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All Journal Dentika Dental Journal Jurnal Kesehatan Masyarakat Folia Medica Indonesiana Jurnal Biosains Pascasarjana Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Jurnal Riset Kesehatan Poltekkes Depkes Bandung Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Dental Medicine Jurnal Pengabdian UNDIKMA Indian Journal of Forensic Medicine & Toxicology Strada Jurnal Ilmiah Kesehatan (SJIK)
Theresia Indah Budhy Sulisetyawati
Departemen Imunologi, Sekolah Pascasarjana,Universitas Airlangga
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The Role Of Moringa Leaf Extract (Moringa Oleifera) On Interleukin-10 Levels In Chronic Inflammation Of The Dermis Of White Wistar Rats (Rattus Norvegicus) Nurwinda Enni Rosyidah; Theresia Indah Budhy
Jurnal Biosains Pascasarjana Vol. 24 No. 1 (2022): VOL 24, NO 1 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1.2022.23-28

Abstract

Traumatic injury can cause chronic inflammation that lasts several months to years. Interleukin-10 plays an important role in the repair of tissue fibrosis and accelerates wound healing. The active compounds of secondary metabolites in Moringa leaves include flavonoids, saponins, alkaloids, and tannins that can accelerate wound closure and act as anti-inflammatory effect to help vasoconstriction in blood vessels so as to minimize signs of inflammation. The aim of this study was to analyze the role of Moringa leaf extract on Interleukin-10 levels in chronic dermis inflammation. This study used a true experimental research with a post-test only control group design. This experimental procedure using 20 male Wistar rats, aging 2-3 months, weighing 150-200 grams and divided into four groups, a negative control group and experiment group with treatment of Moringa leaf extract at concentration of 5%, 10% and 15%. The extract was administered for 3 days after the creation of chronic inflammation in the dermis. Blood serum were taken after 3 days administration of Moringa leaf extract. Analysis using Kruskal Wallis with 5% of error rate. The results showed p=0.040 (p<0.005), which means interleukin-10 levels in experiment group with treatment of Moringa leaf extract were significantly increased. The leaf extract of Moringa oleifera had a role in increasing Interleukin-10 levels in chronic dermis inflammation of male white Wistar rats (Rattus norvegicus) with the best concentration of 15%.
Differences in Total S-RBD Antibody SARS-CoV-2 Post-vaccination mRNA-1273 3rd Dosage (Heterologous Prime Booster) with Post-prime Vaccination Inactivated Whole Virus Two Doses (Homologous) in Health Personnel Surabaya H2LC Clinic Deddy Hartanto; Jusak A. Nugraha; Theresia Indah Budhy
Jurnal Biosains Pascasarjana Vol. 24 No. 2 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i2.2022.107-114

Abstract

SARS-CoV-2 cases have increased to 463,182,124 reported worldwide as of March 16, 2022 with a death toll of 6,079,600. Indonesia on March 17, 2022 has increased by 5,939,082 with a death toll of 153,212 (KPCPEN, 2022). SARS-CoV-2 is closely related to the coronavirus. One of the efforts made to prevent the risk of severe infection and reduce the death rate from the SARS-CoV-2 virus in Indonesia is a vaccination program. According to IDI (2021) cases of Covid-19 deaths are dominated by men (84%) and women (16%). Clinical trials in China and Brazil have shown that, the immunogenicity of two doses of the vaccine decreases over time and there is a decrease in low antibody concentrations after 6 months of running time. To overcome this potential, the Indonesian government gives priority to the 3rd vaccine booster. The purpose of this study was to analyze the comparison between the total antibody titer for the Spike-RBD (Receptor Binding Domain) SARS-CoV-2 protein after the 3rd dose of mRNA-1273 booster vaccination and post-vaccination of two doses of primary inactivated whole virus in health workers. This research was conducted by observation with a cohort approach. It was concluded that the results of the Mann Whitney two-sided test with a significance value of 0.000, the antibody titer correlation test results with gender had a value of 0.702 and -0.366 for the relationship between antibody titer and age. There was a significant difference between the primary vaccination dose of 2 doses of CoronaVac and the 3rd vaccination (booster) mRNA-1273, gender was strongly associated with S-RBD antibody titer and age was not associated with S-RBD antibody titer.
The Potential of Mangrove Stem Extract (Aegiceras corniculatum) on the Haematocrit Value Gustiadi Saputra; Theresia Indah Budhy; Muji Rahayu; Budi Santosa
Jurnal Biosains Pascasarjana Vol. 24 No. 2 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i2.2022.122-127

