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All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) YUSTISI FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Aisyah : Jurnal Ilmu Kesehatan Yustisi: Jurnal Hukum dan Hukum Islam BIOVALENTIA: Biological Research Journal Jurnal Locus Penelitian dan Pengabdian Journal of Applied Agricultural Science and Technology Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies
Hayun Hayun
Departemen Farmasi FMIPA-UI
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Synthesis of New Indazole Analogs of Curcumin as Antioxidant and Anti-inflammatory Candidates: An In Vitro Investigation Hariyanti, Hariyanti; Hayun, Hayun; Yanuar, Arry; Azminah, Azminah
Indonesian Journal of Chemistry Vol 24, No 5 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.82443

Abstract

The development of analog curcumin compounds by modifying the structure of monocarbonyl into an analog indazole of curcumin (AIC) is recognized to have a great potential. Still, only a few reports have been available. Rarely occurring in nature, indazole molecules are typically created through chemical synthesis. Therefore, this study aimed to synthesize six new AIC compounds with a particular focus on testing in vitro antioxidant activity using the DPPH and FRAP methods, as well as anti-inflammatory activity using the protein denaturation method. The results showed that the compounds formed had high anti-inflammatory activity but low antioxidant activity. All synthesis products produced higher anti-inflammatory activity than standard diclofenac sodium and curcumin compounds. Specifically, compound 3a showed the highest anti-inflammatory activity with an IC50 = 0.548 ± 0.062 μM. Therefore, it was concluded that compound 3a has the potential to be further studied for anti-inflammatory activity.
A Review on Mannich Base Derivatives Some of Natural Compounds: Antimicrobial Activities Siburian, Eva; Hayun, Hayun; Suryadi, Herman
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.50917

Abstract

This review explores the synthesis and antimicrobial potential of Mannich base derivatives derived from various natural compounds. The Mannich reaction, a versatile method in organic synthesis, enables structural modification of bioactive compounds to enhance their pharmacological properties, particularly antimicrobial activities. This study systematically reviews recent literature on the design, synthesis, and biological evaluation of these derivatives against bacterial and fungal pathogens. The findings demonstrate that Mannich base derivatives exhibit improved efficacy through multiple mechanisms of action, such as inhibition of cell wall synthesis, protein synthesis, and membrane disruption. The review highlights the relevance of Mannich-based structural optimization as a promising strategy in the development of novel antimicrobial agents.
Review: Sintesis Senyawa Turunan Dari ?-Amino Alkohol Yang Memiliki Potensi Aktivitas Antibakteri Nafi’ah, Nadya Ismi; Hayun, Hayun; Suryadi, Herman
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4767

Abstract

?-Amino alkohol merupakan senyawa organik yang mengandung gugus amino dan hidroksil pada posisi ? terhadap satu sama lain, dan diketahui memiliki potensi sebagai agen antibakteri. Permasalahan utama dalam penelitian ini adalah terbatasnya informasi sistematis mengenai hubungan struktur-aktivitas senyawa turunan ?-amino alkohol dan metode sintesis optimal untuk menghasilkan senyawa dengan aktivitas antibakteri yang tinggi. Tujuan kajian ini adalah untuk menganalisis berbagai metode sintesis turunan ?-amino alkohol, mengevaluasi potensi aktivitas antibakteri berdasarkan parameter zona hambat dan konsentrasi hambat minimum (KHM), serta mengidentifikasi hubungan struktur-aktivitas untuk pengembangan kandidat antibakteri baru. Metode penelitian menggunakan systematic review dengan pendekatan PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) melalui pencarian literatur pada basis data Perpustakaan Online Universitas Indonesia, Google Scholar, ScienceDirect, Scopus, PubMed, Wiley Journal, dan The Royal Society of Chemistry menggunakan kata kunci "synthesis of ?-amino alcohol", "?-amino alcohol", "antimicrobial", "antibacterial", dan "?-amino alcohol derivatives". Dari 244 artikel yang ditemukan, 4 artikel memenuhi kriteria inklusi dan mengevaluasi aktivitas antibakteri senyawa hasil sintesis. Hasil kajian menunjukkan bahwa sintesis turunan ?-amino alkohol dapat dilakukan melalui berbagai metode seperti pembukaan cincin epoksida, reaksi Mannich, pembentukan basa Schiff, dan reduksi asimetris dengan yield berkisar 68-96%. Senyawa dengan substituen seperti fenil piperazin, imidazol, serta gugus aromatik menunjukkan aktivitas signifikan terhadap bakteri Gram positif (S. aureus, B. subtilis) dan Gram negatif (E. coli, P. aeruginosa) dengan nilai KHM terendah 15,6 µg/mL pada senyawa 1-fenil-2-[(1-fenilpropil)amino]propan-1-ol terhadap Klebsiella pneumoniae. Implikasi penelitian ini menunjukkan bahwa desain struktur kimia yang tepat, terutama keberadaan sistem aromatik dan gugus donor elektron yang kuat, dapat meningkatkan potensi antibakteri senyawa turunan ?-amino alkohol dan mendukung pengembangan lebih lanjut sebagai kandidat antibakteri baru untuk mengatasi resistensi antimikroba.
Application of Ionic Liquids based Microwave-Assisted Extraction to Bioactive Compounds Comfrey (Symphytum officinale L.) Leaves Hasan, Nahrul; Mun'im, Abdul; Hayun, Hayun
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (816.251 KB) | DOI: 10.30604/jika.v7i1.764

