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All Journal Jurnal Kedokteran Diponegoro Jurnal Kesehatan Andalas Biomedical Journal of Indonesia Syntax Literate: Jurnal Ilmiah Indonesia Majalah Kedokteran Andalas Human Care Journal Jurnal Ners Indonesian Journal of Health Sciences Research and Development (IJHSRD) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Eduvest - Journal of Universal Studies Jurnal Penyakit Dalam Indonesia Jurnal Mahasiswa Ilmu Kesehatan Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan
Roza Mulyana
Division Of Geriatric, Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Covid-19 Infection in Elderly with Comorbids Edo Yudistira; Roza Mulyana
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.376

Abstract

The senior population has a higher risk of contracting Covid-19 and is at risk of developing more severe disease. This is due to physiological changes in old age, which causes a decrease in immune function accompanied by an increase in comorbid disorders such as diabetes, hypertension, heart disease, lung disease, and dementia. WHO reports that the mortality rate for Covid-19 patients in the elderly above 80 years in China is around 21.9%, Italy is about 89% at the age above 70 years, and the United States is 85% at the age of 65 years and over. Delirium syndrome often appears as the primary complaint or infrequently; it occurs on the first day the patient is treated and shows fluctuating symptoms. Symptoms of delirium, such as disorientation, difficulty concentrating, and inattention, often occur in the elderly and are associated with a poor prognosis. Management of geriatric patients with covid 19 must be carried out thoroughly and completely, especially in geriatric patients with comorbidities. Management includes primary diseases, namely Covid-19 infection, delirium, nutritional therapy, blood sugar, family education for patient assistance, maintaining the patient's body and environment cleanliness, oral hygiene, and, last but not least, moral support from the family for the patient. With complete management, elderly patients with various comorbid can survive the Covid-19 infection.
Chronic Kidney Disease Related to Cognitive Disorders in the Elderly: A Narrative Literature Review Ajat Sudrajat; Drajad Priyono; Harnavi Harun; Roza Kurniati; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.663

Abstract

Chronic kidney disease (CKD) is characterized by progressive and irreversible kidney damage, leading to the inability of the kidneys to perform their functions. Chronic kidney disease causes hypertension, anemia, vascular dysfunction, uremia, proteinuria, systemic inflammation, and oxidative stress associated with cognitive impairment. Age is a population group aged 60 years or more at risk of experiencing health problems and the consequences associated with CKD. One of the common comorbidities experienced by elderly patients with CKD is cognitive impairment. Current treatment options for CKD with cognitive impairment aimed at common risk factors, including angiotensin converting enzyme inhibitors (ACEI) and, angiotensin receptor blockers (ARBs), SGLT-2 inhibitors., GLP-1 RA, and DPP-4 inhibitors. Other interventions, such as erythropoietin (EPO) compensation and reduction of inflammation and oxidative stress, can help improve patients' clinical symptoms. This literature review aims to describe the relationship between chronic kidney disease and cognitive disorders that occur in the elderly.
Hubungan Obesitas dengan Kejadian Gastroesophageal Reflux Disease di RSUP Dr. M. Djamil Padang Iqbal Muhammad Helmi; Delmi Sulastri; Roza Mulyana
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 3 (2022): September 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i3.930

