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All Journal Medika Tadulako Journal of Islamic Pharmacy Preventif: Jurnal Kesehatan Masyarakat Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JSFK (Jurnal Sains Farmasi & Klinis) JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Health Information : Jurnal Penelitian Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Pharmaceutical Sciences and Research (PSR)
Yusi Anggriani
University of Pancasila, Srengseng Sawah Jagakarsa, Jakarta, Indonesia
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Evaluasi Outcome Klinis Penggunaan Insulin Analog dan Insulin Manusia pada Pasien DM Tipe 2 JKN Rawat Jalan Tahun 2015-2016 Di RSUD Tarakan Retnaningrum, Dyah; Anggriani, Yusi; Tri Kusumaeni, Hesty Utami R.
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.666 KB) | DOI: 10.36418/syntax-literate.v6i3.2375

Abstract

Penelitian ini bertujuan mengetahui perbandingan profil pengobatan, outcome klinis dan biaya antara insulin analog dengan insulin manusia. Penelitian menggunakan metode longitudinal time series melalui pengumpulan data secara retrospektif menggunakan penelusuran rekam medis dan kuitansi biaya pengobatan. Sampel yang diambil adalah pasien DM tipe 2 JKN rawat jalan dengan terapi insulin periode Januari 2015-Desember 2016 di RSUD Tarakan yang memenuhi kriteria inklusi sebanyak 156 orang. Hasil analisis diperoleh penggunaan terbanyak adalah insulin Analog tunggal (98,19%). Proporsi obat non DM (56,15%) dan obat DM (43,85%). Rata-rata outcome klinis GDP (164,74 mg/ dL) dan GDPP (200,48 mg/ dL). Rata-rata outcome klinis HbA1C pengguna insulin analog tunggal (7,82%) lebih baik dibanding pengguna insulin lainnya. Hasil uji Mann Whitney diperoleh outcome klinis GDP, GDPP dan HbA1C insulin analog tunggal dengan insulin manusia tunggal tidak berbeda nyata (p value >0,05). Hasil Outcome klinis GDP dan HbA1C insulin analog tunggal dibanding kombinasi insulin manusia+analog berbeda secara nyata (p value 0,00) , sedangkan GDPP tidak berbeda nyata (p value 0,222). Rata-rata biaya pengobatan 30 hari Insulin analog tunggal dengan insulin manusia tunggal berbeda nyata (p value 0,001). Rata rata biaya pengobatan 30 hari Insulin manusia tunggal dengan kombinasi insulin analog+analog, kombinasi insulin analog+analog+OAD, kombinasi insulin analog+OAD dan kombinasi insulin manusia+analog berbeda nyata (p value 0,00). Kombinasi insulin analog+analog+OAD dengan kombinasi insulin manusia+OAD dan kombinasi insulin analog+OAD berbeda nyata (p value 0,00). Biaya rata-rata kombinasi insulin analog+analog+OAD lebih tinggi dibanding biaya rata-rata kombinasi Insulin analog+OAD dan kombinasi insulin manusia+OAD.
Pengaruh Asuhan Kefarmasian Terhadap Kualitas Hidup Pasien Diabetes Melitus Tipe 2 di Dua Puskesmas Daerah Jakarta Timur Mayasari, Yeshi; Sarnianto, Prih; Anggriani, Yusi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.623 KB) | DOI: 10.36418/syntax-literate.v5i6.1338

