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All Journal JURNAL PENDIDIKAN TAMBUSAI Ensiklopedia of Journal Jurnal Bidan Komunitas Jurnal Ners Jurnal Kesehatan Saintika Meditory Archives of The Medicine and Case Reports Literasi: Jurnal Pengabdian Masyarakat dan Inovasi Jurnal Pengabdian Masyarakat Bangsa JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Riwayat: Educational Journal of History and Humanities Jurnal Medisains Kesehatan Journal Of Humanity Dedication Jurnal Pengabdian Masyarakat
Dina Ayuning Tyas
Universitas Sumatera Barat
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Asuhan Kebidanan Pranikah Dalam Pemberian Imunisasi Tetanus Toxoid (TT) Pada Calon Pengantin Di Puskesmas Mapaddegat Kabupaten Kepulauan Mentawai Marita Ronitua Sinabariba; Dina Ayuning Tyas; Yohana Suganda
Jurnal Medisains Kesehatan Vol. 7 No. 1 (2026): Jurnal Medisains Kesehatan
Publisher : Universitas Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59963/jmk.v7i1.687

Abstract

Premarital health care is a promotive and preventive effort to improve reproductive health and prepare for a healthy pregnancy. One important intervention is the provision of Tetanus Toxoid (TT) immunization to prevent maternal and neonatal tetanus. This study aims to describe premarital midwifery care in providing TT immunization to prospective brides and grooms at the Mapaddegat Community Health Center in the Mentawai Islands Regency. The method used is a case study with a descriptive approach to one prospective bride aged 24 years. Data collection was carried out through anamnesis, physical examination, and supporting examinations. The results of the assessment showed that the client had an incomplete TT immunization status. The midwifery care provided included preconception health education, TT immunization counseling, and immunization administration according to procedures. After the intervention, the client understood the importance of TT immunization and was willing to continue immunization as scheduled. Comprehensive premarital midwifery care has been proven to play a role in increasing the knowledge and readiness of prospective brides and grooms in facing pregnancy. Therefore, the role of health workers, especially midwives, is very important in increasing the coverage of TT immunization as an effort to prevent tetanus in mothers and babies.
Computational Screening of Bioactive Compounds from Aglaia odorata L. Leaves as Potential Inhibitors of Matrix Metalloproteinase-1 for Premature Skin Aging Khoirista Noor Rohmah; Ilham Kurniawan; Febby Yulia Hastika; Dina Ayuning Tyas
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

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Abstract

Premature skin aging is driven by UV‑induced upregulation of matrix metalloproteinase‑1 (MMP‑1), which degrades dermal collagens. Natural products are explored as safer anti‑aging alternatives. This study computationally screened five bioactive compounds from Aglaia odorata leaves (β‑turmerone, phytol, methyl cinnamate, n‑hexadecanoic acid, methyl palmitate) against MMP‑1 (PDB ID: 1HFC) and predicted their drug‑likeness, skin permeability, and safety for topical use. Molecular docking was performed using AutoDock Vina; ADMET properties were predicted with SwissADME and pkCSM. All compounds complied with Lipinski’s Rule of Five (zero violations). Methyl cinnamate formed three hydrogen bonds including with the catalytic residue Glu219. β‑Turmerone showed the highest affinity (ΔG = –6.5 kcal/mol, Ki = 17.0 µM). Phytol, methyl palmitate, and n‑hexadecanoic acid exhibited weaker binding (Ki = 33.5–78.0 µM), while the positive control PLH had ΔG = –7.5 kcal/mol (Ki = 3.14 µM). ADMET predictions showed excellent skin permeability for phytol and the fatty acid derivatives (Log Kp > –3.0 cm/h). All compounds were non‑mutagenic, non‑hepatotoxic, and safe for skin sensitisation. Methyl cinnamate and β‑turmerone are the most promising A. odorata‑derived MMP‑1 inhibitors, supporting further validation as natural anti‑aging cosmeceuticals.
Co-Authors Ardiel, *Vonny Ardiel, Vonny Armalin, Rika Citra M, Resi Danoer, Ira Maulina Sa Dewi Asmawati Elfianti, Elfianti Elwitri Silvia Febby Yulia Hastika Handayani, Welly Harris Effendi Thahar Harris Effendi Thahar Ilham Kurniawan Indan Duka Lara Ira Maulina Ira Maulina Sa’danoer Ira Maulina Sa’danoer Khoirista Noor Rohmah Lara, Indan Duka M. Zaim Marita Ronitua Sinabariba Meli Sundari Metta Julita Nengsih, Novelia Pertiwi, Wulandari Ratih Septiana Arpen Resi Citra Rika Armalini Silvia, Dinda Suganda, Yohana Ulya, Rahmatul Vonny Ardiel Welly Handayani Wulandari Pertiwi Yohana Suganda Yulia Citra Yulia Citra, Yulia Yulia Vivra Rahayu Putri Zaini S, Hanifa