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All Journal Jurnal Sain Veteriner Dentika Dental Journal Jurnal Teknosains Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Jurnal Material Kedokteran Gigi Odonto dental journal

Widowati Siswomihardjo

Universitas Gadjah Mada

Author-ID : 4323450

Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Veterinary

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Pengaruh Desain Stent pada Jumlah Limfosit dan Trombosit Kelinci (Oryctolagus Cuniculus) Widowati Siswomihardjo; Dyah Anindya Widyasrini; Dinar Arifianto; Setyo Budhi; Nahar Taufiq
Jurnal Teknosains Vol 9, No 1 (2019): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.51526

Percutaneous Coronary Intervention (PCI) is an effective treatment for coronary artery diseases. For the procedure, a stent is put in the coronary arteries. There are a variety of stent materials and designs available on the market. The development of stents continues with the goal to reduce the risk of failure. The design and the ability of the stent as a vascular scaffold are important factors for the success of the stent. The implantation of a stent as a foreign body can lead to inflammation. In general, the inflammation is characterized by an increased number of lymphocytes. Then, platelets play a role in coordinating the occurrence of inflammation and immune response. This study aims to determine the effect of stent design on the number of lymphocytes and platelets as a marker of inflammation. The study was conducted on ten rabbits divided into two treatment groups, namely KP1 (new design stent) and KP2 (commercial stent) by placing a stent on the iliac artery. One hour before stenting, 2 ml of blood was collected in all experimental animals. Then, 2 ml of blood was collected again on the 7th and 28th day after stenting. Data was collected based on the number of lymphocytes and platelets from all experimental animals. Statistical analysis using two-way ANOVA shows no significant difference (p> 0.05) on the number of lymphocytes and platelets between the two groups with different stent designs. It can be concluded that the design of a stent does not show a tendency to cause inflammation.

The effect of different concentrations of Neem (Azadiractha indica) leaves extract on the inhibition of Streptococcus mutans (In vitro) Sri Kavi Subramaniam; Widowati Siswomihardjo; Siti Sunarintyas
Dental Journal (Majalah Kedokteran Gigi) Vol. 38 No. 4 (2005): December 2005
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

The Neem plant has a history for treating gum and teeth problems and this plant is used for oral care in India. The active component (Azadirachta indica) has been proven to exhibit antibacterial properties. The objective of this study was to determine the influence of different concentrations of Neem leaves extract on the inhibition of Streptococcus mutans. Neem leaves extract at concentrations of 10%, 20%, 40%, 60%, 80%, and 100% was prepared. Fifty milliliters of each concentration were dropped into holes of 6 millimeters in diameter on a MHA agar that has been inoculated with Streptococcus mutans. Distilled water was used as a control. After 24 hours of incubation, the inhibition diameters were measured and analyzed. The statistical results of the one-way analysis of variance (ANOVA) illustrated that the different concentrations of Neem extract had a significant influence on the inhibition of Streptococcus mutans. This was followed with the Least Significant Difference (LSD) which implied that there were significant differences between all the concentrations of Neem leaves extract used in this experiment. The conclusion of this study was that Neem leaves extract exhibited antibacterial effect towards Streptococcus mutans and different concentration of Neem leaves extract influenced the inhibition of Streptococcus mutans.

Pengaruh Variasi pH Terhadap Pelepasan Monomer dari Resin Komposit Nanofiller Prisca Dhyaning Dentiana; Siti Sunarintyas; Widowati Siswomihardjo
Jurnal Material Kedokteran Gigi Vol 5 No 2 (2016): JMKG Vol 5 No 2 September 2016
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Nanofilled composite resin is a kind of composite thatis used for restorative material. Nanofilled composite resin has nanometer sized silica filler, providinghigh level of aesthetic and refinement properties. Monomerbis-GMA, UDMA dan TEGDMA from composite resincan be releasedwhen in contact with oral fluid. Concentration of monomer release may affect the biocompatibility of composite resin. The objective of this studywas to determine the effect of pH variation on monomer release of nanofilled composite resin.The samples used were nanofilled composite resin Filtek Z250XT (3M ESPE, Seefeld, Germany). Twelve samples with size of 6 x 4 x 2 mm were divided into three groups and then soaked into solution of ± pH 3.5 (citric acid), ± pH 7 (distilled water), and ± pH 8 (sorensen’s phosphate) for 7 days. After 7 days of immersion, eachof the solutions was analyzed using HPLC to determine the concentration of monomer release. Monomer was analyzed using a mobile phase of acetonitrile and water with ratio of 7:3, flow rate 1 ml/min at room temperature. The column used was C18 5 µm, 125 mm in length and 4 mm in diameter. The wavelength used was 220 nm. Data were statistically analyzed usingONE-WAY ANOVA. The means concentration of monomer release (µg/ml) on the three pH groups were 2.97 ± 1.13; 1.50 ± 0.67; and 4.07 ± 0.91. Results of ONE-WAY ANOVA showed that there were differences between means concentration of monomer release from the three groups (ρ<0.05). The conclusion of this study wasthe immersion of nanofilled composite resin in an acid solution and alkaline solution increased thebis-GMAmonomer release from nanofilled composite resin.