Abstract

Latar Belakang: Gastroesophageal Reflux Disease merupakan kondisi patologis akibat refluks kandungan lambung ke esofagus yang terjadi berulang kali. Kondisi obesitas dapat meningkatkan tekanan intra-abdomen dan menurunkan fungsi esofagus serta Lower Esophageal Sphincter sehingga risiko Gastroesophageal Reflux Disease akan meningkat. Objektif: Penelitian ini bertujuan untuk melihat hubungan antara obesitas dan kejadian Gastroesophageal Reflux Disease di RSUP Dr. M. Djamil Padang tahun 2018-2019. Metode: Jenis penelitian ini adalah analitik observasional menggunakan pendekatan retrospektif dengan rancangan penelitian case-control study yang telah berlangsung dari bulan November hingga Desember 2021 di Instalasi Rekam Medis RSUP Dr. M. Djamil Padang. Penelitian ini menggunakan teknik pengambilan simple random sampling dengan jumlah sampel sebanyak 38 pasien kelompok kasus dan 38 pasien kelompok kontrol. Penelitian ini dilakukan menggunakan uji Chi-Square dengan cara membandingkan frekuensi penderita obesitas pada kelompok kasus dan kontrol. Hasil: Hasil penelitian ini memperoleh 52,6% kelompok kasus mederita obesitas dan 10,5% kelompok kontrol menderita obesitas. Berdasarkan uji Chi-square, terdapat hubungan yang bermakna antara obesitas dengan kejadian Gastroesophageal Reflux Disease (p=0,001, OR=9,444). Kesimpulan: Kesimpulan pada penelitian ini adalah terdapat hubungan yang bermakna antara obesitas dengan kejadian Gastroesophageal Reflux Disease di RSUP Dr. M. Djamil.
The Role of Corticosteroids in the Management of Drug Allergy: A Narrative Literature Review Rivani Sintia Suratman; Rudy Afriant; Roza Mulyana; Saptino Miro; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.773

Abstract

Drug allergy is an adverse drug reaction that occurs through an immune reaction that occurs through IgE or a rapid hypersensitivity reaction with various mechanisms and clinical presentations. One of the therapeutic modalities for drug allergies is corticosteroids. In allergic processes, corticosteroids can suppress the production and effects of humoral factors involved in the inflammatory response, inhibit the migration of leukocytes to sites of inflammation, and interfere with the function of endothelial cells, granulocytes, mast cells, and fibroblasts. This literature review aimed to describe the role of corticosteroids in the management of drug allergies. Corticosteroids are used very widely in the treatment of various allergic diseases because of their strong anti-inflammatory properties. Corticosteroids inhibit the synthesis of a number of cytokines, such as the interleukins IL-1 to IL-6, tumor necrosis factor-α (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF). In conclusion, corticosteroids are one of the therapeutic modalities in various manifestations of drug allergies. Every drug allergy gets the anti-inflammatory effects of corticosteroids with different choices, routes, and doses for each manifestation.
Hubungan Rasio Neutrofil-Limfosit dengan Derajat Keparahan COVID-19 pada Pasien Diabetes Zahara Findi; Beni Indra; Netti Suharti; Muhammad Zulfadli Syahrul; Roza Mulyana; Elfira Yusri
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i2.1072

