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All Journal Dentika Dental Journal Jurnal Kesehatan Masyarakat Jurnal Biosains Pascasarjana Majalah Kedokteran Gigi Indonesia Dentino: Jurnal Kedokteran Gigi Jurnal Kimia Riset Dental Journal (Majalah Kedokteran Gigi) Smart Medical Journal Jurnal Riset Kesehatan Poltekkes Depkes Bandung Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal ABDINUS : Jurnal Pengabdian Nusantara Indonesian Journal of Dental Medicine Jurnal Pengabdian UNDIKMA Indian Journal of Forensic Medicine & Toxicology Journal of Multidisciplinary Applied Natural Science PENITI BANGSA (Pemanfaatan Ilmu Pengetahuan dan Teknologi bagi Masyarakat) Strada Jurnal Ilmiah Kesehatan (SJIK) Folia Medica Indonesiana
Theresia Indah Budhy Sulisetyawati
Departemen Imunologi, Sekolah Pascasarjana, Universitas Airlangga
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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The Potential of Moringa Leaf Nanoparticles (Moringa oleifera) on the Expression of TNFα, IL10, and HSP 27 in Oral Cavity Cancer Theresia Indah Budhy; Deddy Adam; Zulikran Moh Rizki Azis; Vania Syahputri; M Gandul Atik Yuliani; Muhammad Febriano Sugiarso Suwarto; Fery Setiawan
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.198

Abstract

Oral cancer is currently the sixth leading malignancy in the world, with over 330,000 cases resulting in death. Several cytokines and proteins protect the survival of cancer cells, such as TNF-α, HSP27, and IL-10. Moringa oleifera is an herbal medicine with anti-cancer properties. Nanoparticles of M. oleifera have the property to be easily absorbed by water-soluble cells, so only small doses are needed to be used as anti-cancer ingredients. This research aims to prove the ability of M. oleifera nanoparticle extract against oral cancer through the expression of tumour necrosis factor α (TNF-α), heat shock protein (HSP27), and interleukin 10 (IL-10). Rat as non-human experimental subjects were divided into four groups: control group (K), treatment group 1 (P1), treatment group 2 (P2), and treatment group 3 (P3). Cancer induction was carried out by injecting with benzo[a]pyrene, and then M. oleifera nanoparticle extract was administered in three forms of treatment doses of 125 μg/mL (P1), 250 μg/mL (P2), and 500 μg/mL (P3). Immunohistochemical examination was analysed through TNF-α, HSP27, and IL-10’s expression. The expression of TNF-α and HSP27 between control and treatment groups was significantly different. P2 had the lowest expression of TNF-α and HSP27. The expression of IL-10 between control and treatment groups was also significantly different. P1 had the lowest expression of IL-10. M. oleifera nanoparticle extract can reduce oral cancer progression by decreasing the expression of TNF-α, HSP27, and IL-10.
Mutant p53 Expression Of Oral Transformed Epithelium Cell In Rats Injected By Benzo[A]Pyrene Sawitri Dwi indah Pertami; I Ketut Sudiana; Theresia Indah Budhy; Retno Palupi; Ira Arundina
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 1 (2020): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i1.234

Abstract

Benzopyrene is a polycyclic aromatic hydrocarbons (PAHs) compound that can cause transformation of normal cells into malignant in order to its genotoxic,mutagenic,and carsinogenic ability. DNA mutation in tumor suppressor genes p53 make cells immortal which results in cell transformation and develops into malignancies. This study consist of five groups including the control group (without benzopyrene injection) and 4 treatment groups injected with benzopyrene each for 4 weeks (P1), 6 weeks (P2), 8 weeks (P3) and 10 weeks (P4). Therefore, the mutant p53 expression was calculated and analyzed statistically with the One Way Anova Test. There was signifficance difference in mutant p53 expression of oral transformed epithelium cell injected by benzopyrene (p=0.000) and the highest expression was at 10th week. It can be concluded that the mutant P53 expression of oral transformed epithelium cells in rats was increased after injected by benzopyrene
Correlation between IL-1beta and IL-18 Levels with Dengue Virus Infection Severity Sari, Arabella Vonia; Aryati, Aryati; Budhy, Theresia Indah; Ma`ruf, Anwar; Husada, Dominicus; Palupi, Retno; Sunari, I Gusti Agung Ayu Eka Putri; Indrasari, Yulia Nadar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2682

