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All Journal Dentika Dental Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry JITEKGI Jurnal Ilmiah dan Teknologi Kedokteran Gigi Journal of Health and Dental Sciences Jurnal Kedokteran Gigi Terpadu JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Abdimas Kesehatan Terpadu Sriwijaya Journal of Dentistry
Harryanto Wijaya
Fakultas Kedokteran Gigi Universitas Trisakti
Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Efficacy of Probiotics, Cetylpyridinium Chloride, and Enzymes Toothpaste Formulations Against Periodontal Pathogens in Fixed Orthodontic Patients: A Review Michelle; Joko Kusnoto; Harryanto Wijaya
Sriwijaya Journal of Dentistry Vol. 6 No. 2 (2025): Sriwijaya Journal of Dentistry
Publisher : Dentistry Study Program, Faculty of Medicine Universitas Sriwijaya 

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/yvwn2814

Abstract

Introduction: Fixed orthodontic appliances complicate oral hygiene and promote biofilm accumulation, increasing the risk of periodontal disease. Toothpaste formulations with antimicrobial properties such as Lactobacillus paracasei probiotics, cetylpyridinium chloride (CPC), and amyloglucosidase–glucose oxidase enzymes are commonly used to manage oral biofilm and control pathogenic bacteria. However, the extent of their effectiveness against periodontal pathogens in orthodontic patients remains unclear. Purpose: This review aims to map and summarize the current evidence on the efficacy of various toothpaste formulations in reducing periodontal pathogens among patients undergoing fixed orthodontic treatment. Methods: A comprehensive search of electronic databases (e.g., PubMed, Scopus, Google Scholar) was conducted to identify relevant studies published from 2015 to 2025. Data were extracted and synthesized narratively, focusing on types of formulations, study outcomes, and microbial targets. Results: Formulations containing antimicrobial agents such as probiotics, enzymes, and cetylpyridinium chloride showed variable effects on specific periodontal pathogens, including Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Each mechanism antimicrobial, probiotic, and enzymatic addresses different aspects of biofilm regulation. Conclusion: Toothpastes containing L. paracasei probiotics, CPC, and amyloglucosidase–glucose oxidase enzymes offer complementary ways to control periodontal pathogens in orthodontic patients. Combining these mechanisms may enhance biofilm control and microbial balance, though further research is needed to confirm their long-term benefits.
RELATIONSHIP OF FACIAL SKELETAL VERTICAL DIMENSION AND PALATAL LENGTH TO MIDPALATAL SUTURE Caitlin Reva Isman; Harryanto Wijaya; Sariyani Pancasari Audry Arifin
Journal of Health and Dental Sciences Vol. 6 No. 1 (2026): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

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Abstract

Malocclusion can significantly impact facial aesthetics, oral function, and quality of life, with cases often involving maxillary constriction treated by rapid palatal expansion (RPE). Treatment success depends on the evaluation of midpalatal suture maturation that is often done through CBCT, whose routine use is limited by concerns related to radiation exposure, cost, and accessibility. This study aims to evaluate the relationship between facial skeletal vertical dimension and palatal length with midpalatal suture maturation as potential noninvasive clinical indicators. An analytical observational study with a cross-sectional design was conducted using cephalography and CBCT images from 47 subjects aged 8–19 years. The facial skeletal vertical dimension was determined using the SN–MP parameter, palatal length was measured by linear cephalometric analysis, and midpalatal suture maturation was assessed using the Angelieri method. Fisher’s exact test and t-test were used for statistical analysis. The results showed no significant relationship between facial skeletal vertical dimension (p=0.197) or palatal length (p=0.477) and midpalatal suture maturation. In conclusion, facial skeletal vertical dimension and palatal length does not have a significant relationship with midpalatal suture maturation and should not be used as predictive clinical parameters. DOI : 10.54052/jhds.v6n1.p11-24
Co-Authors Abdul Gani Soulisa Adi Hidayat Adi Hidayat Andarini Joyowidarbo Andy Wirahadikusumah Annisa Putri Ariyani Arifin, Sariyani Pancasari Audry Ariyani, Annisa Putri Armelia Sari Caitlin Reva Isman Deviyanti Pratiwi Elline, Elline Ferry Sandra Fibryanto, Eko Irawati Gandadinata Irawati Gandadinata James Handojo Janti Sudiono Joko Kusnoto Juslily, Marta Kit, Yeoh Chiew Komariah Komariah Komariah Komariah Marie Louisa Michelle Natassya, Priska Novliana, Shelly Olivia Nauli Komala, Olivia Pragustine, Yenny Riko Nofrizal Rosalina Tjandrawinata Sari, Armelia Sariyani Pancasari Audry Arifin Soulisa, Abdul Gani Suwartini, Tien Velisya Velisya Yohana Yusra Yuliasari, Hani