Abstract

Asuhan kefarmasian merupakan rangkaian penatalaksanaan penyakit yang diharapkan dapat meningkatkan kualitas hidup pasien Diabetes Melitus. Tujuan penelitian ini untuk melihat asuhan kefarmasian dapat meningkatkan kepatuhan dan kualitas hidup pasien DM tipe 2. Penelitian dengan desain quasi experimental non-equivalent control group Pretest-Posttest. Sampel 160 pasien DM tipe 2 terdiri dari 80 pasien dari Puskesmas Kecamatan Cipayung [kelompok intervensi] dan 80 pasien Puskesmas Kecamatan Kramatjati [kelompok kontrol]. Metode total sampling untuk kelompok Prolanis, dan kelompok non-Prolanis secara purposive sampling. Data dikumpulkan menggunakan kuesioner MMAS-8 (kepatuhan), SF-36 (kualitas hidup) dan data gula darah puasa (GDP) dari laboratorium Puskesmas. Karakteristik pasien DM meliputi usia rata-rata 58 tahun, jenis kelamin perempuan, pendidikan SMA, ibu rumah tangga. Lama DM 2-3 tahun dan nilai IMT obesitas I. Hasil Uji Wilcoxon (p < 0,05) terdapat petingkatan kepatuhan, kualitas hidup, dan keterkendalian kadar GDP pada kelompok intervensi. Hasil uji Mann-Whitney terdapat peningkatan kepatuhan, kualitas hidup dan keterkendalian kadar GDP akibat asuhan kefarmasian pada pasien Non-Prolanis dengan nilai (p < 0,05). Hasil uji Spearman’s rho menunjukkan adanya hubungan positif antara tingkat kepatuhan dan keterkendalian GDP dengan kualitas hidup. Dapat disimpulkan bahwa asuhan kefarmasian dapat meningkatkan kepatuhan, kualitas hidup dan keterkendalian GDP kualitas hidup pasien DM 2 peserta Prolanis dan non-Prolanis, pada puskesmas tertentu di Jakarta Timur. Kata Kunci: Asuhan kefarmasian, kepatuhan, kualitas hidup dan diabetes melitus
Pengaruh Asuhan Kefarmasian Terhadap Kualitas Hidup Pasien Diabetes Melitus Tipe 2 di Puskesmas Kabupaten Cirebon Yava Rony, Devi; Sarnianto, Prih; Anggriani, Yusi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.988 KB) | DOI: 10.36418/syntax-literate.v5i6.1324

Abstract

Asuhan kefarmasian pada pasien Diabetes Melitus tipe 2 diharapkan dapat meningkatkan kepatuhan minum obat sehingga glukosa darah terkendali dan kualitas hidup optimal. Penelitian ini dilakukan untuk mengetahui pengaruh asuhan kefarmasian dalam meningkatkan kepatuhan minum obat, pengendalian kadar glukosa darah dan kualitas hidup pasien DM tipe 2. Penelitian bersifat prospektif menggunakan desain kuasi eksperimental komparatif (control group design withpre-test-post-test). Sebanyak 80 pasien terdiri dari 40 pasien non-Prolanis Puskesmas Talun (intervensi, diberi asuhan kefarmasian) dengan total sampling dan 40 pasien non-Prolanis Puskesmas Karangsari (kontrol, tanpa asuhan kefarmasian) dengan consecutive sampling. Data diperoleh dari kuesioner MMAS-8 (kepatuhan), SF-36 (kualitas hidup) dan kadar GDP, GDPP dari hasil laboratorium. Hasil Uji Wilcoxon menunjukkan peningkatan signifikan (p < 0,005) sebelum dan sesudah asuhan kefarmasian terhadap tingkat kepatuhan, kadar GDP, GDPP dan kualitas hidup pasien kelompok intervensi.Hasil Uji Mann Whitnney menunjukkan peningkatan signifikan (p < 0,05) tingkat kepatuhan, kadar GDP, GDPP dan kualitas hidup akibat asuhan kefarmasian pada pasien kelompok intervensi. Asuhan kefarmasian dapat meningkatkan kepatuhan, keterkendalian kadar GDP, GDPP dan kualitas hidup pasien non-Prolanis DM tipe 2 pada puskesmas tertentu di Kabupaten Cirebon. Kata kunci: Asuhan kefarmasian, Kualitas hidup dan Pasien DM.
Faktor-Faktor Risiko Pasien Hemodialisis di RSUD Arjawinangun dan RSUD Waled Kabupaten Cirebon Yani, Dosi Ahmad; Sarnianto, Prih; Anggriani, Yusi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.712 KB) | DOI: 10.36418/syntax-literate.v5i1.857

