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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Ilmiah Kedokteran Duta Wacana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Indonesian Journal of Biomedicine and Clinical Sciences
Satiti Retno Pudjiati Satiti Retno Pudjiati
Department Of Dermatology And Venereology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada Yogyakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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A rare case of syringocystadenoma papilliferum: clinical and histopathological insights Andayani, Raden Roro Rini; Pudjiati, Satiti Retno; Harsono, Erliana Tantri; Rizkiani, Dwinanda Almira; Hanggoro Tri Rinonce; Rita Cempaka; Indra Wahono; Siti Isya Wahdini; Dyah Ayu Mira Oktarina
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17146

Abstract

Syringocystadenoma papilliferum (SCAP) is a rare benign adnexal neoplasm originating from apocrine or eccrine sweat glands, first reported by Stokes in 1917. Clinically, SCAP manifests in various forms such as nodules, plaques, or warts, predominantly affecting the scalp in adolescents or children. Histopathologically, it is characterized by papillary and ductal invaginations lined with a two-layered epithelium. This condition can be present at birth or emerge during puberty. We present a 19-year-old female with a congenital, pinkish-brown, wart-like lesion on her scalp that progressively enlarged and spread to the face. Physical examination revealed a verrucous plaque with central erosion, extending from the temporal scalp to the lateral face. Dermoscopy showed papillary structures with defined lesion borders, while histopathological findings confirmed SCAP. The patient underwent surgical excision, and no new lesions were detected during a 3 mo follow-up. Syringocystadenoma papilliferum is often confused with other neoplasms such as sebaceous nevus or verruca vulgaris, but its definitive diagnosis relies on histopathology. The tumor’s characteristic features include cystic invaginations into the dermis with a two-layered epithelium, differentiating it from other conditions. Surgical excision remains the treatment of choice to prevent potential malignant transformation and improve cosmetic outcomes. Syringocystadenoma papilliferum, though rare, can be effectively managed through timely diagnosis and surgical excision. In this case, the patient’s postoperative outcome was favorable, with no recurrence of the lesion. Histopathological evaluation is crucial for accurate diagnosis and guiding treatment strategies.
Co-Authors Affendi Purbananto Agnes Sri Siswati AGUNG PRANOTO Alfieri, Alessandro Andayani, Raden Roro Rini Ann Kautsaria Putri Arum Krismi Ayu Wikan Sayekti Devi Artami Susetiati Dewi Kartikawati Paramita Dwi Retno Adi Winarni Dwi Retno Adiwinarni Epi Panjaitan Fajar Waskito Febiyanto, Novian Febriana, Sri Awalia Giantoro, Jeffrey Hanggoro Tri Rinonce Hardyanto Soebono Harsono, Erliana Tantri Herwinda Brahmanti Imtihani, Hajar Indra Wahono Iwan Dwiprahasto Kristiana Etnawati Luthfiandi, Mochammad Rifky Nadia Akita Dewi Niken Indrastuti Oktarina, Dyah Ayu Mira Puspitasari, Monika Putri, Ann Kautsarina Rita Cempaka Rizkiani, Dwinanda Almira Saihas Sauda Sayekti, Ayu Wikan Sekar Sari Arum Palupi Siti Aminah Tri Susilo Estri, Siti Aminah Tri Susilo Siti Isya Wahdini Vina Ajeng Puspa Dewi Vina Ajeng Puspa Dewi, Vina Ajeng Puspa Wahyuanggradewi, Elliana Widiasri, Kharisma Yuliasis Winarni, Dwi Retno Adi Yohanes Widodo Wirohadidjojo Zubairi Djoerban