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All Journal Indonesian Journal of Chemistry Legal Standing : Jurnal Ilmu Hukum FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Aisyah : Jurnal Ilmu Kesehatan Rambideun : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Legality of Law Journal of Community Development Shautuna: Jurnal Ilmiah Mahasiswa Perbandingan Mazhab Journal Of Human And Education (JAHE) Jurnal Locus Penelitian dan Pengabdian Journal of Applied Agricultural Science and Technology Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies
Hayun Hayun, Hayun
Departemen Farmasi FMIPA-UI,
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Application of Ionic Liquids based Microwave-Assisted Extraction to Bioactive Compounds Comfrey (Symphytum officinale L.) Leaves Hasan, Nahrul; Mun'im, Abdul; Hayun, Hayun
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (816.251 KB) | DOI: 10.30604/jika.v7i1.764

Abstract

Extraction of bioactive compounds from comfrey leaves (Symphytum officinale L.) was carried out by comparing organic solvents and ionic liquids between conventional and microwave-assisted extraction (IL-MAE) methods. The comfrey leaf powder was extracted under various conditions. The types of organic solvents used are 65% ethanol and ionic liquids. The extraction methods used are reflux and microwave-assisted extraction. The ionic liquid was extracted by microwave-assisted extraction with the following conditions: ionic liquid concentration of 1 mol/L, the solid-liquid ratio of 1:20 (g/mL), extraction time of 10 minutes, and power of 30% (270 Watt). The total phenolic content of the extract was analyzed with a microplate reader. Allantoin and retrorsine N-oxide levels were analyzed by thin-layer chromatography – densitometry. MAE extraction in a solvent containing 65% ethanol resulted in the highest total phenolic content of 1.038±0.012. The highest levels of allantoin were also obtained from MAE extraction with 65% ethanol solvent at 2.922 ± 0.123. The highest levels of retrorsine N-oxide were obtained by extraction of MAE with (BMIM)Br with a concentration of 0.049 ± 0.007. Extraction of comfrey leaves using the MAE method of 65% ethanol produced the highest total phenolic and allantoin content compared to other methods. (BMIM) Br extraction with MAE can attract the highest retrorsine N-oxide in comfrey leaves.  Abstrak: Ekstraksi senyawa bioaktif daun komfrey (Symphytum officinale L.) dilakukan dengan membandingkan pelarut organik dan cairan ionik, antara metode konvensional dengan metode microwave assisted extraction. Serbuk daun komfrey diekstraksi dengan berbagai kondisi. Jenis pelarut organik yang digunakan yaitu etanol 65% dan cairan ionik. Metode ekstraksi konvensional yang dilakukan, yaitu refluks dan microwave-assisted extraction. Cairan ionik diekstraksi denganmicrowave-assistedextraction dengan kondisi: konsentrasi Cairan ionik 1 mol/L, Rasio padatcair 1:20 (g/mL), waktu ekstraksi 10 menit dan power 30% (270 Watt). Kadar fenol total dalam ekstrak dianalisis dengan microplate reader. Sedangkan kadar allantoin dan retrorsine N-oxide dianalis dengan kromatografi lapis tipis–densitometri. Ekstraksi MAE dengan pelarut etanol 65% menghasilkan kadar fenol total tertinggi, yaitu 1,038 ± 0,012. Kadar Allantoin tertinggi didapatkan juga dari ekstraksi MAE dengan pelarut etanol 65% sebanyak 2,922 ± 0,123. Kadar retrorsin N-oksida tertinggi didapatkan dengan ekstraksi MAE dengan (BMIM) Br dengan konsentrasi 0,049 ± 0,007. Ekstraksi daun komfrey dengan metode MAE etanol 65% menghasilkan kadar fenol total dan allantoin paling tinggi dibandingkan dengan metode lain. Ekstraksi (BMIM) Br dengan MAE dapat menarik kadar retrorsin N-oksida paling tinggi dalam daun komfrey.
Peningkatan Pemahaman Tentang Perancangan Pembuatan Peraturan Desa (PERDES) Mashendra, Mashendra; Gurusi, La; Karim, La Ode Muhammad; Satria, Eko; Hayun, Hayun; Hasri, Hasiruddin; Kahar, Amrun; Mansyah, Muh Sutri; Waru, Ahmad Zein L
Journal Of Human And Education (JAHE) Vol. 4 No. 1 (2024): Journal Of Human And Education (JAHE)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jh.v4i1.655

