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All Journal Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Indonesian Journal of Tropical and Infectious Disease Biomedika Jurnal Respirologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Respiratory Science Narra J Bioscientia Medicina : Journal of Biomedicine and Translational Research Malang Respiratory Journal

INDRA YOVI

Department Of Pulmonology, Faculty Of Medicine, Universitas Riau/Arifin Achmad General Hospital, Pekanbaru –Indonesia

Author-ID : 423637

Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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GAMBARAN EFEK SAMPING OBAT ANTI TUBERKULOSIS (OAT) LINI KEDUA PADA PASIEN TUBERCULOSIS-MULTIDRUG RESISTANCE (TB-MDR) DI POLIKLINIK TB-MDR RSUD ARIFIN ACHMAD PROVINSI RIAU Qurratul Aini; Indra Yovi; Muhammad Yulis Hamidy
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRACTMultidrug resistant tuberculosis (MDR-TB) is one of tuberculosis resistance to at leasttwo anti tuberculosis drugs rifampicin and isoniazide. Second line drugs used in MDRTBtreatment had a greater toxicity compared with first line and a lot of adverse event, itcauses patient would have symptoms of side effect during treatment . The purpose of thisresearch had to know adverse event of second line anti-TB drug in MDR-TB patient inMDR-TB polyclinic Arifin Achmad General Hospital of Riau Province. This research wasused as mixed methods with quantitative and qualitative approachment. Adverse eventwas also discussed in qualitative data as a complement. Samples in this research wereobtained by total sampling method as many as 12 MDR-TB patient were diagnosedbetween April 2013 to Juni 2014 . Quantitative study results showed that adverse eventwere experienced by 100% patient. Prevalence of nausea and vomiting was 100%,headache 100%, arthralgia 91,67%, injected location pain 91,67%, peripheralneuropathy 83,33%, depression 83,33%, sleep disturbance 83,33%, allergic reaction75%, anorexia 75%, gastritis 66,67%, hearing distrubance 66,67%, vertigo 58,33%,tendinitis 58,33%, psychosis 50%, visual disturbance 50%, minor electrolite disturbance(hypokalemia) 41,67%, diarrhea 16,67%, severe electrolite disturbance 16,67%, gasterbleeding 8,33%. Qualitative study results showed that patient had difference adverseevent experienced. Management of adverse event by clinical officer in MDR-TBpolyclinic have done their duty based on standart operational procedures.Key word: multidrug resistant tuberculosis (MDR-TB), adverse event of second line anti-TB drug, adverse event of MDR-TB treatment.

Lung Function Impairment Among Firefighter After Forest Fire Disaster in Riau, Sumatra Rudi Kurniawan; Seira Putri Boru Rambe; Indra Yovie; Erlang Samoedro; Agus Dwi Susanto; Jamal Zaini
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.210

Background: The 2015 forest fire disaster affected almost 2.6 million hectares of land in Indonesia, and Riau was among the worst. Firefighters were the first responders to deal with the disaster, but a little was known about the influence of extinguishing forest fire activities with their health. This study aimed to evaluate respiratory symptoms and lung function among firefighters 6 months after forest fire exposure.Methods: Interviews were conducted regarding sociodemographic factors, respiratory symptoms, and history of forest fire exposure during the disaster. Spirometry and chest X-ray were also carried out with standard techniques. Statistical analysis was performed based on the existing data. Ninety firefighters participated in this study, most were male with mean age of 33 years old. About 66% were smoker, had been working as firefighters for 2 to 10 years, and had been on extinguishing forest fire duty around 2–5 hours/day during the disaster.Results: All firefighters reported respiratory symptoms after 3 months. Pulmonary function was abnormal in 50% of subjects with mild restrictive characteristic. The analysis showed that body mass index (BMI) and duration of exposure had a significant correlation with pulmonary function abnormality.Conclusion: Pulmonary function was found abnormal in most subjects 6 months after forest fire exposure in Riau.

