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All Journal Dentika Dental Journal Jurnal Kesehatan Masyarakat Jurnal Biosains Pascasarjana Majalah Kedokteran Gigi Indonesia Dentino: Jurnal Kedokteran Gigi Jurnal Kimia Riset Dental Journal (Majalah Kedokteran Gigi) Smart Medical Journal Jurnal Riset Kesehatan Poltekkes Depkes Bandung Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal ABDINUS : Jurnal Pengabdian Nusantara Indonesian Journal of Dental Medicine Jurnal Pengabdian UNDIKMA Indian Journal of Forensic Medicine & Toxicology Journal of Multidisciplinary Applied Natural Science PENITI BANGSA (Pemanfaatan Ilmu Pengetahuan dan Teknologi bagi Masyarakat) Strada Jurnal Ilmiah Kesehatan (SJIK) Folia Medica Indonesiana
Theresia Indah Budhy Sulisetyawati
Departemen Imunologi, Sekolah Pascasarjana, Universitas Airlangga
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The Role Of Moringa Leaf Extract (Moringa Oleifera) On Interleukin-10 Levels In Chronic Inflammation Of The Dermis Of White Wistar Rats (Rattus Norvegicus) Nurwinda Enni Rosyidah; Theresia Indah Budhy
Jurnal Biosains Pascasarjana Vol. 24 No. 1 (2022): VOL 24, NO 1 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1.2022.23-28

Abstract

Traumatic injury can cause chronic inflammation that lasts several months to years. Interleukin-10 plays an important role in the repair of tissue fibrosis and accelerates wound healing. The active compounds of secondary metabolites in Moringa leaves include flavonoids, saponins, alkaloids, and tannins that can accelerate wound closure and act as anti-inflammatory effect to help vasoconstriction in blood vessels so as to minimize signs of inflammation. The aim of this study was to analyze the role of Moringa leaf extract on Interleukin-10 levels in chronic dermis inflammation. This study used a true experimental research with a post-test only control group design. This experimental procedure using 20 male Wistar rats, aging 2-3 months, weighing 150-200 grams and divided into four groups, a negative control group and experiment group with treatment of Moringa leaf extract at concentration of 5%, 10% and 15%. The extract was administered for 3 days after the creation of chronic inflammation in the dermis. Blood serum were taken after 3 days administration of Moringa leaf extract. Analysis using Kruskal Wallis with 5% of error rate. The results showed p=0.040 (p<0.005), which means interleukin-10 levels in experiment group with treatment of Moringa leaf extract were significantly increased. The leaf extract of Moringa oleifera had a role in increasing Interleukin-10 levels in chronic dermis inflammation of male white Wistar rats (Rattus norvegicus) with the best concentration of 15%.
Differences in Total S-RBD Antibody SARS-CoV-2 Post-vaccination mRNA-1273 3rd Dosage (Heterologous Prime Booster) with Post-prime Vaccination Inactivated Whole Virus Two Doses (Homologous) in Health Personnel Surabaya H2LC Clinic Deddy Hartanto; Jusak A. Nugraha; Theresia Indah Budhy
Jurnal Biosains Pascasarjana Vol. 24 No. 2 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i2.2022.107-114

Abstract

SARS-CoV-2 cases have increased to 463,182,124 reported worldwide as of March 16, 2022 with a death toll of 6,079,600. Indonesia on March 17, 2022 has increased by 5,939,082 with a death toll of 153,212 (KPCPEN, 2022). SARS-CoV-2 is closely related to the coronavirus. One of the efforts made to prevent the risk of severe infection and reduce the death rate from the SARS-CoV-2 virus in Indonesia is a vaccination program. According to IDI (2021) cases of Covid-19 deaths are dominated by men (84%) and women (16%). Clinical trials in China and Brazil have shown that, the immunogenicity of two doses of the vaccine decreases over time and there is a decrease in low antibody concentrations after 6 months of running time. To overcome this potential, the Indonesian government gives priority to the 3rd vaccine booster. The purpose of this study was to analyze the comparison between the total antibody titer for the Spike-RBD (Receptor Binding Domain) SARS-CoV-2 protein after the 3rd dose of mRNA-1273 booster vaccination and post-vaccination of two doses of primary inactivated whole virus in health workers. This research was conducted by observation with a cohort approach. It was concluded that the results of the Mann Whitney two-sided test with a significance value of 0.000, the antibody titer correlation test results with gender had a value of 0.702 and -0.366 for the relationship between antibody titer and age. There was a significant difference between the primary vaccination dose of 2 doses of CoronaVac and the 3rd vaccination (booster) mRNA-1273, gender was strongly associated with S-RBD antibody titer and age was not associated with S-RBD antibody titer.
The Potential of Mangrove Stem Extract (Aegiceras corniculatum) on the Haematocrit Value Gustiadi Saputra; Theresia Indah Budhy; Muji Rahayu; Budi Santosa
Jurnal Biosains Pascasarjana Vol. 24 No. 2 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i2.2022.122-127

