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All Journal Buletin Veteriner Udayana Jurnal Kedokteran Brawijaya Journal of Nutrition College Jurnal Tumbuhan Obat Indonesia e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Majalah Obstetri dan Ginekologi Jurnal Gizi Klinik Indonesia Medical and Health Science Journal Abdimasku : Jurnal Pengabdian Masyarakat Journal of Community Development Jember Medical Journal (JMJ) International Journal of Health and Information System (IJHIS) Indonesian Journal of Biomedicine and Clinical Sciences HARENA: Jurnal Gizi
Elly Nurus Sakinah, Elly Nurus
Departemen Farmakologi, Fakultas Kedokteran, Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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The role of Cholecalciferol in the Improvement of Insulin Resistance in Diabetic Mice Model Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6146

Abstract

Insulin resistance is an important predictor of the incidence of diabetes mellitus. Vitamin D deficiency is one of the risk factors for insulin resistance, and there is a relationship between hypovitaminosis vitamin D with the prevalence of diabetes mellitus. Cholecalciferol is one form of vitamin D3. HOMA-IR levels are one of the parameters of insulin resistance. This study aims to prove that administration of cholecalciferol can improve insulin resistance conditions in diabetic mice model. This study used 20 mice divided into 5 groups negative control(STZ+propilen glycol), positive control (STZ+metformin), P1(STZ+cholealciferol 25ng), P2(STZ+cholealciferol 50ng), P3(STZ+cholealciferol 100ng). Mice given STZ dose 150mg / KgBB intraperitoneal to obtain hyperglycemia conditions. Administration of cholecalciferol for 14 days. The result obtained average HOMA-IR level after treatment is negative control(2,32), positive control (0,825), P1(0,975), P2(0,5), P3(0,3). The result obtained average HOMA-B level after treatment is negative control (2,76), positive control (11,92), P1 (18,4), P2(10,88), P3(35,35). The result of statistical analysis using Kruskall wallis test obtained p <0,005. The conclusion of this study is that administration of cholecalciferol may improve insulin resistance in diabetic model mice. Keyword : cholecalciferol, HOMA-IR, HOMA-B, streptozotocin
Analysis of the Relationship between Laboratory Biomarkers and the Severity of COVID-19 at Kaliwates General Hospital Jember Nadzir Ansharullah Akbar; Angga Mardro Rahardjo; Dita Diana Parti; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.29062

Abstract

Coronavirus Disease 2019 (COVID-19) has become a global health problem since the WHO declared the disease a pandemic. In July 2021, Indonesia experienced a very sharp spike in cases and an increase in mortality due to COVID-19, including at the Kaliwates General Hospital in Jember. Laboratory biomarkers in the form of Neutrophile Lymphpocyte Ratio (NLR), D-dimer, and SpO2 can be a clue to assess the severity of COVID-19 patients. This research is an observational analytical study using a Cross Sectional Study with the aim of knowing the relationship between laboratory biomarkers and the severity of COVID 19 at RSU Kaliwates Jember. This study uses secondary data in the form of medical records of COVID-19 patients during July 2021 with a total of 50 samples. The results of this study were carried out by the Spearman correlation test and it was found that there was a correlation between NLR values ​​and oxygen saturation with the severity of COVID-19, but there was no relationship between D-dimer levels and the severity of COVID-19. The conclusion of this study is that NLR biomarkers and oxygen saturation can be used as predictors of the severity of COVID-19.
The Correlation between Ferritin Levels and Glutation (GSH) Levels in Major Beta Thalassemia Patient at dr. Soebandi Jember Hospital Amalia Nur Zahra; Rini Riyanti; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6322

