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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis JURNAL PHARMASCIENCE Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa JKKI : Jurnal Kedokteran dan Kesehatan Indonesia International Journal of Health and Pharmaceutical (IJHP) Jurnal Farmasi Sains dan Praktis Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian
Yandi Syukri
Department Of Pharmacy, Faculty Of Mathemathics And Natural Sciences, Universitas Islam Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Jurnal Ilmiah Farmasi

 1 
UJI DISINTEGRASI DAN DISOLUSI TERBANDING TABLET ALOPURINOL GENERIK BERMEREK DAN GENERIK BERLOGO YANG BEREDAR DI PASARAN Bambang Hernawan Nugroho; Yandi Syukri; Anik Ariyani
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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ABSTRACTAllopurinol is a pyrimidine derivative that effective to normalize levels of uric acid in bloodand urine. Allopurinol is very slightly soluble in water, but it has high permeability (BCS class II) sothat the dissolution is an important determine to express the drug bioavailability. Additional materialdifferences and the production process of each plant can cause differences in the quality of theresulting allopurinol tablets. This study aimed to compare the quality of branded generic andgeneric products allopurinol tablets in the quality of disintegration and dissolution. This study used 5kinds branded generic (A, B, C, D, E) and 5 kinds of generic products (F, G, H, I, J). Disintegrationtest carried out according to USP-NF 32ndedition by the medium of water at 37 ± 2°C. Dissolutiontests conducted according to USP-NF 32ndedition using apparatus 2 (paddle methode), the speedof rotation 75 rpm, in 0.01 N HCl medium at 37 ± 0.5°C. The data obtained compared with therequirements listed in the Indonesia Pharmacopoeia 4thedition and USP-NF 32ndedition, and thenstatistically analyzed by T test at 95% confidence interval. Results of disintegration and dissolutiontests met the requirements in the literature. Statistical test results showed that products haddifferent disintegration and dissolution profile.Keywords: allopurinol, disintegration, dissolution, tablets
FORMULASI EMULSI GANDA VIRGIN COCONUT OIL (VCO) DENGAN EMULGATOR SPAN 80 DAN TWEEN 60 Yandi Syukri; Siti Zahliyatu; Maulia Ulfa
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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ABSTRACTVirgin Cocunut Oil (VCO) is a pure coconut oil, it has many advantages in health. It hasbeen circulated in market with unpleasant taste. Therefor, an innovation to find an acceptableformula by consumer should be carried out. The aimed of this research is to find out theinfluence of mix emulsifier toward physical stability of emulsion. Multiple emulsions w/o/wwere made by mix Span 80 with variation concentration 20%, 15%, 10%, and Tween 80. In orderto know the physical stability of emulsion w/o/w should be carried out viscosity test, separation inroom temperature, separation at 40ºC, separation due to centrifugation, creaming volume,paticle size, homogenity for 4 weeks storage, and respondent survey with 20 person. The testresult for 3 formulation emulsion for 4 weeks storage showed that formulation are nothomogeneous, but arter the formulas were shaken, it become homogeneous. In variousconcentration of Span 80, the longer preperations were storage the higher volume sedimentationand viscosity. Moreover, the longer preparations were storage, creaming volume and particle sizedecrease. Emulsifier combination between Span 80 with variation concentration 20%, 15%, 10%,and tween 60 in multiple emulsion w/o/w influenced physical stability multiple emulsi w/o/w.Moreover, this formulation also would be pleasant by consumen.Keywords: Multiple emulsion w/o/w, Span 80, Tween 60, Virgin Coconut Oil
PENINGKATAN DISOLUSI FUROSEMIDA DENGAN PEMBENTUKAN KOMPLEKS INKLUSI MELALUI KOPRESIPITASI MENGGUNAKAN β- SIKLODEKSTRIN Nurul Ainah; Yandi Syukri; M. Hatta Wibowo