Pengaruh Polyethylene Fiber pada Material Resin Komposit Terhadap Jumlah Koloni Streptococcus mutans Karina Larasati; Widowati Siswomihardjo; Siti Sunarintyas
Jurnal Material Kedokteran Gigi Vol 6 No 2 (2017): JMKG Vol 6 No 2 September 2017
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Fiber reinforced composite (FRC) is a material made of polymer matrix and fiber. Polyethylene fiber is one of the commonly used fiber due its good strength. FRC in the oral cavity will interact with saliva and microorganisms.S. mutans is microorganisms present in oral cavity. The purpose of this study was to determine the effect ofpolyethylene fiber on FRC to S. mutans colony counts. Flowable composite and polyethylene fiber are material used in this study. Bar-shaped samples sized 5 x 4 x 2 mm (n = 4) immersed in 5 mL saliva for 1 hour, then immersed in suspension containing S. mutans and incubated for 24 hours at 37°C. The suspension diluted to 10 then 0.1 mL of the dilution were put in a solid medium and incubated for 48 hours at 37°C. Streptococcus mutans were grown on solid media was determined by direct count. Data were statistically analyzed using unpaired t-test. The results of unpaired t-test showed a significance difference of S. mutans colony between composite resin and FRC with polyethylene fiber (p <0.05). The conclusion from this study was the addition of polyethylene fiber on the composite material significantly increased the number of colonies of Streptococcus mutans.

Pengaruh Lama Perendaman E-Glass Fiber Reinforced Composite dalam Obat Kumur Terhadap Kekuatan Fleksural Hasna Syifa Yuniva; Widowati Siswomihardjo; Siti Sunarintyas
Jurnal Material Kedokteran Gigi Vol 8 No 1 (2019): JMKG Vol 8 No 1 Maret 2019
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jmkg.v8i1.302

Fiber reinforced composite (FRC) is a material consisting of a composite resin (matrix), fiber (reinforced) and silanes (to improve the adhesion strength). FRC can be used as a crown framework. More people used mouthwash for oral hygient. The objective of this study was to know the effect of the duration of E-glass FRC immersion into the mouthwash against the flexural strength. The research materials were E-glass (Fiber Splint Polydentia Multi-Layer, Switzerland), composite resin (Master Flow Biodynamic, Brazil), silane (Monobond Ivoclar Vivadent) and mouthwash (Listerine® Multi Protect). Twelve the beam-shaped specimens (25x2x2) mm The specimens were divided into 3 groups: K1 control group (was not immersed) K2 and K3 treatment groups (was immersed for 24 and 48 hours). The flexural strength value was measured using a universal testing machine (Pearson, Texas). The data were analyzed using one-way ANOVA followed-up by LSD. The results showed decrease of the average flexural strengths of mouthwash K1, K2 and K3. The one-way ANOVA test results showed that there was a significant P>0.05 in the duration of E-glass FRC immersion into the mouthwash against the flexural strength. The LSD test results showed significant differences between all treatment groups. The conclusion of this study is that the duration of E-glass FRC immersion into mouthwash will lower the strength of flexural E-glass FRC.

Pengaruh Polyethylene Fiber pada Material Resin Komposit terhadap Jumlah Koloni Candida albicans Raymund Octavius Kusuma Buwana; Widowati Siswomihardjo; Siti Sunarintyas
Jurnal Material Kedokteran Gigi Vol 6 No 2 (2017): JMKG Vol 6 No 2 September 2017
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Fiber reinforced composite (FRC) is a material combination of polymer matrix and fiber. Fiber that commonly used in dentistry is polyethylene fiber due its resistance to abrasion. During placement of FRC in mouth, interaction will occur between the material with mucosa, saliva, and microorganisms. Candida albicans is one of many microorganisms present in oral. The purpose of this study was to determine the effect of addition polyethylene fiber on composite resin to C. albicans colony counts. Flowable composite and polyethylene fiber are material used in this study. Bar-shaped samples which sized 5x4x2 mm (n=4) immersed in 5 ml saliva for 1 hour, then immersed in suspension containing C. albicans and incubated for 2 hours at 37°C. The suspension was diluted to 10 then 0.1 mL were put in a solid medium and incubated for 48 hours at 37°C. The amount of C. albicans was determined by direct count. Data were statistically analyzed by using unpaired t-test.The result of unpaired t-test showed a significance differences of C. albicans colony between composite resin and FRC with polyethylene fiber (p <0.05). The conclusion was there was a significant increasing number of C. albicans colonies on composite resin with addition of polyethylene fiber.

