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FORMULASI DAN UJI STABILITAS FISIK GEL EKSTRAK ETANOL DAUN TEMBELEKAN (Lantana camara L.) SEBAGAI ANTIINFLAMASI TOPIKAL Alvionida, Fitra; Iswarni, Wirda; Nurman, Salfauqi
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 9, No 2 (2023): Oktober 2023
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v9i2.4216

Abstract

Tumbuhan tembelekan (Lantana camara L.) merupakan tumbuhan yang tumbuh liar di berbagai tempat, tumbuhan ini termasuk famili Verbenacae. Tumbuhan tembelekan mempunyai banyak manfaat, salah satu diantaranya adalah sebagai antiinflamasi. Tujuan dari penelitian ini yaitu untuk mengetahui senyawa aktif dari ekstrak etanol daun tembelekan, untuk membuat formulasi gel dan mengetahui stabilitas fisik dari formulasi sediaan gel ekstrak etanol daun tembelekan. Metode penelitian yang digunakan adalah metode eksperimental laboratorium dan deskriptif. Proses ekstraksi menggunakan metode maserasi dengan pelarut etanol 96%. Uji fitokimia dilakukan untuk melihat senyawa aktif. Formulasi sediaan gel dibuat dalam 4 formula yaitu F1 (sediaan gel tanpa ekstrak), F2 (sediaan gel dengan penambahan EEDT 2 g), F3 (sediaan gel dengan penambahan EEDT 4 g) dan F4 (sediaan gel dengan penambahan EEDT 6 g). Uji stabilitas fisik sediaan gel yang dilakukan meliputi uji organoleptis, uji pH, uji daya sebar, uji homogenitas dan uji kesukaan. Rendemen yang dihasilkan dari proses ekstraksi daun tembelekan ialah 22,95%. Hasil uji fitokimia menunjukkan bahwa EEDT mengandung senyawa fenolik, tanin, steroid, saponin dan flavonoid. EEDT memiliki senyawa antiinflamasi yaitu saponin dan flavonoid. Sediaan gel EEDT yang optimal adalah F2. Sifat fisika kimia yang dihasilkan F2 yaitu pH 5,7, daya sebar 6 cm, bersifat homogen dan tidak ada butiran kasar, warna kuning kecoklatan, aroma seperti teh/cincau dan teksturnya semisolid. F2 paling disukai dibandingkan F3 dan F4 dilihat dari warna, aroma dan tekstur sediaan gel. Kata kunci: Daun tembelekan, ekstrak etanol, antiinflamasi, gel, stabilitas fisik gel.Tembelekan plant (Lantana camara L.) are plants that grow wild in various places, these plants belong to the Verbenacae family. The plant have many benefits, one of them is as anti-inflammatory. The purpose of this research are to know the active compound from ethanol extract of tembelekan leaf, to make gel formulation and to know the physical stability of the formulation of gel preparation of ethanol extract of tembelekan leaf. The research method used in this research was laboratory experimental and descriptive method. The extraction process uses a maceration method with 96% ethanol solvent. Phytochemical tests were performed to see the active compounds. The gel preparation formulation was prepared in 4 formulas, F1 (gel preparation without extract), F2 (gel preparation with addition of 2 g EEDT), F3 (gel preparation with 4 g EEDT addition) and F4 (gel preparation with 6 g EEDT addition). Physical stability test of gel preparation that havebeen done include organoleptic test, pH test, spreading test, homogeneity test and favorite test. The yield of tembelekan leaf extraction process was 22.95%. The results of phytochemical test showed that EEDT containes phenolic compounds, tannins, steroids, saponins and flavonoids. EEDT has antiinflammatory compounds namely saponins and flavonoids. The optimal EEDT gel preparation was F2. Physical properties of chemical F2 was pH 5.7, the power of spread of 6 cm, was homogeneous without coarse grains, brownish yellow, tea aroma / cincau and semisolid texture. F2 was the most preferred compared to F3 and F4 seen from the color, aroma and texture of the gel preparation.Keywords: Tembelekan leaf, ethanol extract, anti-inflammatory, gel, physical stability gel.
Ekstrak Etanol Kopi Hijau Arabika (Coffea arabica L.) sebagai Antihiperglikemi pada Mencit (Mus musculus) Hamdani, Irawati; Nurman, Salfauqi
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2122

Abstract

Diabetes mellitus is an excessive level of blood sugar concentration disease. One of the compounds that can moderate the blood sugar level is chlorogenic acid that mostly found in green coffee. This study aims to determine the extract activity of Arabica (Coffea arabica L.) green coffee in decreasing the blood sugar level of mice (Mus musculus) that induced by alloxan monohydrate. The method is True Experimental Laboratories with the analysis of chlorogenic acid levels using a UV-Vis spectrophotometer. The research design is Post Test Control Group Design, using 24 mices that divided into six treatment groups. The groups consist of negative control (distilled water), Dose I (100 mg/kg bw), Dose II (200 mg/kg bw), Dose III (300 mg/kg bw), Dose IV (400 mg/kg bw), and positive control (metformin). Blood sugar levels of the mice is measured at the intervals of 1st day, 7th day, 21st day. The data is analyzed using the SPSS program with normality tests (Kolmogorov-Smirnov), homogeneity tests (Levene Test), and parametric statistical tests (One-Way ANOVA). The data results was normally distributed and homogeneous (P> 0.05) with several pairs of data in the treatment group were significantly different (P> 0.05). The extract of Arabica (Coffea arabica L.) green coffee contained 4.235% chlorogenic acid, could reduced the hyperglycemia mice blood sugar levels by the dose of 10.72% (Dose I); 19.85% (Dose II); 27.20% (Dose III); and 31.60% (Dose IV) with dose IV as the effective dose.
Optimizing the Use of Radar when the Ship is Moving in MT. Green Plus: Optimalisasi Penggunaan Radar saat Kapal Berolahgerak di MT. Green Plus Harahap, Ferry Aulia; Siregar, Muhammad Sapril; Nurman, Salfauqi; Kusturi, Nanda Afra; Nurmala, Eka
ALTAIR: Jurnal Transportasi dan Bahari Vol. 1 No. 1 (2024): ALTAIR - Mei 2024
Publisher : PT. Alpha Trianguli Australis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62554/h48xtc23

