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All Journal Buletin Veteriner Udayana Jurnal Kedokteran Brawijaya Journal of Nutrition College Jurnal Tumbuhan Obat Indonesia e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Majalah Obstetri dan Ginekologi Jurnal Gizi Klinik Indonesia Medical and Health Science Journal Abdimasku : Jurnal Pengabdian Masyarakat Journal of Community Development Jember Medical Journal (JMJ) International Journal of Health and Information System (IJHIS) Indonesian Journal of Biomedicine and Clinical Sciences HARENA: Jurnal Gizi
Elly Nurus Sakinah, Elly Nurus
Departemen Farmakologi, Fakultas Kedokteran, Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Pengaruh Pemberian Cuka Apel 'A' terhadap Kadar MDA Hepar Tikus Wistar Jantan yang Diinduksi Parasetamol Dosis Toksik Niki Niki Rahmawati; Sugiyanta Sugiyanta; Elly Nurus Sakinah
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7667

Abstract

High dose of paracetamol is metabolized by cytochrome P-450 become free radical N-acetyl-p-benzoquinoneimine (NAPQI) but liver Glutathione (GSH) is not adequate to change it become nonreactive metabolite so that NAPQI bind to unsaturated fatty acid of cell membrane, causing lipid peroxidation and increase liver Malondialdehyde (MDA). 'A' apple vinegar contains anthocyanin with an antioxidant effect by electron donor to NAPQI and acetic acid to improve liver GSH level. The aim of research was to investigate the effect of 'A' apple vinegar on the rat liver MDA induced by toxic dose of paracetamol. Research groups consist of normal control (CMC Na 1% 1 ml for 14 days), negative control (CMC Na 1% 1ml for 14 days + paracetamol 291.6 mg/200gBW on the day 12nd,13rd,14th), and treatment group ('A' apple vinegar 0.4 ml/150gBW for 14 days + paracetamol 291.6 mg/200gBW on the day 12nd,13rd,14th). Liver MDA was measured on the day 15th with competitive ELISA. The average of normal control group was 21.58 ng/ml, negative control group was 70,71 ng/ml, treatment group was 37,67 ng/ml. One way ANOVA and Post hoc LSD test showed significantly differences between all groups (p<0,05). It can be concluded that 'A' apple vinegar had an effect on the liver MDA induced by toxic dose of paracetamol. Keywords: Paracetamol, NAPQI, MDA, 'A' apple vinegar, antioxidant
The Effect Of Cholecalciferol On Fasting Blood Glucose In Streptozotocin-induced Hyperglycemia Mice Elly Nurus Sakinah
UNEJ e-Proceeding Indonesian Protein Society (IPS), International Seminar and Workshop 2014
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Glucose uptake into skeletal muscle cells require insulin-dependent and insulin independent signaling pathways, both leading to the translocation of glucose transporter-4 (GLUT4) to the plasma membrane. Insulin resistance occurs due to failure of insulin signaling to translocate GLUT4 resulting in the failure of glucose uptake and causing hyperglycemia. Cholecalciferol is known to have a function in regulating calcium homeostasis was shown to increase the synthesis of insulin and increasing insulin sensitivity. The purpose of this study is to explain the role of cholecalciferol to decreased fasting blood glucose in streptozotocin-induced hyperglyemia mice. 30 mice adapted for one week and then induced using 150mg/kgBW streptozotocin (STZ) intraperitoneally, After experiencing hyperglycemia mice were divided into 5 groups (n=6 each), Group I (hyperglycemic control), group II (25ng cholecalciferol), group III (50ng cholecalciferol), group IV (100ng cholecalciferol), and group V (metformin 300mg/kgBBB). Cholecalciferol given orally for 14th days. On day 15th the examination of fasting blood sugar levels were taken and the mice. Fasting blood sugar levels measured using a glucometer. Based on statistical analysis showed that there were significant differences in fasting blood sugar levels between treatment groups (p<0,001). Based on univariate regression analyses there was negative correlation of cholecalciferol with fasting blood glucose (p<0,001). Cholecalciferol may lower fasting blood sugar levels in hyperglycemia mice models. Keywords: cholecalciferol, fasting blood glucose, STZ.
EFEK FRAKSI AIR EKSTRAK UMBI BIDARA UPAS (Merremia mammosa (LOUR.)) TERHADAP KEPADATAN KOLAGEN PADA LUKA TIKUS DIABETES Gusfita Trisna Ayu Putri; Elly Nurus Sakinah
Jurnal Tumbuhan Obat Indonesia Vol 13 No 1 (2020): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v13i1.1116

