancer screening program.
The Effect of Methylmetacryalte Exposure on The Incidence of Asthma Bronchiale Muchammad Arief Gunawan; Indah suci Widyahening; Muhammad Ilyas
The Indonesian Journal of Community and Occupational Medicine Vol. 3 No. 1 (2023): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v3i1.83.36-41

Abstract

Background: Asthma is one of the major health problems in the world. An estimated 300 million people worldwide suffer from asthma, with 250.000 deaths each year from asthma. The prevalence of asthma has continued to increase in recent years, Asthma affects 1 in 14 people in America in 2001 while in 2009 the rationale was 1 patient in 12 people The aim of this report is to get a systematically searching in order to get an answer about the risk factor of the Asthma bronchiale and the prevention measure.Methods: A 40-year-old woman who works as a dental technician complains of experiencing symptoms of shortness of breath, wheezing, coughing and cold. A search was carried out to obtain clinical answers with databases obtained from: PubMed, and ProQuest. With the keyword “Worker”, “Methyl Methacrylate OR Acrylic” AND “Occupational Asthma” with inclusion criteria cohort studies, case control studies, cross sectional studies, methyl methacrylate, occupational asthma, occupational, and case report. Results: One study was found that there was a relationship between asthma and exposure to methacrylate. Risk of doctor-diagnosed asthma within 12 months (OR 27.6, 95% CI 1.19 - 7-54) and adult-onset asthma (2.65, 1.14-7.24) when compared with those not exposed to methyl methacrylate.Conclusion: From the two studies that we have been reviewed there was a significant relationship between exposure of methyl methacrylate or acrylic to the incidence of asthma.
Correlation of Plasma Melatonin Concentration and Alertness Level Among Female Nurses in Jakarta Indonesia Kresna, Andreas; Fuk, Liem Jen; Widyahening, Indah Suci; Soemarko, Dewi Sumaryani; Fitriani, Dewi Yunia
Occupational and Environmental Medicine Journal of Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Working in shift especially night shift could alter alertness level, increase fatigue, and working accident. One of the factors that affect the circadian rhythm were melatonin. Melatonin was a hormone that regulate the wake and sleep cycle that have an impact on alertness levels. This study was aimed to find correlation between plasma melatonin and alertness level. Methods A cross-sectional study was conducted on 40 female night shift nurses. Individual characteristics were obtained by self-administered questionnaire. Plasma melatonin concentrations and alertness level was collected twice at night time (11 pm – 00 am) and at morning (7 am − 8 am). Spearman or Pearson test was used to find correlation between melatonin concentrations and Psychomotor Vigilance Test (PVT). Results Mean age was 28.4 (±4.9) years with working experience varied from 1-16 years. Plasma melatonin concentrations among female night shift nurses were higher before working hours than after duty. Range of plasma melatonin value was 10-240 pg/ml and Alertness was in the same manner with average alertness level at night was 301.2 ± 51.6 ms and 293.2± 49.7 ms at morning. There was a weak correlation between plasma melatonin concentration and alertness level difference before and after duty (r = 0.37; p = 0.016). Conclusion There was weak correlation between plasma melatonin and alertness level in night shift workers before and after duty. To Maintain alertness level reduction and melatonin secretion, night shift workers should rest at least 30 minutes during their working hours, always keep the lights on while on duty and should not work more than one shift on the same day, and providing healthy foods.
Prognosis of COVID-19 on Workers with History of Asthma: An Evidence-Based Case Report Parmitasari, Parmitasari; Fitriani, Dewi Yunia; Widyahening, Indah S
Occupational and Environmental Medicine Journal of Indonesia Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

