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All Journal Jurnal Gizi dan Pangan The Indonesian Journal of Public Health Universa Medicina Paediatrica Indonesiana Journal of Medicine and Health Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal The New Ropanasuri Journal of Surgery Indonesian Journal of Global Health research JK Unila (Jurnal Kedokteran Universitas Lampung) The Indonesian Journal of Community and Occupational Medicine eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Tirtayasa Medical Journal Occupational and Environmental Medicine Journal of Indonesia Tirtayasa Medical Journal Journal of Medicine and Health
Indah S. Widyahening
Department Of Community Medicine, Faculty Of Medicine Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Comparative analysis of COVID-19 incidence and neutralizing antibody response after primary COVID-19 vaccination and heterologous booster doses in adolescents vs. adults: the Indonesian experience Karyanti, Mulya Rahma; Satari, Hindra Irawan; Munasir, Zakiudin; Hadinegoro, Sri Rezeki; Widyahening, Indah Suci; Sasmono, R Tedjo
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.316-24

Abstract

Background The Indonesian COVID-19 immunization program has provided primary doses of a COVID-19 vaccine to adolescents and adults, while booster doses were given to adults only. Evaluation of this program is crucial to determine if boosters should be recommended for adolescents. Objective To compare COVID-19 incidence and SARS-CoV-2 IgG neutralizing antibody levels after COVID-19 vaccination in adolescents given a primary dose vs. adults given a primary dose and a booster. Methods: In this cross-sectional study, participants were given questionnaires on their COVID-19 history and evaluated for SARS-CoV-2 IgG neutralizing antibody titers. We included healthy individuals aged 12 years or older who resided in Jakarta and consented to participate, had received primary COVID-19 vaccine doses, and for adults, booster doses. Participants were stratified into two age groups, adolescents (12-17 years) and adults (18 years and above). We compared the incidence of COVID-19 and SARS-CoV-2 antibody titers between the two age groups. Results Out of 419 participants who met the inclusion criteria, 159 had blood specimens drawn for measurement of SARS-CoV-2 antibody titers. Before the widespread administration of the vaccine, the incidence of COVID-19 in was 4.9% in adolescents vs. 10.2% in adults (P=0.036). After widespread vaccination, the incidence of COVID-19 remained lower in adolescents than in adults (2.2% vs. 8.8%, respectively; P=0.005). The median SARS-CoV-2 antibody titer post-COVID-19 vaccination was 97.85 (range 46.46-98.23) U/mL in adults vs. 96.78 (range 22.08-98.23) U/mL in adolescents (P<0.05). Conclusion While the incidence of COVID-19 was significantly lower in vaccinated adolescents than in vaccinated adults, titers of SARS-CoV-2 IgG neutralizing antibody in adolescents were significantly lower compared to that of adults.
Body Composition Parameters, Adiponectin, Leptin and Adiponectin/Leptin Ratio are Correlated with LH/FSH Ratio in Women with PCOS but not in Women without PCOS Gita Pratama; Wiweko, Budi; Asmarinah; Widyahening, Indah Suci; Andraini, Trinovita; Hartanto Bayuaji; Andon Hestiantoro
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 1 January 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i1.2031