Abstract

ABSTRACT The data showed that 63.10% of Indonesian people choose self-medication, and 21.41% of them take traditional medicine and only 3.96% of them take an other treatments. North Sumatra is one of the province which have a variety of medicinal plants. In the year of 2000 until 2006 there was an increasing of the traditional medicine utilization that reach of 23.10%. This fact showed that traditional medicinal plants have a pivotal role in improving the economy of North Sumatra Province. This study aims to determine: (1) the development of traditional medicinal plant production, (2) the form of consumption of traditional medicinal plants, (3) the trade of traditional medicinal plants in North Sumatra, (4) the relationship between the exchange rate and the amount of exports of traditional medicinal plants. The research was carried out by literature study and quantitative approach study. The population and sample study was the people who use medicinal plant and traditional medicine in the North Sumatera Province. The study also used secondary data from various sources related to the use of traditional medicinal plants. The results of the study revealed that (1) Production of traditional medicinal plants (jahe, laos, kencur, kunyit, lempuyang, temulawak, temuireng, temulawak, temukunci, cucumber, kapulaga, mengkudu, mahkota dewa, kejibeling, sambiloto and lidah buaya) in North Sumatra Province from 2013-2017 were very fluctuatif (2) Consumption of traditional medicinal plants in the North Sumatra province from 2013-2017 has increased to meet the demand of the pharmaceutical industry, traditional medicine industry and microbusiness of traditional medicine, (3) traditional medicinal plants trading in North Sumatra Province carried out between districts, provinces and international (export) (4) there is no relationship between international trade in medicinal plants with the exchange rate of the rupiah. Keywords: traditional medicinal plants, trade, consumption, exchange rates, exports ABSTRAK Data menyebutkan bahwa 63,10% masyarakat Indonesia memilih pengobatan sendiri, dimana 21,41% diantaranya melakukan pengobatan tradisional dan 3,96% melakukan pengobatan lain. Sumatera Utara merupakan salah satu provinsi penghasil aneka ragam tanaman obat tradisional. Dalam kurun waktu 6 tahun dari tahun 2000 sampai 2006, terjadi peningkatan penggunaan obat tradisional sebanyak 23,10 %. Kondisi tersebut menunjukkan bahwa tanaman obat tradisional memiliki potensi yang kuat dalam meningkatkan perekonomian Provinsi Sumatera Utara. Penelitian ini bertujuan untuk mengetahui (1) perkembangan produksi tanaman obat tradisional, (2) bentuk konsumsi tanaman obat tradisional, (3) perdagangan tanaman obat tradisional di Sumatera Utara dan (4) hubungan antara nilai kurs dengan jumlah ekspor tanaman obat tradisional. Metode penelitian yang digunakan adalah studi literatur dan analisis kuantitatif. Populasi dan sampel penelitian merupakan masyarakat yang melakukan pengobatan secara tradisional di berbagai kabupaten yang ada di Provinsi Sumatera Utara dan juga menggunakan data sekunder dari berbagai sumber terkait penggunaan tanaman obat. Hasil penelitian menunjukkan bahwa (1) Produksi tanaman obat tradisional (jahe, lengkuas, kencur, kunyit, lempuyang, temulawak, temuireng, temulawak, temukunci, dringgo, kapulaga, mengkudu, mahkota dewa, kejibeling, sambiloto dan lidah buaya) di Provinsi Sumatera Utara mengalami fluktuasi dari tahun 2013-2017 (2) Konsumsi tanaman obat tradisional di Provinsi Sumatera Utara mengalami peningkatan dari tahun 2013-2017 dan konsumsi dilakukan dalam bentuk ramuan oleh masyarakat serta dijadikan sebagai bahan baku untuk industri farmasi, industri tanaman obat tradisional dan usaha mikro tanaman obat tradisional, (3) perdagangan tanaman obat tradisional di provinsi Sumatera Utara dilakukan antar kabupaten, provinsi sampai level internasional (ekspor) (4) tidak ada hubungan antara perdagangan tanaman obat secara internasional dengan nilai kurs rupiah. Kata kunci: tanaman obat tradisional, perdagangan, konsumsi, kurs, ekspor
Antibiotic sensitivity on pathogenic bacteria causing bacterial vaginosis Shiwi Linggarjati; Dita Diana Parti; Elly Nurus Sakinah
Majalah Obstetri dan Ginekologi Vol. 29 No. 1 (2021): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V29I12021.18-22

