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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Mandala Pharmacon Indonesia Reswara: Jurnal Pengabdian Kepada Masyarakat Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Farmasi Sains dan Praktis Journal of Health, Education, Economics, Science, and Technology (J-HEST) JURNAL BIOLOGI PAPUA GEMBIRA (Pengabdian Kepada Masyarakat) ABDIKOM Indonesian Journal of Pharmacology and Therapy Jurnal Pengabdian Kepada Masyarakat
Juniarto Mende
Universitas Cenderawasih
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Predictors of clinical outcomes in ischemic stroke patients with infectious complications Juniarto Mende; Graciano A. Maturbongs; Yohana K.A. Mbulang
Jurnal Biologi Papua Vol 18 No 1 (2026)
Publisher : Jurusan Biologi FMIPA Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31957/jbp.5249

Abstract

Infection in stroke patients is a significant health problem that is associated with poor prognosis and increased treatment costs. This infection can intensify immune system dysregulation, worsen the risk of cognitive decline, and increase mortality and neurological disability. This study aimed to evaluate predictors influencing clinical outcomes in ischemic stroke patients with infectious complications. The study used a cross-sectional design. Retrospective data were collected from medical records at Jayapura Regional Hospital for the period from January 1, 2023, to May 31, 2025. The study subjects were all patients with ischemic stroke who received antibiotics. Clinical outcomes were evaluated based on clinical improvement, defined by vital signs within the normal range, symptom improvement within three to five days after antibiotic administration, and improvement in laboratory values to within the normal range. A total of 50 patients were included after meeting the study inclusion criteria. The results showed significant relationships between risk factors such as hypertension, kidney failure, respiratory tract infection (pneumonia), and rational antibiotic use, with p-values of 0.007, 0.016, 0.023, and 0.007, respectively, and the clinical outcomes of ischemic stroke patients with infectious complications. Multivariate analysis showed that the factors influencing clinical outcomes were hypertension (OR= 7.292; 95% CI 1.510–35.202; p= 0.013), kidney failure (OR= 1.565; 95% CI 0.027–0.810; p= 0.028), respiratory tract infection (pneumonia) (OR= 5.760; 95% CI 1.147–28.920; p= 0.033), and rational antibiotic use (OR= 7.292; 95% CI 1.510–35.202; p= 0.013). Monitoring risk factors in post-infectious ischemic stroke patients is therefore essential. Pharmacists can play an important role in monitoring patients’ clinical conditions to prevent post-stroke complications by paying close attention to patient risk factors.
Co-Authors Andre Anusta Barus Budiman, Eren Arif Claudius Hendraman B. Tobi Elieser Kulimbang Elsye Gunawan Elvionita, Cindy Felycitae Ekalaya Appa Fita Rahmawati Graciano Aristides Maturbongs Idris, Irma Ika Puspitasari Kartikawati, Nurfina Dian Krisna Dewi Mahmuda, Hartati Manemi, Putri Winduri Mariyo Jane Sanggel More, Evasiana Mustika Endah Pratiwi Nur Fadilah Bakri Nurfina Dian K. Nurfina Dian K. Nurhidayah, Annisa Nurkhalika, Rachmi Pasaribu, Ezra Pawan, Elvis Pustap, El Shaddai Sandhy Rani Dewi Pratiwi Rosa, Stella Rusnaeni Rusnaeni Taborat, Miranda Tamaela, Josepha Mariana Titami, Arina Yohana Krisostoma Anduk Mbulang