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All Journal JURNAL PENDIDIKAN TAMBUSAI Ensiklopedia of Journal Jurnal Bidan Komunitas Jurnal Ners Jurnal Kesehatan Saintika Meditory Archives of The Medicine and Case Reports Literasi: Jurnal Pengabdian Masyarakat dan Inovasi Jurnal Pengabdian Masyarakat Bangsa JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Riwayat: Educational Journal of History and Humanities Jurnal Medisains Kesehatan Journal Of Humanity Dedication Jurnal Pengabdian Masyarakat
Dina Ayuning Tyas
Universitas Sumatera Barat
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Computational Screening of Bioactive Compounds from Aglaia odorata L. Leaves as Potential Inhibitors of Matrix Metalloproteinase-1 for Premature Skin Aging Khoirista Noor Rohmah; Ilham Kurniawan; Febby Yulia Hastika; Dina Ayuning Tyas
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.57331

Abstract

Premature skin aging is driven by UV‑induced upregulation of matrix metalloproteinase‑1 (MMP‑1), which degrades dermal collagens. Natural products are explored as safer anti‑aging alternatives. This study computationally screened five bioactive compounds from Aglaia odorata leaves (β‑turmerone, phytol, methyl cinnamate, n‑hexadecanoic acid, methyl palmitate) against MMP‑1 (PDB ID: 1HFC) and predicted their drug‑likeness, skin permeability, and safety for topical use. Molecular docking was performed using AutoDock Vina; ADMET properties were predicted with SwissADME and pkCSM. All compounds complied with Lipinski’s Rule of Five (zero violations). Methyl cinnamate formed three hydrogen bonds including with the catalytic residue Glu219. β‑Turmerone showed the highest affinity (ΔG = –6.5 kcal/mol, Ki = 17.0 µM). Phytol, methyl palmitate, and n‑hexadecanoic acid exhibited weaker binding (Ki = 33.5–78.0 µM), while the positive control PLH had ΔG = –7.5 kcal/mol (Ki = 3.14 µM). ADMET predictions showed excellent skin permeability for phytol and the fatty acid derivatives (Log Kp > –3.0 cm/h). All compounds were non‑mutagenic, non‑hepatotoxic, and safe for skin sensitisation. Methyl cinnamate and β‑turmerone are the most promising A. odorata‑derived MMP‑1 inhibitors, supporting further validation as natural anti‑aging cosmeceuticals.
Speech Act of Demand by the Community of Speaking on the Buying Transaction of Sand Mining on the River Banks in the Sungai Sariak Region, Padang Pariaman Regency *Vonny Ardiel; Dina Ayuning Tyas; Ira Maulina Sa'danoer; Welly Handayani; Yulia Citra; Wulandari Pertiwi; Indan Duka Lara
Riwayat: Educational Journal of History and Humanities Vol 5, No 2 (2022): Agustus 2022, History, Learning Strategy, Economic History and Social Knowledge
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jr.v5i2.27531

Abstract

Speech Act is communication activity which contains the intent to be conveyed when speaking (the illocutionary power of an utterance) and the effect the speaker wants to achieve (perlocutionary speech). In the sale and purchase of sand mining on the banks of the Sariak River, Padang Pariaman Regency, there is a speech act between the miner and the buyer of the sand. The researcher wants to reveal the lexicon and meaning in speech acts as linguistic documentation and the richness of the lexicon. The purpose of this research is to develop linguistics in a sociopragmatic perspective. The theory used in this study is the theory of speech acts in sociopragmatic science. In this study the author uses a qualitative approach. The researcher found the syntactic aspect in the form of words and sentences. The syntactic form found is in the form of nouns that turn into adverbs due to changes in meaning in speech acts based on the context. Then find the sentence mode in the speech act of request by using declarative and interrogative sentences/questions, and using terms and language that are in accordance with the social context of interaction and culture of the community, so that efficient communication is achieved.
Co-Authors Ardiel, Vonny Armalin, Rika Citra M, Resi Danoer, Ira Maulina Sa Dewi Asmawati Elfianti, Elfianti Elwitri Silvia Febby Yulia Hastika Handayani, Welly Harris Effendi Thahar Harris Effendi Thahar Ilham Kurniawan Indan Duka Lara Ira Maulina Ira Maulina Sa’danoer Ira Maulina Sa’danoer Khoirista Noor Rohmah M. Zaim Marita Ronitua Sinabariba Meli Sundari Metta Julita Nengsih, Novelia Ratih Septiana Arpen Resi Citra Rika Armalini Silvia, Dinda Suganda, Yohana Ulya, Rahmatul Vonny Ardiel Welly Handayani Wulandari Pertiwi Yohana Suganda Yulia Citra Yulia Vivra Rahayu Putri Zaini S, Hanifa