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The comparative of free energy binding between Pyrimethamine-pDHFR double mutant and Pyrimethamine-pDHFR quadruple mutant: Structure-based approach Abdjan, Muhammad Ikhlas; Aminah, Nanik Siti; Kristanti, Alfinda Novi; Takaya, Yoshiaki; Siswanto, Imam
Journal of Bio-Molecule Research and Engineering Vol 1 No 2 (2022)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbiome.v1i2.43982

Abstract

Structure-based was performed to understand the mechanism inhibition of pyrimethamine (CP6) against Plasmodium Falciparum mutants at the molecular level. A molecular docking process was carried out to obtain the initial conformation of each system. The data showed in the form of RMSD values, hydrogen bonds, and grid scores. The results show that the RMSD value in the redocking process meets the criteria of the CP6-1J3J and WRA-1J3K complexes with a value of ≤ 2 í…. Several hydrogen bonds bind to receptor-active sites, including Ile14, Asp50, Ile164, and Asn108. Additionally, the grid score (kcal/mol) binds well on the active site: CP6-1J3J (-46.86), WRA-1J3K (-65.40), and CP6-1J3k (-44.71). Furthermore, molecular dynamics simulation was carried out to determine the free energy (∆Gbind) of each complex using the MM/GBSA approach. The results show ∆Gbind (kcal/mol) in each complex, namely CP6-1J3J (-28.24), WRA-1J3K (-36.62), and CP6-1J3k (-24.23). Information on this research was expected to provide molecular insight into pyrimethamine as an antimalaria inhibitor.
THE INTEGRATION OF COMPUTATIONAL CHEMISTRY TO SUPPORT INTERACTIVE LEARNING MEDIA FOR SENIOR HIGHSCHOOL: AN INNOVATIVE STRATEGY TO IMPLEMENT ‘KURIKULUM MERDEKA’ Haq, Kautsar Ul; Kristanti, Alfinda Novi; Suwito, Hery; Aminah, Nanik Siti; Rusdipoetra, R. Aryabraga; Alfian, Fariz Rizky; Asyura, Syarifah
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 4 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i4.2024.526-536

Abstract

Simulation or chemical modeling with computers is a major topic in computational chemistry. This subject is not covered in high school material, however, this method can be applied to support a more interactive learning process. Computational chemistry can be used as a virtual teaching aid and can also be used to help explain or predict chemical reactivity. The aim of this Community Service is to improve teachers' understanding of computational chemistry, both in theory and practice, according to the curriculum. The training activities were conducted using two methods: Lectures and practical sessions. Avogadro 1.2.0 and MOPAC2016 software were used for this training. The outcome of this program were evaluated using quantitative and qualitative analysis. The sustainability of the program was analyzed from the assignments regarding the plan to integrate the material provided into the learning process at schools. Based on the evaluation results, participants felt that the training they had received met their teaching needs. After participating in this training, the participants had various ideas for integrating computational chemistry into learning activities.
TRAINING ON FOOD PACKAGING FOR MSMEs SENDEN VILLAGE TRENGGALEK BY UNAIR TEAM & PARTNER UNIVERSITIES Aminah, Nanik Siti; Kristanti, Alfinda Novi; Ramadhan, Rico; Hendradi, Rimuljo; Takaya, Yoshiaki; Khoso, Mir Hasan; Baharin, Siti Nor Atika; Abdjan, Muhammad Ikhlas
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 9 No. 2 (2025): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v9i2.2025.238-248

