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All Journal Jurnal Sains Materi Indonesia Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease MEDISAINS Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Chemistry Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology Indonesian Community Journal Prosiding Seminar Nasional Unimus JURNAL REKAYASA KIMIA & LINGKUNGAN

Prihartini Widiyanti

Biomedical Engineering Study Program, Department Of Physics, Faculty Of Science And Technology, Universitas Airlangga Institute Of Tropical Disease, Universitas Airlangga

Author-ID : 508655

Agriculture, Biological Sciences & Forestry Arts Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing Herry Wibowo; Prihartini Widiyanti
Folia Medica Indonesiana Vol. 58 No. 2 (2022): June
Publisher : Universitas Airlangga

Highlights: Sodium diclofenac is one of NSAID a common treatment to relieve pain associated with bone fractures. Sodium diclofenac with a some dose of body weight could decrease the callus quality on fracture healing. Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac sodium, are standard treatments to relieve pain associated with bone fractures. The bone healing process consists of four stages: inflammation, soft callus formation, complex callus formation, and bone remodeling. Previous studies mentioned that intake of NSAIDs (sodium diclofenac) could inhibit the bone healing process. This study examined the effect of diclofenac sodium intake on callus formation in fracture healing. In this study, thirty-six rats (Rattus Norvegicus) with fractures were used and divided into two groups, namely 18 rats for the control and 18 rats for the treatment group. In the treatment group, each rat was given 1.8 mg sodium diclofenac/150 grams of body weight per day. In the control group, each rat was given CMC-Na 0.5% with equal volume as diclofenac sodium in the treatment group. After 28 days, all the rats were stunned until dead, and the diameter and strength of their calluses were measured. In the treatment group with diclofenac sodium1.8 mg/ 150 grams BW/ 28 days after the tibia bone callus was pressed using the Shimadzu tool, the lowest callus strength was found to be 56.500 N, and the highest callus strength was 59.000 N. The lowest callus diameter in the treatment group was 4 mm, the highest was 5 mm. In the control group, the lowest callus strength was 76 N, and the highest callus strength was 77 N. The lowest callus diameter in the control group was 6 mm, and the highest was 8 mm. The strongest callus in the treatment group was found in the sixth observation, with a value of 59 N and a diameter of 4 mm. In the control group, the highest callus strength was 77 N, with a diameter of 7-8 mm. These measurements were found on the 5th, 7th, 8th, 9th, 16th, and 17th observations. Diclofenac sodium with a dose of 1.8 mg/150 grams of body weight could decrease the callus quality parameters, such as callus strength and diameter on fracture healing.

In Vitro Characterization of Poly(Ethylene Glycol) Dimethacrylate-Nanofibrillated Cellulose as an Injectable Biomaterial for Herniated Nucleus Pulposus Substitute Prihartini Widiyanti; Yurituna Firda; Aminatun; Herry Wibowo
Folia Medica Indonesiana Vol. 60 No. 1 (2024): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i1.50084

Highlights:1. Novel synthetic biopolymer hydrogels were successfully prepared from pristine poly(ethylene glycol) dimethacrylate (PEGDMA) and nanofibrillated cellulose (NFC) using the photopolymerization method.2. PEGDMA-NFC biocomposite hydrogel can be developed as an affordable biomaterial for herniated nucleus pulposus substitute, with the potential to meet clinical application standards. Abstract Herniated nucleus pulposus develops when the intervertebral disc portudes through the annulus fibrosus due to the rupture of the annulus fibrosus or a decrease in proteoglycans. Hydrogel implant material can be injected into the disc space to restore disc thickness caused by disc degeneration with minimal invasiveness. This study aimed to characterize poly(ethylene glycol) dimethacrylate-nanofibrillated cellulose (PEGDMA-NFC) in vitro as a potential biomaterial for herniated nucleus pulposus substitute. This study utilized PEGDMA-NFC to treat first-degree herniated nucleus pulposus using the photopolymerization method. PEGDMA was selected because of its hydrophilic ability to produce hydrogel. The addition of NFC to the PEGDMA precursor was expected to show mechanical properties as a hydrogel bio composite candidate. The characterization of PEGDMA-NFC was conducted using three tests: Fourier-transform infrared spectroscopy (FTIR), viscosity assessment, and an in vitro injection testing model. The normal distribution of the data was analyzed using the Kolmogorov-Smirnov test, while the homogeneity was assessed using Levene's test. Homogenous and normally distributed data were analyzed using a one-way analysis of variance (ANOVA) with a p-value of <0.05. The explored concentrations of PEGDMA-NFC included a ratio of 1:0 for the control samples and ratios of 1:0.5 (K1), 1:0.75 (K2), and 1:1 (K3) for the experimental samples. The FTIR analysis revealed the presence of various functional groups in PEGDMA-NFC, indicating its potential classification as a hydrogel biomaterial. The characterization data showed that the K3 sample yielded the most favourable outcome with a viscosity value of 74.67 dPa·s. From the in vitro injection testing result, the addition of NFC demonstrated that the hydrogel would not rupture when released from the mold. The hydrogel could be injected with an 18 gauge needle. The statistical analysis results showed a significant difference among the samples (p<0.05). This study concludes that the PEGDMA-NFC hydrogel biocomposite can be effectively applied in herniated nucleus pulposus cases.