Abstract

Latar Belakang: Corona Virus Disease 2019 (COVID-19) merupakan penyakit yang disebabkan oleh SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2). Peningkatan kasus COVID-19 di Indonesia cukup cepat dan menyebar ke berbagai wilayah di Indonesia. Diabetes Melitus merupakan salah satu komorbiditas yang berkaitan dengan infeksi berat COVID-19, gagal napas akut, dan peningkatan mortalitas pasien COVID-19. Oleh karena itu, diperlukan penanda klinis yang ekonomis, cepat, dan bersifat sensitif dan spesifik. Peningkatan rasio neutrofil-limfosit merupakan biomarker peradangan yang mudah dianalisis untuk memprediksi risiko COVID-19 dan menilai keparahan COVID-19. Objektif: Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara rasio neutrofil-limfosit dengan derajat keparahan COVID-19 pada pasien diabetes. Metode: Jenis penelitian adalah kohort retrospektif dengan teknik convenience sampling. Sampel pada penelitian ini adalah 84 pasien diabetes yang terkonfirmasi COVID-19 pada bulan April 2020 hingga Agustus 2021 di RS Universitas Andalas. Data dianalisis menggunakan uji Chi-square dan Independent group t-test. Hasil: Hasil penelitian didapatkan derajat keparahan COVID-19 paling banyak pada derajat berat (32,1%). Terdapat hubungan yang signifikan antara rasio neutrofil-limfosit dengan derajat keparahan COVID-19 (p = 0,00). Gula darah sewaktu pada kasus severe (291.82 mg/dL) lebih tinggi dibandingkan dengan kasus non severe (272.33 mg/dL), tetapi secara statistik tidak signifikan (p = 0,389). Kesimpulan: Kesimpulan dari penelitian ini adalah terdapat hubungan yang signifikan antara rasio neutrofil-limfosit dengan derajat keparahan COVID-19 pada pasien diabetes. Peningkatan rasio neutrofil-limfosit ini dapat digunakan sebagai penanda awal yang mempengaruhi derajat keparahan COVID-19 pada pasien diabetes.
Perbedaan Kadar Insulin-Like Growth Factor-1 dan Tumor Necrosis Factor-α Serum pada Berbagai Derajat Sarkopenia Pasien Lanjut Usia: Studi Potong Lintang Tamayo, Auliangi; Mulyana, Roza; Martini, Rose Dinda
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Sarcopenia is a phenomenon of progressive decline in muscle function that occurs due to the aging process. Insulin-like growth factor-1 (IGF-1) and tumor necrosis factor-α (TNF-α) have an important role in the occurrence of sarcopenia as a positive and negative regulator of muscle mass. Research shows differences in IGF-1 and TNF-α levels between sarcopenia and non-sarcopenia groups, but research on differences in severity of sarcopenia remains unclear. The purpose of this study was to determine the difference in levels of IGF-1 and TNF-α in various degrees of sarcopenia in elderly patients. Methods. This was an analytical observational study with a cross-sectional approach involving 45 subjects of elderly patients who came to the internal outpatient clinic of RSUP dr. M. Djamil Padang and met the criteria for inclusion and exclusion. Subjects were grouped into possible sarcopenia, sarcopenia, and severe sarcopenia. Then, serum IGF-1 and TNF-α examinations were performed using the enzyme linked immunosorbent assay (ELISA) method. Data was analyzed using SPSS 26.0. Results. Median of serum IGF-1 levels in the total sample were 41.36 ng/mL. The highest levels of IGF-1 were found in the possible sarcopenia group (55.28 ng/mL), while the lowest level was in the severe sarcopenia group (31 ng/mL). Median of serum TNF-α levels in the total sample were 157.63 ng/L with the lowest was found in the possible sarcopenia group (111.41 ng/L) and the highest was in the severe sarcopenia group (241.1 ng/L). There was a significant difference in serum levels of IGF-1 and TNF-α in the three sarcopenia groups (p= 0.001). IGF-1 levels decreased according to the severity of sarcopenia, while TNF-α levels increased according to the severity of sarcopenia. Conclusions. There are differences in serum levels of IGF-1 and TNF-α between possible sarcopenia, sarcopenia, and severe elderly sarcopenia.
Hubungan Tingkat Nyeri LBP dengan ADL pada Lansia di Puskesmas Padang Kandis Natasya Alamanda Martias; Roza Mulyana; Yuliarni Syafrita
Jurnal Mahasiswa Ilmu Kesehatan Vol. 3 No. 1 (2025): Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v3i1.2221

