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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences MNJ (Malang Neurology Journal) Universa Medicina Majalah Kesehatan FKUB Journal of Educational Research and Evaluation
Masruroh Rahayu, Masruroh
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Agriculture, Biological Sciences & Forestry Humanities Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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EFFECT OF THE RADIATION OF GAMMA RAYS ON CASPASE-3 EXPRESSION IN RATTUS NORVEGICUS WISTAR MALE VARIANT BRAIN CELL WITH IMMUNOHISTOCHEMISTRY METHOD Alam, Ahmad Bayhaqi Nasir; Rahayu, Masruroh; Islani, Ahmad Zaki Sukma
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (627.979 KB) | DOI: 10.21776/ub.mnj.2015.001.02.5

Abstract

 Background. The brain is an organ that has an important function potentially exposed to bad influences of radiation, especially on the head neck tumors. Gamma rays interact with body molecules causing damage to DNA and subsequently apoptosis. Caspase-3 plays an important role in apoptosis as effector caspase. Objective. To prove that the radiation of cobalt-60 gamma rays in Rattus norvegicus Wistar male variant causes brain cell apoptosis by the number of apoptotic cells more than in the single-dose fractionation. Methods. This Experimental research using animals were randomly divided into 3 groups: control, single and fractionation.Results. An increase in apoptotic index in the irradiated brain cells in single dose and fractionation dose compared by control group were significant (ANOVA, p > 0.05 ). Sequentially, the highest apoptotic index in a single group, fractionation, and control.Conclusion. The provision of radiation Cobalt - 60 gamma rays cause brain cell apoptosis Rattus norvegicus Wistar male variant and a single dose to cause apoptosis of brain cells more than the dose fractionation.
THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE Raisa, Neila; Sujuti, Hidayat; Purnomo, Hari; Rahayu, Masruroh; Dalhar, Mochamad
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.5

Abstract

Background: Serum Glial Fibrillary Acidic Protein (GFAP) is a great potential for biomarker that is widely studied as a diagnostic biomarker of acute stroke. Sampling within 6 hours after onset is the best time window, but in Indonesia, stroke patients often arrive late more than 6 hours.Objective: To identify the difference in time of blood sampling with serum GFAP levels within 24 hours onset of ischemic stroke (IS) patients and intracerebral hemorrhage (ICH) strokes.Methods: Cross-sectional analysis with purposive sampling, sampling in IS and ICH strokes that arrive at the ER within 24-hour on-site. The serum GFAP examination was performed with ELISA.Results: In this study, 41 acute stroke patients with 24-hour onset of each stroke were grouped into group 1 (<6 hours), group 2 (6-12 hours) and group 3 (12-24 hours). One Way ANOVA and Tukey's analysis showed no significant difference in GFAP levels among the three groups in both IS and ICH. Conclusion: There was no significant difference in GFAP levels in samples <6 hours, 6-12 hours, and 12-24 hours in ischemic strokes and ICH strokes.
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS Prabawati, Risma Karlina; Ratnawati, Retty; Rahayu, Masruroh; Prakosa, Ardani Galih
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.6

Abstract

Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been 2 found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic.Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’s caspase-3 expressiom, and spatial memory function in diabetic model of Wistar rats.Methods: This is an experimental study using diabetic model rats. The sample was divided into negative and positive control, anthocyanin dose of 10 mg/kg, 20 mg/kg, and 80 mg/kg groups. MDA levels were measured using spectrophotometer, caspase-3 expression with immunohistochemistry, and spatial memory function using Morris water maze test.Results: Tukey test showed that anthocyanin 10, 20, and 80 mg/kg lowering MDA levels, caspase-3 expression, and Morris water maze’s travel time compared to control positive (p = 0.000). But anthocyanin 80 mg/kg make a significant increase on these three variabels compared to 10 and 20mg/kg groups (p = 0.010). Pearson test showed that there no correlation between anthocyanin’s dose, MDA levels, caspase-3 expression, and Morris water maze test.Conclusion: Anthocyanin doses 10 and 20 mg/kg lowering MDA levels and caspase-3 expression, also improves spatial memory function on diabetic model of Wistar rats.
Correlation of Malondialdehyde (MDA) and C-reactive Protein (CRP) Level to Neurodevelopmental Outcome in Children After the Episode of Convulsive Type Status Epilepticus Restuningwiyani, Sintha; Ariani, Ariani; Sujuti, Hidayat; Rahayu, Masruroh; Subandiyah, Krisni
Journal of Tropical Life Science Vol 8, No 3 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.772 KB) | DOI: 10.11594/jtls.08.03.07