Abstract

Extraction of bioactive compounds from comfrey leaves (Symphytum officinale L.) was carried out by comparing organic solvents and ionic liquids between conventional and microwave-assisted extraction (IL-MAE) methods. The comfrey leaf powder was extracted under various conditions. The types of organic solvents used are 65% ethanol and ionic liquids. The extraction methods used are reflux and microwave-assisted extraction. The ionic liquid was extracted by microwave-assisted extraction with the following conditions: ionic liquid concentration of 1 mol/L, the solid-liquid ratio of 1:20 (g/mL), extraction time of 10 minutes, and power of 30% (270 Watt). The total phenolic content of the extract was analyzed with a microplate reader. Allantoin and retrorsine N-oxide levels were analyzed by thin-layer chromatography – densitometry. MAE extraction in a solvent containing 65% ethanol resulted in the highest total phenolic content of 1.038±0.012. The highest levels of allantoin were also obtained from MAE extraction with 65% ethanol solvent at 2.922 ± 0.123. The highest levels of retrorsine N-oxide were obtained by extraction of MAE with (BMIM)Br with a concentration of 0.049 ± 0.007. Extraction of comfrey leaves using the MAE method of 65% ethanol produced the highest total phenolic and allantoin content compared to other methods. (BMIM) Br extraction with MAE can attract the highest retrorsine N-oxide in comfrey leaves.  Abstrak: Ekstraksi senyawa bioaktif daun komfrey (Symphytum officinale L.) dilakukan dengan membandingkan pelarut organik dan cairan ionik, antara metode konvensional dengan metode microwave assisted extraction. Serbuk daun komfrey diekstraksi dengan berbagai kondisi. Jenis pelarut organik yang digunakan yaitu etanol 65% dan cairan ionik. Metode ekstraksi konvensional yang dilakukan, yaitu refluks dan microwave-assisted extraction. Cairan ionik diekstraksi denganmicrowave-assistedextraction dengan kondisi: konsentrasi Cairan ionik 1 mol/L, Rasio padatcair 1:20 (g/mL), waktu ekstraksi 10 menit dan power 30% (270 Watt). Kadar fenol total dalam ekstrak dianalisis dengan microplate reader. Sedangkan kadar allantoin dan retrorsine N-oxide dianalis dengan kromatografi lapis tipis–densitometri. Ekstraksi MAE dengan pelarut etanol 65% menghasilkan kadar fenol total tertinggi, yaitu 1,038 ± 0,012. Kadar Allantoin tertinggi didapatkan juga dari ekstraksi MAE dengan pelarut etanol 65% sebanyak 2,922 ± 0,123. Kadar retrorsin N-oksida tertinggi didapatkan dengan ekstraksi MAE dengan (BMIM) Br dengan konsentrasi 0,049 ± 0,007. Ekstraksi daun komfrey dengan metode MAE etanol 65% menghasilkan kadar fenol total dan allantoin paling tinggi dibandingkan dengan metode lain. Ekstraksi (BMIM) Br dengan MAE dapat menarik kadar retrorsin N-oksida paling tinggi dalam daun komfrey.
Antibacterial Synergy Detection of Lignin Extract from Oil Palm Empty Fruit Bunches (Opefb) Combined with Amoxicillin Against Staphylococcus Aureus Using The Azdast Method Hendri, Rifki Anshory; Suryadi, Herman; Hayun, Hayun
Journal of Applied Agricultural Science and Technology Vol. 8 No. 1 (2024): Journal of Applied Agricultural Science and Technology
Publisher : Green Engineering Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55043/jaast.v8i1.191