Abstract

Hematocrit examination is an examination used to measure the concentration of red blood cells (erythrocytes) in the blood stated in percent (%). The usual hematocrit examination uses the anticoagulant EDTA, is expensive, and rarely distributed in remote area. Alternative anticoagulants are currently being studied, one of which is the extract of mangrove stems (Aegiceras corniculatum). This study aims to determine the difference in hematocrit values ​​using the anticoagulant EDTA and extract of mangrove stems (Aegiceras corniculatum). The type of this research was analytic observational with a cross-sectional research design. Samples were taken by non-random purposive sampling of 16 female students from a total of 31 students of class D semester VIII of Health Analyst Universitas Muhammadiyah Semarang. The results showed average hematocrit value using EDTA anticoagulant was 42.38% by using the microhematocrit method. Meanwhile, the average hematocrit value using mangrove stem extract (Aegiceras corniculatum) is 20.88%. The hematocrit examination using the EDTA anticoagulant were higher than using the extract of mangrove stems (Aegiceras corniculatum). It showed a value of 0.000 with a significant level of 0.05, which is 0.000 <0.05. Therefore, there is a difference in hematocrit value using EDTA anticoagulant and mangrove stem extract (Aegiceras corniculatum).
Effect of Modisco-Cookies Combined with Auriculopuncture therapy on Increment of Body Weight Latifah, Maasyitoh Sari; Puruhito, Edith Frederika; Budhy, Theresia Indah; Azis, Zulfikran Moh Rizki
KEMAS: Jurnal Kesehatan Masyarakat Vol 18, No 2 (2022)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v18i2.33052

Abstract

Being underweight is a common problem in developing countries, including Indonesia, that may cause infections, including viral ones. The solution to this problem is to provide Modisco cookies and auriculopuncture therapy with seed-pressing methods. Auriculopuncture is a traditional Chinese therapy using the seed-pressing method at the auricular point stimulating to relieve other body pathologies. While Modisco cookies have energy-dense, high- calories, digestible cookies that aim to help accelerate weight gain. This study aims to determine the effect of Modisco cookies compared to a combination of Modisco cookies with auriculopuncture on the increase of body weight among male adolescents. This study observed 22 male teenagers with low body weight for three weeks. The subjects are categorized into two treatment groups: (1) the Modisco cookies group and (2) the combination of Modisco cookies and the auriculopuncture treatment group every day for three weeks (26 days). This study compared the mean of the pretest and posttest of the weight changes using a T-test. Furthermore, the average weight changes between the two groups were compared using Manova repeated measured test. The Modisco cookies have nutrient-dense and easy to digest, while Auriculopuncture may stimulate to a certain point in the ear. The hypothalamus has a role in the production of the ghrelin hormone. The therapy may increase hormone appetite and reduce the use of fat reserves. It may increase the body weight of underweight adolescents significantly (p=0.00). A combination of Modisco cookies and auriculopuncture therapy gave a significant increase in adolescent body weight compared to modisco cookies.
THE EFFECT OF GIVING SNAKEHEAD FISH SUPPLEMENTATION THERAPY (STRIATED CHANNA) ON BODY WEIGHT IN TUBERCULOSIS PATIENTS AT THE SIDOTOPO HEALTH CENTER IN SURABAYA Alfia Andriyani; Jusak Nugraha; Retno Indrawati; Theresia Indah Budhy
Jurnal Biosains Pascasarjana Vol. 25 No. 2 (2023): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v25i2.2023.123-127