Abstract

As the elderly age, there are changes in physical changes that affect all systems, including the musculoskletal system. One of the daily health problems that often interfere with Activity of Daily Living in the elderly is low back pain (LBP)./1. This study aims to determine the relationship between LBP pain levels and ADL in elderly women in the Padang Kandis Health Center working area, Lima Puluh Kota Regency. This study is an observational analytic study with a cross sectional approach. The sampling technique used consecutive sampling technique with a total sample of 45 samples. Data collection using the Visual Analogue Scale (VAS) questionnaire, LBP, Katz Basic Activities Of Daily Living Scale (Index Katz). Data analysis using the Pearson Chi-Square test. The results of the Chi-Square test obtained a significant value (p-value) of 0.000 (p < 0.05). The p-value is smaller than 0.05 (0.000 <0.05), so the test decision is Ha accepted, which means “there is a relationship between the level of LBP pain and ADL in the elderly in the Padang Kandis Health Center working area, Guguak District, Lima Puluh Kota Regency, West Sumatra Province”. This study shows that there is a relationship between the level of LBP pain and ADL.
Correlation Of Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio With Severity Of COVID-19 Warman, Fadil Ahmadhia; Yulia, Dwi; Kadri, Husnil; Mulyana, Roza; Yusri, Elfira; Putra, Syandrez Prima
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1361-1375.2024

Abstract

The neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) tests are simple tests can be done before a COVID-19 patient hospitalized. This examination is useful for determining the diagnosis and prognostic of the patient. The aim of the study was to determine the correlation between NLR and PLR with the severity of COVID-19. This research was an analytical study with a cross-sectional approach using secondary data from 289 medical records of patients with confirmed COVID-19 for the period June-August 2021. The total sampling technique was used and processed with the chi-square test. Most of the research subjects were in the range of 26-45 years (28.4%). More than half of the subjects were female (61.6%). There were 99 patients (34.3%) with severe conditions. Less than half of the patients had abnormal leukocyte and platelet examination results, namely 64 (22.1%) and 56 (19.4%). Patients with abnormal NLR and PLR examinations were 135 (46.7%) and 123 (42.6%). There was a significant correlation between NLR and the severity of COVID-19 inpatients (p<0.001, OR=9.452). There is a significant correlation between PLR and the severity of COVID-19 inpatients (p<0.001, OR=7.268). This study concludes a significant correlation between NLR and PLR with the severity of COVID-19.
Kekuatan Genggaman Tangan Sebagai Marker Klinis Keterbatasan Mobilitas Fahrurozi, R. Ifan Arief; Mulyana, Roza; Martini, Rose Dinda; Triansyah, Fandi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i1.56211

Abstract

Adanya penurunan fungsi organ tubuh secara alamiah pada lansia menimbulkan berbagai gangguan fungsional tubuh seperti gangguan mobilitas mulai dari penurunan kecepatan berjalan, fungsi keseimbangan, kemampuan fungsional dan kemandirian dalam aktivitas kehidupan sehari – hari. Salah satu prediktor penting dari mobilitas adalah kekuatan otot. Kekuatan genggaman tangan digunakan sebagai indikator dalam evaluasi frailty dan sarkopenia yang terkait dengan berbagai luaran klinis negatif pada lansia. Penelitian ini merupakan penelitian kuantitatif deskriptif dengan pendekatan cross-sectional, yang bertujuan untuk menganalisis hubungan antara kekuatan genggaman tangan, massa otot, dan kinerja fisik pada individu lanjut usia. Terdapat korelasi yang signifikan antara pengukuran kekuatan genggaman tangan dengan keterbatasan mobilitas. Temuan ini mengindikasikan bahwa kekuatan genggaman tangan dapat digunakan sebagai alat skrining yang efektif dan marker klinis untuk mengidentifikasi lansia dengan risiko tinggi terhadap keterbatasan mobilitas sehingga dapat membantu dalam perencanaan intervensi dan pengelolaan lansia dengan frailty dan sarkopenia.
Dietary BCAAs (Branched Chain Amino Acids) and Cognitive Function: Implications for Nutritional Interventions in Elderly Populations Willya Eka Putri; Nur Indrawaty Lipoeto; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1286

