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All Journal Majalah Obat Tradisional Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Syntax Idea Jurnal Pengabdian Masyarakat (ABDIRA) Proceeding of Mulawarman Pharmaceuticals Conferences AMMA : Jurnal Pengabdian Masyarakat Usadha Journal of Pharmacy Journal of Pharmaceuticals and Natural Sciences Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Al Qodiri: Jurnal Pendidikan, Sosial dan Keagamaan
Hifdzur Rashif Rija’i
Laboratorium Penelitian Dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Studi Kasus: Pasien Gagal Ginjal Kronis (Stage V) dengan Edema Paru dan Ketidakseimbangan Cairan Elektrolit: Case Study: Chronic Kidney Disease (Stage V) Patient with Pulmonary Edema and Fluid Electrolyte Imbalance Angga Cipta Narsa; Vina Maulidya; Dea Reggina; Wina Andriani; Hifdzur Rashif Rijai
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1685

Abstract

Gagal Ginjal Kronik (GGK) merupakan kondisi gangguan fungsi ginjal yang progresif dan tidak dapat pulih kembali, dimana tubuh tidak mampu memelihara metabolisme dan gagal memelihara keseimbangan cairan dan elektrolit. Pada penelitian ini pengambilan data dilakukan secara retrospektif yang dilihat dari data rekam medik. Penelitian ini bertujuan untuk membahas pengkajian pengobatan pada pasien gagal ginjal kronik dengan komplikasi. Seorang pasien Ny. WN usia 42 tahun masuk rumah sakit dengan keluhan sesak nafas, dada berdebar, mual muntah, pusing, demam dan BAB encer. Dari hasil pemeriksaan fisik dan laboratorium diketahui diagnose pasien adalah gagal ginjal kronik (GGK) stage 5 disertai edema paru, dyspnea, hipokalsemia, hiponatremia dan hiperkalemia. Pasien memiliki riwayat Hipertensi yang merupakan salah satu faktor resiko terjadinya gagal ginjal kronik (GGK).Terapi yang telah diberikan pada studi kasus ini adalah terapi yang telah sesuai dengan asuhan kefarmasian pada pasien GGK stage 5.
Aktivitas Peredaman Radikal Bebas DPPH Ekstrak dan Fraksi Daun Knema pallens W.J.deWilde Hifdzur Rashif Rija'i; La Ode Rijai; Arman Rusman
Usadha Journal of Pharmacy Vol. 5 No. 2 (2026): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v5i2.1043

Abstract

Knema pallens W.J.deWilde, yang secara lokal dikenal dengan nama Penggugut, merupakan tumbuhan endemik Kalimantan yang termasuk ke dalam famili Myristicaceae. Spesies ini umumnya ditemukan di ekosistem hutan dataran rendah, wilayah berpasir, serta kawasan hutan bakau. Meskipun memiliki potensi hayati yang khas, kajian ilmiah mengenai aktivitas bioaktif dari spesies ini masih sangat terbatas. Penelitian ini bertujuan untuk menentukan persentase rendemen, profil fitokimia, serta aktivitas peredaman radikal bebas secara kuantitatif dari ekstrak dan fraksi daun Knema pallens. Metode yang digunakan meliputi ekstraksi secara maserasi menggunakan pelarut metanol, dilanjutkan dengan fraksinasi cair-cair menggunakan pelarut n-heksana, etil asetat, dan n-butanol. Uji aktivitas antiradikal dilakukan dengan metode peredaman radikal DPPH (2,2-difenil-2-pikrilhidrazil) yang dinyatakan dalam nilai Inhibitory Concentration 50% (IC₅₀). Hasil penelitian menunjukkan bahwa rendemen tertinggi diperoleh dari fraksi n-heksana sebesar 28,9%, diikuti oleh fraksi n-butanol (9,8%), ekstrak metanol (8,04%), dan fraksi etil asetat (7,83%). Skrining fitokimia mengindikasikan adanya senyawa alkaloid, flavonoid, fenolik, serta steroid/triterpenoid dalam ekstrak dan fraksi yang diuji. Hasil uji aktivitas antiradikal menunjukkan nilai IC₅₀ sebesar 50,426 ppm (ekstrak metanol), 80,863 ppm (fraksi n-heksana), dan 40,981 ppm (fraksi etil asetat). Fraksi etil asetat menunjukkan aktivitas peredaman radikal paling kuat dengan nilai IC₅₀ terkecil. Dengan demikian, dapat disimpulkan bahwa ekstrak dan fraksi daun Knema pallens memiliki potensi antiradikal yang tergolong kuat hingga sangat kuat. Temuan ini mengindikasikan bahwa daun Knema pallens berpotensi untuk dikembangkan sebagai sumber agen antioksidan alami yang prospektif dalam bidang farmasi dan kesehatan.
AKTIVITAS ANTIHIPERURISEMIA INFUSA DAUN KENIKIR (Cosmos caudatus Kunth.) PADA MODEL MENCIT HIPERURISEMIA TERINDUKSI KALIUM OKSONAT Erwin Samsul; Muhammad Romi Adipasa Pratama; Baso Didik Hikmawan; Herman Herman; Junaidin Junaidin; Lizma Febrina; Arsyik Ibrahim; Rolan Rusli; Hifdzur Rashif Rijai; Islamudin Ahmad; Arman Rusman; M. Arifuddin
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 9 No. 1 (2026): Jurnal Farmasi Medika/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v9i1.66746