Abstract

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. This study aims to determine the effect of supplementing snakehead fish (Channa striata) on body weight at the Sidotopo Health Center. The method used in this study was a one group pre test post test design involving 20 patients using a purposive sampling. The study inclusion criteria were clients who had just been diagnosed with active tuberculosis, took OAT regularly, aged 18-60 years. Exclusion criteria were TB patients who refused the study, MDR (Multi drug Resistance) TB, smokers, had a history of allergies, took other supplements. This research was conducted in June 2022 at the Sidotopo Health Center in Surabaya. Laboratory analysis was carried out at the Tropical Disease Institute, Airlangga University. The results of statistical tests in this study were that there were differences in the administration of snakehead fish (Channa striata) on body weight in tuberculosis patients with a p-value = 0.000 (<0.005). The pretest reached 46.25 kg, while the post test body weight was 48.20 kg. This shows that there is an increase in body weight in TB patients at the Sidotopo Health Center in Surabaya. Keywords : Weight, Tuberculosis, Snakehead fish
Viability of 7F2 pre-osteoblast after Sulawesi stingless bee (Tetragonula biroi) 1% propolis nanoemulsion extraction Sitalaksmi, Ratri Maya; Amalia, Nadya Rafika; Nugraha, Alexander Patera; Budhy, Theresia Indah; Ramadhani, Nastiti Faradilla; Situmorang, Putri Cahaya; Noor, Tengku Natasha Eleena binti Tengku Ahmad; Shariff, Khairul Anuar
Majalah Kedokteran Gigi Indonesia Vol 10, No 2 (2024): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.98860

Abstract

Produced by a stingless bee (Tetragonula biroi) from Sulawesi Island, propolis is an active compound that requires further studies to determine its herbal-based medicinal applications. In addition, propolis is well known as a potential natural ingredient for herbal medicine with minimal side effects. The stingless honeybee, native to Sulawesi, produces propolis, a resin. Propolis from Trigona stingless bees in Sulawesi has the highest flavonoid content compared to Apis mellifera bees. Flavonoids are the most common compounds contained in propolis. Propolis from stingless bees may have the potential to stimulate osteoblast cell proliferation and be responsible for bone regeneration. The objective of this study is to investigate the viability of the 7F2 pre-osteoblast cell line after administration of the stingless bee’s 1% propolis nanoemulsion extract (PNE). A 1% PNE was formulated by maceration methods and diluted into several concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, and 0.78%. A particle size analysis was done to examine the particle size and zeta potential of the 1% PNE. A Tetrazolium Technique assay was carried out to examine 1% PNE application on a 7F2 pre-osteoblast cell line on days 1, 3, and 7. The highest viability of 7F2 pre-osteoblast cells was at 0.78% concentration on day 7, and the lowest viability was observed at 100% concentration on day 1, with significant differences among groups (p < 0.05). A 1% PNE with a particle size of 151.28 to 182.2 nm and a zeta potential of −32.76 mV was successfully formulated. The 1% PNE was non-toxic to 7F2 pre-osteoblast cells, with a cell toxicity limit at a concentration of 1.56%.
Curcumin in Turmeric (Curcuma longa L.) for Treatment of Oral Lichen Planus: A Narrative Review Purwaningrum, Vegananda Wahyu; Elizabeth, Laurencia Dwiamanda; Pratiwi, Chandrasasi Berlian; Nugraha, Ilyas Yakob Nurul; Setiawan, Kresna Erlangga; Maulina, Syafriaz Zulfa; Rahmah, Shafwa Aisha; Shallomitha, Aginta Gracia; Firjani, Putri Nabila; Supandji, Rafaelle Raditya; Salsabila, Alisya Rachel; Islamy, Azzahra Hasnur; Livesey, Gisele Nefertari Love; Masitoh, Hindun Fitria; Fadila, Okta Mulia Nur; Putri, Destiana Hardianti; Cinantya, Aulia Dian; Syahdiar, Aura Zalfa Ghassani; Wati, Sisca Meida; Rahayu, Retno Pudji; Budhy, Theresia Indah; Banerjee, Abhishek
Indonesian Journal of Dental Medicine Vol. 7 No. 1 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i1.2024.40-43