Abstract

Hematocrit examination is an examination used to measure the concentration of red blood cells (erythrocytes) in the blood stated in percent (%). The usual hematocrit examination uses the anticoagulant EDTA, is expensive, and rarely distributed in remote area. Alternative anticoagulants are currently being studied, one of which is the extract of mangrove stems (Aegiceras corniculatum). This study aims to determine the difference in hematocrit values ​​using the anticoagulant EDTA and extract of mangrove stems (Aegiceras corniculatum). The type of this research was analytic observational with a cross-sectional research design. Samples were taken by non-random purposive sampling of 16 female students from a total of 31 students of class D semester VIII of Health Analyst Universitas Muhammadiyah Semarang. The results showed average hematocrit value using EDTA anticoagulant was 42.38% by using the microhematocrit method. Meanwhile, the average hematocrit value using mangrove stem extract (Aegiceras corniculatum) is 20.88%. The hematocrit examination using the EDTA anticoagulant were higher than using the extract of mangrove stems (Aegiceras corniculatum). It showed a value of 0.000 with a significant level of 0.05, which is 0.000 <0.05. Therefore, there is a difference in hematocrit value using EDTA anticoagulant and mangrove stem extract (Aegiceras corniculatum).
Effect of Modisco-Cookies Combined with Auriculopuncture therapy on Increment of Body Weight Latifah, Maasyitoh Sari; Puruhito, Edith Frederika; Budhy, Theresia Indah; Azis, Zulfikran Moh Rizki
KEMAS: Jurnal Kesehatan Masyarakat Vol 18, No 2 (2022)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v18i2.33052

Abstract

Being underweight is a common problem in developing countries, including Indonesia, that may cause infections, including viral ones. The solution to this problem is to provide Modisco cookies and auriculopuncture therapy with seed-pressing methods. Auriculopuncture is a traditional Chinese therapy using the seed-pressing method at the auricular point stimulating to relieve other body pathologies. While Modisco cookies have energy-dense, high- calories, digestible cookies that aim to help accelerate weight gain. This study aims to determine the effect of Modisco cookies compared to a combination of Modisco cookies with auriculopuncture on the increase of body weight among male adolescents. This study observed 22 male teenagers with low body weight for three weeks. The subjects are categorized into two treatment groups: (1) the Modisco cookies group and (2) the combination of Modisco cookies and the auriculopuncture treatment group every day for three weeks (26 days). This study compared the mean of the pretest and posttest of the weight changes using a T-test. Furthermore, the average weight changes between the two groups were compared using Manova repeated measured test. The Modisco cookies have nutrient-dense and easy to digest, while Auriculopuncture may stimulate to a certain point in the ear. The hypothalamus has a role in the production of the ghrelin hormone. The therapy may increase hormone appetite and reduce the use of fat reserves. It may increase the body weight of underweight adolescents significantly (p=0.00). A combination of Modisco cookies and auriculopuncture therapy gave a significant increase in adolescent body weight compared to modisco cookies.
Viability of 7F2 pre-osteoblast after Sulawesi stingless bee (Tetragonula biroi) 1% propolis nanoemulsion extraction Sitalaksmi, Ratri Maya; Amalia, Nadya Rafika; Nugraha, Alexander Patera; Budhy, Theresia Indah; Ramadhani, Nastiti Faradilla; Situmorang, Putri Cahaya; Noor, Tengku Natasha Eleena binti Tengku Ahmad; Shariff, Khairul Anuar
Majalah Kedokteran Gigi Indonesia Vol 10, No 2 (2024): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.98860