Abstract

Sangat penting untuk meningkatkan kualitas sumber daya manusia, terutama pejabat pemerintah desa. Aparat pemerintah desa yang secara proaktif berhubungan dengan masyarakat. Tujuan dari pengabdian kepada masyarakat ini adalah untuk memastikan bahwa perangkat desa memahami hal-hal yang berkaitan dengan perumusan peraturan di dalam Peraturan desa, untuk memastikan bahwa peraturan tersebut memenuhi standar. Secara khusus, pengabdian ini bertujuan untuk membahas aspek filosofis, aspek sosiologis, dan aspek yuridis. Standar-standar yang baik ditegakkan dalam peraturan desa terkait aspek filosofis, sosiologis, dan yuridis. Metode yang digunakan adalah ceramah dan diskusi yang diakhiri dengan sesi tanya jawab. Sebagai hasil dari pengabdian masyarakat ini, perangkat desa telah memperoleh pengetahuan tentang proses teoritis dan teknis yang terlibat dalam pembuatan peraturan di tingkat desa, termasuk peraturan yang spesifik untuk desa dan peraturan kepala desa. Keahlian dan pengetahuan aparatur desa dalam pembuatan peraturan diperlukan untuk memastikan bahwa setiap peraturan yang dirumuskan secara konsisten menguntungkan bagi desa dan untuk memastikan bahwa masyarakat desa selalu mendapatkan manfaat dari pembuatan peraturan desa.
Upaya Pemerintah Dalam Penanggulangan Narkoba Melalui Sosialisasi Hukum Di Desa Napa Kecamatan Mawasangka Hayun, Hayun; Mashendra, Mashendra; Hasri, Hasirudin; Safira, Nabila
Journal Of Human And Education (JAHE) Vol. 4 No. 6 (2024): Journal of Human And Education (JAHE)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jh.v4i6.1942

Abstract

Saat ini, penyebaran narkoba di Indonesia telah memasuki zona krusial. Cakupan penyebarannya semakin meluas dan berusaha untuk menjangkau semua kalangan. Sangat penting bagi semua aspek masyarakat untuk mengambil tindakan serius dan menerapkan langkah-langkah penanggulangan dalam menanggapi situasi ini. Sebagai contoh, salah satu metode yang paling berhasil untuk mengatasi penanggulangan narkoba yaitu upaya peningkatkan keterlibatan pemerintah desa dalam melaksanakan kegiatan pemberdayaan masyarakat, sebagaimana disebutkan dalam Pasal 26 (1) UU No. 6 Tahun 2014 tentang Desa, merupakan salah satu teknik efektif yang dapat dilakukan untuk mengatasi masalah penyalahgunaan narkoba. Sudah menjadi tanggung jawab pemerintah desa yang menjadi ujung tombak dalam pelaksanaan tanggung jawab pemerintahan di tingkat pemerintahan untuk mengatasi dan menangani permasalahan sosial seperti permasalahan narkoba. Strategi pencegahan penggunaan narkoba dapat dilakukan melalui program penyuluhan hukum yang secara rutin diberikan kepada masyarakat di tingkat desa oleh lembaga-lembaga yang relevan dengan masalah tersebut. Melalui program ini, masyarakat desa dapat memperoleh pengetahuan dan kesadaran yang diperlukan untuk memahami dampak dan risiko yang ditimbulkan oleh narkoba terhadap diri mereka sendiri, serta ketertiban dan ketentraman lingkungan.
Peningkatan Kesadaran Hukum Dalam Memahami Pendaftaran Merek Bagi Pelaku Usaha Umkm Di Desa Wakambangura Kecamatan Mawasangka Kabupaten Buton Tengah Hasri, Hasirudin; Mashendra, Mashendra; Hayun, Hayun; Satria, Eko; Safira, Nabila; Nisa, Fias Nurul
Journal Of Human And Education (JAHE) Vol. 4 No. 6 (2024): Journal of Human And Education (JAHE)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jh.v4i6.1943

