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All Journal Medali Jurnal : Media Dental Intelektual ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Odonto dental journal Jurnal Pengabdian Masyarakat Dentmas Journal of Fisheries & Marine
Islamy Rahma Hutami, Islamy Rahma
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Journal : Journal of Fisheries

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Saltwater Fish Nanoparticles: Biological Effects on COL1A1 Expression in Fetal Mice and Tablet Formula Optimization Christiono, Sandy; Hutami, Islamy Rahma; Suparmi, Suparmi; Afroz, Shaista; Clarasya, Amara Danish; Ahmad, Rayyan Orvin Pradipta; Subiyono, Amelia Febriani
Jurnal Ilmiah Perikanan dan Kelautan Vol. 18 No. 1 (2026): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v18i1.76746

Abstract

Graphical Abstract  Highlight Research Saltwater fish Nano powder modulates the expression of matrix proteins, influencing early dental tissue development. Administration significantly decreases COL1A1 expression in fetal mouse teeth, affecting biomineralization. Increasing talc concentration improves flowability and formulation stability by reducing angle of repose, Carr’s index, and Hausner ratio. Findings suggest marine-derived nanoparticles regulate cellular differentiation during dental development. Supports potential applications of marine natural materials in prenatal nutrition and dental tissue engineering.   Abstract Saltwater fish nanoparticle-based tablets represent a novel nutritional strategy aimed enhancing dental hard tissue density, particularly enamel. These tablets incorporate bioactive proteins, omega-3 fatty acids, and essential minerals such as calcium, phosphate, and magnesium to support enamel biomineralization. The nanoparticle formulation facilitates efficient cellular absorption, thereby increasing the expression of key enamel proteins like collagen type I alpha 1 chain (COL1A1) during enamel matrix development. This study investigated the effect of saltwater fish nanoparticles on COL1A1 expression in ameloblast cells and evaluated the physicochemical properties of tablets with talc concentrations of 1%, 5%, and 10%. Using a true experimental design with a post-test only control group, two groups of mice were assigned: a control group fed standard diet, and a treatment group fed a standard diet supplemented with saltwater fish nanoparticles (2.17 mg/0.5 mL). Tablet formulations were analyzed across the three talc concentrations. Data were subjected to independent T-tests for COL1A1 expression and One-way ANOVA for physicochemical properties. Results revealed a significant reduction in COL1A1 expression in the treatment group. Additionally, talc concentration significantly influenced tablet physicochemical characteristics, with the 10% talc formulation exhibiting the most optimal properties. These findings suggest potential for nanoparticle-based nutritional interventions to promote enamel formation.
Saltwater Fish Powder for Amelogenesis in Zebrafish Larvae (Danio rerio) Christiono, Sandy; Pradopo, Seno; Hutami, Islamy Rahma; Indasari, Novia; Nurhapsari, Arlina; Rochmah, Yayun Siti Rochmah; Ibrahim, Zurairah; Yuniar, Savira Nurazky; Suparmi
Jurnal Ilmiah Perikanan dan Kelautan Vol. 16 No. 2 (2024): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v16i2.54677

Abstract

Graphical Abstract Highlight Research 1. The saltwater fish powder is rich in omega3, vitamin D, and calcium which helps tooth amelogenesis. 2. LC50 Toxicity Test was carried out using zebrafish larvae (Danio rerio) with negative control, positive control using 3,4-dichloroanilin, and treatment groups with saltwater fish powder solution in 6 different concentration. 3. No signs of zebrafish embryo mortality or developmental abnormalities on treatment group from the lowest (125μg/ml) nor highest concentration (4000μg/ml). 4. Saltwater fish powder has proven lack of toxicity. Abstract Many nutrients found in saltwater fish are thought to promote amelogenesis in ameloblast cells during tooth development. Although its toxicity is uncertain, saltwater fish powder provided benefits for amelogenesis. Zebrafish embryos have complex metabolic pathways and comprehensive physiological reactions. The LC50 toxicity of saltwater fish powder on zebrafish embryos was investigated in this study. The aim of the of the study is to determine the effect of LC50 toxicity on saltwater fish powder on zebrafish embryos. The experimental research method was a post-test-only control group design, consisting of eight groups, namely the negative control and the internal group using embryo media, the positive control using 3,4-dichloroanillin, and the treatment group 125μg / ml, 250μg / ml, 500μg / ml, 1000μg / ml, 2000μg / ml, and 4000μg / ml using 384 zebrafish embryos. Saltwater fish powder is diluted and observed for 96 hours, controlled every 24 hours. It was found that saltwater fish powder was not toxic because there were no dead zebrafish embryos from various concentrations, negative control, and internal control.
Co-Authors Afroz, Shaista Ahmad, Rayyan Orvin Pradipta Arlina Nurhapsari Azka Putri Anisa Clarasya, Amara Danish Dewi, Rizqa Citra Dimas P. P., Muhammad Evy Tri Utami Evy Tri Utami Finsa Tisna Sari Finsa Tisna Sari, Finsa Tisna Grahita Aditya Helmi Fathurrahman, Helmi Ibrahim, Zurairah Iftitah Nabiilah Ramadhani Indasari, Novia Indrawati, Silvia Vera Juni Handajani Mayangsari, Regilia Shinta Naila Salsabila Noor Aziza Novia Indasari Nurazky, Savira Rahadian, Arief Rama Putranto Rebecca Azary Kuncoro Rebecca Azary Kuncoro, Rebecca Azary Recita Indraswary Rizki Amalina Rochmah, Yayun Siti Rochmah Rochman Mujayanto Rosa Pratiwi, Rosa S.Pd. M Kes I Ketut Sudiana . Safangat, Muhamat Muhtar Salma, Nuris Salwa Febria Monica Sandy Christiono Savira Nurazky Yuniar Seno Pradopo Seno Pradopo Shella Indri Novianty, Shella Indri Silvia Vera Indrawati Siska Nurlivia Subiyono, Amelia Febriani Suhartono, Budi Sukarno, M. Faiz Faz Sunnah, Tahta Danifatis Suparmi Suparmi Suparmi Suparmi Suryono Suryono Welly Anggarani Yayun Siti Rochmah Yayun Siti Rochmah Rochmah Yuniar, Savira Nurazky Zurairah Ibrahim