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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Biosains Pascasarjana Jurnal Penelitian Kesehatan Suara Forikes Jurnal Media Analis Kesehatan Jurnal Kesehatan BERNAS: Jurnal Pengabdian Kepada Masyarakat Anakes: Jurnal Ilmiah Analis Kesehatan Jurnal EduHealth Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Journal of Medical Laboratory in Infectious and Degenerative Diseases Biomedika Sadewa: Jurnal Pengabdian Masyarakat
AHDIAH IMROATUL MUFLIHAH
Fakultas Ilmu Kesehatan, Universitas Dr. Soebandi
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Effect of Boiled Mung Bean Seeds on Alanine Aminotransferase Levels in Rats (Rattus norvegicus L.) Induced by NaNO2 dwi ayu pratiwi, nabila; Mufidah, Hartalina; Imroatul Muflihah, Ahdiah; Anggitasari, Wima
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 2 No. 2 (2024): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v2i2.26

Abstract

Background: Sodium nitrite is a chemical compound used in the coloring and preserving process of processed meat. Excess sodium nitrite entering the body can have clinical impacts on health, especially the liver. Disorders of the liver can be identified by increased levels of Alanine Aminotransferase. Mung beans contain antioxidants, a compound that has benefits as a hepatoprotection. Purpose: This study aims to determine the effect of Mung bean stew on Alanine aminotransferase levels in rats (Rattus norvegicus L.) with anemia before and after administration. Method: This research design is an experimental study with quantitative data collection. This study was conducted in June–July 2024. The sample in this study was rats (Rattus norvegicus), which were taken randomly using random sampling techniques. The Mung beans used in this study were Mung beans that had undergone an infusion process. After collecting data, the researcher processed the data using Paired sample-t test analysis, One-Way ANOVA, and Post Hoc Tukey using SPSS. Results: The Paired sample-t test for Alanine Aminotransferase levels in rats (Rattus norvegicus) with anemia showed sig>0.05 in all treatment groups. The test results of the average change in Alanine Aminotransferase levels before and after between groups showed a sig value <0.05. Conclusion: Based on this study, it can be concluded that Based on this research, it can be concluded that there is no effect of boiled Mung beans on Alanine aminotransferase levels.
EDUKASI MASYARAKAT MANDIRI DESA SIAGA ANTI DIABETES AHDIAH IMROATUL   MUFLIHAH; Rian Anggia Destiawan
Jurnal SADEWA Vol 3 No 01 (2025): Sadewa: Jurnal Pengabdian Masyarakat
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/js.v3i01.841

Abstract

Diabetes mellitus is a disease or metabolic disorder characterized by increased sugar levels and accompanied by impaired metabolism of carbohydrates, lipids, and proteins. Common problems in the community are diabetes and hypertension. Diabetes can be prevented by eating a healthy diet and controlling blood sugar levels. One way to control blood sugar levels is to measure blood sugar levels using a tool, but the problem is that many people cannot use the tool. The community service aims to implement a community-based education program that facilitates the community in increasing knowledge about early detection and self-examination of Diabetes Mellitus. Methods In this study, diabetes mellitus education and demonstration of tools for detecting blood sugar levels. The results are community support to reduce diabetes levels by exercising, getting enough rest, and regularly checking blood sugar. The conclusion is that the community after education understands how to control blood sugar levels and conduct independent examinations.
Aktivitas Madu Trigona (Trigona sp) Terhadap Gambaran Infiltrasi Sel Radang di Dermis pada Tikus (Rattus novergicus) dengan Model Luka Bakar Rian Anggia Destiawan; Anas Fadli Wijaya; Ahdiah Imroatul Muflihah
Jurnal Penelitian Kesehatan SUARA FORIKES 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf13nk342

