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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Matematika & Sains JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmiah Farmasi Farmasyifa Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Riset Farmasi Bandung Conference Series: Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Pengabdian Masyarakat (Jupemas)
Fetri Lestari Fetri Lestari
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Islam Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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Efektivitas Antibiotik terhadap Parameter Klinis Pasien Pneumonia Pediatri di RSUD Bandung Kiwari Nurul Azmi Fatarani; Fetri Lestari; Suwendar Suwendar
Bandung Conference Series: Pharmacy 675 - 684
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25403

Abstract

Abstract. Pneumonia is one of the leading causes of mortality and morbidity in children worldwide. The success of antibiotic therapy in patients with pneumonia is assessed not only by bacterial eradication but also by improvements in clinical parameters such as respiratory rate, oxygen saturation, and body temperature. This study aims to determine which antibiotics tend to be effective based on changes in these clinical parameters in pediatric pneumonia patients. The study used a descriptive observational design with a retrospective cross-sectional approach based on medical records of pediatric pneumonia patients who met the inclusion criteria. A total of 40 patients met the study criteria. All antibiotic regimens showed improvement in clinical parameters during the treatment period. The greatest reduction in respiratory rate was observed with the ceftriaxone regimen followed by azithromycin, with an average decrease of 17 breaths per minute. The greatest increase in oxygen saturation was achieved with the combination of cefotaxime and gentamicin, at 17%. The greatest reduction in body temperature occurred with the combination of levofloxacin and azithromycin, at 3.1°C. Nevertheless, cefotaxime monotherapy showed the most consistent trend of effectiveness across all clinical parameters, marked by a reduction in respiratory rate of 8.6 breaths/minute, an increase in oxygen saturation of 6.7%, and a reduction in body temperature of 2.0°C, Thus, it has the potential to be one of the effective regimens for the management of pediatric pneumonia; however, its use must still take the patient’s clinical condition into account. Abstract. Pneumonia is one of the leading causes of mortality and morbidity in children worldwide. The success of antibiotic therapy in patients with pneumonia is assessed not only by bacterial eradication but also by improvements in clinical parameters such as respiratory rate, oxygen saturation, and body temperature. This study aims to determine which antibiotics tend to be effective based on changes in these clinical parameters in pediatric pneumonia patients. The study used a descriptive observational design with a retrospective cross-sectional approach based on medical records of pediatric pneumonia patients who met the inclusion criteria. A total of 40 patients met the study criteria. All antibiotic regimens showed improvement in clinical parameters during the treatment period. The greatest reduction in respiratory rate was observed with the ceftriaxone regimen followed by azithromycin, with an average decrease of 17 breaths per minute. The greatest increase in oxygen saturation was achieved with the combination of cefotaxime and gentamicin, at 17%. The greatest reduction in body temperature occurred with the combination of levofloxacin and azithromycin, at 3.1°C. Nevertheless, cefotaxime monotherapy showed the most consistent trend of effectiveness across all clinical parameters, marked by a reduction in respiratory rate of 8.6 breaths/minute, an increase in oxygen saturation of 6.7%, and a reduction in body temperature of 2.0°C, Thus, it has the potential to be one of the effective regimens for the management of pediatric pneumonia; however, its use must still take the patient’s clinical condition into account. Abstrak. Pneumonia merupakan salah satu penyebab mortalitas dan morbiditas pada anak di seluruh dunia. Keberhasilan terapi antibiotik pada pasien pneumonia tidak hanya dinilai dari eradikasi bakteri, tetapi juga melalui perbaikan parameter klinis seperti frekuensi napas, saturasi oksigen, dan suhu tubuh. Penelitian ini bertujuan untuk menentukan antibiotik yang cenderung efektif berdasarkan perubahan parameter klinis tersebut pada pasien pneumonia pediatri. Penelitian menggunakan desain deskriptif observasional dengan pendekatan potong lintang retrospektif berdasarkan data rekam medis pasien pneumonia pediatri yang memenuhi kriteria inklusi. Sebanyak 40 pasien memenuhi kriteria penelitian. Seluruh regimen antibiotik menunjukkan perbaikan parameter klinis selama masa perawatan. Penurunan frekuensi napas terbesar ditemukan pada regimen ceftriaxone yang dilanjutkan azitromisin dengan penurunan rata-rata sebesar 17 kali/menit. Peningkatan saturasi oksigen terbesar diperoleh pada kombinasi cefotaxime dan gentamisin sebesar 17%. Penurunan suhu tubuh terbesar terjadi pada kombinasi levofloxacin dan azitromisin sebesar 3,1°C. Meskipun demikian, cefotaxime monoterapi menunjukkan kecenderungan efektivitas yang paling konsisten pada seluruh parameter klinis, ditandai dengan penurunan frekuensi napas sebesar 8,6 kali/menit, peningkatan saturasi oksigen sebesar 6,7%, serta penurunan suhu tubuh sebesar 2,0°C, sehingga berpotensi menjadi salah satu regimen yang efektif dalam penatalaksanaan pneumonia pediatri, namun penggunaannya tetap perlu mempertimbangkan kondisi klinis pasien.
Efektivitas Analgesik dalam Manajemen Nyeri Tingkat Sedang Pasca Operasi Sectio Caesarea Silviya Nur Hasanah; Fetri Lestari; Umi Yuniarni
Bandung Conference Series: Pharmacy 717 - 726
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25640