Abstract

Sebagian besar masyarakat yang tinggal di Kabupaten Buton Tengah , terlibat dalam Usaha Mikro, Kecil, dan Menengah (UMKM). Usaha Mikro, Kecil, dan Menengah (“UMKM”). Ada berbagai jenis usaha di antara UMKM ini, seperti Perdagangan, Industri Pertanian, dan Industri Non-Pertanian. Namun, masih banyak pelaku usaha dalam bisnis UMKM yang belum mendaftarkan merek dagang mereka karena tidak punya uang atau tidak tahu betapa pentingnya merek tersebut. Tujuan dari program PKM ini adalah untuk membantu para pelaku bisnis UMKM di Desa Wakambangura akan pentingnya pendaftaran merek bagi palaku usaha UMKM. 2. Menyadarkan para pelaku usaha UMKM akan pentingnya merek dan pendaftaran merek bagi UMKM di Desa Wakambangura, Kecamatan Mawasangka, Kabupaten Buton Tengah; dan 3. Mendorong para pelaku usaha UMKM untuk melindungi produk baru mereka melalui kekayaan intelektual (KI) melalui penyampaian materi penyuluhan hukum. Selain itu, metodologi yang digunakan dalam Pengabdian Masyarakat ini melibatkan pendekatan lokakarya, dilengkapi dengan ceramah pada sesi tanya-jawab di akhir acara.
Antibacterial Synergy Detection of Lignin Extract from Oil Palm Empty Fruit Bunches (Opefb) Combined with Amoxicillin Against Staphylococcus Aureus Using The Azdast Method Hendri, Rifki Anshory; Suryadi, Herman; Hayun, Hayun
Journal of Applied Agricultural Science and Technology Vol. 8 No. 1 (2024): Journal of Applied Agricultural Science and Technology
Publisher : Green Engineering Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55043/jaast.v8i1.191

Abstract

Oil palm empty fruit bunches (OPEFB) are waste generated by the palm oil industry and are generally considered an environmental problem due to their large quantity and difficult recyclability. This study's objective was to examine the potential of OPEFB lignin extract combined with amoxicillin in inhibiting the growth of Staphylococcus aureus bacteria. The Synergism Test of the OPEFB lignin extract-antibiotic combination was conducted using the AZDAST method (Ameri Ziaei Double Antibiotic Synergism Test). The lignin extraction process was a steam process using a 4% oxalic acid solution under optimal conditions. Then, Calcium ions precipitate 4% oxalate by adding Ca(OH)2 to the extract. The Lignin content was determined by UV-Vis spectrophotometry at 280 nm, and then the lignin extract was combined with antibiotics for antibacterial assay. The results showed a lignin content of 1.06 %. The AZDAST test results revealed clear zones from the combination of OPEFB lignin extract and amoxicillin with a diameter of 20.23 mm for the extract containing oxalate and 15.83 mm for the oxalate-free extract. Meanwhile, on average, the clear zone of single amoxicillin was only 14.13 mm. Based on these results, the combination of OPEFB lignin extract with amoxicillin was stronger than amoxicillin alone in inhibiting the growth of S. aureus, but it was not significantly different (p-value> 0.05). In conclusion, the potential of OPEFB lignin extract synergistically worked with the antibiotic amoxicillin in inhibiting the growth of S. aureus.
Utilization of Near-Infrared Spectroscopy Combined with PLS-2 Regression Learner to Predict Metformin HCL Tablet Dissolution Profile Zakaria, Mohamad Rahmatullah; Sutriyo, Sutriyo; Hayun, Hayun; Rukmana, Taufiq Indra
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.1566