Abstract

Burns are caused by chemicals, hot liquids and fires. Burns cause skin tissue necrosis, thus removing cell components including heat shock protein (HSP), monosodium urate, high-mobility group box protein 1 (HMGB1), extracellular ATP, and mitochondrial DNA including nucleic acids which are referred to as Damage Associated Molecules. Patterns (DAMPS). DAMPS cause increased infiltration of inflammatory cells into tissues. The purpose of this study was to determine the activity of trigona honey (Trigona sp) based on inflammatory cell infiltration in rats (Rattus novergicus) with the burn model. The research method was to group into 5 groups, including KN (negative control), K-1 (burns + placebo), K-2 (burns + silver sulfadiazine), K-3 (burns + 50% trigona honey), and K-4 (burns + 100% trigona honey), then stained with Hematoxylin Eosin (HE) to see the presence of inflammatory cell infiltration. Statistical analysis using the Kruskal Wallis and Mann-Whitney tests. Microscopically (inflammatory cell infiltration score) it showed that the KN group had a score of 0, group K-1 had a score of 4, group K-2 had a score of 2, groups K-3 and K-4 had a score of 4 and 2. statistically, there was no difference between groups. The conclusion of this study is that 100% trigona honey can reduce inflammatory cell infiltration in the dermis area of skin that has experienced burns.Keywords: burns, trigona honey, silver sulvadiazine ABSTRAK Luka bakar disebabkan oleh bahan kimia, cairan panas, dan kebakaran. Luka bakar menyebabkan nekrosis jaringan kulit, sehingga mengeluarkan komponen-komponen sel diantaranya heat shock protein (HSP), monosodium urate, high-mobility group box protein 1 (HMGB1), ekstraseluler ATP, dan DNA mitokondria termasuk asam nukleat yang disebut sebagai Damage Associated Molecullar Pattern (DAMPS). DAMPS menyebabkan peningkatan infiltrasi sel radang ke dalam jaringan. Tujuan penelitian ini adalah mengetahui aktivitas madu trigona (Trigona sp) berdasarkan infiltrasi sel radang pada tikus (Rattus novergicus) dengan model luka bakar. Metode penelitian ini adalah melakukan pengelompokan menjadi 5 kelompok, di antaranya KN (kontrol negatif), K-1 (Luka bakar + placebo), K-2 (Luka bakar + silver sulfadiazine), K-3 (Luka bakar + madu trigona 50%), dan K-4 (Luka bakar + madu trigona 100%), kemudian dilakukan pewarnaan Hematoksilin Eosin (HE) untuk melihat adanya infiltrasi sel radang. Analisa statistik menggunakan uji Kruskal Wallis dan Mann-Whitney. Secara mikroskopis (skor infiltrasi sel radang) menunjukkan bahwa pada kelompok KN nilai skoringnya 0, kelompok K-1 nilai skoringnya 4, kelompok K-2 nilai skoringnya 2, pada kelompok K-3 dan K-4 nilai skoringnya 4 dan 2. Namun secara statistik, tidak terjadi perbedaan antar kelompok. Kesimpulan dari penelitian ini adalah bahwa madu trigona 100% dapat menurunkan infiltrasi sel radang di daerah dermis pada kulit yang mengalami luka bakar.Kata kunci: luka bakar, madu trigona, silver sulvadiazine
Sosialisasi Peningkatan Gerakan 1 Rumah 1 Jumatik Untuk Pengendalian Demam Berdarah Dengue Mufidah, Hartalina; Agustin, Ayu Tri; Wijaya, Anas Fadli; Muflihah, Ahdiah Imroatul
Kolaborasi: Jurnal Pengabdian Masyarakat Vol 5 No 3 (2025): Kolaborasi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/kolaborasi.v5i3.511

Abstract

Introduction: Dengue Hemorrhagic Fever remains a significant health problem in Jember Regency. Jember Regency is among the top three districts with the highest dengue cases in East Java, reporting 781 cases, alongside Malang Regency was 1,224 cases and Ngawi Regency was 673 cases. It situation may be attributed to the lack of public awareness about maintaining a mosquito-free environment and the suboptimal implementation of the "1 House 1 Mosquito Monitor" (G1R1J). Kamal Village is one of the areas with environmental conditions conducive to mosquito breeding and the spread of Dengue Hemorrhagic Fever. Socializing the "1 House 1 Mosquito Monitor" is crucial to increasing public knowledge about the causes of Dengue Hemorrhagic Fever and the importance of Jumantik's role. Objective: The purpose of this service was promote the "1 House 1 Mosquito Monitor" and conduct screening IgM/IgG in Duplang Hamlet, Kamal Village, Arjasa District, Jember Regency Method: This public service was conducted by by socializing the definition of dengue disease, symptoms, prevention and the 1 House 1 Mosquito Monitor using leaflet. Then it was followed by IgG and IgM assay using Rapid test. The number of residents who participated was 16 people. Result: Socialization of One House One Mosquito Monitor were 3M Plus Dengue Prevention (Drain, Cover, Bury), control the mosquito breeding, and Larvacide applications. The IgG and IgM test results showed negative Conclusion: This community service was the successful socialization of the "1 House 1 Mosquito Monitor". None of them had been exposed to the dengue virus.
Effect of Lime Juice (Citrus Aurantifolia) on Blood Urea Nitrogen and Creatinine Levels in Wistar Rats Induced by Gentamicin Sufi, Queen Nurul; Mufidah, Hartalina; Muflihah, Ahdiah Imroatul; Hidayati, Sholihatil
Biomedika Vol 17, No 1 (2025): Biomedika Februari 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i1.7163

