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All Journal Jurnal Kefarmasian AKFARINDO ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita Public Health and Safety International Journal (PHASIJ) Jurnal Pengabdian Masyarakat (Jupemas) Jurnal Komunitas Farmasi Nasional PharmaCine: Journal of Pharmacy, Medical and Health Science Indonesian Journal of Herbal Science and Innovation
Kharina Septi Lestari
Universitas Bhakti Kencana
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Toksisitas Akut Ekstrak Etanol Rimpang Pacing (Costus speciosus) pada Embrio Zebrafish (Danio rerio) Kharina Septi Lestari; Aulia Utami Widiati; Aulia Nurfazri Istiqomah
Indonesian Journal of Herbal Science and Innovation Vol. 1 No. 1 (2025): Indonesian Journal of Herbal Science and Innovation
Publisher : PT CENDEKIA SCIENCE AND TECHNOLOGY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64673/ijherbsi.v1i1.2

Abstract

The Costus speciosus plant, commonly known as pacing, is widely used both as an ornamental plant and in traditional medicine. All parts of the plant, particularly the rhizomes, are known to possess various pharmacological activities, including anti-diabetic, anti-cancer, anti-bacterial, and anti-inflammatory properties. However, with the extensive use of the rhizomes in traditional medicine, it is essential to assess their safety. This study aims to determine the LC50 value of ethanol extract from Costus speciosus rhizomes (EERP) and evaluate its acute toxicity level. The Fish Embryo Acute Toxicity (FET) Test was used to assess toxicity, employing zebrafish (Danio rerio) embryos as the model organism. Zebrafish are chosen because their genetic makeup shares about 60-70% similarity with humans, making them a suitable model for mapping toxic effects. The study involved seven experimental groups: two control groups (negative and positive controls) and five groups treated with varying concentrations of EERP (62.5 ppm, 31.25 ppm, 15.63 ppm, 7.81 ppm, and 3.91 ppm). The results revealed an LC50 value of 11.707 ppm for EERP, indicating that the extract falls under the "slightly toxic" category. These findings provide valuable insights into the potential toxicity of Costus speciosus, which is crucial for determining safe dosage levels in its use as a traditional medicine. Further research is needed to explore the underlying toxic mechanisms of this extract.
An Evaluation of Reported Anti-Tuberculosis Drug Reactions at the DOTS Pharmacy Depot in Al-Ihsan Regional Hospital, West Java Kharina Septi Lestari; Endah Astri Wijiastuti; Yanni Dhiani Mardhiani
Indonesian Journal of Herbal Science and Innovation Vol. 1 No. 2 (2025): Indonesian Journal of Herbal Science and Innovation (IJHerbSI)
Publisher : PT CENDEKIA SCIENCE AND TECHNOLOGY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64673/ijherbsi.v1i2.9