Abstract

One of the assurances of pharmaceutical tablet's quality, effectivity, and safety is the dissolution test, which is commonly known by pharmaceutical manufacturers. Conventionally, this test is performed by simulating the release rate of a drug using a Dissolution Tester, which mimics the human gastrointestinal condition. As stated by the current compendial for tablet dosage form, the dissolution rate is mandatory, with no exception for Metformin HCl tablets. This laboratory method is often time-consuming, unsafe for organic reagent exposure, and produces waste. This problem requires rapid, simple, and nondestructive technologies, hence having powerful analytical performance. One of the technologies that is widely used is Near Infrared (NIR) spectroscopy. This study utilized the NIR spectrum as a predictor to generate a mathematical model using Partial Least Square Regression (PLS-2) to build a dissolution rate model for the Metformin HCl tablet, which uses the Farmakope Indonesia IV <1231> (FI-IV) dissolution method as the compendial reference method. The PLS-2 model was built, which shows the low difference between SEC and SECV in each sampling point and a good correlation in the coefficient of determination (R2) of each point's time of dissolution within 0.900 to 0.953. The challenge test was performed to prove the predictability of the PLS-2 model with NIR against the actual reference FI-IV method using differential and similarity Factors (f2 & f1), enabling real-time release testing (RTRT).
PENYULUHAN HUKUM TENTANG PENCEGAHAN DAN PENINDAKAN KEKERASAN DALAM RUMAH TANGGA Muh Sutri Mansyah; Hasri, Hasirudin; Hayun, Hayun; Muhammad Karim, La Ode; Nurchyo, Edy; Bunga, La Ode; Zudin, Zudin; Merdekawati, Vera
RAMBIDEUN : Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2024): Rambideun: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Al Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51179/pkm.v7i2.2433

Abstract

This Community Service Activity aimed to provide knowledge and understanding about preventing and taking action against Domestic Violence in Sampuabalo Village, Buton Regency. It is hoped that this activity will be able to provide legal awareness about how to prevent and take action against domestic violence. The methods for carrying out activities were counseling, lectures and discussions. The results of the implementation of thiscommunity service activities showed that there are efforts to increase public knowledge and awareness, one of which is in the form of legal education to the Sampuabalo Village Community and the participants who attended were dominated by people who were married, and the participants looked very enthusiastic and the community even hoped for further legal education so that they could increase their knowledge about law.
Perkembangan Hukum Ekonomi Indonesia Melalui Cyber Notaris Hayun, Hayun; Mashendra, Mashendra; Hasri, Hasirudin; Aulia, Riska
Legal Standing : Jurnal Ilmu Hukum Vol. 9 No. 1 (2025): Januari-April
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ls.v9i1.11335

Abstract

This research aims to analyze the development of Indonesian economic law through the implementation of the cyber notary system. The method used is a normative approach. The data used are legal materials, both primary (legislation), secondary (doctrine, jurisprudence), and tertiary (dictionary, legal encyclopedia), to analyze and interpret legal norms. Data sources include laws and regulations, jurisprudence (court decisions), legal doctrine (opinions of legal experts), and other legal materials such as draft laws and minutes of discussion. The results show that cyber notarization increases the value of electronic documents by legalizing them, for example, in addition to digitizing notary operations. Nevertheless, the implementation of this project will take a considerable amount of time due to the many components that must be prepared. It is stipulated in Article 1868 of the Indonesian Civil Code that an authentic deed is a legal document made before a public official and in a certain form stipulated by law.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Munim Arif Arrahman, Arif Arry Yanuar Aulia, Riska Azminah Azminah Baitha Palanggatan Maggadani, Baitha Palanggatan Berna Elya Bunga, La Ode Catur Jatmika, Catur Citra Nur Azizah, Citra Nur Dini Hariria, Dini Eko Satria Fajriati, Annisa Febriyanti, Lilis Gurusi, La Harianto Harianto Hariyanti Hariyanti Hasan, Nahrul Hasri, Hasiruddin Hasri, Hasirudin Hendri, Rifki Anshory Herman Suryadi Hezradian, Rahma Fathan Kahar, Amrun Karim, La Ode Muhammad Kusmardi Kusmardi Luh Putu Ratna Sundari Mansyah, Muh Sutri mashendra, Mashendra Masrijal, Camelia D.P. Merdekawati, Vera Muh Sutri Mansyah Muhammad Karim, La Ode Mulia, Wa Ode Anggun Rahmadhani Mun'im, Abdul Nafi’ah, Nadya Ismi Nelly D. Leswara Nisa, Fias Nurul Novi Fajar Utami Nurchyo, Edy Rukmana, Taufiq Indra Safira, Nabila Sherly Meilianti, Sherly Siburian, Eva Sutriyo Sutriyo, Sutriyo Syamsu Nur, Syamsu Ulfah Aunillah, Ulfah Waru, Ahmad Zein L Yahdiana Harahap Yenti, Yenti Zakaria, Mohamad Rahmatullah Zarkasih, Lutfhi Zudin, Zudin