Abstract

Repeated blood transfusions in patient with Major Beta Thalassemia leads to iron overload marks by the increased of serum ferritin levels. Free iron caused the change of H2O2 to oxidants by fenton reaction and caused oxidative stress. These oxidants will be counteracted by GSH as antioxidants. The purpose of this study was to investigate the correlation between ferritin levels with GSH in patients with major beta thalassemia in RSD dr. Soebandi hospital Jember. The samples of this study are fifteen (15) patients age 1-18 years who were regularly transfused. Serum ferritin levels were measured by Enzyme-Linked Fluorescent Immuno Assay (ELFA) and plasma GSH levels were measured by Ellman method. Data was analyzed using Pearson correlation test. Serum feritin levels were increased in Major Beta Thalassemia children with average of 3540,46 ± 3925,37 ng/mL. The mean of GSH is 10,46 ± 2,58 µmol. We found significant and negative correlation between serum ferritin and GSH with p value=0,000 and r=-0,951 in Major beta thalassemia patient at RSD dr. Soebandi Jember. Keywords: Thalassemia, Oxidative stress, Feritin, GSH
Analysis of Morphology and Erythrocyte Count in Rat after Electrical Exposure Hilda Nur Achfidawati; Ulfa Elfiah; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.6806

Abstract

Electrical burns cause high mortality and morbidity and various complications, although the incidence is only 4% of all burns. Joule heating phenomenon occurs in electric burn patients which cause changes in erythrocyte morphology resulting hypercoagulability that contribute to the formation of thrombus. Changes in erythrocyte morphology may cause tissue oxygenation disorders and decrease in erythrocyte count leading to hypoxia. Until now there have been no reports of changes in erythrocyte morphology and reduction in the number of erythrocytes in burn patients due to electricity. This study aims to observe and analyze morphological and erythrocyte count in rats after electrical exposure of 140 V for 17 seconds. This is a true experimental laboratories study with post-test only control group design. The sample used were 24 rats consisting of one control group (K) and five treatment groups (P). Treatment groups were distinguished by days of blood sampling that is days 0 (P1), 3 (P2), 7 (P3), 10 (P4), and 14 (P5) post electrical exposure of 140 V for 17 seconds. Assessment in erythrocyte morphology was performed using giemsa staining that observed with 1000x magnification while erythrocyte count was performed using improved neubauer counting chamber. One Way Anova showed that there was no significant change in rats erythrocyte count after electrical exposure of 140 V for 17 seconds (p = 0.110). Descriptive analysis showed that there is morphological changes in erythrocyte morphology after electrical exposure of 140 V for 17 seconds, in terms of shape there are more fragmentosit, microsite, tear drops, stomatocytes, and cell target, in terms of size there are more microsite, and in terms of color there are more hypochromic erythrocytes. Keywords: Burn Injury, Erythrocyte Morphology, Erythrocyte Count
Syzygium Samarangense Leaves Ointment Enhances Wound Healing Process Of Skin Burn Based On Collagen Ain Yuanita Insani; Mega Citra Prameswari; Novail Alif Muharrom; Toyibatul Hidayati; Arista Prima Nugrahani; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6160