Abstract

Produced by a stingless bee (Tetragonula biroi) from Sulawesi Island, propolis is an active compound that requires further studies to determine its herbal-based medicinal applications. In addition, propolis is well known as a potential natural ingredient for herbal medicine with minimal side effects. The stingless honeybee, native to Sulawesi, produces propolis, a resin. Propolis from Trigona stingless bees in Sulawesi has the highest flavonoid content compared to Apis mellifera bees. Flavonoids are the most common compounds contained in propolis. Propolis from stingless bees may have the potential to stimulate osteoblast cell proliferation and be responsible for bone regeneration. The objective of this study is to investigate the viability of the 7F2 pre-osteoblast cell line after administration of the stingless bee’s 1% propolis nanoemulsion extract (PNE). A 1% PNE was formulated by maceration methods and diluted into several concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, and 0.78%. A particle size analysis was done to examine the particle size and zeta potential of the 1% PNE. A Tetrazolium Technique assay was carried out to examine 1% PNE application on a 7F2 pre-osteoblast cell line on days 1, 3, and 7. The highest viability of 7F2 pre-osteoblast cells was at 0.78% concentration on day 7, and the lowest viability was observed at 100% concentration on day 1, with significant differences among groups (p < 0.05). A 1% PNE with a particle size of 151.28 to 182.2 nm and a zeta potential of −32.76 mV was successfully formulated. The 1% PNE was non-toxic to 7F2 pre-osteoblast cells, with a cell toxicity limit at a concentration of 1.56%.
Curcumin in Turmeric (Curcuma longa L.) for Treatment of Oral Lichen Planus: A Narrative Review Purwaningrum, Vegananda Wahyu; Elizabeth, Laurencia Dwiamanda; Pratiwi, Chandrasasi Berlian; Nugraha, Ilyas Yakob Nurul; Setiawan, Kresna Erlangga; Maulina, Syafriaz Zulfa; Rahmah, Shafwa Aisha; Shallomitha, Aginta Gracia; Firjani, Putri Nabila; Supandji, Rafaelle Raditya; Salsabila, Alisya Rachel; Islamy, Azzahra Hasnur; Livesey, Gisele Nefertari Love; Masitoh, Hindun Fitria; Fadila, Okta Mulia Nur; Putri, Destiana Hardianti; Cinantya, Aulia Dian; Syahdiar, Aura Zalfa Ghassani; Wati, Sisca Meida; Rahayu, Retno Pudji; Budhy, Theresia Indah; Banerjee, Abhishek
Indonesian Journal of Dental Medicine Vol. 7 No. 1 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i1.2024.40-43

Abstract

Background: Turmeric (Curcuma longa L.) has long been used as a traditional medicine. The primary active component of turmeric is curcumin. It has potential anti-inflammatory effects and high antioxidant activity. Curcumin contained in turmeric has been reported as an effective treatment for Oral lichen planus (OLP). OLP is a chronic autoimmune, inflammatory disease of the oral mucosa associated with systemic disease. This disease involves the skin and mucous membranes (mucocutaneous) of stratified squamous epithelium. Purpose: This narrative review conducted on Google Scholar, PubMed, Research Gate, and ScienceDirect databases aims to study the effectiveness of curcumin contained in Turmeric (C. longa L.)   in OLP treatment. Review(s): OLP is a condition of the oral mucosa that is a chronic autoimmune mucocutaneous disease. As many as 0.5% to 2.2% of cases of OLP occur in the adult population. Systemic and topical corticosteroid drugs are usually used to treat OLP. However, the use of these drugs has many side effects, so it needs searching for a new active substance to treat OLP. Curcumin is a hydrophobic polyphenol extracted from the rhizome of the herb Curcuma longa (turmeric), which has a low molecular weight. The repeated use of steroids can cause side effects that cause atrophy of the mucosa and candidiasis. One natural product that is superior to corticosteroids is curcumin. This is due to curcumin's anti-inflammatory, antioxidant, and chemopreventive properties in several diseases. Conclusion: This review suggests that OLP treatment using curcumin in Turmeric (C. longa L.)   is effective because curcumin exhibits antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic activities, as well as immunomodulatory properties.
Mutant p53 Expression Of Oral Transformed Epithelium Cell In Rats Injected By Benzo[A]Pyrene Sawitri Dwi indah Pertami; I Ketut Sudiana; Theresia Indah Budhy; Retno Palupi; Ira Arundina
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 1 (2020): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i1.234