Abstract

Refractory and mortality associated with status epilepticus (SE) were correlated with the degree of inflammation-induced neuronal cell death. This study was aimed to investigate the correlation of oxidative stress (Malondialdehyde, MDA) and inflammation (C-reactive protein, CRP) process with neurodevelopmental outcome in children after the episode of convulsive type SE. This study was designed as cross sectional which included 26 convulsive type SE subjects and 15 control subjects. MDA level was measured by thiobarbituric acid (TBA) method, while CRP level was measured by ELISA method. Neurodevelopmental outcome was measured by Bayley-III Scale of Infant and Toddler Development 3 month after the convulsive type SE episode. Results showed that both MDA (independent t-test, p &lt; 0.05) and CRP (Mann-Whitney test, p &lt; 0.05) level was significantly higher in convulsive type SE group as compared to control group. Further analysis also showed that MDA (Spearman correlation test, p = 0.000, r = 0.756) and CRP (Spearman correlation test, p = 0.000, r = 0.835) level was positively correlated with convulsive type SE. In convulsive type SE group, MDA level was negatively correlated with neurodevelopmental outcome but CRP was not. We concluded that MDA level was negatively correlated with neurodevelopmental outcome in children with convulsive type SE, but CRP was not.
ALPHA-PINENE ATTENUATES MICROGLIAL NF-ΚB ACTIVATION AND INOS EXPRESSION IN GP120-INDUCED NEUROINFLAMMATION Rahayu, Masruroh; Widodo, M Aris; Lyrawati, Diana; Widjadjanto, Edi
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.16

Abstract

Background: Neuro-inflammation plays a role in the pathogenesis of HIV-associated dementia (HIV). Activation of microglia is essential for triggering inflammatory-mediated neurotoxicity. HIV-1 120 kDa envelope glycoprotein (gp120) induces microglial NF-κB signaling which in turn induce pro-inflammatory and iNOS gene transcription. Continuous or excessive activation of NF-κB signaling lead to persistent production of TNF-α and nitric oxide by microglia and induce neuronal apoptosis. Alpha-pinene is a natural substance found in pine tree and has efficacy on inhibiting NF-κB signaling.Objective: This study was designed as a true experimental study and aimed to investigate the effect of alpha-pinene administration toward inflammatory response represented by the percentage of microglia containing activated NF-κB and iNOS expression.Methods: Neuron-glia primary culture from brain tissue of rat fetus was divided into 5 groups as follows: negative control; positive control (gp120 1nM); treatment I, II, and III (gp120 1 nM + alpha-pinene 0.4 µg/mL, 2 µg/mL, and 10 µg/mL, respectively). Microglial NF-κB and iNOS expression were analyzed using immunohistochemistry method. Neuronal apoptosis was measured by TUNNEL method.Results: Result showed that alpha-pinene administration on gp120-treated neuron-glia at all dosages decrease NF-kB activation, iNOS expression, and apoptotic neuron significantly as compared to the gp120-only treated group (p<0.05). Furthermore, alpha-pinene did not affect NF-kB activation and neuronal apoptosis (p>0.05), but significantly elevate iNOS expression (p<0.05) mainly in dosage I and II.Conclusion: We concluded that alpha-pinene has neuroprotective effect on gp120-treated neuron-glia cells through modulation of NF-kB and iNOS expression thus inhibit neuronal apoptosis.
Aluminum chloride impaired spatial memory, but not senile plaques formation in the rat model of Alzheimer’s disease Narwanto, Muhammad Ihwan; Rahayu, Masruroh; Soeharto, Setyawati; Nurdiana, Nurdiana
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022): June 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.4 KB) | DOI: 10.30659/sainsmed.v13i1.18102

Abstract

Aluminum compounds can be easily found in the environment. Aluminum contamination is the environmental factor as one of the risk factors for Alzheimer's disease (AD). In the animal model, aluminum chloride (AlCl3) induces inflammation and oxidative stress. Inflammation and oxidative stress are important pathogenesis pathways in the AD. This study was conducted to determine whether AlCl3 can impair spatial memory and induce senile plaques formation. A total of 24 young adult Wistar rats were used in this study. The rats were divided into four groups; one control group and three AlCl3 treated groups with doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg, respectively for 8 weeks. The spatial memory test was measured using Morris water maze and the histopathology was done by identification of senile plaques formation in the hippocampal tissue. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Tukey's test for multiple comparisons. The level of statistical significance was set at a p value < 0.05. This study showed that there are significant differences (p<0,05) between the control group and all the AlCl3 treatment groups in the memory test, however, there is no change in the senile plaque’s expression in all groups. Administration of AlCl3 for 8 weeks can cause the impaired of spatial memory without senile plaques formation.
MANAGEMENT DYSPHAGIA IN POST-STROKE PATIENTS RECOMMENDATIONS FOR INDONESIAN NURSING INTERVENTION STANDARDS: A LITERATURE REVIEW Syahrun, Syahrun; Hany, Alfrina; Rahayu, Masruroh
MNJ (Malang Neurology Journal) Vol. 8 No. 1 (2022): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.01.9