Abstract

Background: The World Health Organization (WHO) estimates the number of death in 2014 caused by burns is 265,000. Burns can caused skin damage as well as other complication problems such as dehydration, infection, and other multiple organ failures. Syzygium samarangense leaves contain flavonoids and saponins that can increase the activation of macrophages and TGF-B which is important to accelerate the process of collagen formation and wound healing process. Objective: Knowing the effect of Syzygium samarangense leaf extract on the healing process of burn based on collagen. Method: This in vivo study use true experimental design. We made burns by placing a coin that already heated in oven at 70ºC for 10 seconds. Rattus Wistar as experimental animals dividedinto 6 groups (n = 4) with details of Group A (normal), B (positive), C (negative). Groups D, E, and F were the groups that given ointment extract topically in doses of 15%, 30%, and 45% each day’s. Termination is done on day 7. Test statistics by using Anova and Kruskal Wallis. Results and discussion: From this research, Syzygium samarangense leaf extract can reduce the wound area (p <0,05) and increase the amount of collagen (p <0,05). Conclusion: Syzygium samarangense leaf extract ointment can accelerate the healing process of burns. Keywords : Burns, Syzygium samarangense Leaves ointment, Saponin, Flavonoid, Collagen
The Activity of Ethanolic Extract of Cyclea barbata Miers as Inhibitor of Bacterial Biofilm Formation of Salmonella typhi Dimes Atika Permanasari; Elly Nurus Sakinah; Ali Santosa
Journal of Agromedicine and Medical Sciences Vol 2 No 2 (2016)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Biofilm is a matrix consist of extracelullar polysaccharides from the replication of microbial cells that are irreversibly attached on the cell surface. Biofilm in bacteria S.typhi strain DT104 contains food substance for protection. Biofilm can be attached to the clutery, causing food contaminaton. Cyclea barbata Miers is a plant has flavonoid that can inhibited bacteria biofilm formation. Flavonoid is phenolic compounds that has function as antibacterial by forming complex compounds disturbing the integrity of cell membranes and inhibiting biofilm. This study aims to determine the activity of the Cyclea barbata Miers as inhibitor of S.typhi DT 104 biofilm formation. This study used Quasy Experimental design with completely randomized design This study used 28 samples consist of 5 doses groups (0.29 mg/ ml, 0.33 mg / ml, 0.40 mg / ml, 0.50 mg / ml, 0.67 mg / ml), positive group (a bacterial suspension with H2O2) and negative group (a bacterial suspension with H2O) The result showed that the increasing doseof extract will decrease the biofilm formation revealed by decreasing of Optical Density and showed One Way Anova test resulted p = 0.004. In conclusion, the ethanolic extract of Cyclea barbata Miers was able to inhibit S.typhi DT 104 biofilm formation and there was a correlation between the concentration of ethanoic extract of Cyclea barbata Miers and inhibition of S.typhi biofilm formation. Key words: biofilm, Cyclea barbata Miers, S.typhi
Efek kandungan serat beras analog terhadap ekspresi GLUT4 otot rangka tikus diabetes Azka Darajat; Elly Nurus Sakinah; Hairrudin Hairrudin
Jurnal Gizi Klinik Indonesia Vol 16, No 1 (2019): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1070.355 KB) | DOI: 10.22146/ijcn.31806

Abstract

Effect of analog rice’s fiber on skeletal muscles GLUT4 expression in diabetic rats Background: Disruption of glucose transportation in skeletal muscle through GLUT4 becomes a problem in diabetes. Analog rice that had been modified by adding dietary fiber could improve the expression of GLUT4.Objective: This study aims to know the effect of dietary fiber toward GLUT4 expression and to know the dietary fiber percentage in analog rice.Method: The research type is true experimental with post-test only group design. The samples consist of 24 male Wistar rats that are group into 4 groups (n=6 each group). Three groups were induced by giving a high-fat diet for 40 days and streptozotocin (STZ) 35 mg/kg BW was given at 33th day and one group was not induced. After the blood glucose level exceeded 135 mg/dl, the treatment was given. After 3 weeks, the rats were terminated and quadriceps femoris muscle tissue was taken for immunohistochemistry examination using rat GLUT4 polyclonal antibody. GLUT4 expression was quantified using an immunoreactive score (IRS-GLUT4). The data were analyzed using the Kruskal-Wallis test and Spearman test.Results: Statistical analyses showed that there were significant differences between groups with a moderate positive correlation (correlation coefficient=0,651; p=0,003).Conclusion: Dietary fiber in analog rice could improve skeletal muscle GLUT4 expression in Wistar rat diabetic model.
The Correlation Between Mother's Knowledge about Complementary Feeding with The Incidence of Stunting in Toddlers Under Two in Mayang, Jember Dwita Aryadina Rachmawati; Ranindya Putri Cipta Indraswari; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 8 No 2 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i2.25606