Abstract

Background: The aging process is often accompanied by a decline in cognitive function, impacting memory, attention, and decision-making. Malnutrition, including protein deficiency, is recognized as a contributing factor to cognitive decline in elderly populations. Branched-chain amino acids (BCAAs), essential amino acids obtained solely from dietary sources, play a pivotal role in various physiological processes, including neurotransmitter synthesis and protein synthesis in the brain. This study aims to investigate the relationship between serum BCAA levels and cognitive function in elderly individuals. Methods: A cross-sectional study was conducted on 25 elderly subjects (age > 60 years) in Padang, Indonesia. Serum BCAA levels were measured using High-Performance Liquid Chromatography (HPLC), and cognitive function was assessed using the Montreal Cognitive Assessment - Indonesian version (MoCA-Ina). Statistical analysis was performed to determine the correlation between BCAA levels and MoCA-Ina scores. Results: The mean serum levels of total BCAAs, leucine, isoleucine, and valine in the elderly subjects were 0.40 ± 0.15 mM, 0.09 ± 0.06 mM, 0.05 ± 0.02 mM, and 0.26 ± 0.10 mM, respectively. The median MoCA-Ina score was 23 (range: 8-27), indicating a significant proportion of participants with cognitive impairment. Statistical analysis revealed no significant correlation between total BCAA levels and MoCA-Ina scores (r = 0.071, p = 0.735). However, a moderate positive correlation was observed between isoleucine levels and MoCA-Ina scores (r = 0.344, p = 0.092), although not statistically significant. Conclusion: This study suggests that serum BCAA levels, particularly isoleucine, may have implications for cognitive function in elderly populations. Further research with a larger sample size and longitudinal design is warranted to elucidate the complex relationship between dietary BCAAs, serum BCAA levels, and cognitive health in aging individuals.
Co-Authors Afriwardi Afriwardi Ajat Sudrajat Almurdi Almurdi Amatullah, Afifah Amel Yanis Amir , Arni Arief, Muhammad Arina Widya Murni Asir, Taufik Rizkian Auliangi Tamayo Beni Indra, Beni Bobby Indra Utama Deka Viotra Delmi Sulastri Dian Pertiwi Drajad Priyono Dwitya Elvira, Dwitya Edo Yudistira Elfira Yusri Elmatris Sy Erlina Rustam Ety Yerizel Eva Decroli Fadrian, Fadrian Fahrurozi, R. Ifan A. Fahrurozi, R. Ifan Arief Fandi Triansyah Fandi Triansyah Fika Tri Anggraini Firdawati Firdawati Haegha Satya Negara Harun Harnavi Hendra Permana Husna Fauziah Husnil Kadri Iqbal Muhammad Helmi Jersivindo Ranazeri Kuntjoro Harimurti Laksono Trisnantoro Malinda Meinapuri Martini, Rose D Martini, Rose D Muhammad Bintang Alvinanda Muhammad Imam Arrasyid Muhammad Ridho Azhari Murni, Arina W Nani Hendriani, Nani Natasya Alamanda Martias Netti Suharti Nidya Angryni Noto Dwimartutie Noverika Windasari Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurhayati, Nurhayati Nurul Fadila Putri, Rauffi Hayatul R. Ifan Arief Fahrurozi R. Ifan Arief Fahrurozi Rahmani Welan Rahmatini . RAVEINAL RAVEINAL Raveinal Raveinal Rika Susanti Rivani Sintia Suratman Rose Dinda Martini Rose Dinda Martini Roza Kurniati Rudy Afriant Saptino Miro Saptino Miro, Saptino Sasqia Trizolla Sisi Ermoniza Siti Setiati Syahrul, Muhammad Zulfadli Syandrez Prima Putra Tamayo, Auliangi Triansyah, Fandi Vesri Yoga Vyora Ulvyana Warman, Fadil Ahmadhia Willya Eka Putri Yorencia Akmal yossa tamia marisa Yudistira, Edo Yugo Berri Putra Rio Yulia, Dwi Yuliarni Syafrita Yulistini Yunia Habsari Yusri, Elfira Zaffarsyah, Muhammad Irsyad Zahara Findi