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Journal : Journal of Multidisciplinary Applied Natural Science

Phytochemical Profiling, Antibacterial Properties and Toxicity of Amla Fruit Tea (Phyllanthus emblica L.): An In Vitro and In Silico Study Cahyaningrum, Putu Lakustini; Sudaryati, Ni Luh Gede; Bogoriani, Ni Wayan; Asih, Ida Ayu Raka Astiti; Adnyana, I Made Dwi Mertha; Jenar, Putut Dewantha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.284

Abstract

Antimicrobial resistance represents a critical global health challenge, necessitating the exploration of alternative therapeutic agents. This study investigated the antimicrobial potential of amla fruit tea (Phyllanthus emblica L.) through comprehensive phytochemical characterization, antibacterial assessment, and computational modeling to identify potential mechanisms of action. LC-HRMS analysis was employed for phytochemical profiling, antibacterial activity was evaluated via disk diffusion method against Staphylococcus aureus and Escherichia coli, and molecular docking studies were conducted against tyrosyl-tRNA synthetase and FimH adhesin proteins. Analysis identified 89 bioactive compounds, with oxidized hydroxytetrahydrofuranyl acetate, L-α-palmitin, and ellagic acid predominating. Antibacterial activity against S. aureus and E. coli was evaluated via the disk diffusion method, revealing that moderate inhibition increased at higher concentrations (25%) and with extended exposure, with E. coli exhibiting greater susceptibility than S. aureus. Molecular docking studies against tyrosyl-tRNA synthetase (S. aureus) and FimH adhesin protein (E. coli) identified the W-18 benzenesulfonamide derivative as the most promising compound, which demonstrated strong binding affinities of -11.01 and -7.48 kcal/mol, respectively. While all five principal compounds met Lipinski's drug-likeness criteria, toxicological assessment revealed varying safety profiles, with two compounds classified as "possibly hazardous" and two as "toxic when swallowed." These findings suggest that amla fruit tea has antibacterial properties through two mechanisms: disruption of protein synthesis and bacterial adhesion. However, its efficacy remains considerably lower than that of conventional antibiotics, suggesting potential applications as complementary therapy rather than antibiotic replacement.
Co-Authors AA Putu Agung Mediastari Adi Suwi Setyawat, Anak Agung Istri Adnyana , I Made Dwi Mertha Agung Istri Adi Suwi Setyawati, Anak Anak Agung Ayu Reka Andjani Anak Agung Ayu Sauca Sunia Widyantari Anak Agung Istri Adi Suwi Setyawat Anak Agung Putu Agung Mediastari Andjani, Anak Agung Ayu Reka Ariani, Ni Putu Rela Armita, Pande Made Nova Astuti, Ni Made Widi Ayu Made Yuliari, Sang Bagus Putra Suta, Ida Budiani, Ketut Cahayani Ariawa, Dewi Citra Diah Lestari, Ni Kadek Citra Lestari, Ni Kadek Cokorda Javandira Dirgayasa, Pande Nyoman Selamet Gusti Ayu Linda I Gede Mahardika I Gusti Ayu Diah Yuniti I Kadek Indra Wiguna I Made Agus Gelgel Wirasuta I Made Dira Swantara I Nyoman Arsana I Nyoman Arsana, I Nyoman I Putu Sudiartawan I Wayan Martadi Santika I Wayan Tanjung Aryasa I. A. R. Astiti Asih IDA BAGUS PUTRA SUTA Ida Bagus Putra Suta Ida Bagus Wiryanatha Kadek Citra Lestari, Ni Kartina, Ni Luh Made Dwi Made Kresna Aditama Duarba Made Novia Indriani Mirah Ayu Putri Trarintya, Mirah Ayu Putri N. W. Bogoriani Ni Kadek Citra Lestari Ni Kadek Warditiani Ni Luh Gede Sudaryati Ni Luh Made Dwi Kartina Ni Made Widiastuti Ni Nyoman Ari Mayadewi Ni Putu Rahayu Artini Ni Wayan Wina Premayani, Ni Wayan Wina Pande Made Nova Armita Putra Suta, Ida Bagus Putri, Ni Made Ayu Diana Putri, Putu Ayu Cempaka Putu Lasmi Yuliyanthi Sapanca Putut Dewantha Jenar rahayu artini yuan Riska Dewi, Ni Putu Sang Ayu Made Yuliari Saraswati, Ida Ayu Asri Diva Sari, Ida Ayu Putu Putrami Sari, Made Dwi Kemala Sriani, Ni Luh Komang Srinadi, Ni Komang Ayu Suarniti, Ni Luh Kade Sudiartawan, I Putu Susilawati, Ni Luh Putu Arya Suta, Ida Bagus Putra Widyanata, Komang Agus Jerry Widyantari, A.A A Sauca Sunia