Abstract

Abstract. Postoperative pain following Caesarean section (CS) requires effective analgesic management to promote optimal recovery. This study aimed to identify the analgesic utilization profile and evaluate the effectiveness of analgesic combinations for postoperative pain management in patients undergoing CS at a regional public hospital in Bandung, Indonesia. An analytical observational study with a retrospective design was conducted using medical records of patients who met the inclusion criteria. Analgesic effectiveness was assessed by changes in the Numeric Rating Scale (NRS) score during the first 24 hours after surgery. Data were analyzed using the Kolmogorov–Smirnov and Kruskal–Wallis tests. The results showed that the paracetamol–ketorolac combination was the most frequently prescribed regimen (110 patients; 81.5%), followed by paracetamol–tramadol (16 patients; 11.9%) and paracetamol–dexketoprofen (9 patients; 6.7%). Among patients with moderate pain, the paracetamol–dexketoprofen combination produced the greatest mean reduction in NRS score (Δ = 1.44). However, the Kruskal–Wallis test demonstrated no statistically significant difference in analgesic effectiveness among the three combinations in the moderate pain group (p > 0.05). These findings indicate that paracetamol–ketorolac, paracetamol–dexketoprofen, and paracetamol–tramadol provide comparable effectiveness for postoperative pain management after Caesarean section and may be selected according to patients' clinical conditions. Abstrak. Nyeri pasca operasi Sectio Caesarea (SC) merupakan komplikasi yang memerlukan penatalaksanaan analgesik yang efektif untuk mendukung proses pemulihan pasien. Penelitian ini bertujuan mengidentifikasi profil penggunaan analgesik serta mengevaluasi efektivitas kombinasi analgesik dalam manajemen nyeri pasca operasi SC di salah satu RSUD Kota Bandung. Penelitian ini menggunakan desain observasional analitik dengan pendekatan retrospektif terhadap data rekam medis pasien yang memenuhi kriteria inklusi. Efektivitas analgesik dievaluasi berdasarkan perubahan skor Numeric Rating Scale (NRS) selama 24 jam pertama pasca operasi dan dianalisis menggunakan uji Kolmogorov-Smirnov serta uji Kruskal-Wallis. Hasil penelitian menunjukkan bahwa kombinasi paracetamol-ketorolac merupakan regimen yang paling banyak digunakan yaitu sebanyak 110 pasien (81,5%), diikuti paracetamol-tramadol sebanyak 16 pasien (11,9%) dan paracetamol-dexketoprofen sebanyak 9 pasien (6,7%). Pada kelompok nyeri sedang kombinasi paracetamol-dexketoprofen memberikan rerata penurunan skor NRS tertinggi (Δ=1,44). Namun, uji Kruskal–Wallis menunjukkan tidak terdapat perbedaan efektivitas yang bermakna antar ketiga kombinasi analgesik baik pada kelompok nyeri sedang (p>0,05). Sehingga dapat disimpulkan kombinasi paracetamol-ketorolac, paracetamol-dexketoprofen, dan paracetamol-tramadol memiliki efektivitas yang relatif setara dalam manajemen nyeri pasca operasi Sectio Caesarea dan dapat digunakan sebagai pilihan terapi sesuai kondisi klinis pasien
Uji Aktivitas Antibakteri Obat Kumur Ekstrak Kulit Rambutan terhadap Steptococcus Mutans Muhammad Fauzan Mutaqien; Siti Hazar; Fetri Lestari
Bandung Conference Series: Pharmacy 771 - 778
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25703

