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All Journal Interaksi Online Journal of Politic and Government Studies Jurnal Mudarrisuna: Media Kajian Pendidikan Agama Islam Indonesian Journal of Cardiology Heart Science Journal Narra J Jurnal Abdimas Kartika Wijayakusuma JUSTIN (Jurnal Sistem dan Teknologi Informasi) Jurnal Klinik dan Riset Kesehatan Jurnal Penelitian Dan Pengkajian Ilmiah Sosial Budaya Eduvest - Journal of Universal Studies JRIIN :Jurnal Riset Informatika dan Inovasi Karimah Tauhid Adil Indonesia Journal
Indra Prasetya
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Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Sudden Cardiac Death In Young Age, What Should We Know? Rochmawati, Icmi Dian; Rizal, Ardian; Putri, Valerinna Yogibuana Swastika; Prasetya, Indra
Heart Science Journal Vol. 5 No. 2 (2024): Challenges in the Management of Congenital Heart and Structural Heart Diseases
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.02.7

Abstract

While young sudden cardiac death (SCD) is statistically uncommon, its dramatic presentation and the impact it has on families and communities make it a newsworthy issue. Nonetheless, it is important to view SCD in children and adolescents as a public health concern and devise strategies based on research and consensus to address it. Both individuals with and without a history of cardiovascular illness are susceptible to sudden cardiac death. Employing cardiovascular disease risk screening for healthy individuals and those with a family history of sudden cardiac death can serve as a preventive approach against sudden cardiac death. Assessing the severity of cardiovascular disease in people becomes essential in order to prevent disease progression and minimize the risk of mortality from cardiovascular conditions.
Utilizing APACHE IV and GRACE Scores as Predictors of Mortality Compared with SAPS-3 Scores for Acute Coronary Syndrome Patients in the Cardiac Vascular Care Unit Nugraha, Tria Yudha; Prasetya, Indra; Anjarwani, Setyasih
Heart Science Journal Vol. 5 No. 3 (2024): The Science and Art of Revascularization in Acute Coronary Syndrome
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.03.8

Abstract

Background: Acute coronary syndromes (ACS) frequent cause of hospitalization in the cardiovascular care unit. Positive predictive data are being developed and shown to be effective for patients with ACS; the Global Registry of Acute Coronary Events, or GRACE, has shown the most accurate outcomes. In contrast, prognostic scores derived from diverse cohorts of critically ill patients are predominantly employed by intensive care clinicians. Prominent examples of such scores include APACHE IV and SAPS 3. The objective of this research endeavor was to assess and contrast the efficacy of these three scores across an unselected sample of ACS cases.Objective: The Cardiovascular Care Unit of RSUD Dr. Saiful Anwar Malang treats Acute Coronary Syndrome patients. This study compares SAPS 3, GRACE, and APACHE IV score parameters through calibration and discrimination tests to predict patient mortality.Methods: The study included all ACS patients admitted from August 2021 to November 2023. Hospital mortality prediction was assessed using score calibration and discrimination.Results: There were 843 patients in total included. SAPS 3 could not be calibrated appropriately, whereas APACHE IV and GRACE could. Across all scores, discrimination was exceptional (area under the curve values of 0.811 for APACHE IV, 0.740 for GRACE, and 0.732 for SAPS 3).Conclusions: GRACE and APACHE IV were calibrated thoroughly in this cohort of intensive care unit-admitted ACS patients; however, SAPS 3 lacked such calibration. All three scores exhibited exceptional discrimination. GRACE and APACHE IV may be utilized to predict the risk of mortality in patients with ACS.
The role of colchicine on ventricular remodelling following myocardial infarction and ischemia-reperfusion injury: article review Caesario, Fahreza; Prasetya, Indra
Heart Science Journal Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2024.005.04.3

Abstract

Acute myocardial infarction (AMI) is a major cause of cardiac dysfunction, arrhythmias, and a poor prognosis. Even though new technologies have been developed to aid in opening the culprit coronary artery and correcting ischemia-related stenosis by percutaneous coronary intervention (PCI), the ventricular remodelling that induces cardiac failure as a consequence of AMI remains unchanged. Colchicine, a versatile anti-inflammatory medication, has been documented in mitigating cardiac remodelling and enhancing cardiac function following AMI. This article provides an in-depth review of the processes by which colchicine affects ventricular remodeling after AMI, highlighting the potential role of inflammation in the pathogenesis and progression of ventricular dysfunction.
Hypokalemia Induced Ventricular Arrhythmia In Heart Failure Patient With Complete Revascularization: A Case Report Rochmawati, Icmi Dian; Rizal, Ardian; Rohman, Mohammad Saifur; Prasetya, Indra
Heart Science Journal Vol. 4 No. 4 (2023): The Science and Art of Caring for Critically III Patients in Intensive Cardiac
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2023.004.04.7