Profil and Evaluation of Resistant Tuberculosis Drug’s Side Effect in Diabetes and Non Diabetes Mellitus Patient at RSUD Arifin Achmad Dani Rosdiana; Dewi Anggraini; Indra Yovi; Marlina Tasril
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.119

Backgrounds: Diabetes mellitus (DM) increases the risk of reactivation of tuberculosis included multi-resistant drug tuberculosis (MDR-TB). This situation is threatening Riau province due to the high prevalence of DM. Since 2014 Arifin Achmad Hospital as a referral hospital of MDR-TB management. It’s treatment especially in DM patients, requires an evaluation of both outcome and side effects. This evaluation needs to be compared with non-DM MDR TB patients. The aim of this study was to evaluate and analyse patient’s characteristic, conversion of smear or culture, drugs side effect and treatment outcome. Methods: This is a cross sectional retrospective study in RSUD Arifin Achmad Pekanbaru on April-October 2018. Sample of this study were all patients from 2014 – 2017. This study was divided into 2 groups, namely the DM and non-DM groups, then analysed the differences between the two groups Results: There were 113 MDR TB patients had its treatment, which 61% of the patients were male. Baseline data show 26.5% of MDR TB patients have comorbid DM. The most common side effects were nausea and vomiting (100%) in all subjects. In the MDR TB DM group, we found included: well controlled plasma glucose level was 33.3%, severe side effects was16.7%, conversion in the second month 40% and cured or complete treatment was 30%. Conclusions: As many as 26,5% of MDR TB patients had DM comorbidity. There were no differences in the percentage of drugs side effects, smear conversion in the second month and treatment outcome between MDR TB DM and MDR TB non-DM group. (J Respir Indo. 2020; 40(3): 156-62)

The Relationship of Chest X-Ray in COVID-19 Patients and Disease Severity in Arifin Achmad General Hospital Riau Aulia Rahman; Sri Melati Munir; Indra Yovi; Andreas Makmur
Jurnal Respirasi Vol. 7 No. 3 (2021): September 2021
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Coronavirus Disease 2019 (COVID-19) pandemic is caused by SARS-CoV-2 which spreads rapidly throughout the world and causes clinical manifestations in various organs, especially in the lungs. Clinical symptoms arise from asymptomatic, mild, moderate, severe, and critical symptoms in patients with or without comorbid disease. Chest X-ray examination is one of the modalities in the management of COVID-19 which is cheap and easy to do.Methods: This study was performed by analyzing medical record data of confirmed COVID-19 patients from March to December 2020. This study aimed to examine the relationship between chest X-ray and the degree of disease severity.Results: The results showed that from the examined 542 total samples, the highest number was found in the age group of 40-49 years old (23.6%), women (53%), mild degree of COVID-19 (67.9%), normal chest X-ray (54.6%), predominance on the lower zone of the lung, peripheral and bilateral on abnormal chest X-ray, no comorbid (56.3%), hypertensive in comorbid disease (26.6%). There was a significant relationship between chest X-ray and comorbidity towards COVID-19 severity (p = 0.000).Conclusion:Chest X-ray can determine disease severity, therefore it can be used as the first modality for triage and treatment evaluation in COVID-19 patients.

Bedaquiline Correlation to QT Interval Prolongation in DR-TB Patients Vandu Primadana; Indra Yovi; Dyah Siswanti Estiningsih
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: The regimen of drug-resistant tuberculosis (DR-TB) is Bedaquiline. One of the adverse events is QT interval prolongation, which can increase the risk of Torsade de Pointes (TdP) and lead to death. DR-TB patient screening before starting the treatment and monitoring QT interval during the treatment should be performed. This study aimed to determine Bedaquiline correlation to QT interval prolongation in DR-TB patients. Methods: This was a retrospective study using an observational design by viewing medical records of DR-TB patients who underwent treatment from January 2019 to March 2022. Results: This study involved 46 DR-TB patients with an average age of 41.4 years old, and 58.7% were males with a regimen of Bedaquiline. The comparison of Baseline QT intervals before and after one month of therapy showed QT interval prolongation (457.1 ± 18.2 ms and 443.8 ± 10.2 ms; p < 0.001). The comparison of QT intervals before the therapy and six months after the therapy showed prolongation QT intervals (443.8 ± 10.2 ms and 458.4 ± 23.7 ms; p < 0.001). QT intervals after one month of therapy compared to six months after the therapy showed insignificant slight prolongation (457.1 ± 18.2 ms and 458.4 ± 23.7 ms; p = 0.587). Conclusion: QT interval prolongation occurred in DR-TB patients who received treatment using Bedaquiline regimen. It was seen significantly between baseline QT interval and after receiving the therapy for one month and six months.

