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All Journal Jurnal Gizi dan Pangan The Indonesian Journal of Public Health Universa Medicina Paediatrica Indonesiana Journal of Medicine and Health Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) World Nutrition Journal The New Ropanasuri Journal of Surgery Indonesian Journal of Global Health research JK Unila (Jurnal Kedokteran Universitas Lampung) The Indonesian Journal of Community and Occupational Medicine eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Tirtayasa Medical Journal Occupational and Environmental Medicine Journal of Indonesia Tirtayasa Medical Journal Journal of Medicine and Health
Indah S. Widyahening
Department Of Community Medicine, Faculty Of Medicine Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Body Composition Parameters, Adiponectin, Leptin and Adiponectin/Leptin Ratio are Correlated with LH/FSH Ratio in Women with PCOS but not in Women without PCOS Gita Pratama; Wiweko, Budi; Asmarinah; Widyahening, Indah Suci; Andraini, Trinovita; Hartanto Bayuaji; Andon Hestiantoro
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 1 January 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i1.2031

Abstract

Objective: To investigate the correlation between body composition parameters, adiponectin, leptin and the adiponectin/leptin ratio and the LH/FSH ratio in women with polycystic ovary syndrome (PCOS). Methods: A cross-sectional study was conducted at Reproductive Cluster Yasmin, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, with sixty women with PCOS and sixty healthy women as controls (matched for age and BMI). Body composition parameters, including body weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), percent body fat (PBF), visceral fat area (VFA), percent subcutaneous fat (PSF) and skeletal muscle mass (SMM), were measured; levels of fasting glucose, fasting insulin, testosterone, and sex hormone binding globulin (SHBG) were measured; and homeostatic model assessment for insulin resistance (HOMA-IR) values, anti-Mullerian hormone (AMH), free androgen index (FAI), Ferriman-Gallwey (FG) score, adiponectin levels, leptin levels, adiponectin/leptin ratio, LH, FSH and LH/FSH ratio were measured. Results: Body composition parameters (body weight, BMI, WC, WHR, PBF, VFA, PSF, SMM) were not significantly different between women with PCOS and controls. Fasting insulin (P<0.05), HOMA-IR (P<0.05), AMH (P<0.01), FAI (P<0.01), FG score (P<0.01) and LH/FSH ratio (P<0.05) were higher in PCOS women. Adiponectin (P<0.01) was lower in PCOS women, while leptin and the adiponectin/leptin ratio were not significantly different between groups. Most of body composition parameters, adiponectin, leptin and adiponectin/leptin ratio were correlated with HOMA-IR in both groups. SMM was positively correlated with the LH/FSH ratio, while body weight, BMI, WC, PBF, VFA, and PSF were inversely correlated with the LH/FSH ratio in PCOS patients but not in controls. WHR was not correlated in either group. Leptin (r=-0.278; P<0.05) was negatively correlated with the LH/FSH ratio only in the PCOS group. Adiponectin (r=0.394; P<0.01) and the adiponectin/leptin ratio (r=0.413; P<0.01) were also positively correlated with the LH/FSH ratio only in the PCOS group. AMH was correlated with the LH/FSH ratio, whereas testosterone level, FAI, FG score, fasting insulin level and HOMA-IR value were not correlated with the LH/FSH ratio in PCOS women. Conclusion: Most of the body composition parameters, leptin, adiponectin and the adiponectin/leptin ratio were significantly correlated with HOMA-IR in both groups. However, correlations of those parameters with LH/FSH ratio were found only in PCOS but not in women without PCOS. Adiponectin and leptin may play a significant role in the mechanism of neuroendocrine disorders in PCOS, which is characterized by an increased LH/FSH ratio. Keywords: adiponectin, adiponectin/leptin ratio, body composition, HOMA-IR, leptin, LH/FSH ratio, PCOS
McKenzie Exercise for Reducing Low Back Pain Complaints in Office Worker: An Evidence-based Case Report Pahlavie, Bonnie Medana; Soemarko, Dewi S; Widyahening, Indah Suci
Occupational and Environmental Medicine Journal of Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Low back pain (LBP) is pain that is felt in the lower back area, namely between the corners of the lowest ribs and the lower buttocks (lumbar or lumbo-sacral area) and can be local pain or radiate to the upper thighs/legs or both. Low back pain is a 10% debilitating condition that results in a change in life expectancy due to disability. Low back pain is not a malignancy and is a self-limiting condition, but patients always seek treatment to reduce the severity of their symptoms. Chronic Low Back Pain can alter lifestyle and increase the rate of prolonged absenteeism at work resulting in physical limitations. Discomfort due to chronic low back pain is a sign that requires immediate treatment. Methods: The purpose of this evidence-based case report is to get the right answer about McKenzie exercise in reducing low back pain in office workers. Article searches were conducted through PubMed, Embase and Cochrane Library. Inclusion criteria were Systematic Review, Meta-Analysis, Randomized Control Trial (RCT), Adult or Productive Age, Non Specific Chronic Low Back Pain and McKenzie Exercise. Then critically reviewed using Oxford CEBM criteria for intervention-therapy studies Results: 1 research article was obtained that met the inclusion criteria with the type of Randomized Control Trial (RCT). Conclusion:. The critical review showed that McKenzie exercise can reduce complaints of low back pain at 5 weeks of treatment, but this exercise did not show a clinical effect in the form of a reduction in complaints of low back pain after being implemented for 3,6 and 12 months. Keywords: Low Back pain; McKenzie; Exercise
Examining The Relationship between Shift Work and Diabetes Mellitus among Nurses: An Evidence-based Case Report Arifianto, Angga; Widyahening, Indah Suci; Khoe, Levina Chandra; Mokoagow, M. Ikhsan
Occupational and Environmental Medicine Journal of Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

