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Antibacterial effect of alpha-mangostin from Garcinia mangostana. L against oral streptococci and staphylococci biofilms: a systematic review Praptiningsih, Rahmawati Sri; Siswomihardjo, Widowati; Jonarta, Alma Linggar; Yulianto, Heribertus Dedy Kusuma; Syifa, Liftia Layyinatus; Rochmah, Yayun Siti; Ichwan, Solachuddin Jauhari Arief
Padjadjaran Journal of Dentistry Vol 36, No 2 (2024): July 2024
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol36no2.53957

ABSTRACTIntroduction: Interactions among competing bacteria, which inhibit each other's growth to maintain the balance of microorganisms in the biofilm, can influence oral cavity homeostasis. Natural products contain compounds with the potential to combat various diseases, including caries. Alpha-mangostin from Garcinia mangostana. L exhibits antibacterial properties against oral streptococci and staphylococci, acting through several mechanisms, including the disruption of peptidoglycan, which ultimately leads to cell brittleness and rupture. This study aims to assess the impact of antibacterial alpha-mangostin on oral streptococci and staphylococci biofilm. Methods: The research methodology employed secondary data collection through a systematic review study. We conducted searches across databases including PubMed, ScienceDirect, and Google Scholar to identify Indonesian and English references encompassing textbooks, research findings, reviews, and internet articles relevant to the topic published between 2014 and 2024. Following a thorough screening process, we selected articles deemed pertinent for inclusion in the review. Subsequently, these articles underwent evaluation for full-text accessibility, language compatibility, and availability of information from the respective journals, resulting in the selection of 20 articles. Results: Analysis was carried out on 20 articles. Ten articles described the effects of alpha-mangostin's inhibit oral biofilm, 6 articles discussed the effects of alpha-mangostin's antibacterial activity against Streptococcus mutans and Streptococcus sanguis, 3 article state mechanism alpha-mangostin inhibit membrane enzymes such as F(H+)-ATPase and the phosphoenolpyruvate-sucrose phosphotransferase system on Staphylococcus aureus. Additionally, one article described inhibition mechanisms of aldolase, glyceraldehyde-3-phosphate dehydrogenase, and lactic dehydrogenase on Staphylococcus epidermidis. Conclusion: Alpha-mangostin inhibits and disrupts biofilm defense mechanisms. It possesses antimicrobial properties effective against oral streptococci and staphylococci, including Streptococcus mutans, Streptococcus sanguis, Staphylococcus aureus and Staphylococcus epidermidis. These properties operate through various mechanisms, including enhancing the permeability of bacterial cell walls, ultimately leading to bacterial cell death.KEYWORDSOral biofilm, alpha-mangostin, oral streptococci, staphylococci

Effect of corncob powder concentration on properties of inlay waxes Irnawati, Dyah; Harsini; Widjijono; Siswomihardjo, Widowati; Sunarintyas, Siti; Yasnawi, Mohammad Imanuddin; Verani, Dhea Maurilla
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p242-248

Background: Corncob powder is a promising filler that needs to be assessed when it is incorporated into inlay waxes to modified its properties. Purpose: This study aims to investigate the effect of different concentrations of corncob powder filler on physical and mechanical properties of inlay waxes. Methods: Five groups of inlay waxes were prepared from paraffin, corncob powder, carnauba wax, and beeswax in varying proportions (w/w%), namely, group I (70:0:25:5), II (65:5:25:5), III (60:10:25: 5), IV (55:15:25:5), and V (50:20:25:5). The wax mixture was heated at 80°C, filtered, added with corncob powder, and stirred until homogeneous then poured into mold for melting point, residue on ignition, flow, hardness, and trimming samples. They were based on ANSI/ADA specification no.122 and ASTM D 1321. The data were analyzed through one-way ANOVA, post-hoc LSD, and Tamhane tests (p = 0.05), except trimming test data. Results: One-way ANOVA revealed that the concentration of corncob filler influenced all inlay waxes properties (p<0.05). LSD and Tamhane post-hoc test, showed significant different among mostly between groups of tests. Addition corncob powder increased the melting point, hardness, and residue of inlay waxes but decreased the flow of inlay waxes. Addition corncob did not influence the trimming property of inlay waxes. Conclusion: The concentration of corncob filler added in inlay wax compositions influenced the melting point, flow, hardness and residue properties but did not influence trimming properties. Inlay wax containing 10% corncob filler potential as a local inlay wax, but further research should be done to overcome the residue on ignition property that higher than standards.

Perilaku dan Gambaran Hematologis Beruk (Macaca nemestrina) yang Dipasang Bare metal stent pada Arteri Iliaca Arifianto, Dinar; Wijayanti, Agustina Dwi; Budhi, Setyo; Wijayanto, Heri; Siswomihardjo, Widowati
Jurnal Sain Veteriner Vol 43, No 2 (2025): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.70940