Abstract

Background: Turmeric (Curcuma longa L.) has long been used as a traditional medicine. The primary active component of turmeric is curcumin. It has potential anti-inflammatory effects and high antioxidant activity. Curcumin contained in turmeric has been reported as an effective treatment for Oral lichen planus (OLP). OLP is a chronic autoimmune, inflammatory disease of the oral mucosa associated with systemic disease. This disease involves the skin and mucous membranes (mucocutaneous) of stratified squamous epithelium. Purpose: This narrative review conducted on Google Scholar, PubMed, Research Gate, and ScienceDirect databases aims to study the effectiveness of curcumin contained in Turmeric (C. longa L.)   in OLP treatment. Review(s): OLP is a condition of the oral mucosa that is a chronic autoimmune mucocutaneous disease. As many as 0.5% to 2.2% of cases of OLP occur in the adult population. Systemic and topical corticosteroid drugs are usually used to treat OLP. However, the use of these drugs has many side effects, so it needs searching for a new active substance to treat OLP. Curcumin is a hydrophobic polyphenol extracted from the rhizome of the herb Curcuma longa (turmeric), which has a low molecular weight. The repeated use of steroids can cause side effects that cause atrophy of the mucosa and candidiasis. One natural product that is superior to corticosteroids is curcumin. This is due to curcumin's anti-inflammatory, antioxidant, and chemopreventive properties in several diseases. Conclusion: This review suggests that OLP treatment using curcumin in Turmeric (C. longa L.)   is effective because curcumin exhibits antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic activities, as well as immunomodulatory properties.
Rumah Imun dan Ambulan Motor sebagai Upaya Pencegahan Stunting dan Sarana Kegawatdaruratan di Desa Pagung Kabupaten Kediri Sulisetyawati, Theresia Indah Budhy; Roestamadji, Retno Indrawati; Megasari, Ni Luh Ayu; Imannia, Ristya Sylva; Wardhani, Renita Gusti; Maulanasari, Ersa Afifah; Cheardi, Natallensi Deara; Buana, Dwi Candra
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 8 No 2 (2024): Volume 8 Nomor 2 Tahun 2024
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v8i2.23173

Abstract

This community service aims to improve the skills and knowledge of the surrounding community as well as first aid accommodation to health service facilities in the community of Pagung Village, Semen District, Kediri Regency, East Java. The implementation method of this community service is a field survey to identify stunting problems, making pocket books on emergencies and stunting, making motorbike ambulances (LANTOR) to facilitate access to health services, and counseling related to emergencies, balanced nutrition, and stunting. The results of this community service show that counseling and training related to first aid and emergencies can improve the knowledge and skills of the community in Pagung Village, in addition, the provision of "LANTOR" can facilitate and smooth community mobility to the nearest health service facilities.
Edukasi Pengelolaan Sampah Berbasis Eco enzyme untuk Mengurangi Dampak Pencemaran Lingkungan dan Resiko ISPA di Desa Karangdiyeng Kabupaten Mokokerto Zulqaida, Salma; Indah Budhy, Theresia; Megasari, Ni Luh Ayu; Minan Zuhri, Fu’ad; Qalbani Putri, Ardhanita; Rahmawati, Annisa; Elpira, Ririn; Kristianto, Sonny; Eryna Putri, Rury
PENITI BANGSA (Pemanfaatan Ilmu Pengetahuan dan Teknologi bagi Masyarakat) Vol 2 No 2 (2024): PENITI BANGSA
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/PENITI-BANGSA.v2i22024.421

Abstract

Waste management issues and its environmental and health impacts, particularly Acute Respiratory Infections (ARI), are significant concerns in Desa Karangdiyeng, Kabupaten Mojokerto. A large portion of the community still practices waste burning, which harms both the health and the environment. This community service activity aimed to increase public awareness of environmental pollution risks from waste burning and provide training on creating eco enzymes as an eco-friendly waste management solution. The methods used included seminars on environmental pollution and ARI, as well as practical eco enzyme production training. Results showed a significant improvement in community knowledge, with an average pretest score increasing by 47.5% after attending the seminar and training. Participants were also able to practice making eco enzymes and were given plant seedlings to utilize the eco enzyme as fertilizer. This activity successfully provided benefits by raising awareness of proper waste management and its health impacts, as well as offering practical skills in eco enzyme-based waste management.
BIOACTIVE COMPOUNDS OF Moringa oleifera AS KRASG12C INHIBITORS IN COLORECTAL CANCER: IN SILICO STUDY Marviella, Sephia Tiara; Zulqaida, Salma; Sulisetyawati, Theresia Indah Budhy; Ma'ruf, Anwar
Jurnal Kimia Riset Vol. 9 No. 2 (2024): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v9i2.64871