Efficacy of pretomanid-containing regiments for drug-resistant tuberculosis: A systematic review and meta-analysis of clinical trials Simanjuntak, Arya M.; Daenansya, Raehan; Afladhanti, Putri M.; Yovi, Indra; Suyanto, Suyanto; Anggraini, Dewi; Rosdiana, Dani
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.402

Concerns regarding the rise of drug-resistant tuberculosis (DR-TB) infections and the need for new drugs with shorter treatment time and fewer side effects have been voiced by the World Health Organization (WHO). The WHO revised its guideline to treat multi-drug resistant tuberculosis (MDR-TB) with a 6-month course of BPaLM (bedaquiline, pretomanid, linezolid and moxifloxacin) in 2022. However, a thorough study and meta-analysis of available evidence is required due to the limited confidence of the evidence confirming the effectiveness of pretomanid-containing regiments. The aim of this systematic review and meta-analysis was to evaluate the effectiveness of pretomanid-containing regiments in treating DR-TB patients. Data from six search engines were searched using inclusion criteria based on the PICOS framework. The keywords of pretomanid and tuberculosis or their alternatives were used. Using RoB2 Cochrane risk-of-bias tool for randomized clinical trials, data were independently extracted and the quality of the data was evaluated. Odds ratio (OR) and heterogeneity tests were used and the findings were presented in ORs and forest plots. A total of four studies with 237 patients was included in the final analysis and 204 (86%) patients had favorable outcome (cured) and 33 (14%) was not cured. Pretomanid-containing regimen (OR: 46.73; 95%CI: 11.76–185.7) and BPaLM/BPaL (OR: 41.67; 95%CI: 8.86–196.73) regimens were associated with favorable outcome (cured). This meta-analysis indicates that the pretomanid-containing regimen and the BPaLM/BPaL regimen could increase the chance to have favorable outcome in DR-TB patients.

A comparative analysis between next-generation sequencing and conventional culture method to detect empyema-associated microorganisms: A systematic review Yovi, Indra; Syah, Nur A.; Anggraini, Dewi; Simanjuntak, Arya M.; Hanifah, Zulfa N.; Elliyanti, Aisyah
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.650

Empyema poses a significant global health concern, yet identifying responsible bacteria remains elusive. Recent studies question the efficacy of conventional pleural fluid culture in accurately identifying empyema-causing bacteria. The aim of this study was to compare diagnostic capabilities of next-generation sequencing (NGS) with conventional pleural fluid culture in identifying empyema-causing bacteria. Five databases (Google Scholar, Science Direct, Cochrane, Research Gate, and PubMed) were used to search studies comparing conventional pleural fluid culture with NGS for identifying empyema-causing bacteria using keywords. Positive results identified through conventional pleural fluid culture and NGS were extracted. In addition, bacterial profiles identified by NGS were also documented. Joanna-Briggs Institute (JBI) critical appraisal tool was employed to assess quality of included studies. Descriptive analysis was employed to present outcome of interests. From five databases, three studies, with 354 patients, were included. Findings from three studies showed that NGS outperformed conventional pleural fluid culture in detecting empyema-causing bacteria even in culture-negative samples. Moreover, dominant bacterial profiles identified through NGS included Streptococcus pneumoniae, Staphylococcus aureus, and anaerobic bacteria. In conclusion, NGS outperforms conventional pleural fluid culture in detection empyema-causing bacteria, yet further studies with larger samples and broader bacterial profiles are needed to increase confidence and urgency in its adoption over conventional pleural fluid culture.