Abstract

Gentamycin is an antibiotic that has the effect of acute kidney failure. Increased levels of BUN and Creatinine can characterize acute kidney failure. Lime juice (Citrus aurantifolia) contains flavonoid compounds as antioxidants that can regenerate kidney function. This study aims to determine the difference in BUN and Creatinine levels before and after being given lime juice. This study uses an experimental study design with a pretest-postest design. In the model mice, gentamicin was induced at a dose of 60 mg/KgBB for 10 days, and then BUN and creatinine levels were checked. This study was divided into 5 groups, including the negative, healthy, and treatment groups 1, 2, and 3, with a dose of lime juice 0.5 ml/KgBB, 1.0 ml/KgBB, and 1.5 ml/KgBB. The results showed that the average change in BUN levels before and after between groups was significant (sig < 0.05), and the average change in creatinine levels before and after between groups was significant (sig < 0.05). This study concluded that the average decrease in BUN levels in treatment group 3 was significant by 7.9 mg/dl, and the average decrease in creatinine levels in treatment groups 2 and 3 was significant by 0.8 mg/dl.
Gambaran Morfologi Sel Neutrofil Pada Pewarnaan Giemsa dengan Variasi Waktu Pada Larutan Pengencer Akuades Muflihah, Ahdiah Imroatul; Destiawan, Rian Anggia; Wijaya, Anas Fadli; Widia, Leny Yulia; sufi, Queen Nurul; Azizah, Laila Camelia Nur; Makki, Alisa Alfiya
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 10 No. 1 (2024): ANAKES: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v10i1.1470

Abstract

Giemsa staining is a microscopic staining technique that aims to identify the morphology of leukocyte cell types. One of the methods that uses giemsa staining is the method of examining peripheral blood smear preparations which aims to evaluate the calculation of leukocyte type. The dyeing quality of giemsa is greatly influenced by the type of diluent material, namely buffer and aquadest. This study aims to determine the morphological picture of neutrophil cells in giema staining with time variations in aquadest diluent solution. The method of this study was to take blood from adults aged 20-25 years and had no history of illness as many as 24 samples. It was divided into 2 dilution groups, namely pH buffer 6.8 and aquadest, where each dilution was divided into 4 groups, namely group 1 soaking the peripheral blood smear preparation for 10 minutes, group 2 soaking the peripheral blood smear preparation for 20 minutes, group 3 soaking the peripheral blood smear preparation for 30 minutes, group 4 soaking the peripheral blood smear preparation for 40 minutes. Then a qualitative analysis was carried out, namely by comparing the background of the preparation and the morphology of neutrophil cells microscopically in each group. The results of this study are that microscopically groups 1 and 2 have a clear preparation background, while in groups 3 and 4 the preparation background is dirty and there are neutrophil granules and morphology in groups 1 and 2 show dark blue neutropnhil cells, groups 3 and 4 show purple and bluish-purple neutrophil cells. The conclusion of this study is based on the background of the preparation, and the morphology of neutrophil cells, the group that has the best results is groups 1 and 2. Key words : Aquadest, eosinophil cells, eutrophil cells, Giemsa staining
Immunomodulator Effect of Cnidoscolus aconitifolius Leaves Extract on CD4+ and CD8+ Expression in Salmonella typhimurium infected mice Hidayati, Sholihatil; Susanti, Dhina Ayu; Destiawan, Rian Anggia; Muflihah, Ahdiah Imroatul; Handayani, Rizka; Anggitasari, Wima
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27050