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTFurosemide is a diuretic drug, which is insoluble in water. Due to this condition, it is needed away to increase the dissolution rate with forming of inclusion complex in copresipitation systemwhich produce as solid dispersion product using β-cyclodextrin carrier. The copresipitation systemwas made up of 1 : 0,5; 1 : 1; 1 : 1,5 and 1 : 2 variation concentration of furosemide- β-cyclodextrin. The characteristic forming of inclusion complex in solid dispersion system wasevaluated by infrared analysis and then followed by HyperChem molecular model analysis. Thedissolution test was done in order to see the increasing of dissolution rate and this test is usedbuffer phosphate pH 5,8 as the medium with rotation speed 100 rpm at 37 ± 0,50C for 60 minutes.The amount of dissoluted furosemide was then analyzed by spectrophotometric test. Thedissolution parameter with Dissolution Efficiency (DE) is conducted in 10, 30, and 60 minutes. Thedata were analyzed with Two Way ANOVA at p
PERBANDINGAN EFEKTIVITAS TRAGAKAN DAN PVP SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK JAHE (Zingiber officinale Roxb.) Wintari Taurina; Melinda Dewi M; Yandi Syukri; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTGinger (Zingiber Officinale Roxb) is a traditional plants usually used to relieve pain, rheumatism,and neutralize poison. The aim of this study was to get the optimum concentration of tragacanthand PVP as a binding agent in ginger lozenges formulation. The components from ginger wereextracted using percolation with ethanol 70% and then evaporated using rotary evaporator.Lozenges were made in three formulas ; formula 1 (5%), 2 (7,5%), 3 (10%) of tragacanth and PVPusing wet granulation method. Granules and tablets were tested for its physical properties, andanalyzed using Pearson correlation. The result showed that, all of three formulas were good,comply with a regulation of physical properties and disolution time in the mouth. Variation oftragacanth and PVP concentration affected physical properties of tablets. It showed that the greaterconcentration of tragacanth and PVP, the larger the hardness and the longer the disolution time oftablets. The third formula (tragacanth 10% b/v) gave an optimum physical properties and solubletime of tablets, with weight variety deviation 0,98%, hardness 10,18 kg, friability 0.11% anddisolution time 11.50 minutes. The three formulas were received by respondens withprerequirement of improving sweetness, repairing form and the color of tablets.Key words :Ginger lozenges, tragacanth, PVP, wet granulation method.
KARAKTERISASI DISPERSI PADAT IBUPROFEN-SSG (Sodium Starch Glycolat) DENGAN TEKNIK KNEADING Bambang Hernawan Nugroho; Shinta Dewi; Yandi Syukri
Jurnal Ilmiah Farmasi Vol. 7 No. 1 (2010)
Publisher : Universitas Islam Indonesia

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Ibuprofen merupakan Obat Anti Inflamasi Non Steroid (OAINS). Salah satu permasalahan yang dimiliki oleh ibuprofen ialah ibuprofen praktis tidak larut dalam air. Penelitian ini bertujuan untuk meningkatkan kelarutan ibuprofen dalam sistem dispersi padat dengan teknik kneading. Dispersi padat dengan teknik kneading dan campuran fisik disiapkan dengan perbandingan ibuprofen-Sodium Starch Glycolate (SSG) 1:1, 1:2, 1:3, dan 1:4 b/b. Dispersi padat dengan teknik kneading disiapkan dengan pembuatan pasta menggunakan pelarut air dan etanol 96%, yang kemudian dikeringkan dengan oven pada suhu 500C selama 24 jam. Interaksi dispersi padat dianalisis dengan spektrofotometer inframerah, dan uji disolusi dilakukan dengan metode keranjang dengan medium disolusi berupa dapar fosfat pH 7,2 dengan kecepatan putar 100 rpm pada suhu 37° ± 0,5°C selama 60 menit. Karakterisasi dispersi padat dilakukan berdasarkan uji spektrofotometri inframerah, uji disolusi, dan uji ukuran partikel. Parameter uji disolusi yang digunakan pada penelitian ini adalah Dissolution Efficiency (DE10, DE30, dan DE60). Data yang didapatkan dari uji tersebut dianalisis secara statistik menggunakan one way ANOVA dengan taraf kepercayaan 95%. Hasil uji spektra inframerah menunjukkan bahwa ada pergeseran dalam spektra dari dispersi padat maupun campuran fisik. Hasil tersebut menandakan adanya interaksi antara ibuprofen dan SSG. Hasil uji disolusi menunjukkan bahwa peningkatan jumlah SSG sebagai pembawa dapat menurunkan kelarutan dispersi padat dengan teknik kneading. Untuk campuran fisik, peningkatan jumlah SSG dapat meningkatkan kelarutan sampai level tertentu, dan selanjutnya mengalami penurunan kelarutan. Hasil uji disolusi terbaik diperoleh dari formula campuran fisik 1:1, dengan selisih nilai DE60 sebesar 12,23 dibandingkan dengan ibuprofen murni.