C-Reactive Protein and Procalcitonin as Markers for Post-Bronchoscopic Complications: A Literature Review Indriani, Sri Indah; Yovi, Indra; Syaf, Syarlidina; Simatupang, Elvando Tunggul Mauliate
Jurnal Respirologi Indonesia Vol 44, No 2 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i2.638

In the respiratory system, bronchoscopy is a basic procedure utilized for both diagnostic and therapeutic purposes. Despite being a generally safe procedure, bronchoscopy can result in complications that range in severity from moderate to severe. Pulmonary infection is among the potential complications that can happen after a bronchoscopy procedure. An incidence of 0.2% to 5.2% has been described typically for complications such as empyema, lung abscess, and pneumonia that may develop after bronchoscopy procedures. Although these complications are uncommon, their prognosis can be quite bad. The risk of pulmonary infection, specifically pneumonia, has been related in several studies to sepsis and mortality in patients enduring bronchoscopy procedures. The initiation of the infection exposure process into the lung can be assisted through a variety of factors, including the underlying diagnosis and the type of intervention performed during the bronchoscopy procedure. A critical complication that needs additional consideration is the potential transmission of infection through bronchoscopy procedures. It is beneficial to consider prophylactic antibiotics before a procedure due to the possibility that infectious agents will be transferred from one patient to another. Antibiotic prophylaxis may involve the utilization of C-reactive protein (CRP) and Procalcitonin (PCT) testing as determining parameters. Serial PCT and CRP 24–96 hours post-bronchoscopy procedure might help to determine one of the post-bronchoscopy complications.

Bacterial Profile and Antimicrobial Resistance Patterns of Pleural Empyema in Pekanbaru Hospitals Yovi, Indra; Safari, Dodi; Syah, Nur Afrainin; Anggraini, Dewi; Hanifah, Zulfa Nur; Shapira, Vanesya Zahrani; Elliyanti, Aisyah
Jurnal Respirologi Indonesia Vol 44, No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.590

Background: Empyema is a problem worldwide due to its high incidence, mortality, and morbidity rates. So, administering antibiotics is mandatory to treat the disease. It should be sensitive to the causal microorganisms and avoid resistant ones for treatment efficacy. This research aimed to determine bacterial profile and antimicrobial resistance, which can be fundamental foundations for clinical practices in the treatment of patients, especially in Pekanbaru.Methods: This was a cross-sectional study from medical records at Arifin Achmad and Eka Hospitals from January 1, 2015, to December 31, 2022, including culture and antibiotic resistance test results with samples from pleural fluid and antibiotic susceptibility test using VITEK 2.0.Results: A total of 197 pleural fluid specimens were obtained. Gram-negative bacteria were found to be the most prevalent at 79.7%, namely Klebsiella pneumoniae (18.5%), Escherichia coli (12.0%), and Pseudomonas aeruginosa (11.0%). Gram-positive bacteria were found at 12.2%, the most common being Staphylococcus aureus (6.1%) and Enterococcus faecalis (2.0%). Antibiotic sensitivity tests for Gram-negative bacteria showed that amikacin and tigecycline were the most sensitive, and Gram-positive bacteria showed the most sensitivity to linezolid, tigecycline, and vancomycin. The resistance of Klebsiella pneumoniae and Escherichia coli to cephalosporins was 18.5% and 75.0%, respectively. The resistance of Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa to carbapenems was 8.0%, 13.0%, and 53.0%, respectively.Conclusion: Gram-negative is the most common microorganism found in pleural empyema. The resistance of multiresistant bacteria to antibiotics is high and requires supervision to apply appropriate antibiotic administration based on local antimicrobial patterns and the need to strengthen antimicrobial stewardship programs.