Background. As the COVID-19 pandemic occurs, those with asthma were thought to have an increased risk of infection. Question arisen whether special preparation for severe clinical outcomes might be needed for remote site workers. Method. A literature search was conducted through PubMed, Scopus and ProQuest databases, as well as hand searched. The inclusion criteria were systematic review, cohort study, retrospective study, cross sectional study, COVID-19, asthma, and ICU. Then, they were critically appraised based on Center of Evidence-Based Medicine, Oxford University, Critical Appraisal for Prognostic Studies and Systematic Reviews. Result. Three systematic review studies and three retrospective cohort studies were found. Systematic reviews by Sunjaya, et al. (2021) and Hussein, et al. (2021), also retrospective cohort study by Calmes, MD, et al. (2021) showed no significant difference in risk requiring admission to ICU for asthmatic compared to non-asthmatic (RR 1.19; CI 95%: 0.93 – 1.53; p= 0.16), (RR= 1.64, 95%CI = 0.67-3.97; p=0.27), and (OR = 1.4 (95% CI = 0.64-3.2); p =0.39), respectively. Systematic review by Liu (2021), showed no significant difference in asthma prevalence between ICU and non-ICU patients (RR, 1.19; 95% CI, 0.92-1.54; P =0 .17; I2 = 48.6%;). Cohort study by Choi, et al (2020) showed asthma was not a predictive factor for ICU admission in COVID-19 patients (OR 0.656 (95%CI= 0.295 – 1.440); p value =0.302). Contrary, cohort study by Jin, MMed, et.al (2020) showed that COVID-19 patients with asthma had a higher proportion of ICU admission than those who do not have. Conclusion COVID-19 workers with asthma does not have a higher risk of ICU admission.
Co-Authors Ade Mutiara Adi, Nuri Purwito Aji B Widodo Ambar W Roestam Andon Hestiantoro Andrijono Andrijono Anggraini Alam, Anggraini Anis Karuniawati Anna nasriawati Annang Giri Moelyo Aria Kekalih Arnold Fernando Ascobat, Purwantyastuti Asmarinah Bambang Tridjaja AAP, Bambang Tridjaja Bernath Siagian Brodjonegoro, Sakti R Budi Wiweko Chandra, Dian Novita Danarto, Raden Deandra, Fadhila I. Denta Aditya Episana Dewi Friska Dewi S. Soemarko Dewi Sumaryani Soemarko Dewi Wulandari Dewi Yunia Fitriani Dicky Mahardhika Dina Tri Amalia Faraji, Mahsa Fauzia, Khalida Fedri Rinawan, Fedri Fuk, Liem Jen Gayatri, Anggi Gita Pratama Guntur Darmawan Handaya, Adeodatus Y. Hariwibowo, Rinto Hartanto Bayuaji Hendri, Ahmad Z Herman Mulijadi Hindra Irawan Satari, Hindra Irawan Indrawarman Soeroharjo Indriastuti Soetomo Isbaniah, Fathiyah Iswanto, J. Judhiastuty Februhartanty KASMARA, E. Kokok, Andwi Setiawan Kresna, Andreas Lalisang, Toar JM. Leopando, Zorayda E. Luh Ade Ari Wiradnyani Luh Ade Wiradnyani, Luh Ade Marcellus Simadibrata Marcellus Simadibrata Mardiastuti H Wahid Muchammad Arief Gunawan Muhammad A Aufa Muhammad F Alhas Muhammad Ilyas Muhammad Ilyas Mulya Rahma Karyanti, Mulya Rahma Murdana, Nyoman Nasution, Safruddin Neni Nurainy Nina Mariana, Nina Nur Rasyid Nuri Purwito Adi Parmitasari, Parmitasari Ponco Birowo Prahara Yuri Raden I. Ismail Rakhmi Savitri Hoesein Retno Wibawanti Revata Utama Rimonta F Gunanegara Rimonta F Gunanegara, Rimonta F Rini Mulia Sari Rosdiana, Ano SANTOSO, S. S.I. Sasmono, R. Tedjo Saunar, Rofy S. Setiawati, Elsa P. Sinabutar, Klara Siti Darifah Sofyan, Marwan Sri Rezeki Hadinegoro, Sri Rezeki Sudadi Hirawan SUMAPRAJA, K. Tanoto, Rodri Tirza Z Tamin Tony Loho Trinovita Andraini Usman, Nurhayat Vivi Setiawaty Wangsa, Andrean Wibowo, Suryo Widianto, Eri Yefta Moenadjat Zakiudin Munasir