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All Journal Sari Pediatri Paediatrica Indonesiana Syntax Literate: Jurnal Ilmiah Indonesia AcTion: Aceh Nutrition Journal Jurnal Ilmiah Mahasiswa Kedokteran Medisia AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Budapest International Research in Exact Sciences (BirEx Journal) Narra J The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Peradaban Journal of Religion and Society Narra X
Sulaiman Yusuf
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Journal : Paediatrica Indonesiana

 1 
Treatment duration and dosage of valproic acid and subclinical hypothyroidism incidence in pediatric epilepsy patients Carolina, Infra Yunita; Anidar, Anidar; Andid, Rusdi; Yusuf, Sulaiman; Darussalam, Dora; Sovira, Nora
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.469-72

Abstract

Background Epilepsy is a central nervous system disorder characterized by abnormal electrical activity in the brain.1 Prolonged administration of valproic acid at therapeutic doses can disrupt thyroid function, leading to subclinical hypothyroidism. This condition is marked by elevated thyroid stimulating hormone (TSH) levels, with normal serum free T4 (FT4) levels.2 Objective To investigate for possible associations between valproic acid therapy duration and dosage with the incidence of subclinical hypothyroidism in pediatric epilepsy patients. Methods This analytical, cross-sectional study included children aged 4 months to 18 years treated at the Pediatric Clinic of RSUD Dr. Zainoel Abidin, Banda Aceh, from September to November 2023. Subjects diagnosed with epilepsy and treated with valproic acid for at least 3 months were included in this study and underwent FT4 and TSH examinations. Results Forty-four children met the study criteria. Subclinical hypothyroidism occurred in 5 (11.4%) subjects during valproic acid therapy. Chi-square analysis revealed no significant association between therapy duration ?1 year (OR 1.286; 95%CI 0.193 to 8.568; P=1.00) or therapy dose ?20-40 mg/kg/day (OR 3.429; 95%CI 0.351 to 33.518; P=0.37) with subclinical hypothyroidism incidence. Conclusion Neither the duration nor the dosage of valproic acid therapy were significantly associated with the incidence of subclinical hypothyroidism in children with epilepsy.
Risk factors for poor initial response to valproic acid therapy in children with epilepsy Sari, Eva Devita; Anidar, Anidar; Amna, Eka Yunita; Andid, Rusdi; Yusuf, Sulaiman; Sovira, Nora
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.286-90

Abstract

Background The initial response in the first three months of valproic acid therapy is a prognostic factor for predicting treatment success, and it is considered to be poor if seizures persist during the three months of valproic acid treatment. Several factors might influence the initial response to valproic acid therapy, including gender, age, family history of epilepsy, electroencephalogram (EEG), head circumference, type of seizure, cerebral palsy, and pre-therapy seizure frequency. Objective To determine the risk factors for poor early response to valproic acid therapy in children with epilepsy. Methods This retrospective cohort study was conducted in children newly diagnosed with epilepsy. Data were collected from medical records of patients who had been treated at the Pediatric Polyclinic of dr. Zainoel Abidin Hospital for one year. Results Of 90 subjects, most were male (58; 64.4%) and aged three years or older (79; 87.8%). Forty-five (50%) patients had a family history of epilepsy. More than a quarter of the subjects (35; 38.9%) showed initial poor responses to valproic acid therapy. Bivariate analysis revealed risk factors for poor initial response to valproic acid therapy were age ≥ 3 years, family history of epilepsy, normal EEG, normal head circumference, generalized seizure type, cerebral palsy, and pre-therapy seizure frequency. However, multivariate analysis revealed that risk factors for poor initial response to valproic acid therapy in children with epilepsy that retained significance were family history of epilepsy (RR 6.58; 95%CI 1.67 to 25.95; P=0,001), abnormal EEG (RR 5.27; 95%CI 1.16 to 23.87; P=0,000), focal seizures (RR 7.10; 95%CI 1.15 to 43.80; P=0,000), and cerebral palsy (RR 62.62; 95%CI 3.93 to 996.45; P=0,001). Conclusion The risk factors for poor initial response to valproic acid therapy in children with epilepsy are family history of epilepsy, abnormal EEG, focal seizures, and cerebral palsy.
Risk factors for progression of chronic kidney disease in children with nephrotic syndrome Adrian, Riki; Sovira, Nora; Haris, Syafruddin; Andid, Rusdi; Darnifayanti, Darnifayanti; Yusuf, Sulaiman
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.291-6