Abstract

Abstract. Dental caries is still one of the infectious diseases that occur in the community. One of the causes of dental caries is the growth  of Streptococcus mutans. The use of mouthwash can help inhibit the growth of these bacteria. In this study, an antibacterial activity test was carried out on the ethanol extract of rambutan skin (Nephelium lappaceum L) and mouthwash preparations containing ethanol extract of rambutan skin. This antibacterial activity test was carried out using the diffusion method so that the method of subsidy. Antibacterial activity is shown by the presence of an obstruction diameter around the subsidy. The test concentrations used in this study were 5%, 10% and 20% ethanol extract of rambutan skin and mouthwash preparations of 10% and 20% of rambutan skin ethanol extract. And a chlorhexadine comparator of 0.2%. The results of the activity test showed that the extract and preparation of ethanol extract of rambutan skin had antibacterial activity with the largest inhibitory diameter in ethanol extract with a concentration of 20% of 6.59 mm and a 20% preparation with a diameter of 5.93 mm. Abstrak. Karies gigi masih menjadi salah satu penyakit infeksi yang terjadi dimasyarakat. Salah satu penyebab karies gigi adalah adanya pertumbuhan Streptococcus mutans. Penggunaan obat kumur dapat membantu menghambat pertumbuhan bakteri tersebut. Pada penilitian ini dilakukan uji aktivitas antibakteri ekstrak etanol kulit rambutan (Nephelium lappaceum L) dan sediaan obat kumur yang mengandung ekstrak etanol kulit rambutan. Uji aktivitas antibakteri ini dilakukan menggunakan metode difusi agar cara sumuran. Aktivitas antibakteri ditunjukan daengan adanya diameter hambat disekitar sumuran. Konsentrasi uji yang digunakan pada penelitian ini yaitu ekstrak etanol kulit rambutan 5%, 10% dan 20% serta sediaan obat kumur ekstrak etanol kulit rambutan 10% dan 20%. Dan pembanding klorheksadin 0,2%. Hasil pengujian aktivitas menunjukan bahwa ekstrak maupun sediaan ekstrak etanol kulit rambutan memiliki aktivitas antibakteri dengan diameter hambat terbesar pada ekstrak etanol dengan konsentrasi 20% sebesar 6,59 mm dan sediaan 20% dengan diameter 5,93 mm.
Pengaruh Regimen Terapi Penyakit Jantung terhadap Kadar Kalium di RSUD Welas Asih Provinsi Jawa Barat Periode 2025 Nabila Nuzulhaq Aghnia Fahma; Fetri Lestari; Andrian Hoerul Anwar
Bandung Conference Series: Pharmacy 967 - 974
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.26291