Abstract

Penyakit Ginjal Kronis (PGK) merupakan masalah kesehatan dengan insidensi dan prevalensi gagal ginjal yang semakin meningkat, prognosis yang buruk dan biaya yang tinggi. Faktor-risiko PGK beragam menurut kawasan geografi dan era terkait gaya hidup termasuk konsumsi makanan dan atau minuman. Penelitian ini bertujuan untuk mengetahui faktor risiko apa saja yang ada pada pasien PGK yang menjalani hemodialisis di RSUD Arjawinangun dan Waled Kabupaten Cirebon. Jenis penelitian ini adalah penelitian observasional analitik kasus-kontrol. Kelompok kasus (93 responden) adalah pasien PGK yang melakukan hemodialisis, sementara kelompok kontrol (93 responden) adalah pasien rawat jalan selain pasien PGK, dengan kriteria inklusi dan eksklusi tertentu. Data primer diperoleh melalui wawancara menggunakan kuesioner yang dikembangkan oleh Pusat Riset Obat dan Makanan, dan data sekunder diperoleh dari berkas rekam medis pasien. Analisis data yang dilakukan adalah analisis univariat, bivariat (2x2 chi-square) dan multivariat (regresi logistik). Responden penelitian ini mayoritas berjenis kelamin laki-laki (51,6%), umur rata-rata (minimal-maksimal) 48 (20-75) tahun, status kawin (86%), pendidikan sekolah dasar atau dibawahnya (49,5%), pekerjaan membutuhkan fisik (52,7%), pendapatan sama atau di bawah pendapatan per kapita (57%). Faktor-faktor risiko yang berhubungan secara bermakna dengan kejadian PGK dalam penelitian ini adalah pekerjaan intelektual (OR 0,104; 95% CI = 0,018-0,592); riwayat penyakit hipertensi (OR 46,481; 95% CI = 11,444-188,784); riwayat penyakit diabetes mellitus (OR 25,239; 95% CI = 3,680-116,267); konsumsi air putih 1-4 gelas (OR 46,717; 95% CI = 7,228-301,926); sering mengkonsumsi minuman yang mengandung kadar mineral/gula tinggi (OR 3,808; 95% CI = 1,207-12,012) dan sering mengkonsumsi makanan yang mengandung garam tinggi (OR 10,317; 95% CI = 3,331-31,954). Kata kunci: Faktor Risiko, Penyakit Ginjal Kronis, Hemodialisis
Analysis of Medication, Cost, and Clinical Outcome of Human and Analogue Insulins of Type 2 Diabetes Mellitus at MMC Hospital 2016-2017 Jayati, Turpuk Mannaria; Anggriani, Yusi; Laksmitawati, Dian Ratih; Waspadji, Sarwono
Health Information : Jurnal Penelitian Vol 13 No 2 (2021): Juli-Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v13i2.273

Abstract

Human insulin and analog insulin are available at RS.MMC. The use of analog insulin was more prevalent among doctors between 2016 and 2017. The data collection was conducted retrospectively, taking samples of 132 outpatients type 2 DM using insulin, of which 74 were evaluated for their clinical outcome. The study's goal is to provide information for developing insulin usage guidelines. The medication profile data were collected from the medicine administration at the Hospital Pharmacy Installation. The clinical outcome data, such as fasting plasma glucose (FPG), two-hour postprandial plasma glucose (2HPP), and Hemoglobin A1c (HbA1c), were garnered from the patients’ medical records. The cost data were collected from the outpatients’ payment receipts provided by the Hospital’s Financial Department. Kolmogorov Smirnov normality test was applied in this research. Statistical trials of differences in clinical outcomes and costs using the Kruskal-Wallis test, showed there was a significant difference between human insulin and insulin analogues in terms of clinical outcomes of GDP, GDPP, HbA1c, and cost after follow-up testing with Mann Whitney, showed average cost of using human insulin for 30 days was Rp1,597,066, and analogue was Rp2,497,535 shows that human insulin and analogues differ significantly in terms of cost (p = 0.015).
Faktor Yang Berhubungan Dengan Kepatuhan Minum Obat Pada Penderita Skizofrenia Fase Stabil Di Poli Rawat Jalan RS Jiwa Daerah Provinsi Lampung Tahun 2022 Harissa, Nola; Anggriani, Yusi; Sarnianto, Prih; Septa, Tendry
JFL : Jurnal Farmasi Lampung Vol. 12 No. 2 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i2.1110