Stability studies of mefenamic acid Self-Nanoemulsifying Drug Delivery System (SNEEDS) preparation with oleic acid as the oil phase Yandi Syukri; Septiani Eka Cahyani; Bambang Hernawan Nugroho
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art5

Abstract

AbstractBackground: Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with low solubility in water.Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) play a role to improve the solubility and bioavailabilityof mefenamic acid.Objective: This study aimed to determine the stability of mefenamic acid in SNEDDS formulation throughvarious stability studies.Methods: The stability studies conducted consisted of centrifugation test, heating-cooling cycle test, freezethaw cycle test, robustness to dilution, accelerated storage test, and determination of drug content.Results: The centrifugation test, heating-cooling cycle test, and freeze-thaw cycle test showed no phaseseparation in the samples. The robustness to dilution and accelerated storage test resulted in 2 formulas ofmefenamic acid loaded SNEDDS having good stability with 10% oleic acid, 80% tween 80, 10% PEG 400 and10% oleic acid, 70% tween 80, 20% PEG 400. The determination of drug content in both of these formulationsshowed 98.20 ± 0.04% and 90.98 ± 0.06%.Conclusion: The SNEDDS formulation of mefenamic acid in this study had good stability.Keywords: SNEDDS, mefenamic acid, stability study, oleic acid IntisariLatar belakang: Asam mefenamat merupakan obat anti inflamasi non steroidal (AINS) dengan kelarutan yang rendah di dalam air. Salah satu cara untuk meningkatkan kelarutan dan bioavailabilitas asam mefenamat membuatnya dalam bentuk sediaan Self Nano-Emulsifying Delivery Drug System (SNEDDS)Tujuan: Penelitian ini bertujuan untuk menentukan stabilitas SNEDDS asam mefenamat terhadap berbagai studi stabilitas yang dilakukanMetode: Uji stabilitas dilakukan dengan uji sentrifugasi, uji siklus panas-dingin, uji siklus beku-cair, uji ketahanan, uji penyimpanan dipercepat, dan uji kadar.Hasil: Hasil dari evaluasi uji sentrifugasi yaitu tidak terjadi pemisahan, pada uji siklus panas-dingin dan uji siklus beku-cair tetap stabil dan tidak terjadi pemisahan fase. Hasil dari uji ketahanan dan uji penyimpanan dipercepat menunjukkan 2 formula SNEDDS asam mefenamat yang memiliki stabilitas yang baik dengan komponen Asam Oleat 10%, Tween 80 80%, PEG 400 10% dan Asam Oleat 10%, Tween 80 70%, PEG 400 20%. Pada uji kadar diperoleh kadar asam mefenamat selama penyimpanan pada formula diatas adalah 98,20 ± 0,04 % dan 90,98 ± 0,06 %.Kesimpulan: Dapat disimpulkan sediaan SNEDDS asam mefenamat memiliki stabilitas yang baik terhadap berbagai studi stabilitas yang dilakukan.Kata kunci : SNEDDS, asam mefenamat, studi stabilitas, asam oleat
SISTEM PENGHANTARAN OBAT MELEWATI BARRIER DARAH OTAK Syukri, Yandi