Abstract

Activated monocytes/macrophages and T lymphocytes that generate a cytokine storm are thought to play a critical role in the development of dengue. Cytokine storms, characterized by the excessive production of proinflammatory cytokines, can result in cellular dysfunction and organ failure, often contributing to the severity of dengue in affected patients. Interleukin-18 (IL-18), like IL-1beta, is a proinflammatory cytokine released during inflammation triggered by inflammasome activation. Increased IL-1beta and IL-18 during dengue virus infection (DVI) are known to worsen the host's vascular permeability, increasing hemostasis disorders and potentially, all of which are important elements in the pathophysiology of dengue fever. This study investigates the association between IL-1beta levels, IL-18 levels, age, dengue virus serotype, and the severity of dengue virus infection, aiming to understand how these factors interact and influence disease outcomes. This study is an observational cross-sectional design from 59 DVI patients in Dr. Soetomo General Hospital, Surabaya with positive dengue PCR results. Both IL-1beta and IL-18 levels reveal no significant relationship with the patient's age, infection status, and dengue virus serotype. A weak negative significant relationship between IL-1beta levels and the severity of DVI, indicating an inverse relationship between IL-1beta levels and the severity. Further studies are required to investigate the function of these cytokines in severe dengue.
APPLICATION OF MUSA BALBISIANA LOTION AGAINST STAPHYLOCOCCUS AUREUS Rezky, Muhammad Andyka; Budhy, Theresia Indah; Nuswantoro, Ari; Tika, Dian; Adawiyah, Rabi’atul
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 1 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i1.2818

Abstract

Staphylococcus aureus merupakan bakteri patogen yang dapat menyebabkan berbagai infeksi, terutama pada kulit, seperti bisul, impetigo, dan abses. Infeksi ini sering kali ditandai dengan peradangan, nekrosis, dan pembentukan nanah, yang secara signifikan dapat mengganggu fungsi kulit sebagai pelindung tubuh. Tantangan utama dalam pengelolaannya adalah meningkatnya resistensi antibiotik, termasuk Methicillin-Resistant Staphylococcus aureus (MRSA), sehingga diperlukan alternatif yang efektif, seperti bahan herbal, untuk mengatasi permasalahan ini. Kulit pisang kepok kuning yang sering berakhir sebagai limbah organik, diketahui mengandung senyawa aktif seperti flavonoid, alkaloid, saponin, tanin, dan antioksidan. Senyawa-senyawa tersebut memiliki aktivitas antibakteri yang signifikan, disertai dengan kemampuan melindungi kulit dari kerusakan akibat radikal bebas. Penelitian ini bertujuan untuk menjelaskan perbedaan efektivitas losion berbahan dasar ekstrak kulit pisang kepok kuning dengan tiga konsentrasi berbeda, yaitu formula I (30%), formula II (60%), dan formula III (90%) dalam menghambat pertumbuhan Staphylococcus aureus. Penelitian berbentuk quasi eksperimental desain ini menggunakan metode difusi cakram. Hasil penelitian menunjukkan bahwa rata-rata diameter zona hambat formula I adalah 5,60 mm, formula II adalah 8,30 mm, dan formula III adalah 8,70 mm. Analisis statistik dengan uji Kruskal-Wallis menunjukkan nilai p = 0,004, yang mengindikasikan adanya perbedaan signifikan antar formula. Kesimpulannya, losion ekstrak kulit pisang kepok kuning menunjukkan efektivitas yang signifikan dalam menghambat pertumbuhan Staphylococcus aureus. Efektivitas ini meningkat secara proporsional dengan konsentrasi ekstrak, sehingga produk ini memiliki potensi untuk digunakan sebagai losion antibakteri.
Meningkatkan Kesehatan Masyarakat Guna Mencapai Tujuan SDGs Melalui Penyuluhan Pengelolaan Air Bersih pada Masa Pandemi Covid-19 di Desa Kalimas Kabupaten Situbondo Theresia Indah Budhy S; I Ketut Sudana; Septyana Eka Rahmawati; Roni Handayani
Jurnal Pengabdian UNDIKMA Vol. 3 No. 1 (2022): May
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v3i1.4938