Abstract

BackgroundSudden mortality due to persistent VT or VF accounted for around half of all fatalities in these high-risk individuals. Myocardial ischemia, acute heart failure, electrolyte abnormalities, hypoxia, and drug-related arrhythmogenicity are all risk factors for electrical storms. The most common electrolyte imbalance is hypokalemia.Case illustration:A 54-year-old man was readmitted to ER with palpitations and chest pain. The patient's heart rate was recorded as sinus bradycardia however, shortly the patient developed ventricular tachycardia of approximately 300 beats per minute (bpm) and unstable. Although multiple synchronized cardioversion dosage was administered, the VT reoccurred again. Complete revascularization was demonstrated at his most recent catheterization three months ago. His potassium in the serum was 2.88 mmol/L and corrected with drip KCl. The patient's potassium levels were then normalized stable for the remainder of their hospital stay.ConclusionCareful medication reconciliation is critical for avoiding the potentially fatal cardiovascular effects of severe hypokalemia. Patients with CHF are more likely to have life-threatening hypokalemia and ventricular arrhythmias. The phenotypic expression of ventricular tachycardia in HF results from alterations in neurohormonal signaling, structural remodeling, and electrophysiology.
Effects of the Low-Dose Colchicine Regimen on Left Ventricular Adverse Remodeling and Systolic Function in Acute Myocardial Infarction Patients With Anterior ST Segment Elevation Undergoing Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial Caesario, Fahreza; Prasetya, Indra; Rohman, Mohammad Saifur; satrijo, Budi; Anjarwani, Setyasih
Heart Science Journal Vol. 5 No. 2 (2024): Challenges in the Management of Congenital Heart and Structural Heart Diseases
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.02.9

Abstract

Background: Inflammation in reperfusion injury results in adverse ventricular remodeling and reduced systolic function. The anti-inflammatory effects of colchicine have shown beneficial effects in cardiovascular disease.Objective: To determine the effects of low-dose colchicine on left ventricular (LV) adverse remodeling and systolic function in acute myocardial infarction with anterior ST-segment elevation (anterior STEMI) patients undergoing primary percutaneous coronary intervention (PPCI).Material and Methods: This prospective, randomized, double-blinded study randomly assigned anterior STEMI patients who underwent PPCI to receive either low-dose colchicine (1mg loading dose followed by 0.5mg daily) or a matching placebo for 30 days in addition to standard therapy. Outcomes included adverse LV remodeling and systolic function, determined by transthoracic echocardiography (TTE) in the first and third month.Result: Enrollment comprised 196 patients, with 92 patients in the colchicine group and 104 patients in the placebo group. Adverse LV remodeling and a decrease in systolic function were observed in both groups. No significant differences in LV remodeling were observed between the colchicine and placebo groups, as indicated by the change in LV end-systolic volume index (LVESVI) at the first month (16.5% vs. 18.25% [p=0.091]) and third month (19.5% vs. 21.5% [p=0.124]). Similar results were found in LV systolic function between the colchicine and placebo groups, with a reduction in LV ejection fraction (LVEF) observed in the first month (6.3% vs. 8.95% [p=0.083]) and third month (9.5% vs. 11.5% [p=0.163]). Diarrhea was the only reported side effect, occurring in 6.5% of patients in the colchicine group.Conclusion: Low-dose colchicine administration in anterior STEMI patients undergoing PPCI did not reduce LV adverse remodeling or systolic function.
Correlation between HbA1c levels and intrastent restenosis incidence in patients with diabetes mellitus after percutaneous coronary intervention at Dr. Saiful Anwar General Hospital Millisani, Hayla Iqda; Prasetya, Indra; Rohman, Mohammad Saifur
Heart Science Journal Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2024.005.04.10