Abstract

The International Community Services program (ICS) at Universitas Airlangga, part of the Tri Dharma of the university focusing on community service, aims to enhance human resource capacities within communities. In 2024, the program targeted Senden Village, Kampak sub-District, Trenggalek District, East Java, Indonesia, to assist its MSMEs in overcoming packaging challenges that hinder market interest. Collaborating with domestic and international universities, including Universitas Mayjen Sungkono, SMBBMU University Larkana Pakistan, UiTM Negeri Sembilan Malaysia, UM Malaysia, and Meijo University Japan, the program provided intensive training on innovative and functional packaging techniques. This program was chosen and considered urgent because processed food products produced by local MSMEs are still sold in bulk and packaged haphazardly. Therefore, a touch of hygienic and "eye-catching" packaging technology is needed. Attractive and hygienic packaging technology is expected to increase the selling power of these processed food products. The training included theoretical sessions, focus group discussion (FGD) demonstrations, and the introduction of plastic vacuum sealers to improve product packaging and branding. Food packaging workshop held on July 15, 2024, where participants engaged in hands-on training, group discussions, and label design, resulting in tangible improvements in product marketability. The initiative of this activity is not only to increase the visibility and attractiveness of Senden Village products but also to introduce the natural exotism of the village and local products to the national and international community, encouraging cultural and knowledge exchange. The collaboration of this program strengthens international collaboration and provides invaluable experience for students and lecturers. The successful implementation of this program confirms Airlangga University's commitment to community service and its goal of creating a sustainable positive impact on the village community, which ultimately contributes to the development of better human resources. The training has been carried out very well and each training participant has their own brand with an attractive logo and is hygienically packaged with vacuum technology. All training participants were satisfied with this activity as well as head of village, head of PKK, and all the team involved. They hope that next year's activities can be carried out with other innovations for the progress of Senden village.
Optimalisasi Analisis Harga Komoditas Daging dan Telur Ayam di Jawa Timur dengan Pendekatan Regresi Semiparametrik Chamidah, Nur; Kurniawan, Ardi; Hendradi, Rimuljo; Fatmawati; Kristanti, Alfinda Novi; Siregar, Naufal Ramadhan Al Akhwal; Wulandari, Nuryuliana; Aminy, Aisyah; Herdianto, Muhammad Hendra
Cakrawala Vol. 19 No. 1: Juni 2025
Publisher : Badan Riset dan Inovasi Daerah Provinsi Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32781/cakrawala.v19i1.759

Abstract

Fluktuasi harga yang terlalu tinggi pada komoditas pangan strategis seperti telur dan daging ayam telah menjadi permasalahan krusial, diantaranya disebabkan oleh harga pakan dan tingkat konsumsi masyarakat. Hal ini berdampak pada turunnya daya beli dan kesulitan akses pangan terutama bagi rumah tangga berpendapatan rendah yang mengandalkan kedua komoditas ini sebagai sumber protein utama. Oleh sebab itu, penelitian ini bertujuan untuk menganalisis pengaruh harga jagung sebagai bahan baku pakan ternak dan jumlah penduduk sebagai gambaran tingkat konsumsi masyarakat terhadap harga telur ayam dan harga daging ayam pada 38 Kabupaten/Kota di Jawa Timur tahun 2023 dengan menggunakan data sekunder yang diperoleh melalui aplikasi SISKAPERBAPO dan Badan Pusat Statistik Provinsi Jawa Timur. Metode yang digunakan adalah regresi semiparametrik birespon linear lokal. Hasil analisis menunjukkan bahwa model prediksi memiliki tingkat akurasi sangat tinggi, dengan nilai MAPE sebesar 1,103% untuk harga telur ayam dan 4,474% untuk harga daging ayam. Penelitian ini penting karena dapat menjadi dasar pengambilan kebijakan dalam upaya stabilisasi harga oleh pemerintah daerah maupun pelaku industri perunggasan di Jawa Timur.
Peningkatan Wawasan Kimia Organik dalam Menunjang Pembelajaran Kimia di SMA Kristanti, Alfinda Novi; Aminah, Nanik Siti; Suwito, Hery
ANDAN JEJAMA: Indonesian Journal of Community Engagement (IJCE) Vol. 1 No. 1 (2022): Indonesian Journal of Community Engagement (IJCE) ANDAN JEJAMA
Publisher : FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/ijceaj.v1i1.2