Penyakit kardiovaskuler yang paling banyak diderita oleh masyarakat Indonesia adalah penyakit jantung coroner. Salah satu metode terapi jantung korner adalah dengan pemasangan stent jantung. Saat ini stent jantung yang digunakan oleh kardiolog di Indonesia masih mengandalkan produk impor. Saat ini Universitas Gadjah Mada (UGM) sedang mengembangkan stent dengan desain dan bahan yang telah diteliti sebelumnya yang disebut dengan INA-Stent. Tahap pre-klinis telah dilaksanakan dengan menggunakan hewan beruk (Macaca nemestrina). Pemasangan bare metal stent (tanpa salut obat) telah dipasang pada bulan September tahun 2018. Proses euthanasia dilaksanakan pada bulan September 2021 di ruang kateterisasi Rumah Sakit Hewan pendidikan Prof. Soeparwi Fakultas Kedokteran Hewan (FKH UGM). Sebelum pelaksanaan euthanasia diambil sampel darah sebanyak 1 ml pada tabung ethylene diamine tetra acetic acid (EDTA). Pemeriksaan darah menunjukkan total eritrosit, hemoglobin, PCV, MCV, total leukosit, dan trombosit dalam batas normal. Abnormalitas yang terjadi antara lain limfopenia, monositosis dan hipokromia.

UTILIZATION OF JKN DENTAL PROSTHETIC SERVICES AT FIRST LEVEL DENTAL HEALTH FACILITIES IN BALI Lily, Gusti Ayu Yohanna; Siswomihardjo, Widowati; Hendrartini, Julita; Dipoyono, Haryo Mustiko; Wedagama, Dewa Made
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

ABSTRACTBackground: The utilization of dental prosthesis services in Indonesia is rare, compared to other dental and oral health services. The use of prosthesis services in Bali is still relatively low compared to other parts of Western Indonesia. Based on data from BPJS Kesehatan Denpasar Branch Office, the demand for dental prostheses services by participants in the three working areas of BPJS Kesehatan Denpasar Branch Office is still low. Method: This research was conducted using quantitative research. The population were all participants providers of FKTP BPJS Kesehatan Badung Regency, and samples were taken through purposive sampling. Quantitative data were analyzed using binary logistic regression.Result: The results that the predisposing factors for JKN program participants (income, knowledge of dental prostheses, knowledge of JKN dental prosthesis services, perceptions of service quality, and perceptions of cost); enabling factor (access), and the need factor (the perception of pain when losing a tooth) contributions have a significant positive effect on the utilization rate of JKN dental prostheses. The predisposing factors (age and education) and enabling factor (social support) do not have a significant effect on the utilization rate of JKN dental prostheses. Conclusion: The results that the predisposing factors for JKN program participants contributions have a significant positive effect on the utilization rate of JKN dental prostheses.

UTILIZATION OF JKN DENTAL PROSTHETIC SERVICES AT FIRST LEVEL DENTAL HEALTH FACILITIES IN BALI Lily, Gusti Ayu Yohanna; Siswomihardjo, Widowati; Hendrartini, Julita; Dipoyono, Haryo Mustiko; Wedagama, Dewa Made
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.2.126-130

ABSTRACTBackground: The utilization of dental prosthesis services in Indonesia is rare, compared to other dental and oral health services. The use of prosthesis services in Bali is still relatively low compared to other parts of Western Indonesia. Based on data from BPJS Kesehatan Denpasar Branch Office, the demand for dental prostheses services by participants in the three working areas of BPJS Kesehatan Denpasar Branch Office is still low. Method: This research was conducted using quantitative research. The population were all participants providers of FKTP BPJS Kesehatan Badung Regency, and samples were taken through purposive sampling. Quantitative data were analyzed using binary logistic regression.Result: The results that the predisposing factors for JKN program participants (income, knowledge of dental prostheses, knowledge of JKN dental prosthesis services, perceptions of service quality, and perceptions of cost); enabling factor (access), and the need factor (the perception of pain when losing a tooth) contributions have a significant positive effect on the utilization rate of JKN dental prostheses. The predisposing factors (age and education) and enabling factor (social support) do not have a significant effect on the utilization rate of JKN dental prostheses. Conclusion: The results that the predisposing factors for JKN program participants contributions have a significant positive effect on the utilization rate of JKN dental prostheses.

Long-term preclinical evaluation of a bare-metal stent (INA-Stent) in the iliac arteries of Macaca nemestrina Wijayanti, Agustina Dwi; Arifianto, Dinar; Wijayanto, Hery; Purnomo, Agus; Budi, Setyo; Taufiq, Nahar; Yulianto, Heribertus Dedy Kusuma; Siswomihardjo, Widowati
Jurnal Medik Veteriner Vol. 9 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol9.iss1.2026.234-241

This study represents the final phase of a preclinical investigation assessing the outcomes of bare-metal stent (INA-Stent) implantation in the iliac arteries of Macaca nemestrina. The aim of the study was to evaluate the condition of the stent and to determine the presence or absence of restenosis and inflammation in the surrounding tissue. The INA-Stent was implanted in four healthy adult M. nemestrina. The animals were euthanized at 6- and 9-month intervals to enable clinical and histological evaluation of the implanted stents. This study specifically reports the terminal preclinical evaluation of the final M. nemestrina, in which the stent had been implanted for 36 months. The assessment was conducted to identify clinical signs and to determine the condition of the stent following surgical implantation in the iliac artery. The procedures included clinical evaluation, anesthesia, catheterization, intravascular optical coherence tomography (OCT), followed by euthanasia, necropsy, and scanning electron microscopy (SEM). Based on the SEM and OCT findings, the INA-Stent was well integrated into the arterial wall, did not induce chronic inflammation, and showed no evidence of restenosis at 36 months post-implantation.

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