Abstract

Oil palm empty fruit bunches (OPEFB) are waste generated by the palm oil industry and are generally considered an environmental problem due to their large quantity and difficult recyclability. This study's objective was to examine the potential of OPEFB lignin extract combined with amoxicillin in inhibiting the growth of Staphylococcus aureus bacteria. The Synergism Test of the OPEFB lignin extract-antibiotic combination was conducted using the AZDAST method (Ameri Ziaei Double Antibiotic Synergism Test). The lignin extraction process was a steam process using a 4% oxalic acid solution under optimal conditions. Then, Calcium ions precipitate 4% oxalate by adding Ca(OH)2 to the extract. The Lignin content was determined by UV-Vis spectrophotometry at 280 nm, and then the lignin extract was combined with antibiotics for antibacterial assay. The results showed a lignin content of 1.06 %. The AZDAST test results revealed clear zones from the combination of OPEFB lignin extract and amoxicillin with a diameter of 20.23 mm for the extract containing oxalate and 15.83 mm for the oxalate-free extract. Meanwhile, on average, the clear zone of single amoxicillin was only 14.13 mm. Based on these results, the combination of OPEFB lignin extract with amoxicillin was stronger than amoxicillin alone in inhibiting the growth of S. aureus, but it was not significantly different (p-value> 0.05). In conclusion, the potential of OPEFB lignin extract synergistically worked with the antibiotic amoxicillin in inhibiting the growth of S. aureus.
Utilization of Near-Infrared Spectroscopy Combined with PLS-2 Regression Learner to Predict Metformin HCL Tablet Dissolution Profile Zakaria, Mohamad Rahmatullah; Sutriyo, Sutriyo; Hayun, Hayun; Rukmana, Taufiq Indra
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.1566

Abstract

One of the assurances of pharmaceutical tablet's quality, effectivity, and safety is the dissolution test, which is commonly known by pharmaceutical manufacturers. Conventionally, this test is performed by simulating the release rate of a drug using a Dissolution Tester, which mimics the human gastrointestinal condition. As stated by the current compendial for tablet dosage form, the dissolution rate is mandatory, with no exception for Metformin HCl tablets. This laboratory method is often time-consuming, unsafe for organic reagent exposure, and produces waste. This problem requires rapid, simple, and nondestructive technologies, hence having powerful analytical performance. One of the technologies that is widely used is Near Infrared (NIR) spectroscopy. This study utilized the NIR spectrum as a predictor to generate a mathematical model using Partial Least Square Regression (PLS-2) to build a dissolution rate model for the Metformin HCl tablet, which uses the Farmakope Indonesia IV <1231> (FI-IV) dissolution method as the compendial reference method. The PLS-2 model was built, which shows the low difference between SEC and SECV in each sampling point and a good correlation in the coefficient of determination (R2) of each point's time of dissolution within 0.900 to 0.953. The challenge test was performed to prove the predictability of the PLS-2 model with NIR against the actual reference FI-IV method using differential and similarity Factors (f2 & f1), enabling real-time release testing (RTRT).
IMPLEMENTASI HUKUM PIDANA DALAM PROSES PERADILAN ANAK BERHADAPAN DENGAN HUKUM Mashendra, Mashendra; Karim, La Ode Muhammad; Hayun, Hayun; Hasri, Hasirudin
YUSTISI Vol 13 No 1 (2026)
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/yustisi.v13i1.22649