Abstract

Typhoid fever is a common health problem in the community caused by Salmonella bacteria. The incidence rate of this infection will increase if a person's immune system is weakened. Plant extracts are generally considered to be potential immunomodulatory agents developed, which have smaller side effects. Research shows that Cnidoscolus aconitifolius leaves have medicinal properties including as hepatoprotective, antidiabetic, and anticardiovascular. The results of the antioxidant activity test show the results that Cnidoscolus aconitifolius leaves extract (CAE) has potential as an antioxidant with a very strong category. This study was conducted to determine the effect of giving Japanese papaya leaf extract on CD4+ and CD8+ expression in Babl/c mice induced by Salmonella typhimurium bacteria. The study was started by preparing 70% ethanol extract from Cnidoscolus aconitifolius leaves and preparing 30 Babl/C mice as experimental animals which were divided into 6 groups (healthy control, negative control, positive control and treatment group by giving CAE dose of 100 mg/kgbw, 200 mg/kgbw and 400 mg/kgbw). Induction was carried out by oral infection with Salmonella thypimurium bacteria. After 3 days the infected mice were treated orally once a day for 7 days. Evaluation of CD4+ and CD8+ expression was carried out using the flowcytometer method of the lymph organs. Data analysis was carried out by the Anova test followed by the post hoc test (Tukey) using the SPSS for Windows application. The results showed that giving CAE at doses of 100 mg/kgbw, 200 mg/kgbw and 400 mg/kgbw could increase the expression ratio of CD4+ and CD8+, whereas giving CAE at a dose of 400 mg/kgbw showed significantly different results (p<0.05) to the negative control. This shows that the CAE has potential as an immunomodulatory agent that can improve immune function.
The Effect of Differences Time On The Macroscopic Picture Of Giemsa Staining Using Aquades Diluent Muflihah, Ahdiah Imroatul; Rian Anggia Destiawan; Anas Fadli Wijaya; Lenny Yulia Widia Sari; Queen Nurul Sufi; Alisa alfiya makki; Laila Camelia
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.678 KB)

Abstract

Peripheral Blood Smear Preparation (SADT) is an examination used to see the structure and number of red and white blood cells, besides giemsa staining can be used for malaria examination. The quality of giemsa staining is influenced by one of which is the soaking time of the giemsa solution. The purpose of this study was to determine the quality of slides or blood smears based on the incubation duration of giemsa staining. This research method qualitatively performed giemsa staining on blood smears with different soaking times (10 minutes, 20 minutes, 30 meinit and 40 minutes) then compared with controls. Results showed that at minutes 10 and 20 the giemsa staining showed a smooth surface and no granules, at 30 and 40 minutes the giemsa staining showed a rough surface and many granules. The conclusion of this study was that 10 and 20 min giemsa soaking showed optimal staining of blood smear preparations.    
Pemeriksaan Kesehatan Dan Edukasi Kesehatan Masyarakat Desa Kamal Dalam Upaya Mengontrol Kadar Gula Darah Aggustin, Ayu Tri; Wijaya, Anas Fadli; Muflihah, Ahdiah Imroatul; Hidayati, Sholihatil
PRAXIS: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 3 (2024): PRAXIS April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47776/praxis.v2i3.943

Abstract

This community service activity is a form of effort to support the government program "Healthy Communities that are Independent and Just. The target subjects for partners in this community service activity are the people in Kamal Village, Arjasa District, and Jember Regency. Preliminary studies have been carried out and show that the incidence rate in the village is very high. Thus, health checks and health promotion in an effort to control blood sugar levels through the use of natural germplasm are very necessary. The health checks that will be carried out include random blood sugar checks (GDS). The education provided can include understanding the causes, signs and symptoms, risk factors, and types of healthy nutrition to prevent and control complications of diabetes mellitus. Early screening can be done by carrying out laboratory examinations in the community. After the examination, it was discovered that some people experienced hyperglycemia and some experienced hypoglycemia. Through this activity, the public can understand the material presented and can find out their health status so that early prevention can be carried out.
Co-Authors Aggustin, Ayu Tri Agustin, Ayu Tri Alisa Alfiya Makki Amalia, Nabila Anas Fadli Wijaya Anggitasari, Wima Asista Indarusanti, Delvia Azizah, Laila Camelia Nur Dhina Ayu Susanti Dhina Ayu Susanti dwi ayu pratiwi, nabila Evi Martha Hariani Nurjanah, Mutia Hayati, Farhatul Hidayati, Sholihatil Laila Camelia Laila Camelia Nur Azizah Lenny Yulia Widia Sari Leny Yulia Widia Makki, Alisa Alfiya Mufidah, Hartalina Mutia Hariani Nurjanah Ni Ketut Yuliana Sari Queen Nurul Sufi Rahmawati, Septyana Eka Retno Sasongkowati Rian Anggia Destiawan RIAN ANGGIA DESTIAWAN Rizka Handayani Rizka Handayani Sandi Basuki, Aditya Occy Sholihatil Hidayati Sholihatil Hidayati Sholihatil Hidayati Siti Huzaimah sufi, Queen Nurul Susanti, Dhina Ayu Tiara Wahyu Norbaity Widia, Leny Yulia Wima Anggitasari