Abstract

This community service aims to increase the knowledge of the residents of Kalimas Village about the importance of clean water management as an effort to improve public health in order to achieve the SDGs goals. the service method uses counseling that takes place offline and online to reduce the spread of Covid-19. The results of the service show that the community understands the importance of clean water for health. The construction of reservoirs is proof of the application of infrastructure that supports clean water treatment. The people of Kalimas Village still need material and non-material assistance to increase the SGDs (Sustainable Development Goals) index according to the government's target.
Pengolahan Air Bersih Berbasis Kebutuhan Rumah Tangga dalam Upaya Meningkatkan Kesehatan Masyarakat di Desa Kandat Kabupaten Kediri Ira Arundina; Theresia Indah Budhy S; Roni Handayani; Septyana Eka Rahmawati
Jurnal Pengabdian UNDIKMA Vol. 3 No. 1 (2022): May
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v3i1.4943

Abstract

The purpose of this community service activity is to increase awareness of Kandat Village residents through counseling about clean water treatment for household needs. This service method used a hybrid method, namely offline and online. The results of the service show that the community is aware of the need for clean water for health and daily needs. Utilization of infrastructure to facilitate clean water treatment is indicated by the construction of reservoirs. The achievement of fulfilling clean water is expected to have a positive impact, especially preventing the spread of the Covid-19 pandemic by using clean water to implement health protocols.
MORINGA OLEIFERA EXTRACT CAN INHIBIT GLOMERULUS DAMAGE OF RATTUS NOVERGICUS INJECTED CYCLOPHOSPHAMIDE Laurencia Dwiamanda Elizabeth; Budhy, Theresia Indah; Rahayu, Retno Pudji
Jurnal Biosains Pascasarjana Vol. 26 No. 1 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i1.2024.8-14

Abstract

Cyclophosphamide is a cytostatic used in chemotherapy. Cyclophosphamide has a toxic effect that causes damage to the kidneys. Moringa oleifera is a plant with high antioxidant activity. Its antioxidant content in the form of flavonoids and vitamin C which can inhibit glomerulus damage. Many studies have proven that Moringa oleifera contains high antioxidant activity. However, there has been no research about the potential of Moringa oleifera in inhibiting glomerulus damage that was injected with cyclophosphamide. The purpose of this study was to determine the potential of Moringa oleifera in inhibiting glomerulus damage in Rattus novergicus due to cyclophosphamide injection. This was a laboratory experiment with a post-test only control group design. This study used 18 Rattus norvegicus as samples which was divided into 3 sample groups namely K1 is the group that was only given NaCl, K2 was the group that was given NaCl and injected by cyclophosphamide, and the treatment group was given Moringa oleifera extract. Glomerulus histopathological preparations were stained with Hematoxylin Eosin. Data were analyzed statistically by the Kruskall Wallis and Mann-Whitney tests. The Mann-Whitney test showed significant difference between groups K1 and K2 and groups of P and K2 (p<0.05). There were no significant differences between K1 and P (p>0.05). Giving Moringa oleifera extract can inhibit the glomerular damage of Rattus novergicus, which is injected with cyclophosphamide.
THE EFFECT OF ASTAXANTHIN ON TUMOR NECROSIS FACTOR ALPHA (TNF-<i>α</i>) AND INTERLEUKIN 10 (IL-10) EXPRESSION IN UV-B-INDUCED RATS MODEL Rahman, Akhmad Setyo; Budhy, Theresia Indah; Nugraha, Jusak; Fadhilah, Nur Lailatul
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The skin, the largest organ in the human body, serves as a protective barrier against external factors. Exposure to UV-B radiation accounts for approximately 90% of skin damage, leading to aging characterized by dryness and wrinkles. Proper nutrition has been associated with skin repair and delayed aging. Astaxanthin, known for its pharmacological properties including anti-cancer, anti-diabetic, anti-inflammatory, and antioxidant activities has garnered attention for its ability to improve damaged skin when administered as a daily supplement. This study investigated the roles of TNF-α and IL-10 as inflammatory markers in skin damage and repair, which remain underexplored. A true experimental randomized posttest-only control group design was employed using 24 male white rats divided into four groups: (1) normal group (N), untreated rats; (2) control group (C), rats administered with olive oil (5 ml/kg BW); (3) treatment group 1 (P1), rats exposed to UV-B and administered with olive oil (5 ml/kg BW); and (4) treatment group 2 (P2), rats exposed to UV-B and administered with astaxanthin (10 mg/kg BW) combined with olive oil (5 ml/kg BW). ANOVA and Games-Howell post-hoc tests revealed significant differences (p < 0.05) among groups, except between the control (C) and normal (N) groups. Astaxanthin (10 mg/kg BW) demonstrated both curative and protective effects by reducing TNF-α expression (pro-inflammatory) and increasing IL-10 expression (anti-inflammatory) in UV-B-induced rats. These findings highlight astaxanthin’s potential as a therapeutic agent for UV-B-induced skin damage.
DISTRIBUTION AND FREQUENCY OF MALIGNANT LYMPHOMA AT RSUD DR. SOETOMO BETWEEN 2013 - 2023 Wati, Sisca Meida; Budhy, Theresia Indah; Fidari, Nadila Tahta; Nazhifa, Amira; Zulfa, Najwa Aulina; Ridholia, Ridholia
Dentino: Jurnal Kedokteran Gigi Vol 10, No 2 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i2.24174