Abstract

Objective: To investigate the correlation between body composition parameters, adiponectin, leptin and the adiponectin/leptin ratio and the LH/FSH ratio in women with polycystic ovary syndrome (PCOS). Methods: A cross-sectional study was conducted at Reproductive Cluster Yasmin, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, with sixty women with PCOS and sixty healthy women as controls (matched for age and BMI). Body composition parameters, including body weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), percent body fat (PBF), visceral fat area (VFA), percent subcutaneous fat (PSF) and skeletal muscle mass (SMM), were measured; levels of fasting glucose, fasting insulin, testosterone, and sex hormone binding globulin (SHBG) were measured; and homeostatic model assessment for insulin resistance (HOMA-IR) values, anti-Mullerian hormone (AMH), free androgen index (FAI), Ferriman-Gallwey (FG) score, adiponectin levels, leptin levels, adiponectin/leptin ratio, LH, FSH and LH/FSH ratio were measured. Results: Body composition parameters (body weight, BMI, WC, WHR, PBF, VFA, PSF, SMM) were not significantly different between women with PCOS and controls. Fasting insulin (P<0.05), HOMA-IR (P<0.05), AMH (P<0.01), FAI (P<0.01), FG score (P<0.01) and LH/FSH ratio (P<0.05) were higher in PCOS women. Adiponectin (P<0.01) was lower in PCOS women, while leptin and the adiponectin/leptin ratio were not significantly different between groups. Most of body composition parameters, adiponectin, leptin and adiponectin/leptin ratio were correlated with HOMA-IR in both groups. SMM was positively correlated with the LH/FSH ratio, while body weight, BMI, WC, PBF, VFA, and PSF were inversely correlated with the LH/FSH ratio in PCOS patients but not in controls. WHR was not correlated in either group. Leptin (r=-0.278; P<0.05) was negatively correlated with the LH/FSH ratio only in the PCOS group. Adiponectin (r=0.394; P<0.01) and the adiponectin/leptin ratio (r=0.413; P<0.01) were also positively correlated with the LH/FSH ratio only in the PCOS group. AMH was correlated with the LH/FSH ratio, whereas testosterone level, FAI, FG score, fasting insulin level and HOMA-IR value were not correlated with the LH/FSH ratio in PCOS women. Conclusion: Most of the body composition parameters, leptin, adiponectin and the adiponectin/leptin ratio were significantly correlated with HOMA-IR in both groups. However, correlations of those parameters with LH/FSH ratio were found only in PCOS but not in women without PCOS. Adiponectin and leptin may play a significant role in the mechanism of neuroendocrine disorders in PCOS, which is characterized by an increased LH/FSH ratio. Keywords: adiponectin, adiponectin/leptin ratio, body composition, HOMA-IR, leptin, LH/FSH ratio, PCOS
Co-Authors Ade Mutiara Adi, Nuri Purwito Aji B Widodo Ambar W Roestam Andon Hestiantoro Andrijono Andrijono Anggraini Alam, Anggraini Anis Karuniawati Anna nasriawati Annang Giri Moelyo Aria Kekalih Arnold Fernando Ascobat, Purwantyastuti Asmarinah Bambang Tridjaja AAP, Bambang Tridjaja Bernath Siagian Brodjonegoro, Sakti R Budi Wiweko Chandra, Dian Novita Danarto, Raden Deandra, Fadhila I. Denta Aditya Episana Dewi Friska Dewi S. Soemarko Dewi Sumaryani Soemarko Dewi Wulandari Dewi Yunia Fitriani Dicky Mahardhika Dina Tri Amalia Faraji, Mahsa Fauzia, Khalida Fedri Rinawan, Fedri Fuk, Liem Jen Gayatri, Anggi Gita Pratama Guntur Darmawan Handaya, Adeodatus Y. Hariwibowo, Rinto Hartanto Bayuaji Hendri, Ahmad Z Herman Mulijadi Hindra Irawan Satari Indrawarman Soeroharjo Indriastuti Soetomo Isbaniah, Fathiyah Iswanto, J. Judhiastuty Februhartanty KASMARA, E. Kokok, Andwi Setiawan Kresna, Andreas Leopando, Zorayda E. Luh Ade Ari Wiradnyani Luh Ade Wiradnyani, Luh Ade Marcellus Simadibrata Marcellus Simadibrata Mardiastuti H Wahid Muchammad Arief Gunawan Muhammad A Aufa Muhammad F Alhas Muhammad Ilyas Muhammad Ilyas Mulya Rahma Karyanti, Mulya Rahma Murdana, Nyoman Nasution, Safruddin Neni Nurainy Nina Mariana, Nina Nur Rasyid Nuri Purwito Adi Parmitasari, Parmitasari Ponco Birowo Prahara Yuri Raden I. Ismail Rakhmi Savitri Hoesein Retno Wibawanti Revata Utama Rimonta F Gunanegara Rimonta F Gunanegara, Rimonta F Rini Mulia Sari Rosdiana, Ano SANTOSO, S. S.I. Sasmono, R. Tedjo Saunar, Rofy S. Setiawati, Elsa P. Sinabutar, Klara Siti Darifah Sofyan, Marwan Sri Rezeki Hadinegoro, Sri Rezeki Sudadi Hirawan SUMAPRAJA, K. Tanoto, Rodri Tirza Z Tamin Toar J.M. Lalisang Tony Loho Trinovita Andraini Usman, Nurhayat Vivi Setiawaty Wangsa, Andrean Wibowo, Suryo Widianto, Eri Yefta Moenadjat Zakiudin Munasir