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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Ilmu Kesehatan Kulit dan Kelamin Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Ilmiah Kedokteran Duta Wacana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Indonesian Journal of Biomedicine and Clinical Sciences Folia Medica Indonesiana
Satiti Retno Pudjiati Satiti Retno Pudjiati
Department Of Dermatology And Venereology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada Yogyakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Expressions of Interleukin-4 and Interleukin-5 in Nodular Prurigo and Pruritic Papular Lesions Sayekti, Ayu Wikan; Putri, Ann Kautsaria; Winarni, Dwi Retno Adi; Pudjiati, Satiti Retno
Folia Medica Indonesiana Vol. 60, No. 1
Publisher : Folia Medica Indonesiana

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Highlights: 1. An examination of IL-4 and IL-5 expressions in nodular prurigo and pruritic papular eruption is crucial for enhancing the effectiveness of biological agent therapy, specifically for HIV/AIDS patients. 2. The findings offer evidence suggesting the possibility of IL-4 as a treatment target for individuals diagnosed with nodular prurigo, as well as IL-4 and IL-5 for those diagnosed with pruritic papular eruption. Abstract Pruritic papular eruption is a dermatosis characterized by pruritic symptoms in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Similarly, nodular prurigo is an itchy dermatosis with lesions and histopathological features that resemble those of pruritic papular eruption. Both conditions share a common etiopathogenesis, which involves the cytokines produced by T helper 2 (Th2) cells. Nodular prurigo and pruritic papular eruption are chronic and frequently recalcitrant, thus posing challenges in treatment. The use of biological agents represents a treatment development for chronic and recalcitrant dermatoses. This study aimed to determine the difference in the mean percentage of interleukin-4 (IL-4) and interleukin-5 (IL-5) expressions between nodular prurigo and pruritic papular eruption lesions, which may establish a basis for further biological agent therapy. A cross-sectional study was conducted using paraffin block preparations of the skin lesions of patients diagnosed with nodular prurigo (n=16) and pruritic papular eruption (n=16). Each paraffin block preparation involved immunohistochemical staining using IL-4 and IL-5 monoclonal antibodies. The expressions of IL-4 and IL-5 were assessed through ImageJ for Windows, version 1.53 (National Institutes of Health and the Laboratory for Optical and Computational Instrumentation, University of Wisconsin, USA) by pathologists. The data were analyzed using an unpaired t-test with a significance level of p<0.05. The analytical results indicated that data on the average age of the two groups, disease duration, and storage sample duration followed a normal distribution (p>0.05). The mean percentage of IL-4 expression was significantly different between the nodular prurigo and pruritic papular eruption groups (p=0.000). However, the mean percentage of IL-5 expression was not significantly different between the two groups (p=0.060). In conclusion, the expression of IL-4 was higher in the nodular prurigo group in comparison to the pruritic papular eruption group. Nonetheless, the expression of IL-5 was comparably high in both the nodular prurigo and pruritic papular eruption groups.
CLINICAL OUTCOMES OF ELECTROSURGERY FOR MANAGEMENT OF GIANT CONDYLOMA ACUMINATA: A SYSTEMATIC REVIEW Eviani, Fortunia Mona; Stella, Maureen Miracle; Budiyanto, Arief; Pudjiati, Satiti Retno; Alfieri, Alessandro
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Giant condyloma acuminata (GCA) is a rare sexually transmitted disease that is locally aggressive with a high recurrence rate. Electrosurgery is a minimally invasive procedure that may be less expensive, quicker, and safer than conventional surgery. This study aimed to review the management of GCA with electrosurgery. We followed PRISMA 2020 guidelines to search and retrieve literature in the following databases: PubMed, ProQuest, Taylor & Francis, ScienceDirect, JSTOR, and SAGE without time restrictions. The study inclusion criteria were original articles that studied the outcome of electrosurgery in GCA. The authors evaluated the risk of bias using the Joanna Briggs Institute (JBI) risk-of-bias assessment. From 572 studies, seven were selected. All studies were published in English between 1997 and 2024. The affected regions in the studies include anal/perianal/anorectal (n=6), vulva (n=2), penis (n=2), scrotal (n=1), vagina (n=1), and suprapubic (n=1). Electrosurgical methods used were electrocautery, electrosection, and electrofulguration, with or without adjunctive treatments. Most cases achieved initial clearance, although one case had a rapid recurrence despite multiple interventions and progressed to squamous cell carcinoma. Recurrence was reported in three cases overall, with timing ranging from weeks to months after treatment. A few adverse effects were infrequent and included a burning sensation during application, minor bleeding, depigmentation, superficial atrophic scarring, and a small remnant ulcer. Electrosurgery demonstrates great potential in treating GCA, particularly when combined with other treatment modalities. However, none of the studies was a randomized controlled trial (RCT). To strengthen the evidence base, RCTs are definitely required.
Secondary syphilis psoriasiform in HIV-infected patients: A case series Fitriani, Katia; Alessandro Alfieri; Nurwestu Rusetiyanti; Devi Artami Susetiati; Niken Trisnowati; Satiti Retno Pudjiati
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.26999