Abstract

Hyperuricemia is a metabolic disorder characterized by elevated serum uric acid levels due to excessive production or impaired excretion. Conventional therapy using xanthine oxidase inhibitors such as allopurinol is effective but may cause adverse effects with prolonged use. This study aimed to evaluate the antihyperuricemic activity of kenikir (Cosmos caudatus Kunth.) leaf infusion in a potassium oxonate-induced hyperuricemic mouse model. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and tannins. Twenty-five male mice were randomly assigned into five groups (n=5): negative control (0.5% NaCMC), positive control (allopurinol 100 mg/kgBW), and three treatment groups receiving 10%, 15%, and 20% infusion. Hyperuricemia was induced using chicken liver juice and potassium oxonate (300 mg/kgBW). Each mouse received 0.5 mL orally. Blood uric acid levels were measured hourly for four hours using EasyTouch GCU. Statistical analysis using the Kruskal–Wallis test showed no significant difference among groups (p=0.220). However, descriptively, the 15% concentration demonstrated the highest percentage reduction (56.77%), followed by 20% (41.28%) and 10% (38.74%), compared with allopurinol (66.01%). These findings suggest that kenikir leaf infusion exhibits potential antihyperuricemic activity and supports further investigation with optimized dosing, larger sample size, and enzymatic validation. Keywords: Cosmos caudatus, hyperuricemia, potassium oxonate, uric acid
Efforts to Increase Knowledge about the Impact of Illegal Cosmetics on Students of State Senior High School 5 Samarinda: Upaya Peningkatan Pengetahuan tentang Edukasi Dampak Negatif Kosmetik Illegal Bagi Kesehatan di SMA Negeri 5 Samarinda Hifdzur Rashif Rija'i; Aulia Rahmadita; A. Yuki Angraini Putri Nabila; Ni Kadek Ria Astini
Jurnal Abdita Naturafarm Vol. 3 No. 2 (2026): J Abdita Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jan.v3i2.43

Abstract

Meningkatnya penggunaan produk perawatan kulit dan kosmetik di kalangan remaja menimbulkan kekhawatiran terkait paparan kosmetika ilegal yang mengandung bahan berbahaya, sehingga diperlukan intervensi edukatif yang tepat sasaran. Penelitian ini bertujuan meningkatkan pemahaman siswa mengenai bahaya kosmetika ilegal serta pentingnya penggunaan sunscreen sebagai perlindungan dasar kulit. Program dilaksanakan melalui sesi edukasi kesehatan terstruktur kepada 48 siswa SMA dengan metode penyuluhan langsung, presentasi multimedia, penilaian pre–post test, dan diskusi interaktif. Hasil menunjukkan peningkatan signifikan dalam pengetahuan siswa yang terlihat dari kenaikan nilai post-test serta kemampuan mereka dalam mengidentifikasi ciri-ciri kosmetika ilegal, mengenali bahan berbahaya seperti merkuri dan hidrokuinon, serta memahami pemilihan dan penggunaan sunscreen yang tepat. Siswa juga menunjukkan kesadaran lebih tinggi untuk memverifikasi nomor BPOM dan berpartisipasi aktif dalam sesi tanya jawab. Penelitian menyimpulkan bahwa intervensi edukasi di lingkungan sekolah efektif meningkatkan literasi siswa mengenai keamanan kosmetik dan perilaku perlindungan kulit, sehingga penting untuk mengintegrasikan program promosi kesehatan serupa dalam kurikulum sekolah guna mencegah risiko jangka panjang akibat penggunaan produk yang tidak aman.
Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes M. Arifuddin; Rezti Amanda; Arfiani Arifin; Arfina Sukmawati Arifin; Iswahyudi Iswahyudi; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Arsyik Ibrahim; Laode Rijai
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis M. Arifuddin; Fatur Rahman Azmi; Iswahyudi Iswahyudi; Mahfuzun Bone; Harra Ismi Farrah; Hanggara Arifian; Maria Almeida; Arman Rusman; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Junaidin Junaidin; Lizma Febrina; Rolan Rusli; Arsyik Ibrahim; Islamudin Ahmad; Herman Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
Upaya Peningkatan Pengetahuan Anak Sekolah Dasar terhadap Logo dan Expire Date Obat Hifdzur Rashif Rija'i; Nanda Silvana Alfin; Nur Dwi Martini; Vincentcia Chrisanta Roentoe
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 6, No 3 (2026): Abdira
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v6i3.2137