Abstract

The role of practical work in Organic Chemistry is to provide experience to gain skills and to reinforce concepts that have been obtained from theory and also to increase understanding and to increase interest or motivation. However, practical work has not been an activity that can always be done in high school, especially for chemistry due to facility lack. For this reason, a workshop is needed to increase the understanding of high school chemistry teachers in basic Organic Chemistry, as well as to increase the insight of chemistry teachers in creating practical topics that are in accordance with the facilities available at school. The workshop was held for high school chemistry teachers in Mojokerto. The workshop consisted of an explanation of the basic of Organic Chemistry and the use of Chem Office software, accompanied by practical work in laboratory. The workshop held was successfully added the insights of the teachers and it was hoped that the knowledge obtained would be applied in learning process in their respective high schools.
Pengayaan Biodiversitas Bakteri Penangkap Cahaya Dalam Miniatur Winogradsky Yang Potensial Untuk Pengembangan Zat Warna Alamiah Rahmat Eko Sanjaya, Ni Nyoman Tri Puspaningsih, Afaf Baktir, Ali Rohman, Purkan, Alfinda Novi Krista
ANDAN JEJAMA: Indonesian Journal of Community Engagement (IJCE) Vol. 1 No. 1 (2022): Indonesian Journal of Community Engagement (IJCE) ANDAN JEJAMA
Publisher : FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/ijceaj.v1i1.8

Abstract

Natural dyes are an alternative renewable and environmentally friendly dyes. Natural dyes can be isolated from microorganisms. Winogradsky column is an enrichment culture that is suitable for obtaining various photosynthetic bacteria as sources of natural dyes. Knowledge of the Winogradsky column can be the initial stage for development of natural dyes based on microorganisms. Community service activity related to the Winogradsky column, involving chemistry and biology teachers throughout Malang Regency as partners. The activities are carried out offline at SMAN 1 Lawang and online using Zoom Meeting. The online activity also attended by SMA teachers from outside Java. The first stage of these activities were delivering material related to photosynthetic bacteria, the Winogradsky column, and dyes. The second stage was the practice of making Winogradsky columns followed by focus group discussion. The results of the questionnaire showed a positive response to the activities. The majority of participants gave a “Good” and “Excellent” rating. Participants wanted a follow-up this activity in the form of re-implementing this activity in rotation at different schools.
Phytochemistry and Chemdraw : Innovative Learning Materials for Implementing the "Merdeka Belajar" Program: Fitokimia dan Chemdraw : Bahan Pembelajaran Inovatif untuk Melaksanakan Program “Merdeka Belajar Kristanti, Alfinda Novi; Aminah, Nanik Siti; Ramadhan, Rico; Haq, Kautsar Ul; Wardana, Andika Pramudya; Suhaili, Suhaili; Hariyanto, Geraldo Figo
ANDAN JEJAMA: Indonesian Journal of Community Engagement (IJCE) Vol. 2 No. 1 (2023): Indonesian Journal of Community Engagement (IJCE) ANDAN JEJAMA
Publisher : FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/ijceaj.v2i1.15

Abstract

The city of Mataram, the capital of West Nusa Tenggara province, consists of 6 sub-districts and 50 sub-districts and has 28 public and private high schools. Lecturers and students of the Department of Chemistry, who are members of the community service team, on August 5th, 2023 carried out a workshop for chemistry and biology teachers in the City of Mataram. The title of the activity was "Application of Phytochemical Screening as a medium to increase the insight of Biology and Chemistry High School Teachers in Mataran City, NTB as an alternative implementation of Merdeka Belajar". The workshop was held at SMAN 5 Mataram City involving 51 chemistry and biology teachers as participants. The material provided includes Phytochemicals and the Chemdraw application. Both of these topics are given by lecturing and discussion and also complemented by practical activities. The successful of the activity is reflected in the increase in posttest scores compared to the pretest score. Evaluation of activities in the form of filling out the questionnaires by participants also reflected the participant satisfaction, in which the majority of participants gave positive answers to each question. Similar activities remain relevant and still need to be carried out, especially in areas outside Java to broaden teachers' insight