Abstract

Psoriasiform secondary syphilis is an uncommon and diagnostically challenging variant of secondary syphilis that can closely mimic psoriasis vulgaris, particularly in people with HIV. This case series adds to the limited literature from resource-limited settings by illustrating how psoriasiform secondary syphilis may be misinterpreted as psoriasis both clinically and histopathologically, and how repeated clinicopathologic correlation is essential to avoid inappropriate immunosuppression. We reported three HIV-infected male patients who presented with generalized psoriasiform erythematous scaly plaques, some with palmoplantar involvement, initially diagnosed as psoriasis. One patient had been treated with methotrexate for severalmonths without clinical improvement. Serologic testing in all cases demonstrated active syphilis with reactive nontreponemal and treponemal tests, including a very high venereal disease research laboratory (VDRL) titer in one patient, and all were confirmed HIV-positive. Initial histopathologic examinations variably suggestedsecondary syphilis or psoriasis; in two patients, repeat biopsy or deeper sectioning was required to reveal plasma cell–rich perivascular infiltrates and vascular changes consistent with secondary syphilis, while one case was ultimately considered to represent coexistence of psoriasis and syphilis. All patients received intramuscularbenzathine penicillin G according to syphilis stage, with additional topical or systemic antiinflammatory therapy when indicated, and showed clinical improvement. In conclusion, psoriasiform secondary syphilis should be routinely considered in the differential diagnosis of psoriasiform eruptions in individuals with sexuallytransmitted infection risk or known HIV infection, and that discrepant clinical, serologic, and histopathologic findings warrant repeat biopsy, deeper sectioning, and multidisciplinary review.
Co-Authors Affendi Purbananto Agnes Sri Siswati AGUNG PRANOTO Alessandro Alfieri Alfieri, Alessandro Andayani, Raden Roro Rini Ann Kautsaria Putri Arief Budiyanto Arum Krismi Ayu Wikan Sayekti Devi Artami Susetiati Dewi Kartikawati Paramita Dwi Retno Adi Winarni Dwi Retno Adiwinarni Epi Panjaitan Eviani, Fortunia Mona Fajar Waskito Febiyanto, Novian Febriana, Sri Awalia Fitriani, Katia Giantoro, Jeffrey Hanggoro Tri Rinonce Hardyanto Soebono Harsono, Erliana Tantri Herwinda Brahmanti Imtihani, Hajar Indra Wahono Iwan Dwiprahasto Kristiana Etnawati Luthfiandi, Mochammad Rifky Nadia Akita Dewi Niken Indrastuti Niken Trisnowati Nurwestu Rusetiyanti Oktarina, Dyah Ayu Mira Puspitasari, Monika Putri, Ann Kautsaria Putri, Ann Kautsarina Rita Cempaka Rizkiani, Dwinanda Almira Saihas Sauda Sayekti, Ayu Wikan Sekar Sari Arum Palupi Siti Aminah Tri Susilo Estri, Siti Aminah Tri Susilo Siti Isya Wahdini Stella, Maureen Miracle Vina Ajeng Puspa Dewi Vina Ajeng Puspa Dewi, Vina Ajeng Puspa Wahyuanggradewi, Elliana Widiasri, Kharisma Yuliasis Winarni, Dwi Retno Adi Yohanes Widodo Wirohadidjojo Zubairi Djoerban