Pengaruh Lama Perendaman dalam Obat Kumur Terhadap Kekerasan Polyethylene Fiber-Reinforced Composites Afra Hatim; Widowati Siswomihardjo; Siti Sunarintyas
Jurnal Material Kedokteran Gigi Vol 7 No 2 (2018): JMKG Vol 7 No 2 September 2018
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jmkg.v7i2.366

Fiber-reinforced composites (FRC) is a resin base material that strengthen with fiber. In dentistry, these materials interacts with various fluid, such as mouthwash. Mouthwash that contains alcohol affects the physical and mechanical properties of the material. The aim of this research is to determine the effect of immersion duration in mouthwash towards the hardness of polyethylene fiber reinforced composites. The materials used in this research are polyethylene (Fiber UHMWPE, Vactrise), composite resin (MasterFlow, Brazil), and mouthwash (Original Listerine® Antiseptic). Strip-shaped specimens (5x2x2)mm is light cured for 20 seconds. The specimens is divided into K1 (control group), K2 (immersed for 24 hours) and K3 (immersed for 48 hours). Hardness values is measured using Vickers Hardness Test (Buehler, Germany). The data obtained is analyzed using one way anova and followed by LSD test. The results showed the mean of hardness of groups immersed with mouthwash (0, 24, and 48 hours) are 19±0.82 VHN, 14.33±0.25 VHN, and 8.67±0.84 VHN respectively. One way anova test showed there is a significant effect (p<0,05) of immersion duration in mouthwash towards the hardness of polyethylene FRC. LSD test showed significant differences between all groups. The conclusion of this research is prolonged immersion in mouthwashes decreases the hardness of polyethylene FRC.

Pelepasan Ion Kobalt dari Aloi CoCr L605 pada Saliva Asam Hilda Mutia Hanum; Widowati Siswomihardjo; Siti Sunarintyas
Jurnal Material Kedokteran Gigi Vol 8 No 2 (2019): JMKG Vol 8 No 2 September 2019
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jmkg.v8i2.435

CoCr has high mechanical properties but may release ion in an acidic environment as in the oral cavity. Cobalt (Co) ion can release from CoCr alloy if such material is immersed in acidic environment. This situation may lead to several consequences including allergies and oral lesions. The aim of this research was to determine the influence of pH degree on acidic saliva to the Co ion release concentration of CoCr L605 alloy. This research used CoCr L605 alloy and artificial saliva. Twelve samples of CoCr L605 metal plates were made into (10x10x1.5) mm size. The samples were divided into three groups; each group immersed in 20 ml of artificial saliva for 14 days, 37o C. The pH variables for the groups are 3, 5 and 7. Co ion released was measured by Atomic Absorption Spectroscopy (AAS). Data analysis was performed by one-way ANOVA (Analysis of Variance). The result showed that the mean of concentration value of Co ion released for group pH of 3, 5 and 7 were (3.0970±0.612)ppm; (2.0250±0.609) ppm; and 0.000 ppm respectively. One-way ANOVA showed that pH degree of acidic saliva significantly influenced by the Co ion release concentration (p<0.05). LSD test showed a significant difference between groups. The conclusion of this research was the less pH degree of saliva, the concentration of Co ion released of CoCr L605 alloy was higher.

Effectiveness of Aspergillus sp. extract in denture adhesive on surface roughness of acrylic resin on Candida albicans biofilm formation Fadriyanti, Okmes; Nasution, Ismet Danial; Siswomihardjo, Widowati; Handayani, Dian
Majalah Kedokteran Gigi Indonesia Vol 9, No 2 (2023): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.64485

The denture adhesive increases retention on the denture base and affects oral microorganisms. Adding antifungals to denture adhesives can inhibit the Candida albicans biofilms formation and prevent denture stomatitis. The combination of denture adhesives and herbal medicines is an alternative to antifungals, which have few side effects because it is a plant. Moreover, one of them is the endophytic Aspergillus sp. extract containing chemical compounds that can inhibit the Candida albicans biofilms formation. This study aims to analyze the effectiveness of the endophytic Aspergillus sp. extract in denture adhesive materials for Candida albicans biofilm formation on acrylic resin surfaces. The research method is to extract the Aspergillus sp. extract antibiofilm test. Denture adhesive formulation was adjusted to the standard, and added Aspergillus sp. with concentrations of 3.125%, 6.25%, 12%, and 25%. The research sample used hot polymerized acrylic resin. The control group used X denture adhesive and added nystatin, each group suspended by Candida albicans for 24, 48, and 72 hours. Examination of biofilm formation activity on the surface of acrylic resin used SEM. The analysis used Two Way Anova. Aspergillus sp. extract in denture adhesive effectively prevents Candida albicans biofilm formation within 24 hour incubation time. In conclusion, extract of the endophytic Aspergillus sp. in denture adhesive can inhibit the formation of Candida albicans biofilm on the surface roughness of acrylic resin.