Abstract

Objectives: To identify the sensitivity of antibiotics to pathogenic bacteria that cause Bacterial Vaginosis (BV).Materials and Methods: This type of research was an observational study with a sample of six specimens. The data were taken using primary data from patients who were swabbed in the vagina and then diagnosed BV with amsel criteria on vaginal secretion specimens carried out at Tanggul health center on January 23-February 23, 2020. The specimens were sent to Parahita Clinical Laboratory for bacterial identification and adjusted for sensitivity with CLSI using vitek 2 compact tool.Results: The results of this study identified the bacteria that caused bacterial vaginosis, the E. coli and K. pneumoniae with one sample of suspected ESBL. ESBL is a beta lactamase enzyme produced by bacteria and can induce bacterial resistance to penicillin, cephalosporin generation 1, 2, and 3. The types of bacteria found were E. coli and K. pneumoniae with high sensitivity antibiotics tested including piperacillin/tazobactam, ceftazidime, cefepime, ertapenem, meropenem, amikacin, gentamicin, tigecycline, and nitrofurantoin. Antibiotics with high levels of resistance tested against these bacteria included: ampicillin, amoxicillin, and ampicillin/sulbactam due to the mechanism of beta-lactam antibiotic resistance in the production of beta lactamase from bacteria.Conclusion: The type of bacteria found was E. coli and K. pneumoniae with high resistance levels in beta lactam antibiotics. 
Type 3 Resistant Starch Effect of Cassava (Manihot esculenta Crantz) on Fasting Blood Glucose in Diabetes Mellitus Wistar Rat Models T Ariani Widiastini; Elly Nurus Sakinah; Yudha Nurdian; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6469

Abstract

Type 2 Diabetes Mellitus (T2DM) is a condition in which both insulin secretion and insulin sentivity disturbed. One of therapeutic approach of T2DM is through diet modification using resistant starch (RS) that has proven controlling both postprandial and fasting blood glucose. Cassava starch has 28,57% amylose and 51,24% amylopectin that can be increased through autoclaving-cooling process. Therefore, it can resist the digestion proess by amylose enzyme. The aim was to describe the effect of type 3 resistant starch cassava (Manihot esculenta Crantz) on fasting blood glucose (FBG) in Wistar diabetic rat models. This study was quasy experimental post-test only control group design using 16 Wistar rats divided into 4 groups, KN (normal), K- (DM), P1 (DM + cassava starch diet), and P2 (DM + type 3 RS cassava diet). High fat diet (HFD) and low dose streptozotocin (STZ) used as diabetic agents. Rats fed cassava starch or type 3 RS cassava diet for 28 days. GOD-PAP method used to measure the FBG level. The data analyzed using One Way ANOVA test with p>0,05 as significant value. The result shows no significant differences within experimental groups. Keywords: cassava, autoclaving-cooling, resistant starch, FBG
Increased Plasma GLP-1 Levels after Resistant Starch Type 3 From Cassava Starch (Manihot Esculanta Crantz) Diet on Diabetic Rat Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.7876