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Abstract

Background : Work shifts could cause numerous health problems, such as sleep disorders, weight gain disorders, and unhealthy food intake consumption, leading to obesity and changes in blood glucose levels, that eventually lead to diabetes mellitus. This evidence-based case report aims to provide an evidence of association between shift work and the risk of diabetes mellitus among nurses. Methods : We performed a literature searching from Pubmed, Embase, Cochrane, Scopus, and Google Scholar in September 2023 using keywords ‘shift work’ AND ‘diabetes’ AND ‘nurse’. We included studies that assessed the association between shift work and diabetes among nurses using observational studies, meta-analysis, and systemic review as their study design. The outcome variable was the odd ratio or the relative risk of developing diabetes. We excluded cross-over studies, clinical trials, and cross-sectional studies. In addition, quality assessment was conducted according to The Oxford Center for Evidence-Based Medicine (OCEBM). Results : After title and abstract screening, we found seven out of twenty articles with a total of 689,273 participants. Among these articles, there were three cohort studies which found an increased relative risk (1.08 to 2.60) of diabetes among nurses who worked night and rotating shifts compared to those who did not. Another evidence from two cohort studies and one meta-analysis identified that nurses who worked in full shifts had an increased risk of diabetes (1.05 to 3.60) than those who worked non-shifts. Factors affecting the risk of diabetes were gender, unhealthy lifestyle, sleep disorders, and shift work duration (≥10 years). Conclusions : Shift work in nurses has a significant association with the risk of diabetes mellitus. Nurses had been working shift work for more than 10 years, particularly on night shift, had a higher risk compared to those who had been working for less than 10 years without night shift. Additional factors such as obesity, smoking, lack of physical activity, unhealthy diet, and sleep disorders would increase the risk of diabetes mellitus.
The Effect of Blue Light Filter Lens Glasses on The Occurrence of Asthenopia Symptoms in Visual Display Terminal Users Mustikaningrum, Arif Hening; Soemarko, Dewi Sumaryani; Widyahening, Indah Suci
Occupational and Environmental Medicine Journal of Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