Abstract

KRAS is a GTPase enzyme that regulates cell growth and division. Mutations in KRAS can lead to its permanent activation, resulting in uncontrolled cell growth and cancer progression. Approximately 30–44% of colorectal cancer cases harbor KRAS mutations, with 1–3% involving the KRASG12C variant. Historically considered "undruggable," recent advancements, such as Sotorasib, have demonstrated the potential to target KRASG12C effectively, making it a promising focus for drug discovery. Moringa oleifera, a plant rich in phytochemicals, is a potential source of bioactive compounds with therapeutic applications. In this study, 218 compounds derived from M. oleifera were screened using molecular docking, targeting KRASG12C. Quercetin (3) exhibited the lowest binding affinity (-9.37 kcal/mol) and showed interactions with key residues, including GLN100A, VAL104A, LYS17A, and TYR97A, suggesting a binding mechanism similar to that of Sotorasib as native ligand. The physicochemical analysis further revealed high gastrointestinal absorption, good lipophilicity, and favorable bioavailability scores for Quercetin (3), supporting its potential as a drug candidate. These findings highlight the potential of M. oleifera compounds, particularly quercetin (3), as inhibitors of KRASG12C in colorectal cancer.
Co-Authors Adawiyah, Rabi’atul Akhmad Setyo Rahman Alexander Patera Nugraha Alfia Andriyani Amalia, Nadya Rafika Annisa Rahmawati Ari Nuswantoro Aryati Aryati Azis, Zulfikran Moh Rizki Bambang Sumaryono Banerjee, Abhishek Bayu Indra Sukmana Buana, Dwi Candra Budi Santosa Cheardi, Natallensi Deara Cinantya, Aulia Dian Cyuzuzo Callixte Deddy Adam Deddy Hartanto Dominicus Husada Dwicha Rahma Nuriska Hartono Edhi Jularso Edith Frederika Puruhito, Edith Frederika Elizabeth, Laurencia Dwiamanda Elpira, Ririn Erawati Wulandari Fadhilah, Nur Lailatul Fadila, Okta Mulia Nur Fery Setiawan Fidari, Nadila Tahta Firjani, Putri Nabila Fransiskus Andrianto Gandul Atik Yuliani Gustiadi Saputra I Ketut Sudana Imannia, Ristya Sylva Ira Arundina Iskandar, Assyfa Ulti Islamy, Azzahra Hasnur Jenny Sunariani Jusak A. Nugraha Jusak Nugraha Kristianto, Sonny Latief Mooduto, Latief Latifah, Maasyitoh Sari Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love Ma'ruf, Anwar Marviella, Sephia Tiara Masitoh, Hindun Fitria Maulanasari, Ersa Afifah Maulina, Syafriaz Zulfa Ma`ruf, Anwar Minan Zuhri, Fu’ad Muhammad Febriano Sugiarso Suwarto Muhammad Luthfi Muji Rahayu Nastiti Faradilla Ramadhani Nazhifa, Amira Ni Luh Ayu Megasari Noor, Tengku Natasha Eleena binti Tengku Ahmad Nugraha, Ilyas Yakob Nurul Nur Lailatul Fadhilah Nurwinda Enni Rosyidah Pratiwi, Chandrasasi Berlian Purwaningrum, Vegananda Wahyu Putri, Destiana Hardianti Qalbani Putri, Ardhanita Rahmah, Shafwa Aisha Rahman, Akhmad Setyo Rahmawati, Septyana Eka Ratri Maya Sitalaksmi Retno Indrawati Retno Indrawati Roestamadji Retno Palupi Retno Palupi Retno Pudji Rahayu Rezky, Muhammad Andyka Ridholia, Ridholia Roni Handayani Roni Handayani Rury Eryna Putri S.Pd. M Kes I Ketut Sudiana . Salsabila, Alisya Rachel Sari, Arabella Vonia Sawitri Dwi Indah Pertami Setiawan, Kresna Erlangga Shahzad Shoukat Shallomitha, Aginta Gracia Shariff, Khairul Anuar Sisca Meida Wati Sunari, I Gusti Agung Ayu Eka Putri Supandji, Rafaelle Raditya Syahdiar, Aura Zalfa Ghassani Tika, Dian Tuyishimire Irene Vania Syahputri Vania Syahputri Wardhani, Renita Gusti Yulia Nadar Indrasari Zulfa, Najwa Aulina Zulikran Moh Rizki Azis Zulqaida, Salma