Pemeriksaan Paru dengan Spirometri Serta Edukasi Berhenti Merokok pada Warga Desa Titi Akar Rupat Utara Indra Yovi; Adrianison Adrianison; Said Tryanda Syafitra
ABDI: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 6 No 2 (2024): Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Labor Jurusan Sosiologi, Fakultas Ilmu Sosial, Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/abdi.v6i2.867

Merokok adalah salah satu ancaman kesehatan masyarakat utama yang pernah dihadapi dunia, menyebabkan kematian lebih dari 8 juta orang per tahun di seluruh dunia. Hal ini berdampak langsung pada sistem pernapasan dan menurunkan fungsi paru-paru. Provinsi Riau masih memiliki daerah-daerah yang sulit dijangkau, salah satunya adalah Pulau Rupat yang merupakan salah satu pulau yang termasuk dalam wilayah Kabupaten Bengkalis. Minimnya pengetahuan tentang rokok kepada masyarakat Indonesia khususnya di daerah pedalaman seperti Desa Titi Akar Kecamatan Rupat Utara, sehingga tenaga kesehatan berkewajiban untuk memberikan edukasi tentang bahaya merokok dan pemeriksaan kesehatan paru kepada masyarakat. Kegiatan pengabdian masyarakat yaitu penyuluhan kesehatan tentang edukasi bahaya merokok dan pemeriksaan kesehatan paru bagi warga Desa Titi Akar, Kecamatan Rupat Utara, Kabupaten Bengkalis, Provinsi Riau sangat bermanfaat dan penting bagi warga desa tersebut. Kegiatan pengabdian masyarakat ini dilakukan oleh Dokter Spesialis Paru sehingga para peserta penyuluhan lebih leluasa untuk bertanya mengenai bahaya merokok dan kesehatan paru-paru. Kegiatan ini diharapkan dapat membuat jumlah perokok di desa tersebut berkurang dan wawasan tentang bahaya merokok serta angka kematian yang disebabkan oleh rokok dapat meningkat.

Co-Authors Adrianison Adrianison Adrianison, Adrianison Afladhanti, Putri M. Agus Dwi Susanto Aisyah Elliyanti Andreas Makmur Anggi Rizki Utami Nasution Aulia Rahman Daenansya, Raehan Dani Rosdiana Dewi Anggraini Dewi Anggraini Dina Fauzia Dyah Siswanti Estiningsih Eka Bebasari Eka Zulya Syahputri ELI ERAWATI Elisabet, Adinda Elsa Puspita Erwin Christianto Erwin Christianto Faisal Yunus Febrina, Nidya Gurning, Andi Sarikawan Hanifah, Zulfa N. hanifah, zulfa nur Hatta, Hariadi Ikhsan Fajri, Ikhsan Indriani, Sri Indah Kiki Yuliana Laode Burhanuddin Marbun, Patricia Dean Ully Marlina Tasril Miftah Azrin Muhammad Reza Arifin Muhammad Yulis Hamidy Nur Afrainin Syah Nurfadillah " Purnama, Nori Putri, Chyntia Triana Qurratul Aini Riza Yefri Riza Yefri, Riza Rohani Lasmaria Simbolon, Rohani Lasmaria Rudi Kurniawan Safari, Dodi Said Tryanda Syafitra Salmiyah Samoedro, Erlang Seira Putri Boru Rambe Shapira, Vanesya Zahrani Simanjuntak, Arya M. Simanjuntak, Arya Marganda Simatupang, Elvando Tunggul Mauliate Sri Indah Indriani Sri Indriani Sri Melati Munir Sri Melati Munir Suyanto Suyanto Syaf, Syarlidina Syah, Nur A. Syahira " Syahputri, Eka Zulya Tuti Restuastuti Tuti Restuastuti Vandu Primadana Vivin Anggia Putri Wijaya, Dewi Zaini, Jamal Zarfiardy Aksa Fauzi Zulmaeta

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