Abstract

Diabetes mellitus (DM) occur when human body is unable to produce enough insulin and/or unable to use insulin effectively, resulting in an increase of blood sugar levels (hyperglycemia). Indonesia has ranks fourth after United States, China and India in the prevalence of DM. Controling blood sugar and insulin levels can be done through the stimulation effect of Glucagon- like peptide-1 (GLP-1). The goal of this study was to determine the effects of resistant starch type 3 (RS3) from cassava starch in increasing plasma GLP-1 levels. This reasearch use male mouse (Ratttus novergicus) as a diabetic model by providing a high-fat diet (HFD) for one mounth than combine with intraoperitonel injection of low dose streptozotocin (STZ). The mouse then grouped into 4 groups randomly (1) normal or negative control, (2) cassava starch diet, (3) RS3 diet, (4) positive control. Blood sugar levels were measured before and after STZ injection to determine the diabetic conditions (blood sugar > 200 mg /dL). After 4 weeks of dietary administration blood sugar and plasma GLP-1 levels were examined using ELISA. Statistical analysis showed decreased in blood sugar levels and increased in plasma GLP-1 levels after one mounth of RS3 diet. This research shows that RS3 from cassava starch has a potential role as a nutritional therapy on diabetes mellitus condition. Keywords: Resistant starch type 3, cassava starch, GLP-1, Blood Sugar, Diabetes Mellitus
The Relation between Malondialdehyde (MDA) and Histopatological Appearance in male Wistar Rats Model Febrina Sylva Fridayanti; Erma Sulistyaningsih; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 1 No 1 (2015)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Fractures are a serious health problem in Indonesia due to increasing prevalence. The healing process of fracture is disturbed by the oxidative stress that caused by imbalance quantity of free radical and antioxidant. An antioxidant such as polyphenol, which can be found in cocoa, is needed to suppress oxidative stress. The study aimed to investigate the effect of the ethanolic extract of cacao on fracture healing process in a rat model through MDA concentration and histopatological appearance. This study is in vivo experimental study with post-test only controlled group design. 30 male Wistar rats were randomized and divided into 5 groups. 1 group was rats without fractured. The negative control and three treatment groups were rats with fractured manually on left tibia under anesthesia and immobilized by bandage. The treatment groups treated with cocoa ethanolic extract in a dose of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW orally for 21 days. The result showed that there was a significant different between the treatment groups and the negative control group on MDA concentration and histopatological appearance (p>0,05). The corelation between them were strong and had negative direction (R=-0,771). The study concluded that cocoa ethanolic extract had a positive effect to supress oxidation stress and increases the number of osteoblast on fracture healing process.   Key words: cocoa ethanolic extract, polyphenol, fracture healing process, oxidative stress
Acute Toxicity Tests of Basil Leaves (Ocimumsanctum) Ethanolic Extract Determined By LD50 and Renal Histopathology Cholis Abrori; Khana Nurfadhila; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.6501

Abstract

Basil leaves are widely used as herbal remedies and have proven many benefits because the content of phytonutrients includes antioxidants, but at certain doses a compound retains a probability of causing toxicity in the body. This study aims to determine the acute toxicity of ethanolic extract of basil leaves seen from the value of LD50 range and renal histopathology which is the vital organ of the target of toxicity in the body. The method of acute oral toxicity test was OECD 420 fix dose procedure method with a group of 5 Balb/c female mice given a multilevel dosage. The initial dose is 2000 mg/Kg.b.w selected on a sighting study as a dose that may cause mild toxicity symptoms but does not cause death. There are 2 groups consist of treatment with dose at LD50 value and control. The result of this research showed that LD50 value of ethanol extract of Ocimum sanctum > 2000 mg/Kg.b.w. The mean renal histopathologyc scores between the control and the treatment were significantly different by The Mann-Whitney test with significance value of p=0.018. Ocimum sanctum ethanolic extract is classified as non-toxic compounds but there was a change in renal histopathology of mice in the form of focal lesions after acute exposure at highest dose of OECD 420 method. Keywords: acute toxicity test, renal histopathology, basil leaves
The Performance of Hematological Parameters for Diagnosis of Acute Appendicitis in Children Supangat Supangat; Akhmad Makhmudi; Azka Darajat; Elly Nurus Sakinah; Muhammad Yuda Nugraha; Achmad Ilham Tohari; Tegar Syaiful Qodar; Bagus Wahyu Mulyono
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.25715