EFFECT OF DEACETYLATION DEGREES VARIATION ON CHITOSAN NERVE CONDUIT FOR PERIPHERAL NERVE REGENERATION Qulub, Fitriyatul; Widiyanti, Prihartini; Maulida, Hendita Nur; Indrio, Ludita Woro; Wijayanti, Tia Rahayu
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Universitas Airlangga

Broken nerves could regenerate when exposed to simple injuries by using a nerve conduit that has appropriate physiological and mechanical ability to support the nerves regeneration around the fissure of trauma. One of the biopolymer for the conduit composition is chitosan because it is biocompatible, biodegradable, non-toxic, and has similarity structure as natural glycosaminoglycans. The aim of research is to synthesize chitosan with variation of Degrees of Deacetylation (DD) and characterize the DD influence on mechanical properties and biocompatibility. Research design is prospective observational. Chitosan was treated with a decrease in the DD method and an increase in the temperature with the strength of alkaline solution, which was NaOH solution with concentrations of 5%, 20%, 35%, and 50% within 2 hours with a heating temperature of 95°C. The results of each DD variation were 23.24, 46.55, 53.48, and 55.06. It was characterized by tensile test with tensile strength values of 0.25 - 1.18 MPa. The degradation test results tend to decrease with the increasing concentration of NaOH proving that samples are biodegradable. The surface morphology of samples shows a pore range of 61.52 Î¼m - 220.3 Î¼m. The best result is the chitosan sample with 35% NaOH because due to the tensile characteristic and a pore in accordance with normal standard. Tensile strength is around 0.41 MPa - 3.69 MPa and pore size around 40 Î¼m – 250 Î¼m to accelerate nerve regeneration. The results are expected to provide alternative solution of nerve conduit development for peripheral nerve defects.

In Vitro Characterization of Poly-Glycolyc Lactic-Co Acid (PLGA) –Collagen Based on Red Snapper Fish Scales (Lutjanus Sp.) Coating Chitosan as Duramater Artificial Candidate Jabbar, Hajria; Widiyanti, Prihartini; Paramadini, Adanti Wido; Putri, Dina Kartika; Isfandiary, Andini
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

Head trauma was the third cause of deaths that have a high rank that can make serious head injury for 25.5%-54.9%. This study has been conducted by making a replacement layer of the brain (dura) to overcome the impact of dural defect by utilizing waste fish scales red snapper (Lutjanus sp.). Synthesis brain membranes lining processed by casting method with each various concentrations of chitosan coating of 1%, 1.5%, and 2% then dried using vacuum dry. The samples then were characterized by tensile test, FTIR, SEM and MTT Assay. FTIR test results showed that red snipperscales can produce collagen powder at amide A group with stretching of –NH functional group, amide B group has stretching of CH2 assymetry, amide I area, amide II and amide III area which show –NH bonding. Tensile test results showed that the combination between PLGA-Collagen Chitosan Coating 2% produced the highest tensile strength is 4.8 MPa which meet the standards of human duramater strength. MTT Assay results showed that the dural membrane produced no toxic seen from living cells reached 98.32%. Poly - Glycolyc Lactic - Co Acid (PLGA) - collagen coating chitosan based on red snapper fish scales (Lutjanus sp.) composites has potency as duramater artificial candidate due to the chemistry, biological and physical characteristics.