Abstract

Benzopyrene is a polycyclic aromatic hydrocarbons (PAHs) compound that can cause transformation of normal cells into malignant in order to its genotoxic,mutagenic,and carsinogenic ability. DNA mutation in tumor suppressor genes p53 make cells immortal which results in cell transformation and develops into malignancies. This study consist of five groups including the control group (without benzopyrene injection) and 4 treatment groups injected with benzopyrene each for 4 weeks (P1), 6 weeks (P2), 8 weeks (P3) and 10 weeks (P4). Therefore, the mutant p53 expression was calculated and analyzed statistically with the One Way Anova Test. There was signifficance difference in mutant p53 expression of oral transformed epithelium cell injected by benzopyrene (p=0.000) and the highest expression was at 10th week. It can be concluded that the mutant P53 expression of oral transformed epithelium cells in rats was increased after injected by benzopyrene
Correlation between IL-1beta and IL-18 Levels with Dengue Virus Infection Severity Sari, Arabella Vonia; Aryati, Aryati; Budhy, Theresia Indah; Ma`ruf, Anwar; Husada, Dominicus; Palupi, Retno; Sunari, I Gusti Agung Ayu Eka Putri; Indrasari, Yulia Nadar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2682

Abstract

Activated monocytes/macrophages and T lymphocytes that generate a cytokine storm are thought to play a critical role in the development of dengue. Cytokine storms, characterized by the excessive production of proinflammatory cytokines, can result in cellular dysfunction and organ failure, often contributing to the severity of dengue in affected patients. Interleukin-18 (IL-18), like IL-1beta, is a proinflammatory cytokine released during inflammation triggered by inflammasome activation. Increased IL-1beta and IL-18 during dengue virus infection (DVI) are known to worsen the host's vascular permeability, increasing hemostasis disorders and potentially, all of which are important elements in the pathophysiology of dengue fever. This study investigates the association between IL-1beta levels, IL-18 levels, age, dengue virus serotype, and the severity of dengue virus infection, aiming to understand how these factors interact and influence disease outcomes. This study is an observational cross-sectional design from 59 DVI patients in Dr. Soetomo General Hospital, Surabaya with positive dengue PCR results. Both IL-1beta and IL-18 levels reveal no significant relationship with the patient's age, infection status, and dengue virus serotype. A weak negative significant relationship between IL-1beta levels and the severity of DVI, indicating an inverse relationship between IL-1beta levels and the severity. Further studies are required to investigate the function of these cytokines in severe dengue.
APPLICATION OF MUSA BALBISIANA LOTION AGAINST STAPHYLOCOCCUS AUREUS Rezky, Muhammad Andyka; Budhy, Theresia Indah; Nuswantoro, Ari; Tika, Dian; Adawiyah, Rabi’atul
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 1 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i1.2818