Antibacterial effect of alpha-mangostin from Garcinia mangostana. L against oral streptococci and staphylococci biofilms: a systematic review Praptiningsih, Rahmawati Sri; Siswomihardjo, Widowati; Jonarta, Alma Linggar; Yulianto, Heribertus Dedy Kusuma; Syifa, Liftia Layyinatus; Rochmah, Yayun Siti; Ichwan, Solachuddin Jauhari Arief
Padjadjaran Journal of Dentistry Vol 36, No 2 (2024): July 2024
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol36no2.53957

ABSTRACTIntroduction: Interactions among competing bacteria, which inhibit each other's growth to maintain the balance of microorganisms in the biofilm, can influence oral cavity homeostasis. Natural products contain compounds with the potential to combat various diseases, including caries. Alpha-mangostin from Garcinia mangostana. L exhibits antibacterial properties against oral streptococci and staphylococci, acting through several mechanisms, including the disruption of peptidoglycan, which ultimately leads to cell brittleness and rupture. This study aims to assess the impact of antibacterial alpha-mangostin on oral streptococci and staphylococci biofilm. Methods: The research methodology employed secondary data collection through a systematic review study. We conducted searches across databases including PubMed, ScienceDirect, and Google Scholar to identify Indonesian and English references encompassing textbooks, research findings, reviews, and internet articles relevant to the topic published between 2014 and 2024. Following a thorough screening process, we selected articles deemed pertinent for inclusion in the review. Subsequently, these articles underwent evaluation for full-text accessibility, language compatibility, and availability of information from the respective journals, resulting in the selection of 20 articles. Results: Analysis was carried out on 20 articles. Ten articles described the effects of alpha-mangostin's inhibit oral biofilm, 6 articles discussed the effects of alpha-mangostin's antibacterial activity against Streptococcus mutans and Streptococcus sanguis, 3 article state mechanism alpha-mangostin inhibit membrane enzymes such as F(H+)-ATPase and the phosphoenolpyruvate-sucrose phosphotransferase system on Staphylococcus aureus. Additionally, one article described inhibition mechanisms of aldolase, glyceraldehyde-3-phosphate dehydrogenase, and lactic dehydrogenase on Staphylococcus epidermidis. Conclusion: Alpha-mangostin inhibits and disrupts biofilm defense mechanisms. It possesses antimicrobial properties effective against oral streptococci and staphylococci, including Streptococcus mutans, Streptococcus sanguis, Staphylococcus aureus and Staphylococcus epidermidis. These properties operate through various mechanisms, including enhancing the permeability of bacterial cell walls, ultimately leading to bacterial cell death.KEYWORDSOral biofilm, alpha-mangostin, oral streptococci, staphylococci

Co-Authors Afra Hatim Agustina Dwi Wijayanti Akmal, Syazwani Alma Linggar Jonarta Alva Edy Tontowi Arifianto, Dinar Dewa Made Wedagama Dian Handayani Dinar Arifianto Dyah Anindya Widyasrini Dyah Irnawati Fadriyanti, Okmes Fitri Isnaini Gusti Ayu Yohanna Lily Harsini Haryo Mustiko Dipoyono, Haryo Mustiko Hasna Syifa Yuniva Hengky Bowo Ardhiyanto Heri Wijayanto Heribertus Dedy Kusuma Yulianto Hilda Mutia Hanum Ichwan, Solachuddin Jauhari Arief Jukka Pekka Matinlinna Julita Hendrartini Karina Larasati Liftia Layyinatus Syifa Marsetyawan H.N.E. Soesatyo Marsetyawan Heparis Nur Ekanda Soesatyo Mochammad Taha Ma’ruf Nahar Taufiq Nasution, Ismet Danial Prisca Dhyaning Dentiana R. Rochmadi Rahmawati Sri Praptiningsih Raymund Octavius Kusuma Buwana Rochmadi Rochmadi Setyo Budhi Setyo Budhi Siti Sunarintyas Soesatyo, Marsetyawan Heparis Nur Ekandaru Sri Kavi Subramaniam Syazwani Akmal Titik Ismiyati Verani, Dhea Maurilla W. Widjijono Wibowo, Diva Agrita Dentisia Yasnawi, Mohammad Imanuddin Yayun Siti Rochmah

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