Abstract

Background: Dysphagia often occurs in post-stroke patients, causing aspiration that can result in disability or death. Nurses have an essential role to play in preventing these complications as they 24/7 care for patients. However, there is no written standard of nursing care regarding specific interventions of post-stroke dysphagia in reality.Objective: The purpose of this article is to conduct a literature review of interventions that can be made in patients with post-stroke dysphagia so that it can be a recommendation for Indonesian nursing standards.Design: Electronic literature searches PubMed, EBSCO (Medline), ProQuest, and ScienceDirect databases from January 2011 to October 2020. There was sixteen studies reviewed included in this systematic study were experimental, randomized controlled trials, or systematic reviews (which are also experimental designs, randomized controlled trials). The study focused on non-invasive interventions performed on post-stroke dysphagia patients.Results: Interventions in dysphagia found, namely: The use of food thickeners against the risk of aspiration resulted in the patient's swallowing ability significantly increased by 71.9% (p <0.01); Chin down intervention combined with thickening fluid provides a solution to improve the nutritional needs of patients dysphagia post-stroke; Tongue training interventions, swallowing training and speech therapy; Tongue stretching exercises that have a positive effect on tongue motility and oromotor function in post-stroke dysphagia patients; Intervention of Tongue resistance training that increases the strength of the tongue and reduces fluid residue in the vallecular; and early screening of dysphagia by nurses using formal guidelines to manage dysphagia patients thereby reducing chest infections and mortality.Conclusion: Nurses should not diagnose dysphagia, but can identify post-stroke dysphagia to determine the interventions necessary for nutrition management, hydration, and aspiration prevention. Interventions include early dysphagia screening within 24 hours after stroke, thickening nutrition according to nutritionist recommendations, laryngeal elevation exercises, peripheral stimulation, posture regulation, and education on eating and drinking.
The Effect of Dysphagia Education Through Video on the Level of Knowledge and Screening of Dysphagia and Self-Efficacy of Nurses Syahrun; Hani, Alfriana; Rahayu, Masruroh
Journal of Education Reseach and Evaluation Vol 6 No 2 (2022): May
Publisher : LPPM Undiksha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.982 KB) | DOI: 10.23887/jere.v6i2.37383

Abstract

This study aims to analyze the effect of dysphagia education through knowledge level videos, dysphagia screening, and nurse self-efficacy. The method used descriptive method of analytic entitle True experimental with pretest and posttest control group design. The number of respondents 35 nurses selected using purposive sampling. Data collection used Self-Administered Questionnaire instrument, Questionnaire Modified Nursing Dysphagia Screen, and Generalized Self-Efficacy Scale (GSE-10) and analyzed using T-test dependent samples. The result was significantly the level of dysphagia knowledge in the control group (p value = 0.017), the video group (p value = 0.002). Significant results also occurred at the knowledge level of dysphagia screening in the video group. Meaningless results occurred in the control group at the knowledge level of dysphagia screening and self-efficacy of nurses, as well as self-efficacy in the video group. As shown in educational research dysphagia through video can affect the level of knowledge and level of knowledge of dysphagia screening but is not able to influence the self-efficacy of nurses.
Co-Authors Agung Prasetyo Wibowo Alam, Ahmad Bayhaqi Nasir Alfrina Hany, Alfrina Anastasia Novitasari, Anastasia Annisa Nurul Arofah Ar Rahmah, Kurnia Auliyana Ardani Galih Prakosa, Ardani Galih Ariani Ariani Bambang Soemantri, Bambang Dalhar, Mochamad Diana Lyrawati Dimas Ryan Desetyaputra, Dimas Ryan Dini Jatiya Anggraini, Dini Jatiya Fachriy Balafif, Fachriy Hanestya Oky Hermawan, Hanestya Oky Hani, Alfriana HARI PURNOMO Harun Al Rasyid Hidayat Sujuti Islani, Ahmad Zaki Sukma Krisni Subandiyah M Aris Widodo M. Ihwan Narwanto Machlusil Husna, Machlusil Made Ayu Hariningsih, Made Ayu Masdar Muid Mochammad Dalhar Nurdiana Nurdiana Paundralingga, Obed Trinurcahyo Kinantyo Pramesti, Fathia Annis Raisa, Neila Rakhmani, Alidha Nur Restuningwiyani, Sintha Retty Ratnawati Risma Karlina Prabawati Santoso, Mochamad Istiadjid Eddy Sartika Dewi Utami, Sartika Dewi Setyawati Soeharto, Setyawati Shahdevi Nandar Kurniawan, Shahdevi Nandar Siti Lintang Kawuryan Sri Budhi Rianawati, Sri Budhi Sri Sunarti Syahrun Syahrun, Syahrun Theodorus Dapamede, Theodorus Widjadjanto, Edi