Abstract

Tuberculosis (TB) remained a major public health concern in Indonesia, which ranked second globally after India in TB burden. As TB treatment relied on long-term administration of combined Anti-Tuberculosis Drugs (OAT), patients often experienced treatment challenges, including adverse drug reactions that could reduce adherence and compromise therapeutic success. However, local data regarding the pattern of these reactions—particularly in West Java—had been limited, creating a gap in monitoring practices that were essential for improving patient outcomes. This study aimed to evaluate the types and frequencies of adverse drug reactions reported by TB patients receiving treatment at the DOTS Pharmacy Depot of Al-Ihsan Regional Hospital. This research used a descriptive design with primary data collected from the DOTS Pharmacy Depot. Reported adverse reactions were compiled and analyzed, then presented in tables and graphs to provide a clear overview of the distribution of events. The evaluation focused on patients undergoing Category I OAT therapy during 2023, allowing the study to capture real-world reactions experienced over the course of standard TB treatment. The findings showed that female patients experienced more adverse reactions than males, suggesting potential sex-related differences in susceptibility or reporting. Overall, gastric pain emerged as the most common adverse effect (39.09%), followed by itching (33.04%), headache (11.07%), hyperuricemia (6.64%), nausea and vomiting (5.15%), and epigastric pain (4.13%). These reactions aligned with the known pharmacological profiles of first-line OAT regimens, particularly rifampicin and pyrazinamide, which are commonly associated with gastrointestinal irritation and metabolic disturbances. In conclusion, the study highlighted the urgent need for enhanced pharmacovigilance, early recognition of common adverse reactions, and improved patient education to support treatment adherence. Understanding local patterns of drug reactions provided valuable insights for clinicians and contributed to more effective TB management strategies in West Java.
POTENSI ANTIATEROGENIK KOMBINASI EKSTRAK ETANOL RIMPANG KUNYIT DAN DAUN PEGAGAN DALAM MENURUNKAN RISIKO PENYAKIT KARDIOVASKULAR PADA MODEL HEWAN TIKUS OBES Kharina Septi Lestari; Aulia Nurfazri Istiqomah; Ai Siti Farihah; Dika Azhar Ramadhan; Marita Kaniawati; Agus Sulaeman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2882

Abstract

Obesity is a major risk factor for atherosclerosis and cardiovascular disease, characterized by dyslipidemia and oxidative stress. This study aimed to evaluate the anti-atherogenic effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa) and gotu kola leaves (Centella asiatica) in obese–hyperlipidemic rats.  Male rats were divided into seven groups: normal, induction, comparator (orlistat 10.8 mg/kgBW), and treatment groups receiving single and combined extracts (ERK, EDP, ERKDP 200:100, ERKDP 100:200 mg/kgBW). Obesity and hyperlipidemia were induced using a high-fat and fructose diet for 60 days. Parameters measured included body weight, lipid profile (TG, HDL, LDL, total cholesterol), Atherogenic Index of Plasma (AIP), and aortic histology. The induction group showed significant increases in body weight, triglycerides, LDL, and AIP (P<0.05). All treatment groups significantly improved lipid profiles and reduced AIP compared to the induction group. The ERKDP 100:200 mg/kgBW combination showed the most optimal effect, with a 51.83% reduction in LDL, a 54.60% decrease in AIP, and a 146% increase in HDL. Histological analysis also demonstrated reduced foam cell formation and improved aortic structure in this group. In conclusion, the combination of turmeric and gotu kola extracts, particularly at a dose of 100:200 mg/kgBW, exhibits significant anti-atherogenic potential through lipid profile improvement, AIP reduction, and vascular protection.
Co-Authors Agus Miraj Darajat Agus Sulaeman Ai Siti Farihah Aiyi Asnawi Aligita, Widhya Amelia Kandisa Angga Cipta Narsa Anissa Nadya Oktriyani Antri Ariani Aris Suhardiman Aulia Utami Widiati Boy Ignatius Simamora Budiman Dika Azhar Ramadhan Dyan Kunthi Nugrahaeni Elis Susilawati Endah Astri Wijiastuti Fikri Mourly Wahyudi Imas Fauzya Zahra Istiqomah, Aulia Nurfazri Jamiyanti, Anggi KOSASIH KOSASIH, KOSASIH Marita Kaniawati Marita Kaniawati Novie Elvinawaty Mauliku Novitasari Tsamrotul Fuadah Nur Rakhmanto Heryana Oktriyani, Anissa Nadya Pahlevi, Muhamad Reza Prasesti, Gayuk Kalih Pratama, Reza Purwaniati, Purwaniati - Reza Pratama Rijai, Akhmad Jaizzur Rizky Prabawa Nugraha Roni, Asep Silvi Nur Amalia Simamora, Boy Ignatius Siti Kholisatun Nisa Suhat Suhat Wahyudi, Vierly Stephany Putri Widhya Aligita Yanni Dhiani Mardhiani Zulkaida, Zulkaida