Abstract

Stunting is a condition of toddlers who have a height-for-age less than -2 SD WHO Z-score. The period from a newborn until two years is also known as the golden period. Nutrition obtained after birth affects the growth and development of them. Complementary feeding was given when they were 6 months old. The level of mother's knowledge about complementary foods has an impact on complementary feeding. Inappropriate complementary feeding can lead to stunting. The research objective was to determine the correlation between mother's knowledge about complementary feeding and the incidence of stunting in toddlers under two in Mayang. The research was an analytical observational with a cross sectional study design. The sample was 90 respondents taken using consecutive sampling method. Data collection using a questionnaire on the mother and using height-for-age data from the toddlers. Statistical test using the Spearman test, showed that there was a significant correlation between the level of mother's knowledge about complementary feeding and the incidence of stunting (p=0.024.; rho=-0.238). Due to this result, we recommend continuous health promotion and education among mothers to decrease the risk of stunting in their children. Keywords: stunting, complementary feeding, toddlers under two, mother’s knowledge
EFEK NEEM GUM (Azadiracthta indica) TERHADAP KADAR SGOT SGPT TIKUS WISTAR YANG DIINDUKSI DIAZINON Jauhar Firdaus; Zahrah Febianti; Muhammad Rijal Fahrudin Hidayat; Elly Nurus Sakinah
Journal of Nutrition College Vol 11, No 3 (2022): Juli
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v11i3.33384

Abstract

ABSTRAKLatar belakang: Indonesia sebagai negara agraris 33,48 juta penduduknya bekerja di sektor pertanian dengan kasus keracunan pestisida tercatat 771 kasus pada tahun 2016. Diazinon menjadi salah satu pestisida golongan organofosfat yang cukup banyak digunakan di Indonesia yang memiliki efek neurotoksik dan berpotensi menyebabkan stres oksidatif pada hepar. Neem gum (Azadirachta indica) memiliki kandungan polisakarida dan antioksidan yang dapat mengikat radikal bebas untuk mencegah kerusakan pada hepar.Tujuan: Penelitian ini bertujuan untuk mengetahui efek neem gum terhadap kadar SGOT SGPT tikus wistar yang diinduksi diazinon.Metode: Penelitian ini merupakan penelitian eksperimental melalui pendekatan post test only dengan subjek tikus putih Rattus norvegicus strain wistar jantan sebanyak 25 ekor yang terbagi dalam 1 kelompok kontrol dan 4 kelompok perlakuan dosis larutan neem gum sebesar 3,75 gram/kgBB/hari, 7,5 gram/kgBB/hari, 15 gram/kgBB/hari, dan 30 gram/kgBB/hari.Hasil: Kadar SGOT dan SGPT tertinggi terdapat pada kelompok K dan kadar yang lebih rendah pada kelompok P1, P2, P3, dan P4 seiring penambahan dosis larutan neem gum yang diberikan. Hasil uji Anova kadar SGOT didapatkan signifikansi sebesar 0,013 dan uji Post Hoc terlihat perbedaan signifikan kadar SGOT kelompok P4 terhadap kelompok K sebesar 0,015.  Sedangkan hasil uji Anova kadar SGPT didapatkan signifikansi sebesar 0,014 dan uji Post Hoc terlihat perbedaan signifikan kadar SGPT kelompok P2, P3, dan P4 terhadap kelompok K berturut-turut sebesar 0,044, 0,034, dan 0,033.Simpulan: Larutan neem gum (Azadirachta indica) memiliki efek mencegah peningkatan kadar SGOT dan SGPT pada tikus yang diinduksi Diazinon.  Dosis yang dibutuhkan neem gum untuk mencegah peningkatan kadar SGOT sebanyak 30 gram/kgBB/hari dan dosis yang dibutuhkan untuk mencegah peningkatan kadar SGPT sebesar 7,5 gram/kgBB/hari, 15 gram/kgBB/hari, serta 30 gram/kgBB/hari dan tidak ada perbedaan efek yang signifikan diantara ketiga dosis tersebut. 
RESISTANCE PROFILE OF BACTERIA ISOLATED FROM LAYING HENS MANURE IN JEMBER REGENCY Enny Suswati; Elly Nurus Sakinah; Jauhar Firdaus; Abu Khoiri
Buletin Veteriner Udayana Vol. 15 No. 5 October 2023
Publisher : The Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2023.v15.i05.p17