Detection of Serotypes and Knockdown-resistance Mutations in Dengue and Other Flavivirus Samples Collected from Mengare Island, East Java, Indonesia Tasya Amalia Dwiyanti; Teguh Hari Sucipto; Khoirunnisa Suhandarini; Azizia Kanya Fathiarachman; Nastiti, Helena Putri; Anika Rahma Putri; Shifa Fauziyah; Prihartini Widiyanti; Hariyono; Rehman, Saifur
Folia Medica Indonesiana ON PROGRESS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Highlights:1. By investigating knockdown-resistance (kdr) mutations associated with insecticide resistance, this research addresses a critical gap in understanding how these mutations may affect vector control strategies on Mengare Island, Gresik, Indonesia.2. This study provides essential data on the current status of dengue virus serotypes and resistance mutations in mosquito populations across the region, guiding local health authorities in developing targeted vector control strategies. AbstractDengue fever, caused by the dengue virus (DENV), poses a significant public health challenge, particularly in tropical regions. This study aimed to detect flavivirus presence, DENV serotypes, and knockdown-resistance (kdr) mutations in mosquito samples collected from Mengare Island, Gresik, Indonesia. A cross-sectional experimental design was employed, utilizing reverse transcription polymerase chain reaction (RT-PCR) for flavivirus detection and serotyping, as well as for identifying kdr mutations. Ribonucleic acid (RNA) extraction was performed using the Quick-RNA™ Miniprep Plus Kit (Zymo Research, Irvine, CA, USA), followed by RT-PCR with specific primers for DENV serotypes 1–4 and kdr mutations (V1016G and F1534C). Six adult female Aedes albopictus mosquitoes were analyzed in this study. The results revealed no evidence of flavivirus infection or DENV serotypes in the mosquito samples, as no complementary deoxyribonucleic acid (cDNA) bands corresponding to expected base pair sizes were observed on the agarose gels. Similarly, the analysis of kdr mutations showed that all samples were homozygous wildtype, with no mutations detected at the V1016G or F1534C loci. In conclusion, these findings suggest the absence of active dengue virus transmission or notable insecticide resistance in the studied mosquito population from Mengare Island. This study highlights the importance of continuous monitoring of flavivirus presence and resistance mutations. The variability in kdr mutation frequencies across regions underscores the need for sustained surveillance and effective control measures to mitigate potential outbreaks in high-risk areas such as Mengare Island.

Co-Authors - Aminatun - Siswanto Achmad Ardianto, Achmad Adanti Wido Paramadini Adiana Mutamsari Witaningrum Adiana Mutamsari, Adiana Adri Supardi Agung Prabowo Agung Prabowo Ahmad Fadli Ahmad Fadli Akfiny Hasdi Aimon Akhmad Jayadi Alfian Pramudita Putra Aminatun Amma, Fadli Anggraini Barlian Anika Rahma Putri Arie Wibowo Azizia Kanya Fathiarachman Bambang Prajogo Baskoro, Andhi Bella Wahyu Sukma Wati Bimo Aksono Bimo Dwi Lukito, Bimo Dwi Bramantono Bramantono, Bramantono Budi Utomo Chandra Satria Arisgraha, Franky Cindy Narita Kusuma Astuti Deni Noviana Desi Sandrasari Dio Nurdin Setiawan, Dio Nurdin Dita Ayu Mayasari, Dita Ayu Djony Izak Rudyardjo Dyar Sasmito, Dyar Eko Budi Kuntjoro, Eko Budi Endah Purwanti Eprilina, Alifiani Ernie Maduratna Setiawatie Fathan Aditya Sanjaya Fatkhunisa Rahmawati, Fatkhunisa Fa’ilal Chusna Fendy Purwanda, Fendy Ferdiansyah Ferdiansyah Firdhausi Wardhani, Inten Fitriyatul Qulub Franky Arisgraha, Franky Franky Chandra Satria Arisgraha Hafrizal Riza, Hafrizal Hariyono Helmi Majid Ar Rasyid Heni Ismawati Heri Purnobasuki, Heri Herry Wibowo Herry Wibowo Indrio, Ludita Woro Isfandiary, Andini Ismawati, Heni Jabbar, Hajria Jan Ady Jan Ady Julieta Kartikasari Juniastuti Juniastuti Khoirunnisa Suhandarini Kholifatul Wanda Putri, Kholifatul Wanda Khusnul Ain Kirana Anugerah Putri Lambang Bargowo M. Qushay, M. Maria Inge Lusida Maulida, Hendita Nur Mirzaq Hussein Anwar, Mirzaq Hussein Muhammad Bagas Ananda Muhammad Vitanata Arfijanto, Muhammad Vitanata Nabila Safira Khairina Nasronudin Nasronudin Nastiti, Helena Putri Ni Putu Ermi Hikmawati, Ni Putu Ermi Nilna Faizah Fiddarain, Nilna Faizah Nur Rahma, Osmalina Pramudita, Alfian Putri, Dina Kartika Radicha Arnanda Putri Indrawati Rehman, Saifur Retna Apsari Retno Indrawati Roestamadji Retno Pudji Rahayu Retno puji Rahayu Rihandhita Shinta Meiliana Riries Rulaningtyas Rozykulyyeva, Lale Sari, Gadis Meinar Satrio Adhitioso Savitri, Irma Yosephina Sherina Pradita Eka Wahyudi Shifa Fauziyah Siswanto Siswanto Siswanto Siti Irma Mashitah, Siti Irma Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa, Siti Qomariyah Solly Aryza Suryani Dyah Astuti Tami Bachrurozy Tarissa Diandra Putri Wibowo Tasya Amalia Dwiyanti Teguh Hari Sucipto Tjahjono, Ganis Tomohiro Kotaki, Tomohiro Tri Arif Sardjono, Tri Arif Tria Refi Indriani Veren Audia Nurmansya Wijayanti, Tia Rahayu Wulandari Prima Devi Yufan Fibriawan, Yufan Yurituna Firda

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