Abstract

Staphylococcus aureus merupakan bakteri patogen yang dapat menyebabkan berbagai infeksi, terutama pada kulit, seperti bisul, impetigo, dan abses. Infeksi ini sering kali ditandai dengan peradangan, nekrosis, dan pembentukan nanah, yang secara signifikan dapat mengganggu fungsi kulit sebagai pelindung tubuh. Tantangan utama dalam pengelolaannya adalah meningkatnya resistensi antibiotik, termasuk Methicillin-Resistant Staphylococcus aureus (MRSA), sehingga diperlukan alternatif yang efektif, seperti bahan herbal, untuk mengatasi permasalahan ini. Kulit pisang kepok kuning yang sering berakhir sebagai limbah organik, diketahui mengandung senyawa aktif seperti flavonoid, alkaloid, saponin, tanin, dan antioksidan. Senyawa-senyawa tersebut memiliki aktivitas antibakteri yang signifikan, disertai dengan kemampuan melindungi kulit dari kerusakan akibat radikal bebas. Penelitian ini bertujuan untuk menjelaskan perbedaan efektivitas losion berbahan dasar ekstrak kulit pisang kepok kuning dengan tiga konsentrasi berbeda, yaitu formula I (30%), formula II (60%), dan formula III (90%) dalam menghambat pertumbuhan Staphylococcus aureus. Penelitian berbentuk quasi eksperimental desain ini menggunakan metode difusi cakram. Hasil penelitian menunjukkan bahwa rata-rata diameter zona hambat formula I adalah 5,60 mm, formula II adalah 8,30 mm, dan formula III adalah 8,70 mm. Analisis statistik dengan uji Kruskal-Wallis menunjukkan nilai p = 0,004, yang mengindikasikan adanya perbedaan signifikan antar formula. Kesimpulannya, losion ekstrak kulit pisang kepok kuning menunjukkan efektivitas yang signifikan dalam menghambat pertumbuhan Staphylococcus aureus. Efektivitas ini meningkat secara proporsional dengan konsentrasi ekstrak, sehingga produk ini memiliki potensi untuk digunakan sebagai losion antibakteri.
THE EFFECT OF ASTAXANTHIN ON TUMOR NECROSIS FACTOR ALPHA (TNF-α) AND INTERLEUKIN 10 (IL-10) EXPRESSION IN UV-B-INDUCED RATS MODEL Akhmad Setyo Rahman; Theresia Indah Budhy; Jusak Nugraha; Nur Lailatul Fadhilah
Folia Medica Indonesiana ON PROGRESS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The skin, the largest organ in the human body, serves as a protective barrier against external factors. Exposure to UV-B radiation accounts for approximately 90% of skin damage, leading to aging characterized by dryness and wrinkles. Proper nutrition has been associated with skin repair and delayed aging. Astaxanthin, known for its pharmacological properties including anti-cancer, anti-diabetic, anti-inflammatory, and antioxidant activities has garnered attention for its ability to improve damaged skin when administered as a daily supplement. This study investigated the roles of TNF-α and IL-10 as inflammatory markers in skin damage and repair, which remain underexplored. A true experimental randomized posttest-only control group design was employed using 24 male white rats divided into four groups: (1) normal group (N), untreated rats; (2) control group (C), rats administered with olive oil (5 ml/kg BW); (3) treatment group 1 (P1), rats exposed to UV-B and administered with olive oil (5 ml/kg BW); and (4) treatment group 2 (P2), rats exposed to UV-B and administered with astaxanthin (10 mg/kg BW) combined with olive oil (5 ml/kg BW). ANOVA and Games-Howell post-hoc tests revealed significant differences (p < 0.05) among groups, except between the control (C) and normal (N) groups. Astaxanthin (10 mg/kg BW) demonstrated both curative and protective effects by reducing TNF-α expression (pro-inflammatory) and increasing IL-10 expression (anti-inflammatory) in UV-B-induced rats. These findings highlight astaxanthin's potential as a therapeutic agent for UV-B-induced skin damage.
Co-Authors Adawiyah, Rabi’atul Akhmad Setyo Rahman Alexander Patera Nugraha Amalia, Nadya Rafika Ari Nuswantoro Aryati Aryati Azis, Zulfikran Moh Rizki Bambang Sumaryono Banerjee, Abhishek Bayu Indra Sukmana Budi Santosa Cinantya, Aulia Dian Cyuzuzo Callixte Deddy Hartanto Dominicus Husada Dwicha Rahma Nuriska Hartono Edhi Jularso Edith Frederika Puruhito, Edith Frederika Elizabeth, Laurencia Dwiamanda Erawati Wulandari Fadila, Okta Mulia Nur Firjani, Putri Nabila Fransiskus Andrianto Gustiadi Saputra I Ketut Sudana Indrasari, Yulia Nadar Ira Arundina Ira Arundina Islamy, Azzahra Hasnur Jenny Sunariani Jusak A. Nugraha Jusak Nugraha Latief Mooduto, Latief Latifah, Maasyitoh Sari Livesey, Gisele Nefertari Love Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Ma`ruf, Anwar Muhammad Luthfi Muji Rahayu Nastiti Faradilla Ramadhani Noor, Tengku Natasha Eleena binti Tengku Ahmad Nugraha, Ilyas Yakob Nurul Nur Lailatul Fadhilah Nurwinda Enni Rosyidah Pratiwi, Chandrasasi Berlian Purwaningrum, Vegananda Wahyu Putri, Destiana Hardianti Rahmah, Shafwa Aisha Rahmawati, Septyana Eka Ratri Maya Sitalaksmi Retno Indrawati Roestamadji Retno Palupi Retno Palupi Retno Pudji Rahayu Rezky, Muhammad Andyka Roni Handayani Roni Handayani S.Pd. M Kes I Ketut Sudiana . Salsabila, Alisya Rachel Sari, Arabella Vonia Sawitri Dwi Indah Pertami Setiawan, Kresna Erlangga Shahzad Shoukat Shallomitha, Aginta Gracia Shariff, Khairul Anuar Sisca Meida Wati Sunari, I Gusti Agung Ayu Eka Putri Supandji, Rafaelle Raditya Syahdiar, Aura Zalfa Ghassani Tika, Dian Tuyishimire Irene Vania Syahputri