Abstract

Adherence with antipsychotic treatment is very important to achieve optimal therapeutic results to the people with schizophrenia. The aim of the study is to determine the factors associated with medication adherence in patients with stable phase of paranoid schizophrenia at the Outpatient Polyclinic of the Regional Hospital of Lampung Province in 2022. This study used a crosssectional method with prospective data collection, a sample of 176 and the use of purposive sampling for the sampling technique. The data obtained were analyzed by using the chi square test to find out the relation between the dependent variable which is medication adherence, and the independent variables, namely perceptions of family support, knowledge related to disease, perceptions of drug side effects, and the perceptions of the pharmacist's role. To find out the dominant factors influencing the medicine compliance, the data were analyzed by using ordinal logistic regression. The study obtained of medicine compliance rates in paranoid schizophrenia patients based on the MMAS scale were good in 53 (30.1%), moderate in 62 (35.2%) and poor in 61 (34.7%). There is a relationship between medication adherence and the perception of family support (p value 0.038), knowledge related to disease (p value 0.005), perception of drug side effects (p value 0.003), and perception of the role of pharmacist (p value 0.000). The dominant factor affecting compliance to taking medication is the perception of the pharmacist's role with OR = 2.8, which means patients who get a good pharmacist role are more compliant in taking medication by 2.8 times. Keywords: Medication Compliance, Paranoid Schizophrenia, Stable Phase, Outpatient
Evaluasi Penggunaan Insulin pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di Rumah Sakit X di Jakarta Periode 2016-2017 Anggriani, Yusi; Rianti, Alfina; Pratiwi, Annisa Nadya; Puspitasari, Wulan
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.52-59.2020

Abstract

Type 2 Diabetes Mellitus (DMT2) is a metabolic disease with the characteristics of hyperglycemia that occurs due to abnormal insulin secretion. One of the treatments of DM is insulin therapy. Based on its provenance, insulin consists of human insulin and analogue insulin. This study was conducted to identify profiles of insulin used in DMT2 patients at RSUP X hospital in Jakarta. This was an observational study conducted retrospectively on data from 2016 to 2017. The total sample numbers of DMT2 outpatients using insulin were 218 in 2016, and 225 in 2017. Data on insulin therapy regimens were obtained from medical records and drug use reports. The results obtained from this study indicated that the type of insulin that was widely used by DMT2 outpatients was analogue insulin with a percentage of 99%. The human insulin was rarely used in outpatients. The highest use of analogue insulin was analog premixed insulin (35%).
Survei Rumah Tangga terhadap Profil Obat pada Responden dengan Jaminan Kesehatan Nasional di Jakarta Timur Restinia, Mita; Anggriani, Yusi; Khairani, Sondang; Wijaya, Rulliani Bianca
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.158-163.2020

Abstract

Household surveys are one of the methods to obtain accurate information on medicine utilization in society. The study was carried out to identify the access of medicine and medicine utilization profile. A survey using convenient sampling method was conducted in 30 households with national health insurance (JKN) diagnosed with chronic diseases in East Jakarta. Each family was observed once a week for 8 weeks to analyse their diseases, medication used, and medicine access. About 19 (63.3%) respondents enrolled in this study were male. The mean ± SD of age was 55.87±12.486 years old. About 23(76.7%) respondent had access of medicine through hospital and 7(23.3%) by pharmacy directly. The most common chronic diseases identified were cardiovascular and endocrine disorder. Cardiovascular, alimentary tract and metabolism, and nervous system were medications most commonly used. Most of respondents used about 1-3 kind of medications in a month. About 101 kind of drugs used, 74 kinds of drug among of them were generic and 27 were non generic. About 12 (40%) respondents used vitamin and 8 (26.67%) used supplement. This study highlights respondent access of medicine through hospital and cardiovascular medicines were the most commonly used.
Home Care Improves Knowledge, Attitude, Practice and Blood Pressure Control in Hypertensive Patients: Exploring the Expanded Role of Community Pharmacists Ramadaniati, Hesty Utami; Anggriani, Yusi; Saragi, Sahat; Yazid, Ricky Chaerul
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 3 (2020): J Sains Farm Klin 7(3), Desember 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.3.236-243.2020