Abstract

Background: Patients with chronic uncontrolled diabetes mellitus as indicated by HbA1c levels ≥ 6.5%, increase the risk of atherosclerosis, thereby increasing in-stent restenosis incidence during and after percutenous coronary intervention. Regular monitoring of HbA1c is crucial to reduce the incidence of in-stent restenosis.Objective: This study aims to ascertain the correlation between HbA1c levels and in-stent restenosis incidence in diabetes mellitus patients after percutenous coronary intervention at Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia.Methods/Design: Analytical observational study with a retrospective cohort study approach to determine the correlation between HbA1c levels and the incidence of in-stent restenosis in patients with diabetes mellitus after percutenous coronary intervention. The research sample was carried out by consecutive sampling in January 2021-December 2023.Results: This study has recruited 555 patients with coronary artery disease and diabetes mellitus. The average age of coronary heart disease patients with diabetes mellitus was 59 years. Patients with HbA1c levels ≥6.5 were more prone to experience in-stent restenosis 54 patients, while those with HbA1c levels <6.5 were more prone not to experience in-stent restenosis 388 patients, indicating a significant correlation between HbA1c and in-stent restenosis p=0.024. in-stent restenosis was most frequently observed in the LAD 44 patients, RCA 13 patients, LCx 10 patients, and LM 0 patient. The highest percentage of in-stent restenosis cases was over 70%, with 3VD lesions being the most common 55 patients. OAD therapy is most often given to coronary heart disease patients with diabetes mellitusConclusion: There is a correlation between HbA1c levels and the incidence of in-stent restenosis in diabetes mellitus patients after percutaneous coronary intervention, underscoring the necessity for routine blood glucose monitoring to prevent in-stent restenosis.
Inflammatory cascade unveiled: Exploring complications and therapeutic strategies for post-myocardial infarction inflammation (A literature review) Bahar, Mokhamad Aswin; Prasetya, Indra
Heart Science Journal Vol. 5 No. 3 (2024): The Science and Art of Revascularization in Acute Coronary Syndrome
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.03.4

Abstract

This comprehensive literature review delves into the inflammatory ramifications of myocardial infarction (MI), a global health concern with reported prevalences of 3.8% and 9.5% among those under and over 60 years, respectively. While the inflammatory cascade plays a crucial role in MI healing, its dysregulation can lead to complications. Recent advancements have unveiled intricate cellular and molecular pathways. The common post-MI complication of pericarditis poses diagnostic challenges due to symptom similarities with MI, requiring careful management, particularly in cases of Dressler’s syndrome. Promising therapeutic strategies, including anti-inflammatory approaches and ongoing drug development, are under exploration. Future research directions involve delving into unknown factors, identifying novel therapeutic targets, and validating emerging treatments in larger trials, emphasizing the imperative need for continued investigation into the inflammatory consequences of MI.
Diagnostic Test for Estimation of Plasma Volume on Assessment of Congestive Status in Acute Heart Failure Patients at Saiful Anwar General Hospital Pamuna, Oktafin Srywati; Prasetya, Indra; Astiawati, Tri; Rohman, Mohammad Saifur; Kurnianingsih, Novi
Heart Science Journal Vol. 4 No. 4 (2023): The Science and Art of Caring for Critically III Patients in Intensive Cardiac
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2023.004.04.3

Abstract

BackgroundHeart failure is a severe health issue with high death and morbidity rates globally, including in Indonesia. Congestion is the main symptom of acute heart failure. B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) are well-known markers to confirm the condition. Plasma volume estimation (ePVS)is one of the procedures currently being developed to assess a patient's congestive status at a lower cost. MethodsThis is descriptive observational research with a cross-sectional study method that included all patients with acute heart failure between May 2019-February 2022. Baseline characteristics, medication history, and echocardiography were also included in the statistical analysis. We used univariate and multivariate analysis to assess the effect of each variable on the patient's congestive condition. A diagnostic test of plasma volume estimation was carried out using Receiver Operating Characteristics (ROC) Analysis compared to NT pro-BNP as the gold standard.   Results A total of 506 subjects were diagnosed with acute heart failure at Dr. Saiful Anwar Malang Hospital, who met the inclusion and exclusion criteria. The mean age was older in congestive patients with 62.5% being male. Patients with congestive conditions have a lower ejection fraction with a higher estimated right atrial pressure from echocardiography. The estimation plasma volume status was also higher in congestive conditions (6,90 vs 3,5). The ePVS from ROC analysis has a good diagnostic value with a sensitivity of 91, 7% and specificity of 92,6%. ConclusionThe estimation of plasma volume status has a good sensitivity and specificity value to assess congestive status in patients with acute heart failure who are fluid-overloaded. 
Impact of clinical features on in-hospital outcomes in premature coronary artery disease patients post percutaneous coronary intervention Noverike, Nikhen; Rohman, Mohammad Saifur; Rahimah, Anna Fuji; Rizal, Ardian; Prasetya, Indra
Heart Science Journal Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2024.005.04.11