Abstract

Abstract. Potassium balance is important to monitor in cardiovascular disease patients, as changes in potassium levels can affect cardiovascular status. Cardiac drug regimens, particularly diuretics and agents acting on the renin-angiotensin-aldosterone system, may alter potassium levels through different mechanisms, yet outpatient monitoring is often insufficient. This study aimed to describe potassium levels according to cardiac drug regimens among outpatients with cardiovascular disease at Welas Asih Regional Hospital, West Java Province, in 2025. This retrospective observational study used medical records of outpatients with cardiovascular disease as secondary data. Drug regimens were grouped by drug class based on potential effect on potassium balance, and data were processed descriptively to determine the distribution and mean potassium level per group. Of 159 patients, 149 were categorized into the predefined groups. Mean potassium level was 3.91 mEq/L, with hypokalemia in 32 patients (21.48%), normal levels in 116 patients (77.85%), and hyperkalemia in 1 patient (0.67%). The loop diuretic monotherapy group showed the highest hypokalemia proportion (43.75%), while the MRA-ACEI/ARB combination group showed the highest mean potassium and hyperkalemia occurrence (5.88%). Potassium levels varied across regimen groups. Regular monitoring is recommended for patients receiving therapy that may affect electrolyte balance to support treatment safety. Abstrak. Keseimbangan kadar kalium penting dipantau pada pasien penyakit jantung karena perubahan kadar kalium dapat mempengaruhi kondisi kardiovaskular. Regimen obat jantung, terutama diuretik dan obat yang bekerja pada sistem renin-angiotensin-aldosteron, dapat mempengaruhi kadar kalium melalui mekanisme farmakologis berbeda, namun pemantauan pada pasien rawat jalan masih sering kurang diperhatikan. Penelitian ini bertujuan mengetahui gambaran kadar kalium berdasarkan regimen obat jantung pada pasien rawat jalan penyakit jantung di RSUD Welas Asih, Provinsi Jawa Barat, tahun 2025. Penelitian observasional retrospektif ini menggunakan data rekam medis pasien rawat jalan penyakit jantung sebagai data sekunder. Regimen obat dikelompokkan berdasarkan golongan obat sesuai potensi pengaruhnya terhadap kadar kalium, lalu data diolah deskriptif untuk melihat distribusi dan rata-rata kadar kalium tiap kelompok. Dari 159 pasien, 149 pasien dapat dikelompokkan sesuai kelompok regimen yang ditentukan. Rata-rata kadar kalium sebesar 3,91 mEq/L, dengan hipokalemia pada 32 pasien (21,48%), kadar normal pada 116 pasien (77,85%), dan hiperkalemia pada 1 pasien (0,67%). Kelompok diuretik loop tunggal menunjukkan proporsi hipokalemia tertinggi (43,75%), sedangkan kelompok kombinasi MRA dengan ACEI/ARB menunjukkan rata-rata kadar kalium tertinggi dan kejadian hiperkalemia sebesar 5,88%. Kadar kalium bervariasi antar kelompok regimen obat jantung. Pemantauan kadar kalium berkala disarankan bagi pasien penerima terapi berpotensi mempengaruhi keseimbangan elektrolit guna mendukung keamanan pengobatan.
Co-Authors 10060321013, Lutfi Anggita Adinda Dewani Soetadipura Aliya Rahmah Adriani Ananda Rizkita Najla Cahyadi Andrian Hoerul Anwar Anggietha Zahra Khairunnisa Annas Tasya Pertiwi Aryuqo Ardha Syaqa Avi Admikowati Bambang Tri Laksono Danisa Fadila Fauziah Dendi Ardian Dieni Mardliyani Diva Rachmadita Kusumawardani Esti Rachmawati Sadiyah Faris Fauzan Alkabir Firda Amelya Fitri Nurhalimah Fitriani, Nisa Ghina Hanifah Nur Azizah Gita Cahya Eka Darma Hana Tulia Fazin Hasna Afiyah Kosasih Hilda Aprilia, Hilda Hilda Novianti Putri Iis Rosita Ina Willona Rudi Indah Ayu Lestari Indri - Aryanti Ivanka Salsabilla Nurhadi Kamilah Ratna Khalidah Kartika, Rikka Kiki Mulkiya Yuliawati Laila Afifah AB Lanny Mulqie Levina Geby Dwi Putri Alamsyah Mardliyani, Dieni Maulana, Muhammad Adril Meicia Lutfiah Ivanca Mochamad Tanto Kuswanto Mohamad Vito Gandana Muhamad Erza Ardhana Muhammad Adril Maulana Muhammad Fakhry Ramadhan Muhammad Fauzan Mutaqien Muhammad Raja Fachri Buldan Munadiya Waridatiddiyanah Fauzi Mutiara Dewi Fitaloka Mutiara Nur Afni Nabila Nur Azhari Nabila Nuzulhaq Aghnia Fahma Nashwa Fika Nafillah Niken Suci Meliani Hernawan Nisa Fitriani Nurmala Nurmala Nurul Azmi Fatarani Nurul Susanti Pramudita Putri Azzahra Rani Rani Ratih Aryani, Ratih Ratu Choesrina Ratu Choesrnia Rikka Kartika Riri karima Risa Apriani Hilyah RISA NURRAHWANI Salsa Meika Pramudita Salsabila Ramadhania Sani Ega Priani Silviya Nur Hasanah Siti Alifa Dzulnadifa Siti Aminah Siti Hazar Sonia Vicka Farlinza Sri Peni Fitrianingsih Suwendar Suwendar Syahirah Anissa Arief Taufik Muhammad Fakih Tria Septiani, Tria Septiani Umi Yuniarni Vira Apriliandani Wafda Shofia Yani Lukmayani