The widespread use of Visual Display Terminals (VDTs) is associated with visual and musculoskeletal complaints, particularly Asthenopia, which may reduce productivity. A 32-year-old female financial worker presented with eye discomfort, including sore eyes, blurred vision, dizziness, and twitching on her left temple, particularly during extended computer use. The symptoms were relieved with rest. Most VDTs now use Light Emitting Diodes, which emit more blue light than LCDs and may cause eye fatigue and disrupt sleep. Currently, blue light filter lenses are available in the market, however, further study of existing scientific publications is necessary to ensure the effectiveness of blue light filter lenses, which are claimed to reduce asthenopia symptoms. This Evidence-based case report (EBCR) questions whether blue-light filter lens glasses alleviate symptoms of Asthenopia in workers A literature search in PubMed, Cochrane, and Embase identified Systematic Reviews, Meta-Analyses, and Randomized Controlled Trials (RCTs) evaluating blue light filter lenses in VDT users. These studies assessed objective measures (Critical Flicker Fusion Frequency—CFF) and subjective symptoms via questionnaires. The research papers were critically reviewed using the Oxford CEBM criteria for therapy (intervention) studies. Four Randomized Controlled Trial research articles met our criteria. However, the results did not provide conclusive evidence. There was no significant improvement in Critical Fusion Frequency (CFF), nor a reduction in subjective symptoms based on questionnaires. All studies varied in methodology, filter specifications, outcome tools, and subject characteristics. Therefore, blue light filter lenses cannot yet be clinically recommended for reducing asthenopia symptoms in VDT users. Further research is needed with a stronger design, larger sample size, and clearer standards and operational definitions.
Co-Authors Ade Mutiara Adi, Nuri Purwito Aji B Widodo Ambar W Roestam Andon Hestiantoro Andrijono Andrijono Anggraini Alam, Anggraini Anis Karuniawati Anna nasriawati Annang Giri Moelyo Arifianto, Angga Arnold Fernando Ascobat, Purwantyastuti Asmarinah Bambang Tridjaja AAP, Bambang Tridjaja Bernath Siagian Brodjonegoro, Sakti R Budi Wiweko Chandra, Dian Novita Danarto, Raden Deandra, Fadhila I. Denta Aditya Episana Dewi Friska Dewi S. Soemarko Dewi Sumaryani Soemarko Dewi Wulandari Dewi Yunia Fitriani Dicky Mahardhika Dina Tri Amalia Faraji, Mahsa Fauzia, Khalida Fedri Rinawan, Fedri Fuk, Liem Jen Gayatri, Anggi Gita Pratama Guntur Darmawan Handaya, Adeodatus Y. Hariwibowo, Rinto Hartanto Bayuaji Hendri, Ahmad Z Hindra Irawan Satari Indrawarman Soeroharjo Indriastuti Soetomo Iswanto, J. Judhiastuty Februhartanty KASMARA, E. Khoe, Levina Chandra Kokok, Andwi Setiawan Kresna, Andreas Leopando, Zorayda E. Luh Ade Ari Wiradnyani Luh Ade Wiradnyani, Luh Ade Marcellus Simadibrata Marcellus Simadibrata Mardiastuti H Wahid Mokoagow, M. Ikhsan Muchammad Arief Gunawan Muhammad A Aufa Muhammad F Alhas Muhammad Ilyas Muhammad Ilyas Mulya Rahma Karyanti, Mulya Rahma Murdana, Nyoman Mustikaningrum, Arif Hening Nasution, Safruddin Neni Nurainy Nina Mariana, Nina Nur Rasyid Nuri Purwito Adi Pahlavie, Bonnie Medana Parmitasari, Parmitasari Ponco Birowo Prahara Yuri Raden I. Ismail Rakhmi Savitri Hoesein Revata Utama Rimonta F Gunanegara Rimonta F Gunanegara, Rimonta F Rini Mulia Sari Rosdiana, Ano SANTOSO, S. S.I. Sasmono, R. Tedjo Saunar, Rofy S. Setiawati, Elsa P. Siti Darifah Sofyan, Marwan Sri Rezeki Hadinegoro, Sri Rezeki Sudadi Hirawan SUMAPRAJA, K. Tanoto, Rodri Tirza Z Tamin Toar J.M. Lalisang Tony Loho Trinovita Andraini Usman, Nurhayat Vivi Setiawaty Wangsa, Andrean Wibowo, Suryo Yefta Moenadjat Zakiudin Munasir