Abstract

It is believed that the high number of collisions in narrow shipping lanes is caused by the lack of skill of sailors. Therefore, this analysis aims to determine the role of Radar in preventing collisions at sea. The research approach is qualitative, and the data will be presented using descriptive analysis. The research findings indicate that the decrease in Radar function is due to the non-implementation of Standard Operating Procedures (SOPs), the officers' lack of understanding of the manual books, and damage to the scanner. The consequences of a decrease in Radar function include navigation hazards because the Radar does not function correctly, making it difficult for the watch crew to identify other ships. To optimize the use of Radar when ships are moving at night, it is necessary to regularly check, maintain and repair navigation equipment.
Sintesis dan Karakterisasi Membran Poliuretan dari Minyak Biji Karet dan Heksametilen-1,6-diisosianat Nurman, Salfauqi; Marlina, Marlina; Saiful, Saiful; Saleha, Sitti
Jurnal Rekayasa Kimia & Lingkungan Vol 10, No 4 (2015): Jurnal Rekayasa Kimia & Lingkungan
Publisher : Chemical Engineering Department, Syiah Kuala University, Banda Aceh, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23955/rkl.v10i4.3772

Abstract

Minyak biji karet dapat dimanfaatkan untuk pembuatan membran poliuretan. Minyak biji karet memiliki bilangan hidroksi 40,33 mgKOH/g dan bilangan iod 154,05 gI2/g. Sintesis membran poliuretan menggunakan metode ikatan silang. Ikatan silang terbentuk dengan mereaksikan minyak biji karet sebagai sumber gugus -OH dengan heksametilen-1,6-diisosianat sebagai sumber gugus -NCO. Membran poliuretan yang optimum dihasilkan pada komposisi 4,55:5 (g/g) memiliki sifat homogen, kering, elastis, berwarna kuning kecoklatan, bergelombang, fluks 0,544 L/m2.h.bar dan faktor rejeksi 100%. Hasil karakterisasi membran menunjukkan terbentuknya ikatan uretan pada bilangan gelombang 3480 cm-1, struktur morfologi membran padat, memiliki dua tahap dekomposisi pada 210 oC dan 392 oC, titik transisi gelas 65 oC, kekuatan tarik 1,03 kgf/mm2 dan elongasi 497,14%. Dari hasil karakterisasi membran poliuretan, membran tersebut dapat digolongkan pada tipe membran reverse osmosis.
Polyurethane Membranes From Red Seaweeds For Ammonia Adsorption Kamila, Nurul; Marlina, Marlina; Mustafa, Irfan; Nurman, Salfauqi; Saiful, Saiful
Journal of Carbazon Vol 1, No 1 (2023): June 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jokarbazon.v1i1.32874

Abstract

Polyurethane (PU) membranes were prepared from red seaweed (Gracilaria sp.), castor oil, Toluene Diisocyanate (TDI), and added benzoyl peroxide (BPO) additive to improve membrane performance. The membrane is applied for the adsorption of ammonia in the solution. FT-IR analysis showed the presence of functional group N = C = O at a wavenumber of 2276 cm-1 and the O-H functional group at a wave number of 3373.50 cm-1, indicating the urethane group's formation has been formed during membrane polymerization. SEM images showed the morphological structure of the PU membrane, where the more open structure of the PU membrane by the addition of BPO. The DSC and TGA results showed the membrane's thermal stability with the addition of BPO. The PU membrane has an optimum contact time for ammonia uptake of 40 minutes. The adsorption isotherm of ammonia by the PU membrane follows the Freundlich isotherm model. The adsorption capacity of the PU membrane with the addition of BPO additives was 13.2 mg/g, which shows that the adsorption capacity of the PU-BPO membrane has a better performance than a membrane without the addition of the BPO. The PU-BPO membrane could be used as an alternative method of ammonia removal.
Determinant Factors of Immunization Coverage in Toddlers Under 5 Years Old in Banda Aceh, Indonesia: Cross Sectional Study Masyudi, Masyudi; Usman, Said; Nurman, Salfauqi; Ismail, Ismail; Abubakar , Abubakar
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.5898

Abstract

The aim of this research is to determine the factors related to providing complete basic immunization to toddlers in the working area of ​​the Meuraxa Health Center, Banda Aceh. This research is analytical by design cross sectional. The population in this study were all mothers who had toddlers in the working area of ​​the Meuraxa Health Center in 2023, totaling 1860 people and a sample of 95 people. The research was conducted from 7 to 15 June 2023. Data was processed univariate and bivariate. The research results showed that there was a relationship between knowledge (P value = 0.006), there was a relationship between attitudes (P value = 0.000), there was a relationship between health education (P value = 0.003) and there was a relationship between the role of religious leaders (P value = 0.003) with the provision of complete basic immunization in toddlers at Meuraxa Community Health Center, Banda Aceh City in 2023. The Community Health Center can provide routine outreach to the community, especially mothers who have babies, either individually or in groups. Increase the support of religious figures for immunization by involving them in every immunization activity and making religious figures partners in disseminating immunization information