Abstract

Background Nephrotic Syndrome (NS) is a progressive kidney disease in children that can lead to chronic kidney disease (CKD). Understanding the interactions between various risk factors is critical in developing new strategies to prevent the progression of CKD in pediatric patients with NS. Objective To determine the risk factors for the progression of CKD in children with nephrotic syndrome at Dr. Zainoel Abidin Public Hospital, Banda Aceh. Methods This analytical observational study with a cross-sectional approach was conducted from September 2021 to September 2023. Data were obtained from medical records of 52 children aged 2 to 18 years in the inpatient and outpatient wards of Dr. Zainoel Abidin Public Hospital, Banda Aceh who met the inclusion criteria. Bivariate analysis using the Chi-square and Fisher's tests and multivariate analysis using logistic regression test were performed. Results Of 52 subjects, most were male and over ten years of age; 53.8% of subjects had Stage 1 CKD. The majority of stage 3-5 of CKD cases had immunosuppressive toxicity and anemia, while the majority of all subjects had hyperfiltration and proteinuria. Risk factors for CKD progression in children with NS are Hypertension (OR 2.54; 95%CI 0.32 to 20.1; P=0.003), immunosuppressant toxicity with (OR 33.67; 95%CI 2.59 to 437.5; P=0.007) and anemia (OR 33.92; 95%CI 2.77 to 414.5; P=0.006). Conclusion Hypertension, immunosuppressant toxicity and anemia for CKD progression in children with NS.
Prevalence and associated factors of infantile colic in infants of mothers in medical residency program Muzal Kadim; Wira Febrisandi Irsan; Tjhin Wiguna; Dina Muktiarti; Sulaiman Yusuf; Ade Rachmat Yudianto; Yusri Dianne Jurnalis; Yudith Setiati Ermaya; Wahyu Damayanti; Andy Dharma; Christy Venada
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

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Abstract

Background  Infantile colic, defined according to the Rome IV criteria as excessive crying in otherwise healthy infants without signs of illness or failure to thrive, could be linked to inadequate mother–infant bonding. The risk of infantile colic is increased in mothers with depression and insufficient family support. Infantile colic could lead to recurrent emergency department admissions, unnecessary treatments, and child abuse. Mothers in medical residency programs who often face long working hours, reduced bonding time with their infants, burnout, and depression, may be at an increased risk of having infants with colic. However, data on the prevalence and associated factors of infantile colic in infants of mothers in this specific population are lacking. Objective To determine the prevalence of infantile colic and its associated factors among infants of mothers participating in medical residency programs. Methods We conducted a cross-sectional study involving 67 infants of mothers in medical residency programs across seven centers in Java and Sumatra. We used the Indonesian-translated Parent Report Questionnaire for Children Aged 0-3 Years from the Rome Foundation to obtain information on infantile colic based on Rome IV criteria and the Indonesian version of the Mother-Infant Bonding Scale Questionnaire to assess the risk level of mother-infant bonding problems. An online questionnaire was distributed to subjects’ mothers via WhatsApp© application. Results  Of 67 subjects, 18 (26.8%) experienced infantile colic. High risk of mother–infant bonding problems, as indicated by elevated Mother-Infant Bonding Scale-Indonesian version (MIBS-I) scores, were significantly associated with infantile colic (OR 2.922; 95%CI 1.07 to 4.87; P=0.046). The type of nutrition, whether breast milk or a combination of formula and breast milk, did not significantly differ between infants with and without colic (OR 1.333; 95%CI 0.451 to 3.940; P=0.602). Conclusion Elevated MIBS-I scores, reflecting impaired mother–infant bonding, are ssociated with an increased risk of infantile colic in infants born to mothers in medical residency training programs.
Co-Authors Ade Rachmat Yudianto Adrian, Riki Akbar, Zaki Al-shather, Zain Amna, Eka Yunita Andy Dharma Anidar Anidar Anidar Anidar, Anidar Arqam, Abil Arsa, Iwan Sabardi Badriul Hegar Badriul Hegar Bakhtiar Bakhtiar Carolina, Infra Yunita Christy Venada Cut Zahara Phoenna Darnifayanti Darnifayanti Darnifayanti, Darnifayanti Dina Muktiarti, Dina Dora Darussalam Dora Darussalam, Dora Fajri, Fauzan Feliatra Harrika, Fenny Hasan, Denny I. Herlina Dimiati, Herlina Heru Noviat Herdata Heru Noviat Herdata, Heru Noviat Intan Chaharunia Mulya Ismy, Jufitriani Isra Firmansyah, Isra Jufitriani Ismy Liza Salawati, Liza Maghfirah, Dhiyal Maharani, Cut R. Muliana, Cut Mulya Safri, Mulya Muntadhar, Muntadhar Muslim Akmal Muslim Muslim Muzakkir, Yumna Muzal Kadim Nadia, Nurul Nora Sovira, Nora Nuriyanto, Alivia R. Nurul Maghfirah Octavina Susanti Raihani, Rifa Ramadhan, Muhammad Haris Rusdi Andid Rusdi Andid, Rusdi Sari, Eva Devita Sentosa, Sukmawan F. Siti Hajar Sofia Sofia, Sofia Sri Rezeki Susanti, Nurhayani D. Syafruddin Haris Syafruddin Haris, Syafruddin Syahrun Nur T.M. Thaib Thaib, Teuku Muhammad Tjhin Wiguna Wahyu Damayanti Wira Febrisandi Irsan Yudith Setiati Ermaya Yusri Dianne Jurnalis