Abstract

Penelitian ini bertujuan untuk menganalisis implementasi bantuan bagi anak-anak yang berkonflik dengan hukum (ABH) dalam proses peradilan anak dan mengidentifikasi faktor-faktor yang menghambatnya di Lembaga Pemasyarakatan Kelas II Baubau. Penelitian ini menggunakan metode empiris yudisial dengan pendekatan lapangan, yang mengkaji ketentuan hukum serta praktik nyata pemberian bantuan. Data diperoleh melalui observasi, wawancara, dan studi dokumentasi. Informan penelitian terdiri dari Kepala Lembaga Pemasyarakatan, satu pegawai Lembaga Pemasyarakatan, dan dua anak yang berkonflik dengan hukum. Data dianalisis secara kualitatif menggunakan teknik deskriptif. Hasil penelitian menunjukkan bahwa bantuan ABH diberikan oleh Konselor Masyarakat melalui penelitian komunitas dalam waktu 3 × 24 jam setelah permintaan dari penyidik. Namun, implementasi bantuan masih menghadapi berbagai hambatan, termasuk keterbatasan kesempatan anak untuk menyampaikan pendapatnya di pengadilan, koordinasi yang lemah antara lembaga penegak hukum, jumlah dan kapasitas Konselor Komunitas yang terbatas, serta dukungan anggaran yang minim. Kata kunci: Analisis Hukum; Pidana;Peradilan Anak;
IMPLEMENTASI HUKUM PIDANA DALAM PROSES PERADILAN ANAK BERHADAPAN DENGAN HUKUM Mashendra, Mashendra; Karim, La Ode Muhammad; Hayun, Hayun; Hasri, Hasirudin
YUSTISI Vol 13 No 1 (2026)
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/yustisi.v13i1.22649

Abstract

Penelitian ini bertujuan untuk menganalisis implementasi bantuan bagi anak-anak yang berkonflik dengan hukum (ABH) dalam proses peradilan anak dan mengidentifikasi faktor-faktor yang menghambatnya di Lembaga Pemasyarakatan Kelas II Baubau. Penelitian ini menggunakan metode empiris yudisial dengan pendekatan lapangan, yang mengkaji ketentuan hukum serta praktik nyata pemberian bantuan. Data diperoleh melalui observasi, wawancara, dan studi dokumentasi. Informan penelitian terdiri dari Kepala Lembaga Pemasyarakatan, satu pegawai Lembaga Pemasyarakatan, dan dua anak yang berkonflik dengan hukum. Data dianalisis secara kualitatif menggunakan teknik deskriptif. Hasil penelitian menunjukkan bahwa bantuan ABH diberikan oleh Konselor Masyarakat melalui penelitian komunitas dalam waktu 3 × 24 jam setelah permintaan dari penyidik. Namun, implementasi bantuan masih menghadapi berbagai hambatan, termasuk keterbatasan kesempatan anak untuk menyampaikan pendapatnya di pengadilan, koordinasi yang lemah antara lembaga penegak hukum, jumlah dan kapasitas Konselor Komunitas yang terbatas, serta dukungan anggaran yang minim. Kata kunci: Analisis Hukum; Pidana;Peradilan Anak;
Co-Authors . Harmita A.A. Ketut Agung Cahyawan W Abdul Mun'im Abdul Munim Andika Purnomo Arif Arrahman, Arif Arry Yanuar Ayuningtyas N Putri Azminah Azminah Baitha P Maggadani Baitha Palanggatan Maggadani, Baitha Palanggatan Berna Elya Catur Jatmika, Catur Citra Nur Azizah, Citra Nur Dini Hariria, Dini Fajriati, Annisa Febriyanti, Lilis Fready SIP Gadis Anggraini Harianto Harianto Hariyanti Hariyanti Hasan, Nahrul Hasri, Hasirudin Hendri, Rifki Anshory Herman Suryadi Karim, La Ode Muhammad Kusmadi Kurmardi Kusmardi Kusmardi Lisa N Luh Putu Ratna Sundari mashendra, Mashendra Masrijal, Camelia D.P. Meriska Sukandar Mulia Ade Karina Mun'im, Abdul Nafi’ah, Nadya Ismi Nelly D. Leswara Novi Fajar Utami Nurul Amalina Rukmana, Taufiq Indra Setiajid, Muhammad Aditya Setiajid, Muhammad Aditya Sherly Meilianti, Sherly Siburian, Eva Sutriyo Sutriyo, Sutriyo Syamsu Nur, Syamsu Ulfah Aunillah, Ulfah Yahdiana Harahap Yahdiana Harahap Yenti, Yenti Zakaria, Mohamad Rahmatullah Zarkasih, Lutfhi