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTBrain barrier is effective barrier in drug delivery to brain. For effectiveness drug deliveryneed be desaigned a delivery with nanoparticle technology. Nanoparticles are solid colloidalparticles ranging in size from 1 to 1000 nm that are utilized as drug delivery agents. The primaryadvantages of nanoparticle carrier technology is that nanoparticles mask the blood – brain barrierlimiting characteristics of the therapeutic drug molecule. Furthermore, this system may slow drugrelease in the brain, decreasing peripheral toxicity. The method which elaboration in manufacturenanoparticles are emulsion polimerization, interfacial polimerization, desolvation evaporation andsolvent deposition. Currently, report evaluating nanoparticles for brain delivery have studiedanesthetic and chemoterapeutic agent. These studies are reviewed for efficacy and mechanisms oftransport. Physiological factors such as phagocytic activity of the reticuloendothelial system andprotein opsonization may limit the amount of brain delivered drug. Nanoparticle technology appearsto have significant promise in delivering therapeutic molecules across the blood-brain barrier.Key Word : Drug Delivery System, Nanoparticle, Blood-Brain Barrier
Co-Authors Ade Herlin Aditya Sewanggara Amatyawangsa Wicaksana Aditya Sewanggara Amatyawangsa Wicaksana Agita Dyah Permatasari Agung Endro Nugroho Agung Endro Nugroho Aji Winanta Aldia Dwi Karina Ningrum Aldia Dwi Karina Ningrum Amalia Humairah Amelia Arum Prasetya Anik Ariyani Anisa Nur Fazzri Annisa Fitria Annisa Fitria Arba Pramundita Ramadani Arifa Caryn Dea Aris Perdana Kusuma, Aris Perdana Asih Lestari Asih Triastuti Asita, Nur Ayunanda, Nurul Putri Ramadhani Bambang Hernawan Nugroho Bambang Hernawan Nugroho, Bambang Hernawan Budy Wijiyanto Denox Asih Pertiwi Diny Rizayulianty Dwi Cahyani, Ervita Elfi Susanti V. H. Endang Lukitaningsih Endang Lukitaningsih Farida Ulfa Feris Firdaus Fernenda, Larysa Fissy Rizki Utami Fitriani, Hannie Galuh Annaba Maharani Hakim, Lukman Hakim, Sherina Nabila Putri Hannie Fitriani Hannie Fitriani Hayati, Farida Herianto Pandapotan Herianto Pandapotan, Herianto Iqmal Tahir Isna Qiftayati Isnatin Miladiyah Istanti Istanti Istanti Istanti, Istanti Joko Tri Wibowo Julio, Ivan Kartika Puspitasari Kholidah, Ziyyatul Larysa Fernenda Laryssa Fernenda Lelita Ayu Saputri Lisnawati Tiara Putri Lukman Hakim Lutfi Chabib, Lutfi M. Hatta Wibowo Maulia Ulfa mega octavia Melinda Dewi M Mira Amaliasari Sitorus Muhammad Sulaiman Zubair Mulyanti, Eka Mulyanti, Eka Mutiara Herawati, Mutiara Nadia Hazami Nur Asita Nurul Ainah Octavia, Mega Prima Aulia Putra Primadara Damayanti Ramadhani, Arba Pramundita Ratih Dyah Listianingrum Ratih Lestari Ratih Lestari Redjeki, Tri Rini Utami Rio Fandi Sholehuddin Ririk Purwati Rochmy Istikaharah Rochmy Istikharah Romdhonah Romdhonah Ronny Martien Ronny Martien Saepudin Saepudin Septiani Eka Cahyani Seran, Yuvina Sherina Nabila Putri Hakim Shinta Dewi Sista Werdyani Sista Werdyani Siti Zahliyatu Syafira Tri Nurmala Sari T. N. Saifullah Taher, Muhammad Tamhid, Hady Anshory Tasya Salsabila Tatang Shabur Julianto Tedjo Yuwono Tiara Putri, Lisnawati Utomo, Suryadi Budi Werdyani, Sista Wintari Taurina Yoga Febriana Yuni Darty Yuwono, Tedjo Ziyyatul Kholidah Zubair, Sulaiman