Abstract

Knowledge of drug classifications and expiration dates is an essential component of safe medication use. However, awareness of these topics among school-age students still needs to be improved. This community service activity was conducted to educate students about drug logos and the importance of checking expiration dates before using medicines. The program was carried out through interactive educational sessions, discussions, and the distribution of leaflets as supporting educational materials. Participants’ knowledge was assessed using pre- and post-tests. The results demonstrated an improvement in students’ understanding after participating in the educational program. In addition, students actively engaged in the sessions and were able to answer questions related to the materials presented. The activity had a positive impact on students’ knowledge of proper medication use, highlighting the importance of implementing similar educational programs on a continuous basis to promote safe and responsible medicine use.
Analysis of the Integration of Halal Principles and Sustainable Beauty Principles in Cosmetics: Conceptual and Empirical Review Junaidin Junaidin; Riki Riki; Arman Rusman; Harra Ismi Farah; Maria Almeida; Hanggara Arifian; M. Arifuddin Arifuddin; Hifdzur Rashif Rija'i; Erwin Samsul; Rolan Rusli; Herman Herman; Islamudin Ahmad; Baso Didik Hikmawan; Lizma Febrina; Arsyik Ibrahim
Al Qodiri : Jurnal Pendidikan, Sosial dan Keagamaan Vol. 24 No. 2 (2026): Al Qodiri: Jurnal Pendidikan, Sosial dan Keagamaan
Publisher : Universitas Islam KH. Achmad Muzakki Syah Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53515/alqodiri.v24i2.301

Abstract

The growing convergence of halal and sustainable beauty attributes has created a need to understand how consumers translate these product perceptions into purchase intention. This study examines the effects of Halal Product Perception and Sustainable Beauty Perception on Purchase Intention through Perceived Value and Consumer Trust among cosmetic consumers in Indonesia. A quantitative explanatory design was employed using purposive sampling, involving 300 respondents who had experience using cosmetics and had encountered information about halal cosmetics and/or sustainable beauty. Data were collected through a structured questionnaire comprising 29 reflective indicators measured on a five-point Likert scale and analyzed using Structural Equation Modeling–Partial Least Squares (SEM-PLS) with SmartPLS 4. The findings show that Halal Product Perception and Sustainable Beauty Perception positively influence Perceived Value and Consumer Trust, while both mediators positively influence Purchase Intention. Halal Product Perception also has a significant direct effect on Purchase Intention, whereas Sustainable Beauty Perception does not. Mediation analysis reveals that Halal Product Perception influences Purchase Intention through complementary mediation via Perceived Value and Consumer Trust, while Sustainable Beauty Perception operates through indirect-only mediation. These findings indicate that halal attributes can function as both direct purchasing considerations and sources of value and trust, whereas sustainability perceptions require value and credibility formation before translating into purchase intention. The study contributes to an integrated understanding of halal-sustainable cosmetic consumption and offers practical implications for developing credible product attributes and transparent communication strategies.
Co-Authors A. Yuki Angraini Putri Nabila Almeida, Maria Angga Cipta Narsa Angga Cipta Narsa Annisa Anugrah Putri Arfiani Arifin Arfina Sukmawati Arifin Arman Rusman Arman Rusman Arsyik Ibrahim Arsyik Ibrahim Arsyik Ibrahim Aulia Rahmadita Baso Didik Hikmawan Baso Didik Hikmawan Dea Reggina Elisabeth James Randan Erwin Samsul Erwin Samsul Erwin Samsul Fahrul Rozi Faizah Hanan Lestari Fatur Rahman Azmi Hajrah Hajrah Hanggara Arifian Hanggara Arifian Harra Ismi Farah Harra Ismi Farrah Helmi Helmi Herman Herman Islamudin Ahmad Islamudin Ahmad Islamudin Ahmad Islamudin Ahmad Iswahyudi Iswahyudi Junaidin Junaidin Laode Rijai Lizma Febrina Lizma Febrina Lizma Febrina M. Arifuddin M. Arifuddin M. Arifuddin Arifuddin Mahfuzun Bone Masrurotin Zumaro Muhammad Romi Adipasa Pratama Nanang Fakhrudin, Nanang Nanda Silvana Alfin Ni Kadek Ria Astini Niken Indriyanti Nor Sinta Hidayati Nur Dwi Martini Putri Anggraeni Rezti Amanda Rida Wahda Maulida Tahir Riki Riki Riki Riki Rolan Rusli Rolan Rusli Rusman, Arman Salsabila Jat Dwiningrum Subagus Wahyuono Sulistiarini, Riski Venna Shintary Vina Maulidya Vincentcia Chrisanta Roentoe Wina Andriani Yusri Yusri