Abstract

Antibiotics are becoming more prevalent as environmental pollutants, raising public health concerns. Antibiotics are routinely employed as growth promoters and therapeutic agents in poultry feeds. Because antibiotics are not completely metabolized in chicken body tissues, they are deposited in meat as parent compounds and eventually extruded into the environment via fowl droppings. Organic fertilizers based on chicken litter are typically recycled into the soil to improve the structure and fertility of agricultural land. Chicken litter, a vital source of nutrients for crop productivity, may also carry a variety of human infections that might endanger humans who consume contaminated food or water. A convenience sampling of five places was carried out. Litter samples were collected aseptically. CLSI standards were used to isolate E. coli and Proteus spp. The disc diffusion method was used to determine antibiotic susceptibility. E. coli and Proteus spp. were found in 80% and 60% of the samples. All E. coli and Proteus spp isolates derived from laying hen manure were resistant to sulfamethoxazole, ciprofloxacin, cefixime, tetracycline, amoxiclav, ceftriaxone, and chloramphenicol. However, only 50% and 33% were resistant to azithromycin. All E. coli and Proteus spp. Isolates were multidrug resistant. There was no resistance reported to cefepime or imipenem. Contamination of chicken litter with multidrug-resistant E. coli and Proteus spp. may be an underappreciated source of antimicrobial resistance (AMR) transmission to animals, people, and the environment. This demonstrates the importance of a One Health strategy to AMR surveillance and control in Jember. Monitoring AMR hazards and trends in the chicken litter would be possible with ongoing surveillance.
Co-Authors Abu Khoiri Achmad Ilham Tohari Ain Yuanita Insani Akhmad Makhmudi Ali Santosa Alvin Faizin Lisar Amalia Nur Zahra Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Angga Mardro Rahardjo Apryanita, Hudayah Arifa Mustika Aris Prasetyo Arista Prima Nugrahani Athoillah, Nabil Azham Purwandhono Azka Darajat Azka Darajat Bagus Wahyu Mulyono Barus, Marsha Zahra Adyanda Cahyana, Nugraha Wahyu Candra Agung Wibisana Cholis Abrori, Cholis Cicih Komariah Cindy Meylania Pradana Darajat, Azka Dear Farah Sielma Desie Dwi Wisudanti Dewantari, Septiarina Putri Dimes Atika Permanasari Dita Diana Parti Dwike Rachma Maydaniar Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati ENNY SUSWATI Erma Sulistyaningsih Erma Sulistyaningsih Fawziyah Putri Maulida Febrina Sylva Fridayanti Febrina Sylva Fridayanti, Febrina Sylva Gusfita Trisna Ayu Putri Hairrudin Hairrudin Heni Fatmawati Hilda Nur Achfidawati Inreswari, Laksmi Jauhar Firdaus Khana Nurfadhila Lubis, Arinie Awindya Maria Ulfa Mega Citra Prameswari Mochammad Amrun Hidayat Muhammad Rijal Fahrudin Hidayat Muhammad Yuda Nugraha Muhtar Ady Kusuma Nadzir Ansharullah Akbar Niki Niki Rahmawati Nistiandani, Ana Novail Alif Muharrom Nurud Diniyah Pattipeilohy, Florence Pattipeilohy, Florence Marianty Prasetyo, Aris Ramadhani, Alfiyah Ranindya Putri Cipta Indraswari Ricky Roosdiana Dewi Rini Riyanti Rizka Nuzula Wardani Rosita Dewi Rumastika, Nindya Shinta septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Shinta Madyaning Wuri Shiwi Linggarjati Siswoyo Siswoyo Sudarmanto, Yohanes Sugiyanta Sugiyanta Supangat Supangat Supangat Supangat T Ariani Widiastini Tegar Syaiful Qodar Tira Anjeli Rahmah Toyibatul Hidayati Ulfa Elfiah Vidya Muqsita Wibsono, Sony Yudha Nurdian Yuli Hermansyah Zahrah Febianti