Abstract

Hypertension remains a leading cause of morbidity and mortality.This study aimed to evaluate the impact of community pharmacists-provided home care on knowledge, attitude, practice (KAP) and blood pressure (BP) control of hypertensive patients. A quasi-experimental study was conducted in two pharmacies in Banten involving hypertensive patients regularly refilling prescriptions. Patients in Pharmacy A were assigned in the intervention group (IG), whilst those in Pharmacy B in the control group (CG). IG received home care in addition to standard care. Questionnaires to assess KAP were distributed at the initiation and end of the study. BP was measured monthly. A total of 110 patients (60 in IG vs 50 in CG) were enrolled. At baseline there was no significant difference in demographic and clinical characteristics. Post-intervention, proportion of patients with ‘good’ knowledge was considerably higher in IG (100%) vs 2.0% in CG, IG demonstrated ‘very ideal’ attitude compared to ‘less ideal’ in CG, IG performed ‘good’ practice as opposed to ‘fair’ practice in CG. The decrease of systolic BP in IG was significantly greater (14.8 mmHg) vs 1.8 mmHg in CG. In conclusion, expanded role of community pharmacists in providing home care improves KAP and BP control in hypertensive patients.
Post-Market in vitro bioequivalence study of innovator and generic Gefitinib tablets: evaluation of JKN medicine quality Nurhayati, Fitri; Anggriani, Yusi; Syahruddin, Elisna; Andalucia, Rizka; Ath-Thobari, Jarir; Mulatsari, Esti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1593

Abstract

Gefitinib is one of Tyrosine Kinase Inhibitors (TKIs), as first line therapy for Non-Small Cell Lung Cancer (NSCLC) with positive EGFR mutation. Gefitinib started to be accommodated in Jaminan Kesehatan Nasional (JKN) insurance in 2015 with the innovator gefitinib and was replaced by a generic product in middle of 2021. This research was conducted to see whether the quality of generic gefitinib equivalent to the innovator through post-market in vitro bioequivalence test. Assay method refers to previous research by Sandhya et al 2013 wih High Performance Liquid Chromatography (HPLC), while the dissolution test method is in accordance with the Food and Drug Association (FDA) 2010. We collected innovator from the official distributor and 3 batches (all batches that have been used in JKN program) of generic product from hospitals where lung cancer therapy services were provided. We evaluated the dissolution profile with similarity and unsimilarity factors and assess based on standard specification of dissolution profile that informed in innovator’s BPOM-approved brochure (avarage of 6 samples > 85% and no individual result < 75% at 45 minutes). The assay results met the requirements of ± 5% of what is stated on the label. Although dissolution profile of generic and innovator were not equal through difference and similarity factors calculation, but one batch of generics met dissolution profile standard of innovator. So, both generic and innovator drug met the standards of assay and dissolution, even though the dissolution profile were not equivalent.
Co-Authors Ahriansyah, Andi Andalucia, Rizka Annisa, Rifka Aritonang, MGS Ath-Thobari, Jarir Banun, Agusdini Chaerul Y, Ricky Dian Ratih Laksmitawati Dwi Puspita Sari, Dwi Puspita Elisna Syahruddin Evy Yunihastuti Fitri Nurhayati Fredrick Dermawan Purba Hardi, Devita Harissa, Nola Ilham Maulana Jayati, Turpuk Mannaria L, Dian Ratih Manninda, Reise Mayasari, Yeshi Mita Restinia Mulatsari, Esti Nanang Erlana Pontoan, Jenny Pratiwi, Annisa Nadya R, Hesty Utami Ramadaniati, Hesty Utami Retnaningrum, Dyah Rianti, Alfina Rosanti, Ade Rosiana, Rosiana S.Farm., M.Farm., Apt, Sondang Khairani Sabirin, Briliana Sahat Saragih Saragi, Sahat Sarnianto, Prih Sarnianto, Prih Sarwono Waspadji Septa, Tendry Siti Aisyah Suratni Suratni Tanty, Herty Nur Tri Kusumaeni, Hesty Utami R. Utami R, Hesty Wijaya, Rulliani Bianca Wulan Puspitasari Y, Ricky Chaerul Yani, Dosi Ahmad Yava Rony, Devi Yazid, Ricky Chaerul Yulia Trisna, Yulia