Abstract

Background: Malignant lymphoma is a type of cancer caused by the proliferation of abnormal lymphocyte cells. In Indonesia, Non-Hodgkin's Lymphoma is ranked seventh as the most common new malignancy, while Hodgkin's Lymphoma is ranked 27th. Information on malignant lymphoma in East Java, especially Surabaya, is still limited, especially for a period of more than five years. Therefore, a ten-year study was conducted to gain a more comprehensive understanding of its distribution and frequency. Purpose: To obtain an overview of the distribution and frequency level of malignant lymphoma cases at Dr. Soetomo Hospital, Surabaya in the period 2013-2023. Methods: This observational study with a descriptive approach involved 382 patients as samples, which were analyzed based on the variables of age, gender, type of work, area of residence, anatomical location of the tumor, and size of the tumor. Results: Non-Hodgkin's Lymphoma was found to more dominant (59.4%) compared to Hodgkin's Lymphoma (40.6%). Cases were more common in men (57.3%) than women (42.7%), with the largest age group being in the range of 51–60 years. The majority of patients came from East Java Province, especially Surabaya, and were most often found in individuals working in the private sector (28.8%). The most common anatomical location was the nodal area, with the most common tumor size being less than 2 cm in diameter. Conclusion: This study presents the latest data on the distribution of malignant lymphoma at Dr. Soetomo Hospital, Surabaya and is expected to be a reference for further epidemiological research.  Keywords: distribution, frequency, hodgkin lymphoma, malignant lymphoma, non-hodgkin lymphoma
Ashwagandha and Chronic Stress: A Review of Its Neuroimmune Modulatory Potential Iskandar, Assyfa Ulti; Rahayu, Retno Pudji; Ma'ruf, Anwar; Budhy, Theresia Indah
Smart Medical Journal Vol 8, No 2 (2025): August
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v8i2.105715