Abstract

Early diagnosis of pediatric appendicitis is still difficult to make and 30-40% of cases do not show typical classic symptoms. The negative appendectomy rate and the risk of perforation reach 20% so that new, easy, inexpensive and accurate additional examination is needed. This study aimed to compare platelet distribution width (PDW) and mean platelet volume (MPV) values of appendicitis and control patients. This study is retrospective case control study. Differences in MPV and PDW levels in patients with appendicitis and controls were analyzed with a t-test and determination of sensitivity, specificity and accuracy of the two markers in appendicitis diagnosis were performed by ROC analysis The mean MPV appendicitis was significantly lower (p <0.05) compared to controls (8.3 ± 1.9; 9.2 ± 1.5) while PDW of appendicitis patients did not differ significantly from controls (10.4 ± 1, 4, 10.7 ± 2.4; p> 0.05). AUC MPV as a diagnostic tool for appendicitis 0.619 with a normal limit of 6.6 fl has a sensitivity of 90% and specificity of 30%. MPV can be used for the diagnosis of appendicitis with a normal limit of 6.6 fl having a sensitivity of 90% and specificity of 30%. There was no significant difference between PDW of appendicitis patients with controls. There was no significant difference between MPV levels of patients with simple appendicitis and complications. Keywords: Appendicitis, MPV, PDW, Platelet
The Effectiveness of Nutrition Counseling on The First Thousand Days of Life Group in Improving Knowledge and Attitude on Nutrition Awareness Ancah Caesarina Novi Marchianti; Elly Nurus Sakinah; Nurud Diniyah
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.5331

Abstract

Nutrition status in the first thousand days of life (FTDL) of 270 days during pregnancy and 730 days in the infant's first life is a critical period, since the resulting consequences are permanent and irreparable. There are still many problems in the group of FTDL around the campus of University of Jember which require intensive handling, such as stunting, low energy protein, anemia, underweight and etc. Methods of improving the quality of nutrition for the FTDL group can be done by increasing knowledge about nutrition through counseling by utilizing various media (posters, brochures, videos, demos and presentation slides). This study aims to determine how far is the effectiveness of nutrition counseling in improving knowledge and attitude awareness on nutrition problems. The method used was to give counselling on nutrition in the target groups (members of Posyandu Catleya A and B) and assessed changes by comparing the level of nutritional knowledge and attitude before and after receiving counseling. The results showed there were significant differences in the level of nutritional knowledge and attitude between before and after the counseling about nutrition and food processing technology. It can be concluded that this method is quite effective to raise awareness of FTDL group on nutrition problems. Keywords: food insecurity, nutrition counseling, nutrition awareness
Co-Authors Abu Khoiri Achmad Ilham Tohari Ain Yuanita Insani Akhmad Makhmudi Ali Santosa Alvin Faizin Lisar Amalia Nur Zahra Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Angga Mardro Rahardjo Apryanita, Hudayah Arifa Mustika Aris Prasetyo Arista Prima Nugrahani Athoillah, Nabil Azham Purwandhono Azka Darajat Azka Darajat Bagus Wahyu Mulyono Barus, Marsha Zahra Adyanda Cahyana, Nugraha Wahyu Candra Agung Wibisana Cholis Abrori, Cholis Cicih Komariah Cindy Meylania Pradana Darajat, Azka Dear Farah Sielma Desie Dwi Wisudanti Dewantari, Septiarina Putri Dimes Atika Permanasari Dita Diana Parti Dwike Rachma Maydaniar Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati ENNY SUSWATI Erma Sulistyaningsih Erma Sulistyaningsih Fawziyah Putri Maulida Febrina Sylva Fridayanti Febrina Sylva Fridayanti, Febrina Sylva Gusfita Trisna Ayu Putri Hairrudin Hairrudin Heni Fatmawati Hilda Nur Achfidawati Inreswari, Laksmi Jauhar Firdaus Khana Nurfadhila Lubis, Arinie Awindya Maria Ulfa Mega Citra Prameswari Mochammad Amrun Hidayat Muhammad Rijal Fahrudin Hidayat Muhammad Yuda Nugraha Muhtar Ady Kusuma Nadzir Ansharullah Akbar Niki Niki Rahmawati Nistiandani, Ana Novail Alif Muharrom Nurud Diniyah Pattipeilohy, Florence Pattipeilohy, Florence Marianty Prasetyo, Aris Ramadhani, Alfiyah Ranindya Putri Cipta Indraswari Ricky Roosdiana Dewi Rini Riyanti Rizka Nuzula Wardani Rosita Dewi Rumastika, Nindya Shinta septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Shinta Madyaning Wuri Shiwi Linggarjati Siswoyo Siswoyo Sudarmanto, Yohanes Sugiyanta Sugiyanta Supangat Supangat Supangat Supangat T Ariani Widiastini Tegar Syaiful Qodar Tira Anjeli Rahmah Toyibatul Hidayati Ulfa Elfiah Vidya Muqsita Wibsono, Sony Yudha Nurdian Yuli Hermansyah Zahrah Febianti