Abstract

Background: Premature coronary artery disease (PCAD) is a significant health concern globally, characterized by the onset of coronary atherosclerosis at an early age. The development of PCAD is influenced by a variety of risk factors and leading to substantial morbidity and mortality. Despite advancements in interventions, the clinical and angiographic characteristics influencing in-hospital outcomes for these patients remain underexplored.Objective: This study aims to investigate the relationship between clinical features and in-hospital outcomes in patients with premature CAD post-percutaneous coronary intervention (PCI) at Dr. Saiful Anwar Hospital.Method: A retrospective cohort study was conducted on 1279 patients who underwent PCI for premature CAD from January 2022 to December 2023. Clinical data, including risk factors and angiographic findings, were collected from medical records. Statistical analyses were conducted using SPSS 22, employing univariate, bivariate, and multivariate logistic regression analyses to determine correlations.Result: The study included 1279 patients, with 438 in the premature CAD group and 841 in the non-premature CAD group. Significant differences were observed in age, sex distribution, BMI, lipid profiles, smoking status, and family history between the groups. Premature CAD patients were younger (mean age 50 vs. 64.8, p<0.001) and had higher rates of smoking and dyslipidemia. Angiographic analysis showed significant differences in LAD and LCx involvement and occlusion rates. In-hospital outcomes indicated higher incidences of shock, cardiac complications, and in-hospital mortality in the non-premature CAD group.Conclusion: Clinical and angiographic characteristics significantly influence in-hospital outcomes for premature CAD patients. Younger age, smoking, and dyslipidemia were prevalent risk factors. Enhanced management strategies focusing on these factors could improve patient outcomes.Keywords: Premature coronary artery disease, percutaneous coronary intervention, clinical characteristics, angiographic findings, in-hospital outcomes. 
Increase Cardiovascular Event in Patient with Diabetes Mellitus Undergoing Percutaneous Coronary Intervention Millisani, Hayla Iqda; Prasetya, Indra; Rohman, Mohammad Saifur; Satrijo, Budi
Heart Science Journal Vol. 5 No. 3 (2024): The Science and Art of Revascularization in Acute Coronary Syndrome
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.03.5

Abstract

Diabetes mellitus (DM) associated with increase major risk factors of cardiovascular disease, such as peripheral arteriopathy, ischemic heart disease, or cerebrovascular accident. The Framingham study showed that patient with DM considerably increase coronary artery disease (CAD), particularly in old patient and women. Prevalence of DM is rising and cardiovascular mortality associated with DM is the main problem in the world. Additionally, there is a higher death rate among DM patients following a myocardial infarction with complications, such as stent thrombosis, instent restenosis, and no reflow phenomenon can worse overall long term prognosis with CAD. This review c onsiders the mechanism for diabetes mellitus in CAD patient, expecially patient with DM can increase risk of major complication in patient CAD undergoing percutaneous coronary intervention (PCI).
Co-Authors Adlan El Fatih, Muhammad Afifah, Yuri Agung Sasongko Ahmad Aviv Mahmudi Aji, Nugroho Priyo Anjarwani, Setyasih Anna Fuji Rahimah Arista Candra Irawati Aryanugraha, Teguh Astiawati, Tri Atma Gunawan Bagaswoto, Hendry P. Bahar, Mokhamad Aswin Baskoro, Shalahuddin Suryo Burhan Burhan, Burhan Caesario, Fahreza Cholid Tri Tjahjono Cholid Tri Tjahjono Dadang Suprijatna Danny, Siska S. Dewi U. Djafar, Dewi U. Dewi Utari Djafar, Dewi Utari Dilla Maulida Dyah Puspita Saraswati Dzaki Ilhami, Muhammad Efendi, Rizki Arief Firdaus, Achmad Jauhar firmansyah, Yoki Habib, Faisal Hakim, Dennis I. Hakim, Dennis Ievan Hedi Pudjo Santosa Hendry Purnasidha Bagaswoto Ilhami, Yose R. Ilhami, Yose Ramda Juzar, Dafsah A. Juzar, Dafsah Arifa Karolina, Wella Kurnianingsih, Novi Kushandajani . Lestari, Puspa Martini, Heny Millisani, Hayla Iqda Mohammad S. Rohman Mohammad Saifur Rohman Muhammad Sony Maulana Muzakkir, Akhtar F. Muzakkir, Akhtar Fajar Nita Sari, Nita Noverike, Nikhen Novi Rahmawati Nugraha, Tria Yudha Nugraha, Yudha Tria Nurudinulloh, Akhmad Isna Pamuna, Oktafin Srywati Pashira, Andranissa Amalia Perani Rosyani Prastya, Andhika Primada Qurrota Ayun Priyatno Harsasto Putri, Valerinna Yogibuana Swastika Raden Djuniarsono Rahimah, Anna Fuji Ratna Pancasari Rhiza Amdi, Muh Ririn Handayani Rizal, Ardian Rochmawati, Icmi Dian Rudi, Hasrian Saputri, Vemmy Lian Saskia Dyah Handari Satrijo, Budi Setiawan, Dion Setyowati, Danti Utami Siska Suridanda Danny Sungkar, Safir Wanty Eka Jayanti Widito, Sasmojo Windya Harieska Pramujati Wirawan, Hendy Yogibuana, Valerinna Yudha, Tria zunardi, Lutfi hafiz