Abstract

Introduction: Chronic stress disrupts neuroimmune homeostasis, driving neuroinflammation and neuronal damage. Despite growing interest in natural interventions, comprehensive reviews on ashwagandha’s dual neuro-immunomodulatory mechanisms remain limited. This review examines ashwagandha’s potential in mitigating chronic stress-induced neuroimmune dysregulation.Methods: A review was conducted by searching PubMed, Scopus, and Google Scholar for relevant preclinical and clinical studies published between 2015 and 2025. Studies were selected based on their focus on Ashwagandha’s effects on the hypothalamic–pituitary–adrenal (HPA) axis, cytokine expression, oxidative stress, and neuroprotection. Data were extracted and synthesized thematically.Results: Ashwagandha was found to downregulate pro-inflammatory cytokines (TNF-α, IL-6), inhibit NF-κB signaling, and enhance antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT). Clinical and animal studies reported cortisol reduction, attenuation of microglial activation, increased brain-derived neurotrophic factor (BDNF) levels, improved T-cell proliferation and NK cell activity, and restoration of Th1/Th2 balance. These mechanisms were associated with improved mood, cognition, and stress resilience.Conclusion: Ashwagandha demonstrates multimodal neuroimmune modulation, offering a promising natural therapeutic for stress-related disorders. Standardized extracts warrant further investigation for clinical translation.
Co-Authors Adawiyah, Rabi’atul Akhmad Setyo Rahman Alexander Patera Nugraha Alfia Andriyani Amalia, Nadya Rafika Annisa Rahmawati Ari Nuswantoro Aryati Aryati Azis, Zulfikran Moh Rizki Bambang Sumaryono Banerjee, Abhishek Bayu Indra Sukmana Buana, Dwi Candra Budi Santosa Cheardi, Natallensi Deara Cinantya, Aulia Dian Cyuzuzo Callixte Deddy Adam Deddy Hartanto Dominicus Husada Dwicha Rahma Nuriska Hartono Edhi Jularso Edith Frederika Puruhito, Edith Frederika Elizabeth, Laurencia Dwiamanda Elpira, Ririn Erawati Wulandari Fadhilah, Nur Lailatul Fadila, Okta Mulia Nur Fery Setiawan Fidari, Nadila Tahta Firjani, Putri Nabila Fransiskus Andrianto Gandul Atik Yuliani Gustiadi Saputra I Ketut Sudana Imannia, Ristya Sylva Ira Arundina Iskandar, Assyfa Ulti Islamy, Azzahra Hasnur Jenny Sunariani Jusak A. Nugraha Jusak Nugraha Kristianto, Sonny Latief Mooduto, Latief Latifah, Maasyitoh Sari Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love Ma'ruf, Anwar Marviella, Sephia Tiara Masitoh, Hindun Fitria Maulanasari, Ersa Afifah Maulina, Syafriaz Zulfa Ma`ruf, Anwar Minan Zuhri, Fu’ad Muhammad Febriano Sugiarso Suwarto Muhammad Luthfi Muji Rahayu Nastiti Faradilla Ramadhani Nazhifa, Amira Ni Luh Ayu Megasari Noor, Tengku Natasha Eleena binti Tengku Ahmad Nugraha, Ilyas Yakob Nurul Nur Lailatul Fadhilah Nurwinda Enni Rosyidah Pratiwi, Chandrasasi Berlian Purwaningrum, Vegananda Wahyu Putri, Destiana Hardianti Qalbani Putri, Ardhanita Rahmah, Shafwa Aisha Rahman, Akhmad Setyo Rahmawati, Septyana Eka Ratri Maya Sitalaksmi Retno Indrawati Retno Indrawati Roestamadji Retno Palupi Retno Palupi Retno Pudji Rahayu Rezky, Muhammad Andyka Ridholia, Ridholia Roni Handayani Roni Handayani Rury Eryna Putri S.Pd. M Kes I Ketut Sudiana . Salsabila, Alisya Rachel Sari, Arabella Vonia Sawitri Dwi Indah Pertami Setiawan, Kresna Erlangga Shahzad Shoukat Shallomitha, Aginta Gracia Shariff, Khairul Anuar Sisca Meida Wati Sunari, I Gusti Agung Ayu Eka Putri Supandji, Rafaelle Raditya Syahdiar, Aura Zalfa Ghassani Tika, Dian Tuyishimire Irene Vania Syahputri Vania Syahputri Wardhani, Renita Gusti Yulia Nadar Indrasari Zulfa, Najwa Aulina Zulikran Moh Rizki Azis Zulqaida, Salma