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All Journal Medali Jurnal : Media Dental Intelektual ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Odonto dental journal Jurnal Pengabdian Masyarakat Dentmas Journal of Fisheries & Marine
Islamy Rahma Hutami, Islamy Rahma
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Journal : ODONTO Dental Journal

 1 
POTENTIAL OF NASAL AND ORAL SPRAYS OF ALLYL DISULFIDE GARLIC EXTRACT AS PROTECTION AGAINST SARS-COV-2 Silvia Vera Indrawati; Salwa Febria Monica; Iftitah Nabiilah Ramadhani; Siska Nurlivia; Azka Putri Anisa; Islamy Rahma Hutami
ODONTO : Dental Journal Vol 9: Special Issue 1. April 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.0.131-136

Abstract

Background: Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), a virus that causes COVID-19 disease, occurred in 2019. The prevalence of COVID-19 was increasing and spreading rapidly in several countries including Indonesia. Some efforts have been proposed to reduce the coronavirus outbreak, which is the exploration potentials inhibitor of SARS-CoV-2, vaccination, and improving health protocols by implementing 5M. This study characterized several formulations of nasal spray and evaluated their biological function as antivirus.Method: The garlic was used in this study, crude extract performed by garlic extraction using maseration and evaporated using rotary evaporator. The garlic crude extract was prepared to make nasal and oral sprayer agent and evaluated using thin layer chromatography. Nasal and oral spray composition was modelled and docked with spike glycoprotein of SARS-CoV-2 and angiotensin converting enzyme-2 (ACE-2). Garlic extract showed containing allyl sulfide as bioactive compound in garlic, which was detected at Rf 0.5. biological functions revealed that the component of nasal and oral spray have antiviral agents and block the spike glycoprotein – ACE2 interaction.Result: The allyl disulfide complex detected several active amino acid residues, both with the spike glycoprotein protein and the ACE2 receptor. Conclusion: This study suggested that the nasal and oral spray garlic has the potential as an antiviral, especially inhibiting the interaction between ACE2 and spike glycoprotein. Further in vitro and in vivo studies are required for advance investigation.
The Roles Of Sphingosine-1-Phosphate (S1p) On Arthritis: Review Article HUTAMI, ISLAMY RAHMA
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.115-123

Abstract

Arthritis is a pathological condition that results in degeneration of the joints. RA and OA are the most common types of arthritis. RA is a chronic joint inflammation caused by the immune system's self-attack on tissues. By contrast, OA is chronic joint inflammation caused by cartilage breakdown. Both illnesses cause joint discomfort, stiffness, and edema. One genetic factor in arthritis is sphingosine-1-phosphate (S1P). S1P regulates bone homeostasis and growth using 5 receptors: 1, 2, 3, 4, and 5. Thus, this literature review intends to investigate the impact of S1P on arthritis. Methods: The eligibility criteria comprised cross-sectional studies that were published in English until January 2024 and exclusively addressed the role of S1P in arthritis. Results and discussion: From 396 publications, 17 relevant articles were located, and 6 were chosen for the review. The S1P/S1P2 signaling pathway releases osteoclasts to degrade cartilage in osteoarthritis. S1P also promotes bone growth by differentiating osteoblasts and forming blood vessels in the bone marrow. The miR-25 rs41274221 polymorphism may reduce osteoporosis risk. IL-6 is also produced by osteoblasts with S1P. Osteoarthritis is associated with elevated blood S1P and MMP-3 levels. Cyclic strain and inflammation increase Sphk1 upregulation and S1P release, suggesting a role in osteoarthritis. In conclusion, the expression of S1P by osteoclasts, osteoblasts, chondrocytes, and tenocytes is believed to play a crucial role in regulating cell migration and the production of cytokines or chemokines throughout the process of bone formation. Focusing on the S1P pathway may help treat bone and joint diseases.
Co-Authors Afroz, Shaista Ahmad, Rayyan Orvin Pradipta Arlina Nurhapsari Azka Putri Anisa Clarasya, Amara Danish Dewi, Rizqa Citra Dimas P. P., Muhammad Evy Tri Utami Evy Tri Utami Finsa Tisna Sari Finsa Tisna Sari, Finsa Tisna Grahita Aditya Helmi Fathurrahman, Helmi Ibrahim, Zurairah Iftitah Nabiilah Ramadhani Indasari, Novia Indrawati, Silvia Vera Juni Handajani Mayangsari, Regilia Shinta Naila Salsabila Noor Aziza Novia Indasari Nurazky, Savira Rahadian, Arief Rama Putranto Rebecca Azary Kuncoro Rebecca Azary Kuncoro, Rebecca Azary Recita Indraswary Rizki Amalina Rochmah, Yayun Siti Rochmah Rochman Mujayanto Rosa Pratiwi, Rosa S.Pd. M Kes I Ketut Sudiana . Safangat, Muhamat Muhtar Salma, Nuris Salwa Febria Monica Sandy Christiono Savira Nurazky Yuniar Seno Pradopo Seno Pradopo Shella Indri Novianty, Shella Indri Silvia Vera Indrawati Siska Nurlivia Subiyono, Amelia Febriani Suhartono, Budi Sukarno, M. Faiz Faz Sunnah, Tahta Danifatis Suparmi Suparmi Suparmi Suparmi Suryono Suryono Welly Anggarani Yayun Siti Rochmah Yayun Siti Rochmah Rochmah Yuniar, Savira Nurazky Zurairah Ibrahim